Article
Chemistry, Multidisciplinary
Xuemeng Zhang, Wei Wang, Richard N. Zare, Qianhao Min
Summary: The combination of bio-affinity arrays (BAAs) and nano-electrospray desorption electrospray ionization mass spectrometry (nano-DESI-MS) enables high-throughput identification and quantification of protein/peptide biomarkers from biofluids in a label-free manner. This integrated MS platform has the potential to play a significant role in disease diagnosis and clinical applications.
Article
Food Science & Technology
Yuanhao Zhou, Jiawen Ai, Lingli Cai, Yiyong Yan, Bingzhi Wang, Hongzhen Ma, Quan Yu, Jianhua Zhou, Xinming Huo
Summary: Excessive pesticide use poses a significant threat to food safety. This study developed a rapid on-site screening method for pesticide residues on vegetable surfaces using a miniature mass spectrometer. By combining full scan MS and tandem MS analysis methods, the proposed method achieved high accuracy in qualitative recognition and on-site quantitative analysis.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Chemistry, Analytical
Junhan Wu, Wenpeng Zhang, Zheng Ouyang
Summary: A novel on-demand MS analysis method was developed based on discontinuous ion injection-induced ESI on a miniature MS system, enabling highly efficient ionization under low voltages. This method was found to be softer for ionization of proteins and allowed single-cell analysis with reduced sample consumption.
ANALYTICAL CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Karol Jaroch, Janusz Pawliszyn
Summary: The coated probe electrospray ionization (coated-PESI) and coated blade spray (CBS) techniques are suitable for monitoring drug biotransformation. Coated-PESI is preferred for limited sample volumes, while CBS can achieve the same extraction efficiency as protein precipitation. Both methods provide results in a few minutes with high sensitivity.
JOURNAL OF PHARMACEUTICAL ANALYSIS
(2022)
Article
Environmental Sciences
Ricardo Alves Bernardo, Jean Carlos Pereira Sousa, Matheus Gallimberti, Fernando Barbosa Junior, Boniek Gontijo Vaz, Andrea Rodrigues Chaves
Summary: Concerns over human health risks due to the use of bisphenol A in thermal papers have led to its replacement by bisphenol S. Analyzing bisphenols typically involves laborious and time-consuming steps, but a new paper spray ionization mass spectrometry (PSI-MS) method offers a faster and efficient alternative. The study found that bisphenol S concentrations in BPA-free thermal papers ranged from 1.36 to 6.77 mu g g(-1), while BPA concentrations in all samples of thermal paper ranged from 6.56 to 16.4 mu g g(-1).
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Chemistry, Analytical
Daniel Foest, Alexander Knodel, Sebastian Brandt, Joachim Franzke
Summary: Fast and accurate analysis of complex biological samples is a crucial challenge in clinical and life sciences. Paper spray ionization (PSI) is an ambient ionization technique for mass spectrometry that can be enhanced by the addition of a flexible microtube plasma (FmTP) to detect both polar lipids and non-polar compounds. This approach increases the number of detectable species in a single measurement and serves as a powerful tool for analyzing complex biological samples in clinical and life sciences.
ANALYTICA CHIMICA ACTA
(2022)
Article
Chemistry, Multidisciplinary
Thi Minh Hoa Nguyen, Woo-Young Song, Tae-Young Kim
Summary: This study systematically evaluated the factors affecting the ionization efficiency of paper spray ionization (PSI) and classified the observed paper spray plume into three modes. The rim-jet mode exhibited the highest ionization efficiency among the three modes. The charge density of the droplets generated by paper spray, influenced by the electric field and solvent supply rate, was found to be the main parameter determining the spray mode.
FRONTIERS IN CHEMISTRY
(2022)
Article
Chemistry, Analytical
Xuan Gu, Shanshan Jia, Wangmin Hu, Mengdi Cui, Junling Hou, Rufeng Wang, Mei Zhang
Summary: This study developed a rapid analytical method for the quality evaluation of Chinese herbal medicine based on paper spray ionization-miniature mass spectrometry (PSI-mini-MS/MS). Using Lygodium japonicum as an example, a multi-component quality evaluation strategy was employed, and nine active constituents were selected for quality control. The method showed consistent results between the herbal extracts and standards, and a mini-MS-based quantitative approach was developed. The study demonstrates the feasibility of using mini-MS for quality evaluation of herbal medicines and its potential for future applications.
ANALYTICAL METHODS
(2023)
Article
Chemistry, Analytical
Ping Guo, Ke Min, Wei Luo, Si Huang, Zihui Yang, Ming Ma, Shubin Liu, Zhengfa Fang, Bo Chen, Han Zuilhof
Summary: Ambient ionization of glycans can be achieved efficiently by spraying from a paper surface impregnated with alkali metal salt. This method allows for the formation of abundant alkali metal adduct ions from monosaccharides, oligosaccharides, and ring glycans, resulting in simple and clean mass spectra. The approach is specific for glycans and has been successfully applied in the determination of glycans and glycoconjugates in various biological matrices.
Article
Chemistry, Analytical
Sierra Jackson, Suji Lee, Abraham K. Badu-Tawiah
Summary: Microfluidic paper-based analytical devices (μPADs) are emerging as a prominent platform for disease detection in developing countries. However, their detection limits are inadequate and require test results to be read within a specific time interval for accuracy. This paper presents an on-chip mass spectrometry (MS) detection strategy for immunoassays performed on paper substrates and demonstrates its feasibility in malaria antigen detection.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Meng Chen, Yuhan Shang, Hua Bai, Qiang Ma
Summary: A green analytical protocol has been developed for the analysis of anionic compounds. By optimizing operational parameters and using specific ionization and mass spectrometry analysis strategies, the signal intensity was significantly enhanced, and the accuracy and sensitivity of the method were validated. The high greenness score indicates a wide range of potential applications.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Vincen Wu, Jocelyn Tillner, Emrys Jones, James S. McKenzie, Dipa Gurung, Anna Mroz, Liam Poynter, Daniel Simon, Cristina Grau, Xavier Altafaj, Marc-Emmanuel Dumas, Ian Gilmore, Josephine Bunch, Zoltan Takats
Summary: This study examines the suitability of desorption electro-flow focusing ionization (DEFFI) for mass spectrometry imaging (MSI) of biological tissue, comparing its performance to the traditional desorption electrospray ionization (DESI). The flow focusing mechanism in DESI offers advantages such as a rotationally symmetric electrospray jet, higher intensity, controllable parameters, and better portability. The optimized parameters for DEFFI result in similar images to DESI but with better sensitivity.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Meng Chen, Yuhan Shang, Hua Bai, Qiang Ma
Summary: Green analytical chemistry aims to develop analytical methods that minimize the use and generation of hazardous substances to protect human health and the environment. In this study, a green analytical protocol was developed for the analysis of anionic compounds using ionization spraying and a miniature mass spectrometer. The method achieved efficient analysis of haloacetic acids through optimization of operational parameters and the use of dual-channel ionization and mass spectrometry. The method demonstrated high recoveries, low detection and quantification limits, and displayed a high degree of greenness.
ANALYTICAL CHEMISTRY
(2022)
Article
Biochemical Research Methods
Sangeeta Pandey, Yanyang Hu, Lane R. Bushman, Jose Castillo-Mancilla, Peter L. Anderson, R. Graham Cooks
Summary: In this study, we developed a quantitative point-of-care assay using a miniature mass spectrometer to assess drug concentrations of cabotegravir and rilpivirine in whole blood. The assay demonstrated fast turnaround time, portability, low power consumption, and specificity, making it suitable for measuring drug concentrations using small volumes of patient blood in a walk-in clinic.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Xian-Shuang Meng, Yi-Jing Liu, Hong-Wei Wang, Xing-Zhou Guo, Qing Lyu, Hua Bai, Qiang Ma
Summary: A rapid on-site analytical method for 13 kinds of bisphenol (BP) compounds in toys using magnetic ionic liquid dispersive liquid-liquid microextraction (MIL-DLLME) combined with a miniature mass spectrometer was established. The method demonstrated good linear relationships, low limits of detection and quantification, high recoveries, and low relative standard deviations. It has great potential for the detection of bisphenol compounds in plastic toy products.
CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
(2023)
Article
Engineering, Civil
Qiang Ma, Jia Mou, Henglin Xiao, Zhizao Bao
Summary: JTES pile composite foundation is a new method for treating soft soil ground. Through vertical static load comparison tests, the load-settlement characteristics and load-transfer mechanism of JTES pile composite foundation were studied. The results showed that JTES pile composite foundation has higher ultimate bearing capacity and smaller settlement compared to other foundations.
EUROPEAN JOURNAL OF ENVIRONMENTAL AND CIVIL ENGINEERING
(2023)
Article
Engineering, Civil
Lihua Li, Langling Qin, Henglin Xiao, Zhi Hu, Guofang Xu, Qiang Ma
Summary: This study investigated the effect of particle sizes and sand contents on the mechanical behavior of recycled construction and demolition (C&D) materials. The results showed that adding an appropriate amount of sand can improve the particle gradation and maximum dry density of the materials, as well as increase the overall strength of the specimens.
EUROPEAN JOURNAL OF ENVIRONMENTAL AND CIVIL ENGINEERING
(2023)
Article
Chemistry, Analytical
Fangfang Lu, Yajun Zheng, Yuan Zhang, Qiang Ma, Zhiping Zhang
Summary: Portable sampling of target analytes in complex biofluid samples using paper-in-tip spray ionization enables efficient and high sensitivity mass spectrometric analysis of therapeutic drugs and proteins. This technique allows for a long and stable spray duration with minimal spray solvent, enabling quick analysis of complex samples with high quantitation precision at picogram-per-milliliter levels.
ANALYTICAL METHODS
(2022)
Article
Cell & Tissue Engineering
Xin Zhou, Yufeng Lu, Fangqi Zhao, Ji Dong, Wenji Ma, Suijuan Zhong, Mengdi Wang, Bosong Wang, Yuqing Zhao, Yingchao Shi, Qiang Ma, Tian Lu, Jun Zhang, Xiaoqun Wang, Qian Wu
Summary: This study reveals the cell-type and spatiotemporal characteristics of human hypothalamus development and finds that different cell fates are produced sequentially with spatial developmental asynchrony. Human hypothalamic gliogenesis occurs at an earlier stage compared to mice and shows different transcription profiles. Early oligodendrocyte cells in humans interact with neuronal cells through Wnt, Hippo, and integrin signals to regulate neuronal maturation.
Article
Chemistry, Analytical
Xianshuang Meng, Shanshan Sun, Hua Bai, Qiang Ma
Summary: This study presents the first online coupling of matrix solid-phase dispersion (MSPD) to direct analysis in real time mass spectrometry (DART-MS) with solid-phase analytical derivatization (SPAD) using a graphene oxide nanosheets (GONs)-coated cotton swab. It demonstrates the high-throughput analysis of regulated chemicals in consumer products. The MSPD-DART-MS methodology was optimized and validated, achieving acceptable recovery, repeatability, and sensitivity for 32 target analytes. The developed protocol streamlines the entire analytical workflow, showing promising potential for high-throughput analysis of samples with complex matrices.
ANALYTICA CHIMICA ACTA
(2023)
Article
Biochemical Research Methods
Guoping Li, Jing Chen, Qing Yang, Xuexin Yang, Penglong Wang, Haimin Lei, Ma Mi, Qiang Ma
Summary: A method was developed to analyze the chemical constituents of pomegranate seeds, which led to the identification of 59 compounds. These findings provide a reference for the pharmacodynamic substance research of pomegranate seeds and reveal their potential nutritional and therapeutic applications in the future.
RAPID COMMUNICATIONS IN MASS SPECTROMETRY
(2023)
Article
Biochemical Research Methods
Yuhan Shang, Xianshuang Meng, Juan Liu, Naining Song, Hongyan Zheng, Chao Han, Qiang Ma
Summary: Mass spectrometry (MS) is widely utilized in cosmetic analysis for various purposes including ingredient screening, quality control, risk monitoring, authenticity verification, and efficacy evaluation. This article provides an overview of the role of MS in cosmetic analysis over the past two decades, highlighting the sample preparation methods, ionization techniques, and mass analyzer types commonly employed in this field. Additionally, the article briefly discusses the future development of MS for cosmetic analysis.
JOURNAL OF CHROMATOGRAPHY A
(2023)
Review
Biochemistry & Molecular Biology
Dan Li, Zheng Ouyang, Xiaoxiao Ma
Summary: Mass Spectrometry Imaging (MSI) is a powerful imaging technique for analyzing biological samples, providing valuable insights into the distribution and structure of lipids. Recent advancements in high-resolution MSI have made it essential for studying single-cell or subcellular lipidomics. By preserving intracellular and intercellular information, MSI allows for a comprehensive analysis of lipidomics in cells and organelles, deepening our understanding of lipid diversity and their impact on cellular behavior.
Article
Biochemical Research Methods
Ming Li, Chenrui Zhan, Yueguang Lv, Jiwen Chen, Yutian Wang, Sixian Lu, Yingqi Wan, Qiang Ma
Summary: This study investigates the processing effects of ensemble empirical mode decomposition (EEMD) feature enhancement methods on the determination coefficient (R-2) and relative standard deviation (RSD) of caffeine mass spectrometry signals. The results show that the EEMD method is better than the wavelet analysis method and significantly improves the determination coefficient and RSD of the sample curve, improving the accuracy and stability of the data.
RAPID COMMUNICATIONS IN MASS SPECTROMETRY
(2023)
Article
Biochemical Research Methods
Xiangyu Guo, Junfang Li, Hua Bai, Qiang Ma
Summary: In this study, a rapid on-site analytical workflow was developed for the detection of polycyclic aromatic hydrocarbons and perfluorinated compounds using multiwalled carbon nanotube-modified paper spray ionization coupled with a miniature ion trap mass spectrometer. Critical parameters regarding PSI and miniature mass spectrometry analysis were optimized. The developed method showed a short analysis duration, sufficient linearity, acceptable recovery rates, and reasonable sensitivity, making it a promising solution for the rapid on-site detection of emerging persistent organic pollutants.
RAPID COMMUNICATIONS IN MASS SPECTROMETRY
(2023)
Article
Chemistry, Physical
Qiang Ma, Sha Fu, An-Jun Wu, Qi Deng, Wei-Dong Li, Dan Yue, Bing Zhang, Xiong-Wei Wu, Zhen-Ling Wang, Yu-Guo Guo
Summary: Bidirectionally functional polymer electrolytes (BDFPE) were designed to simultaneously handle the interface issues faced by anodes and cathodes. By constructing the BDFPE, a smooth and dendrite-free lithium deposition is enabled for Li||Li symmetry cells, and Li||LiNi0.6Co0.2Mn0.2O2 batteries demonstrate favorable cycling and rate capability with a stable CEI layer. The study provides a promising design strategy for high energy density lithium metal batteries.
ADVANCED ENERGY MATERIALS
(2023)
Article
Biochemical Research Methods
Tiantian Zhang, Xiwen Ye, Xin Luo, Zengyuan Niu, Huiyong Wang, Qiang Ma
Summary: The study developed a solvent-free pyrolysis gas chromatography-mass spectrometry method to screen for multiple restricted additives in polymer materials. The method successfully screened 33 restricted substances simultaneously, and verified the sensitivity, linear range, and recovery of the method. It also validated the method using various reference materials and applied it to analyze plastic products and recycled plastic samples. The method provided a comprehensive and thorough inspection without sample pretreatment, offering numerous advantages over traditional methods.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Zhijin Yang, Binbin Lin, Xuliang Huang, Bing Shi, Qiang Ma, Chao Han, Yan Shen
Summary: This study uses GC-APCI-MS/MS to detect and identify 8 herbicide residues in plant-based foodstuffs. APCI, as a soft ionization technique, enhances sensitivity and selectivity by generating more molecular ions and/or protonated molecules. The method has a range of 0.5 to 50 ng/mL for calibration curves, with recoveries in the range of 76.3-108.5%. The limit of quantification for all samples is 1.0 μg/kg. The results demonstrate the potential of GC-APCI-MS/MS in routine detection and identification of herbicide residues in plant-based foodstuffs.
MICROCHEMICAL JOURNAL
(2023)
Article
Chemistry, Analytical
Yueguang Lv, Yuhan Shang, Linsen Li, Ying Zhang, Qiang Ma
Summary: An integrated experimental protocol combining in-capillary aptamer-functionalized solid-phase microextraction (SPME), extraction nanoelectrospray ionization (nanoESI), and miniature MS analysis was developed for direct mass spectrometry (MS) analysis of complex samples. The method was successfully applied to analyze caffeine in electronic cigarette liquid and beverage samples, and demonstrated satisfactory analytical performance with high recoveries and low relative standard deviations.
Article
Agriculture, Multidisciplinary
Meng Chen, Ming Li, Wenxi Zhang, Hua Bai, Qiang Ma
Summary: Green analytical chemistry (GAC) is a rapidly growing research field that aims to develop novel analytical approaches with minimal consumption of hazardous reagents and solvents. This study reports on a green analytical method using natural deep eutectic solvents (NADESs) and temperature-mediated strategies for efficient sample pretreatment and mass spectrometry analysis.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Chemistry, Analytical
Qian Wu, Li Tian, Xiangyu Shan, Huiling Li, Chao Li, Juan Lu
Summary: A novel ECL sensor was developed by modifying Fe3CuO4-Ru(bpy)3+ and GO-CdS@ZnS on the electrode for the detection of permethrin. The sensor exhibited high sensitivity and a wide detection range.
Article
Chemistry, Analytical
Tingting Gong, Lei Liao, Bingying Jiang, Ruo Yuan, Yun Xiang
Summary: In this study, a fluorescent biosensing system for high sensitivity detection of MT was established using a new Ag+-stabilized DNA triplex probe (Ag+-SDTP) combined with catalytic hairpin assembly (CHA) and CRISPR/Cas12a signal enhancements. The sensing method is able to selectively detect MT from other non-specific molecules and can achieve low level detection of MT in diluted human serums, demonstrating its potential for monitoring disease-specific MT biomarker at trace levels.
Article
Chemistry, Analytical
Estrella Sanz Rodriguez, Kyra Wood, Paul R. Haddad, Brett Paull
Summary: This study presents a simple, rapid, and reliable method for determining boron in aqueous solutions using suppressed ion chromatography coupled to electrospray ionisation-triple quadrupole mass spectrometry. The method achieved a low limit of detection and demonstrated excellent analytical performance.
Article
Chemistry, Analytical
Aline Cournut, Paul Moustiez, Yannick Coffinier, Christine Enjalbal, Claudia Bich
Summary: Alzheimer's disease is a major cause of senile dementia and is characterized by the aggregation of neurofibrillary tangles and amyloid plaques in the brain. The A beta 1-42 peptide is considered the primary cause of neurotoxicity due to its insolubility and subsequent aggregation. A beta 1-42 and A beta 1-40 have been identified as relevant biomarkers for AD diagnosis, and SurfaceAssisted Laser Desorption/Ionization Mass Spectrometry (SALDI-MS) was used to monitor the A beta 1-42/A beta 1-40 ratio without prior sample treatment.
Article
Chemistry, Analytical
Dotse Selali Chormey, Buse Tugba Zaman, Tulay Borahan Kustanto, Sezin Erarpat Bodur, Suleyman Bodur, Elif Ozturk Er, Sezgin Bakirdere
Summary: This review provides an overview of the harmful effects of endocrine disrupting chemicals (EDCs) on human health and introduces the methods for analyzing EDCs. Recent research has focused on using green chemicals, such as deep eutectic solvents (DESs), for microextraction to ensure environmental safety.
Article
Chemistry, Analytical
Yan Zhang, Renfeng Xu, Jingjing Wu, Zhenghong Zhang, Yuhuang Wang, Hongqin Yang, Sheng Zhang
Summary: This study visualized the pore-like structures in prostate cancer cell membranes after treatment with the anticancer drug paclitaxel, demonstrating its mechanism of action related to oxidative damage.
Article
Chemistry, Analytical
Chihong Ma, Qin Zhou, Jinjin Shi, Hua Gao, Di Huang, Huimin Xue, Han Wang, Zhenzhong Zhang, Sen Yang, Junli Zhang, Kaixiang Zhang
Summary: We developed a CRISPR-empowered electrochemical biosensor, named PER-E-CRISPR, for amplification-free and sensitive detection of miR-21. The biosensor combines the advantages of CRISPR/Cas13a and primer exchange reaction (PER) for target amplification. Under optimized conditions, the PER-E-CRISPR assay exhibits a linear range from 10-13 to 10-7 M and a limit of detection of 30.2 fM. The biosensor shows excellent performance in actual plasma, indicating promising prospects for miRNA detection in molecular diagnosis.
Article
Chemistry, Analytical
Gang Liang, Jie Zhao, Yufei Gao, Tao Xie, Jianhui Zhen, Ligang Pan, Wenwen Gong
Summary: Molecular docking (MD) analysis is widely used for studying the interaction between aptamers and small molecules. This study established steady-state aptamers of tertiary structures (SATS) using specific aptamers of tetracycline antibiotics as docking models. Molecular docking results revealed multiple binding sites in the SATS of aptamers, with significant variations in binding free energy (BFE) and docking score (DS). The study also proposed a method for MD analysis based on SATS, providing insights into binding mode and predicting binding sites.
Article
Chemistry, Analytical
Yixuan Xu, Changchang Teng, Huiping Dang, Dalong Yin, Lifeng Yan
Summary: Stable organic radical molecules with high NIR fluorescence quantum efficiency have been synthesized and encapsulated into nanoparticles, which show great potential for both photodynamic therapy (PDT) and photothermal therapy (PTT) of tumors.
Article
Chemistry, Analytical
Yu Su, Dandan Yang, Yanjie Wang, Jie Ding, Lan Ding, Daqian Song
Summary: In this study, a highly selective molecularly imprinted polymer Cu-MIPs@CS was designed and synthesized for bisphenol A (BPA). Cu-MIPs@CS showed significantly enhanced imprinting factor and selective factor towards BPA compared to MIPs@CS. It also exhibited superior discrimination ability between BPA and its structural analogue. Additionally, Cu-MIPs@CS were successfully applied as a solid phase extraction adsorbent for the determination of BPA in drinking water samples.
Article
Chemistry, Analytical
Yi Qiao, Qiongdan Zhang, Yukun He, Tianguang Cheng, Jing Tu
Summary: Single cell heterogeneity plays an important role in many biological phenomena, and distinguishing cells with specific mutations is beneficial for clinical diagnosis and drug screening. This study introduces a gel plate platform that can distinguish cell types based on their phenotypes, with low equipment requirement. The gel platform has potential in point-of-care circumstances and single-cell stimulation responses that prioritize efficiency and simplicity.
Article
Chemistry, Analytical
Chengke Wang, Shuyang Sun, Ping Wang, Huawei Zhao, Wenling Li
Summary: The food safety of aquatic products is a global concern. Nanotechnology-based analyses have advantages in the detection of bacteria, metal ions, and small molecule contaminants. This review summarizes the recent advances in biosensing strategies for aquatic products and highlights the application of nanomaterials, lateral flow-based biosensors, surface-enhanced Raman scattering, microfluidic chips, and molecular imprinting technologies.
Article
Chemistry, Analytical
Liping Zhu, Zeng Tang, Xuemei Zhang, Li Zhu, Tian Meng, Linying Yu, Ting Xiao, Shasha Lu, Xiaoli Xiong, Xiurong Yang
Summary: A sensitive off-on electrochemiluminescence DNA sensor was developed using Exo III-assisted cascade amplification system. The sensor achieved high selectivity and ultra-high sensitivity in detecting target DNA by utilizing ECL and SPR effects. This study provides a new perspective for designing highly sensitive and programmable ECL biosensors.
Article
Chemistry, Analytical
Tong Li, Mengxu Sun, Suping Xia, Ting Huang, Rong-Tian Li, Chunrong Li, Zong Dai, Jin-Xiang Chen, Jun Chen, Nuan Jia
Summary: Here, we developed a binary system based on DNA tetrahedron and fluorogenic RNA aptamers for highly specific and label-free mRNA imaging in living cells. This system achieved high specificity label-free detection of nucleic acids with a detection limit of 1.34 nM. The method has potential applications in early disease diagnosis and new drug development.
Article
Chemistry, Analytical
Yao Zhao, Shu Zhang, Wang Yao, Yuxuan Zhu, Jing Qian, Juan Yang, Nianjun Yang
Summary: A new hierarchical nanostructured composite with high conductivity and catalytic activity is synthesized. The sensor exhibits significant catalytic effect and high sensitivity for monitoring the environmental endocrine disruptor bisphenol A (BPA).