Article
Chemistry, Multidisciplinary
Dilek Eltemur, Peter Robatscher, Michael Oberhuber, Alberto Ceccon
Summary: NMR spectroscopy is a powerful analytical tool for identifying and quantifying natural compounds in food matrices. However, its low intrinsic sensitivity makes it challenging to detect adulterants or markers for authenticity at low concentrations. This study presents a simple solution to enhance the sensitivity of NMR and successfully applies it to the authentication of milk products.
Review
Biochemistry & Molecular Biology
Karolien Vanhove, Elien Derveaux, Liesbet Mesotten, Michiel Thomeer, Maarten Criel, Hanne Marien, Peter Adriaensens
Summary: In this paper, the authors discuss the metabolic changes in lung cancer patients and the metabolic cooperation between tumor cells and healthy tissue, as well as the potential application of metabolomics in the management of lung cancer patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Thermodynamics
Jingjun Liu, Dandan Pan, Qing Zhang, Yulei Guan, Bolun Yang
Summary: The equilibrium data for glycerol transesterification were measured and correlated using the NRTL model, which successfully reproduced the phase equilibrium trends of the studied systems.
FLUID PHASE EQUILIBRIA
(2022)
Article
Engineering, Biomedical
Dion G. Thomas, Yu-Chieh Tzeng, Petrik Galvosas, Freya G. Harrison, Mary J. Berry, Paul D. Teal, Sean D. Galvin, Sergei I. Obruchkov
Summary: Objective: A single-sided magnet system is developed for measuring Magnetic Resonance relaxation and diffusion parameters. Methods: This system uses an array of permanent magnets to optimize magnet positions and produce a homogeneous B-0 magnetic field that can project into a sample. Results: The magnet produces a 0.2 T field and can measure T-1, T-2, and ADC parameters. In-vivo studies show its potential for non-invasive measurements in the brain, such as monitoring T-2 during cerebral hypoxia.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2023)
Article
Nutrition & Dietetics
Kate M. Bermingham, Mohsen Mazidi, Paul W. Franks, Tyler Maher, Ana M. Valdes, Inbar Linenberg, Jonathan Wolf, George Hadjigeorgiou, Tim D. Spector, Cristina Menni, Jose M. Ordovas, Sarah E. Berry, Wendy L. Hall
Summary: This study characterized the variability and correlations of postprandial metabolite changes in a large cohort. The majority of metabolites showed significant changes after a meal, particularly in very large lipoprotein particles and ketone bodies. Strong correlations were observed between fasting and postprandial metabolites, although some metabolites showed weak correlations.
Article
Biochemistry & Molecular Biology
Mengchen Zhao, Shuji Fujisawa, Tsuguyuki Saito
Summary: Phosphorylated cellulose nanofiber (CNF) is a newly emerged CNF with high functionality, containing monophosphate, polyphosphate, and cross-linked phosphate groups. The phosphorylation process is regioselective at the C2 and C6 positions, with no significant difference in surface degrees of substitution.
Article
Plant Sciences
Daniel Pflugfelder, Johannes Kochs, Robert Koller, Siegfried Jahnke, Carola Mohl, Shree Pariyar, Heike Fassbender, Kerstin A. Nagel, Michelle Watt, Dagmar van Dusschoten, Hideki Takahashi
Summary: This study investigated seedling establishment in winter wheat using MRI technology. The results showed that the timing of root and shoot emergence, as well as the length, angle, and depth of axile roots, significantly varied among different genotypes. The study also demonstrated the importance of root initiation and elongation rates for the root system architecture of wheat seedlings.
JOURNAL OF EXPERIMENTAL BOTANY
(2022)
Article
Medical Laboratory Technology
Erwin Garcia, Irina Shalaurova, Steven P. Matyus, Justyna Wolak-Dinsmore, David N. Oskardmay, Margery A. Connelly
Summary: A high-throughput nuclear magnetic resonance (NMR)-based assay has been developed for measuring choline in serum and plasma. The assay exhibits good performance characteristics and can be used for clinical purposes.
CLINICA CHIMICA ACTA
(2022)
Article
Engineering, Environmental
Huajun Wang, Tingting Liu, Chenyang Jiang, Yidan Wang, Jingjing Ma
Summary: This study prepared a series of deep-eutectic solvents (DESs) and used them as catalysts for the synthesis of glycidol and glycerol carbonate. The results showed that the KOH:MEA(1:2) DES exhibited higher catalytic activity, and the kinetics model accurately predicted the component concentration of the reaction.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Yue-Chiun Li, Chia-Hung Wu, Thi Ha Le, Qingjun Yuan, Luqi Huang, Guo-Fen Chen, Mei-Lin Yang, Sio-Hong Lam, Hsin-Yi Hung, Handong Sun, Yi-Hung Wu, Ping-Chung Kuo, Tian-Shung Wu
Summary: A specific H-1-NMR method has been modified to quantify ephedrine alkaloids. Benzene was identified as the better extraction solvent to eliminate impurities. The locations of ephedrine alkaloids were confirmed using 2D NMR, and the concentrations of ephedrine and pseudoephedrine varied greatly among different species and collection locations of Ephedra plants.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Spectroscopy
Van T. H. Phan, Eric Quirico, Pierre Beck, Yann Le Brech, Lora Jovanovic, Corentin Le Guillou, Sylvain Bernard, Lydie Bonal, Nathalie Carrasco, Thomas Gautier, Jesus Raya
Summary: The determination of the abundances of CHx, C = O, and aromatic groups in chondritic Insoluble Organic Matter (IOM) and coals by Infrared (IR) spectroscopy was carried out in this study. A calibration approach based on a C-13 synthetic model material was used, and the ratios of the cross-sections of these groups were determined. The study found discrepancies in the estimation of aliphatic to aromatic carbon and aliphatic to carbonyl ratio, possibly due to the control of absorption cross-section by the local molecular environment. In coals, the integrated cross-section ratio varied with vitrinite reflectance, with local oxygen speciation playing a critical role in this variation.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Biochemistry & Molecular Biology
Ian W. Burton, Mohsen Kompany-Zareh, Sophie Haverstock, Jonathan Hache, Camilo F. Martinez-Farina, Peter D. Wentzell, Fabrice Berrue
Summary: To address the issue of honey adulteration, a quantitative NMR method was developed to analyze honey samples collected in Canada. Multivariate statistical methods were used to differentiate Canadian honey from other honeys.
Article
Chemistry, Analytical
Klaudia W. Milc, Thomas Oerther, Joshua A. Dijksman, John P. M. van Duynhoven, Camilla Terenzi
Summary: A pressure-driven high-field MRI velocimetry platform was developed to accurately predict cooperative flow in strongly confined flow. Experimental observations showed that the cooperative flow of Carbopol in a 100 μm capillary was independent of flow conditions, while the cooperative flow of heterogeneous fat crystal dispersion (FCD) increased with gap size and applied pressure.
ANALYTICAL CHEMISTRY
(2023)
Article
Energy & Fuels
Gitanjali Pradhan, Yogesh Chandra Sharma
Summary: Glycerol carbonate is a trending value added chemical in various industries, with researchers focusing on its synthesis from glycerol as a by-product of biodiesel. The use of a highly efficient heterogeneous Mg/ZnO base catalyst for the transesterification of glycerol with dimethyl carbonate was successful in producing glycerol carbonate with high conversion rates.
Article
Construction & Building Technology
Hao Liu, Haoliang Huang, Jie Hu, Peng Gao, Jiangxiong Wei, Qijun Yu, Leo Pel
Summary: This study quantitatively determined the curing kinetics of Waterborne Epoxy Resin (WER) in polymer-cement composite using H-1 low-field nuclear magnetic resonance ((HLF)-H-1-NMR). It was found that the curing reaction of WER in a mortar was significantly influenced by the cement hydration. The distribution of WER in the repair materials was affected by both the water-cement ratio of the repair and the relative humidity of the substrate.
CEMENT & CONCRETE COMPOSITES
(2023)
Article
Chemistry, Multidisciplinary
Ashutosh S. Singh, Amjad Ali, Ranjay K. Tiwari, Jogendra N. Behera, Shih-Sheng Sun, Vadapalli Chandrasekhar
Article
Green & Sustainable Science & Technology
Mandeep Kaur, Rashi Malhotra, Amjad Ali
Article
Green & Sustainable Science & Technology
Rashi Malhotra, Amjad Ali
Article
Engineering, Chemical
Avneet Kaur, Amjad Ali
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2020)
Article
Physics, Applied
Rajesh Kondabala, Vijay Kumar, Amjad Ali, Manjit Kaur
MODERN PHYSICS LETTERS B
(2020)
Article
Engineering, Chemical
Himmat Singh, Amjad Ali
Summary: In this study, a heterogeneous catalyst was prepared for the transesterification and esterification of waste cooking oil, achieving a high yield of fatty acid methyl ester under optimized conditions. The catalyst showed stability even in the presence of high moisture and free fatty acid contents.
ASIA-PACIFIC JOURNAL OF CHEMICAL ENGINEERING
(2021)
Article
Engineering, Chemical
Priyanka Gautam, Sanghamitra Barman, Amjad Ali
INTERNATIONAL JOURNAL OF CHEMICAL REACTOR ENGINEERING
(2020)
Article
Chemistry, Organic
Meenakshi Budhiraja, Rajesh Kondabala, Amjad Ali, Vikas Tyagi
Article
Biochemical Research Methods
Rajesh Kondabala, Vijay Kumar, Amjad Ali
Summary: The proposed computational approach utilizes in-silico molecular screening hypothesis to design computational models mimicking natural glucose receptors, with ZINC82047919, ZINC238094340, and ZINC238519600 compounds-based models showing better interactions with glucose. The molecular dynamics simulation results suggest that the receptor designed using compound ZINC238094340 undergoes significant conformation changes and the receptor designed from ZINC238094340 and ZINC238519600 compounds is used as a reference glucose binding receptor in the study.
JOURNAL OF MOLECULAR GRAPHICS & MODELLING
(2021)
Article
Chemistry, Multidisciplinary
Avneet Kaur, Amjad Ali
Summary: The commercial CaO was modified to enhance its moisture resistance properties using aliphatic and aromatic groups, with benzyl-modified CaO catalyst showing better catalytic activity in the transesterification reaction. The modified CaO catalysts were found to resist moisture adsorption better than the native counterpart, with the 0.5-Ben/CaO catalyst forming a hydrophobic layer on the CaO surface to withstand water content in the reaction.
Proceedings Paper
Materials Science, Multidisciplinary
Madhu Katiyar, Km Abida, Amjad Ali
Summary: The immobilization of Candida rugosa lipase on mesoporous silica (SBA-15) was achieved by physical adsorption, resulting in successful transesterification of cotton seed oil with methanol to produce fatty acid methyl esters. The reaction followed a pseudo-first order reaction rate law with a rate constant of 9.6 x 10-4 min-1 and an activation energy of 57 kJ mol-1.
MATERIALS TODAY-PROCEEDINGS
(2021)
Proceedings Paper
Materials Science, Multidisciplinary
Sachin Kumar, Nishant Thakur, Km Abida, Ashish Kumar, Raj Kumar Gupta, Amjad Ali
Summary: The catalytic activities of Ni loaded Zn/CaO mixed oxides were studied for transesterification of triglycerides. The catalyst showed high conversion of biodiesel and could be reused for three consecutive runs. The physico-chemical properties of the catalyst were characterized by various techniques.
MATERIALS TODAY-PROCEEDINGS
(2021)
Article
Chemistry, Applied
Avneet Kaur, Neha Bhardwaj, Amanpreet Kaur, Km Abida, Tejo Prakash Nagaraja, Amjad Ali, Ranjana Prakash
Summary: Two qHNMR-based equations were proposed for the quantification of epoxidized methyl esters (EMO) in the mixture of EMO and methylesters (MO), which showed acceptable agreement with HPLC analysis results. The validity of the method was confirmed using standard mixtures of MO and EMO with different molar concentrations.
JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY
(2021)
Article
Chemistry, Multidisciplinary
Km Abida, Bhupendra Chudasama, Amjad Ali
NEW JOURNAL OF CHEMISTRY
(2020)
Article
Chemistry, Multidisciplinary
Km Abida, Amjad Ali
Article
Chemistry, Analytical
Qian Wu, Li Tian, Xiangyu Shan, Huiling Li, Chao Li, Juan Lu
Summary: A novel ECL sensor was developed by modifying Fe3CuO4-Ru(bpy)3+ and GO-CdS@ZnS on the electrode for the detection of permethrin. The sensor exhibited high sensitivity and a wide detection range.
Article
Chemistry, Analytical
Tingting Gong, Lei Liao, Bingying Jiang, Ruo Yuan, Yun Xiang
Summary: In this study, a fluorescent biosensing system for high sensitivity detection of MT was established using a new Ag+-stabilized DNA triplex probe (Ag+-SDTP) combined with catalytic hairpin assembly (CHA) and CRISPR/Cas12a signal enhancements. The sensing method is able to selectively detect MT from other non-specific molecules and can achieve low level detection of MT in diluted human serums, demonstrating its potential for monitoring disease-specific MT biomarker at trace levels.
Article
Chemistry, Analytical
Estrella Sanz Rodriguez, Kyra Wood, Paul R. Haddad, Brett Paull
Summary: This study presents a simple, rapid, and reliable method for determining boron in aqueous solutions using suppressed ion chromatography coupled to electrospray ionisation-triple quadrupole mass spectrometry. The method achieved a low limit of detection and demonstrated excellent analytical performance.
Article
Chemistry, Analytical
Aline Cournut, Paul Moustiez, Yannick Coffinier, Christine Enjalbal, Claudia Bich
Summary: Alzheimer's disease is a major cause of senile dementia and is characterized by the aggregation of neurofibrillary tangles and amyloid plaques in the brain. The A beta 1-42 peptide is considered the primary cause of neurotoxicity due to its insolubility and subsequent aggregation. A beta 1-42 and A beta 1-40 have been identified as relevant biomarkers for AD diagnosis, and SurfaceAssisted Laser Desorption/Ionization Mass Spectrometry (SALDI-MS) was used to monitor the A beta 1-42/A beta 1-40 ratio without prior sample treatment.
Article
Chemistry, Analytical
Dotse Selali Chormey, Buse Tugba Zaman, Tulay Borahan Kustanto, Sezin Erarpat Bodur, Suleyman Bodur, Elif Ozturk Er, Sezgin Bakirdere
Summary: This review provides an overview of the harmful effects of endocrine disrupting chemicals (EDCs) on human health and introduces the methods for analyzing EDCs. Recent research has focused on using green chemicals, such as deep eutectic solvents (DESs), for microextraction to ensure environmental safety.
Article
Chemistry, Analytical
Yan Zhang, Renfeng Xu, Jingjing Wu, Zhenghong Zhang, Yuhuang Wang, Hongqin Yang, Sheng Zhang
Summary: This study visualized the pore-like structures in prostate cancer cell membranes after treatment with the anticancer drug paclitaxel, demonstrating its mechanism of action related to oxidative damage.
Article
Chemistry, Analytical
Chihong Ma, Qin Zhou, Jinjin Shi, Hua Gao, Di Huang, Huimin Xue, Han Wang, Zhenzhong Zhang, Sen Yang, Junli Zhang, Kaixiang Zhang
Summary: We developed a CRISPR-empowered electrochemical biosensor, named PER-E-CRISPR, for amplification-free and sensitive detection of miR-21. The biosensor combines the advantages of CRISPR/Cas13a and primer exchange reaction (PER) for target amplification. Under optimized conditions, the PER-E-CRISPR assay exhibits a linear range from 10-13 to 10-7 M and a limit of detection of 30.2 fM. The biosensor shows excellent performance in actual plasma, indicating promising prospects for miRNA detection in molecular diagnosis.
Article
Chemistry, Analytical
Gang Liang, Jie Zhao, Yufei Gao, Tao Xie, Jianhui Zhen, Ligang Pan, Wenwen Gong
Summary: Molecular docking (MD) analysis is widely used for studying the interaction between aptamers and small molecules. This study established steady-state aptamers of tertiary structures (SATS) using specific aptamers of tetracycline antibiotics as docking models. Molecular docking results revealed multiple binding sites in the SATS of aptamers, with significant variations in binding free energy (BFE) and docking score (DS). The study also proposed a method for MD analysis based on SATS, providing insights into binding mode and predicting binding sites.
Article
Chemistry, Analytical
Yixuan Xu, Changchang Teng, Huiping Dang, Dalong Yin, Lifeng Yan
Summary: Stable organic radical molecules with high NIR fluorescence quantum efficiency have been synthesized and encapsulated into nanoparticles, which show great potential for both photodynamic therapy (PDT) and photothermal therapy (PTT) of tumors.
Article
Chemistry, Analytical
Yu Su, Dandan Yang, Yanjie Wang, Jie Ding, Lan Ding, Daqian Song
Summary: In this study, a highly selective molecularly imprinted polymer Cu-MIPs@CS was designed and synthesized for bisphenol A (BPA). Cu-MIPs@CS showed significantly enhanced imprinting factor and selective factor towards BPA compared to MIPs@CS. It also exhibited superior discrimination ability between BPA and its structural analogue. Additionally, Cu-MIPs@CS were successfully applied as a solid phase extraction adsorbent for the determination of BPA in drinking water samples.
Article
Chemistry, Analytical
Yi Qiao, Qiongdan Zhang, Yukun He, Tianguang Cheng, Jing Tu
Summary: Single cell heterogeneity plays an important role in many biological phenomena, and distinguishing cells with specific mutations is beneficial for clinical diagnosis and drug screening. This study introduces a gel plate platform that can distinguish cell types based on their phenotypes, with low equipment requirement. The gel platform has potential in point-of-care circumstances and single-cell stimulation responses that prioritize efficiency and simplicity.
Article
Chemistry, Analytical
Chengke Wang, Shuyang Sun, Ping Wang, Huawei Zhao, Wenling Li
Summary: The food safety of aquatic products is a global concern. Nanotechnology-based analyses have advantages in the detection of bacteria, metal ions, and small molecule contaminants. This review summarizes the recent advances in biosensing strategies for aquatic products and highlights the application of nanomaterials, lateral flow-based biosensors, surface-enhanced Raman scattering, microfluidic chips, and molecular imprinting technologies.
Article
Chemistry, Analytical
Liping Zhu, Zeng Tang, Xuemei Zhang, Li Zhu, Tian Meng, Linying Yu, Ting Xiao, Shasha Lu, Xiaoli Xiong, Xiurong Yang
Summary: A sensitive off-on electrochemiluminescence DNA sensor was developed using Exo III-assisted cascade amplification system. The sensor achieved high selectivity and ultra-high sensitivity in detecting target DNA by utilizing ECL and SPR effects. This study provides a new perspective for designing highly sensitive and programmable ECL biosensors.
Article
Chemistry, Analytical
Tong Li, Mengxu Sun, Suping Xia, Ting Huang, Rong-Tian Li, Chunrong Li, Zong Dai, Jin-Xiang Chen, Jun Chen, Nuan Jia
Summary: Here, we developed a binary system based on DNA tetrahedron and fluorogenic RNA aptamers for highly specific and label-free mRNA imaging in living cells. This system achieved high specificity label-free detection of nucleic acids with a detection limit of 1.34 nM. The method has potential applications in early disease diagnosis and new drug development.
Article
Chemistry, Analytical
Yao Zhao, Shu Zhang, Wang Yao, Yuxuan Zhu, Jing Qian, Juan Yang, Nianjun Yang
Summary: A new hierarchical nanostructured composite with high conductivity and catalytic activity is synthesized. The sensor exhibits significant catalytic effect and high sensitivity for monitoring the environmental endocrine disruptor bisphenol A (BPA).
