Article
Chemistry, Analytical
Selen Ayaz, Aysem Uzer, Yusuf Dilgin, Resat Apak
Summary: A novel amperometric method was developed for total antioxidant capacity determination using a copper-neocuproine complex modified electrode in a flow injection system. The electrode exhibited good electrocatalytic activity towards polyphenolic compounds and showed a wide linear range and low detection limit. The method was successfully applied to measure antioxidant capacity in herbal teas, providing results comparable to spectrophotometric methods but with improved precision and sensitivity.
Article
Electrochemistry
Jiatao Chen, Xian Ran, Xiuting Ding, Dongdong Zhang
Summary: In this study, a simple, rapid, and stable electrochemical flow injection amperometry (FI-Amp) system was constructed to investigate the redox mechanism of dopamine (DA). The system utilized a flow cell with two glassy carbon electrodes arranged in series. Dual quantitative analysis of DA was achieved by the oxidation current of DA on the first working electrode (WE1) and the reduction current of its oxidation product on the second working electrode (WE2). The FI-Amp system exhibited excellent repeatability and stability, making it a promising tool for studying molecular redox reactions and electrochemical identification of other electroactive molecules.
ELECTROCHEMISTRY COMMUNICATIONS
(2023)
Review
Chemistry, Analytical
Preeyaporn Reanpang, Pijika Mool-am-kha, Jantima Upan, Jaroon Jakmunee
Summary: A simple, rapid, and cost-effective flow injection amperometric sensor was developed for sensitive determination of uric acid, utilizing a new combination of carbon black and graphene oxide modified screen-printed carbon electrode. The modified electrode showed enhanced sensitivity, stability, and automation for uric acid detection. The system achieved good selectivity, repeatability, and stability, with a detection limit of 0.01 µM and a throughput of 25 injections per hour.
Article
Chemistry, Analytical
Lais Sales Porto, Lucas Franco Ferreira, Wallans Torres Pio dos Santos, Arnaldo Cesar Pereira
Summary: This study presents a fast and highly sensitive electrochemical method for the determination of three organophosphorus compounds. The modified electrode, using a nanocomposite material, provides high selectivity and sensitivity for the analysis of the samples. The method exhibits a high analytical frequency and stability for the direct determination of the compounds in water and food samples.
Article
Chemistry, Analytical
Joanna Smajdor, Marcel Zambrzycki, Mateusz Marzec, Beata Paczosa-Bator, Robert Piech
Summary: A new voltammetric method using a glassy carbon electrode modified with semi-graphitized carbon nanofibers/MnO nanocomposite is proposed for high sensitive THP determination. The method demonstrates high repeatability and sensitivity, with the ability to accurately determine THP in complex matrices.
Article
Chemistry, Applied
K. R. Venugopala Mounesh, K. R. Venugopala Reddy, Anup Pandith, Gaber E. Eldesoky, Bhari Mallanna Nagaraja
Summary: This work synthesized a novel nickel phthalocyanine compound and confirmed its structure using spectroscopic-microscopic methods and electrochemical analysis. The synthesized NiTBBTCAPc-MWCNTs showed enhanced electron transferring ability and electrocatalytic activity compared to bare GCE and other composite materials. The sensor exhibited fast response, good stability, and high selectivity towards nitrite. The modified electrode was successfully applied for quantitative detection of nitrite in drinking water and cabbage vegetable samples.
APPLIED ORGANOMETALLIC CHEMISTRY
(2023)
Article
Electrochemistry
Vita N. Nikitina, Ekaterina D. Maksimova, Marina D. Zavolskova, Arkady A. Karyakin
Summary: This study proposes flow injection amperometry as a potential alternative to classical potentiometry for solid contact ion-selective electrodes, providing faster response time and higher signal-to-noise ratio while eliminating background drift and potential instability.
ELECTROCHIMICA ACTA
(2021)
Article
Chemistry, Applied
Marek Hasso, Ivana Matuskova, Lubomir Svorc
Summary: This paper introduces a new and rapid electroanalytical sensing platform for the quantification of theobromine in food products. The method utilizes batch injection analysis with amperometric detection on screen-printed carbon electrodes. The method has several advantages including minimal sample manipulation, wide linear concentration range, and high analytical frequency.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2023)
Article
Electrochemistry
Kelline Alaide Pereira Sousa, Franciele de Matos Morawski, Carlos Eduardo Maduro de Campos, Renato Luis Tamme Parreira, Mauricio Jeomar Piotrowski, Glaucio Regis Nagurniak, Cristiane Luisa Jost
Summary: Theoretical and electrochemical behavior of the herbicide fluometuron was investigated using a glassy carbon electrode for the first time. The study found that fluometuron exhibited an irreversible profile with a well-defined anodic peak through cyclic voltammetry. The presence of defects on the electrode surface induced the dissociation and adsorption of fluometuron, affecting the electroanalysis. Differential pulse voltammetry was successfully employed for the determination of fluometuron under optimized conditions.
ELECTROCHIMICA ACTA
(2022)
Article
Chemistry, Applied
Wesley McCormick, Cliodhna Muldoon, Denis McCrudden
Summary: Non-enzymatic electrochemical sensors developed for rapid monitoring of reducing sugars in foods showed high selectivity and long-term stability. The sensors achieved optimal performance in phosphate buffer at pH 7.4 with a flow rate of 0.5 mL min(-1) and an applied potential of 0.6 V, providing rapid detection without the need for sample preparation. The sensor results were in good agreement with those from a commercially available enzymatic assay kit.
Article
Chemistry, Multidisciplinary
Mihajlo Kulizic, Milan Stankovic, Marija Rasic, Aleksandar Mijatovic, Rada Baosic, Aleksandar Lolic
Summary: In this study, a simple, sensitive, and precise flow injection system was optimized for the determination of ascorbic acid using a carbon paste electrode modified with a Schiff base copper complex. The developed flow system showed a linear response, low detection limit, and good precision.
Article
Biophysics
B. R. Karishma, G. Manasa, Arvind K. Bhakta, T. Maiyalagan, Ronald J. Mascarenhas, Nagaraj P. Shetti
Summary: P.HCl is an early and commonly used local anesthetic drug, but excessive administration can lead to systemic toxicity. Therefore, it is crucial to develop a sensor for real-time monitoring and quality control of the drug during its industrial preparations. In this study, a simple yet highly selective and sensitive sensor based on BaO-MWCNT/CPE was fabricated for P.HCl detection.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Chemistry, Analytical
Nadine Wenninger, Christina Bernhart, Wolfgang Kappaun, Alexander Kollau, Kurt Kalcher, Astrid Ortner
Summary: An optimized carbon paste electrode (CPE) based on an amperometric flow injection analysis (FIA) method has been developed for the determination of nitric oxide (NO) production from endothelial cells (ECs). The method exhibits excellent sensitivity and selectivity, and allows real-time measurements of NO released from ECs.
Article
Chemistry, Analytical
Joanna Smajdor, Beata Paczosa-Bator, Malgorzata Grabarczyk, Robert Piech
Summary: A new voltammetric method using modified glassy carbon electrodes was proposed for highly sensitive sumatriptan determination. The mixture of carbon black and titanium dioxide as electrode modifier resulted in good repeatability and sensitivity of measurements. The method was successfully applied for sumatriptan determination in complex matrices.
Article
Environmental Sciences
Mohammad Reza Hojatpanah, Akbar Khanmohammadi, Hosin Khoshsafar, Ali Hajian, Hasan Bagheri
Summary: In this study, a novel electrochemical sensor modified with ion-imprinted polymers was developed for the determination of uranyl ions. The modified electrode exhibited excellent selectivity and sensitivity, as demonstrated by experimental and characterization analyses. The sensor showed promising potential for practical applications in real samples.
Article
Chemistry, Analytical
Georgios Bountas, Vlastimil Vyskocil, Bohumil Kratochvil, Alena Michalcova, Anastasios Economou, Jiri Barek
Summary: Nitrophenols are important environmental pollutants due to their genotoxic and ecotoxic properties. A novel silver porous electrode was successfully used for the determination of micromolar concentrations of 2-nitrophenol, 2,4-dinitrophenol, and 2,4,6-trinitrophenol.
Article
Chemistry, Analytical
E. Dorozhko, E. Kazachinskaia, Y. Kononova, A. Zaikovskaya, J. Barek, E. Korotkova, E. Kolobova, P. Sheveleva, M. Saqib
Summary: In this study, silver nanoparticles (AgNPs) were conjugated with immunoglobulins G (IgG) through a passive adsorption method. The composition and properties of freshly prepared (Ab@AgNPs) and aged (Ab@AgNP/Ag2SNPs) conjugates were investigated using various methods. The state of the AgNPs in the conjugates changed during storage, with the newly prepared Ab@AgNPs containing metallic silver and the aged Ab@AgNP/Ag2SNPs having a metallic core coated with Ag2S. The conjugates were successfully tested in an electrochemical immunoassay, offering potential for prolonged use in commercial test systems for immunological studies.
Article
Chemistry, Analytical
Eleni Koukouviti, Dionysios Soulis, Anastasios Economou, Christos Kokkinos
Summary: The development of conductive patterns on wood substrates using laser-induced graphitization is described. A wooden tongue depressor is laser-treated to create an electrochemical biosensing device for oral fluid analysis. The device demonstrates proof-of-principle for simultaneous determination of glucose and nitrite in artificial saliva, making it a potential low-cost and disposable point-of-care chip.
ANALYTICAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Marcel Ehn, Dmytro Bavol, Jonathan Bould, Vojtech Strnad, Miroslava Litecka, Kamil Lang, Kaplan Kirakci, William Clegg, Paul G. Waddell, Michael G. S. Londesborough
Summary: The reaction of AlCl3 with room-temperature tetrachloromethane solutions of anti-B18H22 resulted in the formation of fluorescent isomers, 3,3'-Cl-2-B18H20 and 3,4'-Cl-2-B18H20, with 76% yield. These isomers exhibited stable blue light emission under UV excitation. Other dichlorinated and monochlorinated derivatives, as well as trichlorinated species, were also isolated. The molecular structures and photophysical properties of these chlorinated derivatives were investigated, providing valuable insight into the effect of chlorine substitution on the luminescence of anti-B18H22.
Article
Engineering, Chemical
Miriam Mindova, Petr Distler, Jan John, Karel Stamberg, Dmytro Bavol, Suzan El Anwar, Bohumir Gruner
Summary: The behavior of the CHALMEX system with CyMe4-BTBP extractant in a mixture of 30% tri-n-butyl phosphate and 70% phenyl trifluoromethyl sulfone was studied. A kinetic model based on mass transfer was found to accurately describe the extraction of Am(III) and Eu(III). The distribution coefficients were determined based on temperature, allowing the calculation of changes in free enthalpy and entropy. After irradiation, it was found that radiolytic degradation products/adducts were efficient extractants for Am(III) and Eu(III), operating through an ion-exchange mechanism.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Article
Chemistry, Analytical
Michailia Angelopoulou, Dimitra Kourti, Konstantinos Misiakos, Anastasios Economou, Panagiota Petrou, Sotirios Kakabakos
Summary: A silicon-based optoelectronic immunosensor for the detection of AFM1 in milk, chocolate milk, and yogurt has been developed. The immunosensor consists of ten Mach-Zehnder silicon nitride waveguide interferometers (MZIs) integrated on the same chip with the respective light sources. The detection method is based on a three-step competitive immunoassay and achieves accurate on-site AFM1 determination in milk samples.
Article
Chemistry, Analytical
Margarita Barbatsi, Anastasios Economou
Summary: This work presents a new programmable low-pressure chromatography method with post-column chemiluminescence (CL) detection for the determination of four parabens in cosmetic products. The method involves the use of a programmable mobile phase, a monolithic C18 column, and a flow-through CL detector. The method is fully automated and has a fast separation time, high sensitivity, and low waste production.
Review
Chemistry, Analytical
Muhammad Saqib, Anna N. Solomonenko, Jirf Barek, Elena V. Dorozhko, Elena I. Korotkova, Shojaa A. Aljasar
Summary: Graphene composites have great potential for the determination of carbamates pesticides by electrochemical methods, offering advantages such as high sensitivity, selectivity, rapid detection, and low limit of detection.
ANALYTICA CHIMICA ACTA
(2023)
Review
Electrochemistry
Jiri Barek, Petr Smejkal
Summary: The aim of this article is to show that modern voltammetric methods can still be useful in practical laboratories and to express ideas on what researchers and university teachers should do to initiate a renaissance of voltammetric methods in analytical laboratories.
JOURNAL OF SOLID STATE ELECTROCHEMISTRY
(2023)
Review
Chemistry, Multidisciplinary
Jiri Barek, Fabio Marques
Summary: This article provides an overview of the use of various types of amalgam electrodes for monitoring organic compounds. Amalgam electrodes, made by forming an amalgam between metal and liquid mercury, offer advantages such as a wide range of potential windows and high sensitivity. Different types of amalgam electrodes and their applications in determining organic compounds in various matrices are discussed. Metal solid amalgam electrodes are found to be promising alternatives to hanging mercury drop electrodes for electrochemical measurements.
MONATSHEFTE FUR CHEMIE
(2023)
Review
Chemistry, Analytical
Leda Bousiakou, Omar Al-Dosary, Anastasios Economou, Veronika Subjakova, Tibor Hianik
Summary: This article introduces a novel electrochemical biosensing technology, aptasensors, which utilize aptamers as biological recognition elements. By combining the advantages of aptamers and electrochemical detection, these sensors can be used to fabricate inexpensive and portable analytical platforms for rapid detection or on-site monitoring. The immobilization strategies for aptamers on semiconductor-based substrates, including metal oxides, conductive polymers, and carbon allotropes, are discussed as important methods to preserve functionality and optimize sensor sensitivity.
Article
Chemistry, Analytical
Alexandra Karapa, Christos Kokkinos, Peter R. Fielden, Sara J. Baldock, Nickolas J. Goddard, Anastasios Economou
Summary: This work presents a novel three-electrode plastic sensor chip for the detection of trace Hg(II) using anodic stripping voltammetry. The chip is manufactured by injection moulding, which is an eco-friendly and sustainable method. It consists of three carbon-based electrodes embedded in a plastic holder, and the reference electrode is coated with Ag using e-beam evaporation. By analyzing the sample spiked with Au(III), gold nanoparticles are formed on the working electrode, and Hg(II) co-deposits with the gold nanoparticles to form an Au(Hg) amalgam. The accumulated Hg(II) is then stripped off the electrode and measured using an anodic square wave potential scan. The sensor shows a limit of detection of 0.4 μg/L for Hg(II) and a repeatability of 5.3% at the 20 μg/L level of Hg(III) (n = 10). It is successfully applied to various samples with recoveries ranging from 98% to 107%.
Article
Chemistry, Multidisciplinary
Panagiotis Oikonomopoulos, Varvara Pagkali, Evangelia Kritikou, Anthi Panara, Marios G. Kostakis, Nicolaos S. Thomaidis, Thomais G. Tziotzi, Anastasios Economou, Christos Kokkinos, Giannis S. Papaefstathiou
Summary: Two new Fe(II) Metal-Organic Frameworks (MOFs), namely 3D-Fe-MOF and 2D-Fe-MOF, were successfully synthesized and characterized by adjusting the reaction conditions to achieve the optimal degree of deprotonation of the bridging ligand. Both MOFs showed stability in water and had the ability to sorb glucose, although the sorption capacity was negligible. A 3D-Fe-MOF modified graphite paste sensor (GPE) was fabricated for non-enzymatic glucose detection in aqueous solution, and preliminary results were discussed using differential pulse voltammetry.
CHEMISTRY-SWITZERLAND
(2023)
Article
Chemistry, Analytical
Alba Civera, Sofiia Tvorynska, Maria Gamella, Rebeca M. Torrente-Rodriguez, Maria Pedrero, Patricia Galan-Malo, Luis Mata, Lourdes Sanchez, Jiri Barek, Jose M. Pingaron, Susana Campuzano, Maria D. Perez
Summary: A novel electrochemical bioplatform was developed for the determination of Pru du 6, one of the most abundant and allergenic almond proteins, in processed foods. The bioplatform combines the use of a sandwich immunoassay on magnetic beads with specific antibodies either unmodified or conjugated to horseradish peroxidase. The developed bioplatform showed good selectivity and sensitivity, with a detection limit of 0.12 ng mL-1 of Pru du 6. It could accurately determine Pru du 6 in raw dough and baked cookies with a protein concentration of 0.2 μg g-1, providing comparable results to ELISA technique.
MICROCHEMICAL JOURNAL
(2023)
Article
Chemistry, Analytical
Qian Wu, Li Tian, Xiangyu Shan, Huiling Li, Chao Li, Juan Lu
Summary: A novel ECL sensor was developed by modifying Fe3CuO4-Ru(bpy)3+ and GO-CdS@ZnS on the electrode for the detection of permethrin. The sensor exhibited high sensitivity and a wide detection range.
Article
Chemistry, Analytical
Tingting Gong, Lei Liao, Bingying Jiang, Ruo Yuan, Yun Xiang
Summary: In this study, a fluorescent biosensing system for high sensitivity detection of MT was established using a new Ag+-stabilized DNA triplex probe (Ag+-SDTP) combined with catalytic hairpin assembly (CHA) and CRISPR/Cas12a signal enhancements. The sensing method is able to selectively detect MT from other non-specific molecules and can achieve low level detection of MT in diluted human serums, demonstrating its potential for monitoring disease-specific MT biomarker at trace levels.
Article
Chemistry, Analytical
Estrella Sanz Rodriguez, Kyra Wood, Paul R. Haddad, Brett Paull
Summary: This study presents a simple, rapid, and reliable method for determining boron in aqueous solutions using suppressed ion chromatography coupled to electrospray ionisation-triple quadrupole mass spectrometry. The method achieved a low limit of detection and demonstrated excellent analytical performance.
Article
Chemistry, Analytical
Aline Cournut, Paul Moustiez, Yannick Coffinier, Christine Enjalbal, Claudia Bich
Summary: Alzheimer's disease is a major cause of senile dementia and is characterized by the aggregation of neurofibrillary tangles and amyloid plaques in the brain. The A beta 1-42 peptide is considered the primary cause of neurotoxicity due to its insolubility and subsequent aggregation. A beta 1-42 and A beta 1-40 have been identified as relevant biomarkers for AD diagnosis, and SurfaceAssisted Laser Desorption/Ionization Mass Spectrometry (SALDI-MS) was used to monitor the A beta 1-42/A beta 1-40 ratio without prior sample treatment.
Article
Chemistry, Analytical
Dotse Selali Chormey, Buse Tugba Zaman, Tulay Borahan Kustanto, Sezin Erarpat Bodur, Suleyman Bodur, Elif Ozturk Er, Sezgin Bakirdere
Summary: This review provides an overview of the harmful effects of endocrine disrupting chemicals (EDCs) on human health and introduces the methods for analyzing EDCs. Recent research has focused on using green chemicals, such as deep eutectic solvents (DESs), for microextraction to ensure environmental safety.
Article
Chemistry, Analytical
Yan Zhang, Renfeng Xu, Jingjing Wu, Zhenghong Zhang, Yuhuang Wang, Hongqin Yang, Sheng Zhang
Summary: This study visualized the pore-like structures in prostate cancer cell membranes after treatment with the anticancer drug paclitaxel, demonstrating its mechanism of action related to oxidative damage.
Article
Chemistry, Analytical
Chihong Ma, Qin Zhou, Jinjin Shi, Hua Gao, Di Huang, Huimin Xue, Han Wang, Zhenzhong Zhang, Sen Yang, Junli Zhang, Kaixiang Zhang
Summary: We developed a CRISPR-empowered electrochemical biosensor, named PER-E-CRISPR, for amplification-free and sensitive detection of miR-21. The biosensor combines the advantages of CRISPR/Cas13a and primer exchange reaction (PER) for target amplification. Under optimized conditions, the PER-E-CRISPR assay exhibits a linear range from 10-13 to 10-7 M and a limit of detection of 30.2 fM. The biosensor shows excellent performance in actual plasma, indicating promising prospects for miRNA detection in molecular diagnosis.
Article
Chemistry, Analytical
Gang Liang, Jie Zhao, Yufei Gao, Tao Xie, Jianhui Zhen, Ligang Pan, Wenwen Gong
Summary: Molecular docking (MD) analysis is widely used for studying the interaction between aptamers and small molecules. This study established steady-state aptamers of tertiary structures (SATS) using specific aptamers of tetracycline antibiotics as docking models. Molecular docking results revealed multiple binding sites in the SATS of aptamers, with significant variations in binding free energy (BFE) and docking score (DS). The study also proposed a method for MD analysis based on SATS, providing insights into binding mode and predicting binding sites.
Article
Chemistry, Analytical
Yixuan Xu, Changchang Teng, Huiping Dang, Dalong Yin, Lifeng Yan
Summary: Stable organic radical molecules with high NIR fluorescence quantum efficiency have been synthesized and encapsulated into nanoparticles, which show great potential for both photodynamic therapy (PDT) and photothermal therapy (PTT) of tumors.
Article
Chemistry, Analytical
Yu Su, Dandan Yang, Yanjie Wang, Jie Ding, Lan Ding, Daqian Song
Summary: In this study, a highly selective molecularly imprinted polymer Cu-MIPs@CS was designed and synthesized for bisphenol A (BPA). Cu-MIPs@CS showed significantly enhanced imprinting factor and selective factor towards BPA compared to MIPs@CS. It also exhibited superior discrimination ability between BPA and its structural analogue. Additionally, Cu-MIPs@CS were successfully applied as a solid phase extraction adsorbent for the determination of BPA in drinking water samples.
Article
Chemistry, Analytical
Yi Qiao, Qiongdan Zhang, Yukun He, Tianguang Cheng, Jing Tu
Summary: Single cell heterogeneity plays an important role in many biological phenomena, and distinguishing cells with specific mutations is beneficial for clinical diagnosis and drug screening. This study introduces a gel plate platform that can distinguish cell types based on their phenotypes, with low equipment requirement. The gel platform has potential in point-of-care circumstances and single-cell stimulation responses that prioritize efficiency and simplicity.
Article
Chemistry, Analytical
Chengke Wang, Shuyang Sun, Ping Wang, Huawei Zhao, Wenling Li
Summary: The food safety of aquatic products is a global concern. Nanotechnology-based analyses have advantages in the detection of bacteria, metal ions, and small molecule contaminants. This review summarizes the recent advances in biosensing strategies for aquatic products and highlights the application of nanomaterials, lateral flow-based biosensors, surface-enhanced Raman scattering, microfluidic chips, and molecular imprinting technologies.
Article
Chemistry, Analytical
Liping Zhu, Zeng Tang, Xuemei Zhang, Li Zhu, Tian Meng, Linying Yu, Ting Xiao, Shasha Lu, Xiaoli Xiong, Xiurong Yang
Summary: A sensitive off-on electrochemiluminescence DNA sensor was developed using Exo III-assisted cascade amplification system. The sensor achieved high selectivity and ultra-high sensitivity in detecting target DNA by utilizing ECL and SPR effects. This study provides a new perspective for designing highly sensitive and programmable ECL biosensors.
Article
Chemistry, Analytical
Tong Li, Mengxu Sun, Suping Xia, Ting Huang, Rong-Tian Li, Chunrong Li, Zong Dai, Jin-Xiang Chen, Jun Chen, Nuan Jia
Summary: Here, we developed a binary system based on DNA tetrahedron and fluorogenic RNA aptamers for highly specific and label-free mRNA imaging in living cells. This system achieved high specificity label-free detection of nucleic acids with a detection limit of 1.34 nM. The method has potential applications in early disease diagnosis and new drug development.
Article
Chemistry, Analytical
Yao Zhao, Shu Zhang, Wang Yao, Yuxuan Zhu, Jing Qian, Juan Yang, Nianjun Yang
Summary: A new hierarchical nanostructured composite with high conductivity and catalytic activity is synthesized. The sensor exhibits significant catalytic effect and high sensitivity for monitoring the environmental endocrine disruptor bisphenol A (BPA).
