Article
Chemistry, Analytical
Di Liu, Huimin Gao, Wenji Jiang, Su Yan, Hao Liu, Junjie Chen, Sisi Wen, Wei Zhang, Xu Wang, Bing Zhao, Wei Song
Summary: In this study, three-dimensional Ag aerogel-supported Hg single-atom catalysts were used as an efficient SERS substrate for monitoring enhanced oxidase-like reactions. The effect of Hg2+ concentrations on the SERS properties of 3D Hg/Ag aerogel networks was investigated, and an optimized addition of Hg2+ resulted in specific enhancement. The formation of Ag-supported Hg SACs was confirmed using HAADF-STEM imaging and XPS measurement, and the oxidase-like catalytic mechanism of Hg/Ag SACs was revealed using DFT. This research provides a mild synthetic strategy for fabricating Ag aerogel-supported Hg single atoms with promising prospects in various catalytic fields.
ANALYTICAL CHEMISTRY
(2023)
Review
Chemistry, Physical
Ryan D. Norton, Hoa T. Phan, Stephanie N. Gibbons, Amanda J. Haes
Summary: This review discusses the recent advances in quantitative SERS detection, focusing on intermolecular interactions, surface selection rules, and target molecule solubility and accessibility. The impacts of surface selection rules and enhancement mechanisms on the activation and deactivation of normal Raman modes in SERS are explored. The review also summarizes the experimental conditions that can be used to tune the molecular affinity to and density near SERS substrates.
ANNUAL REVIEW OF PHYSICAL CHEMISTRY
(2022)
Article
Spectroscopy
Quanhong Ou, Biao Tang, Liqin Jiang, Mingcheng Han, Weiye Yang, Junqi Tang, Gang Liu
Summary: In this study, a super-sensitive method of surface-enhanced Raman spectroscopy (SERS) was used to detect carbosulfan residues in vegetables. It was found that carbosulfan easily decomposes into carbofuran and 3-Hydroxy carbofuran. Silver sol was prepared as the SERS substrate and a complex of carbosulfan, chromogenic agent, and sodium hydroxide was mixed with the silver sol in the best proportion for SERS spectra examination. Density functional theory calculations were used to determine the spectral peak positions of carbosulfan. The optimal mixing ratio and the detection limit of carbosulfan were investigated. The results suggest that SERS is a promising technique for detecting single-molecule pesticide residues in vegetables.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Chemistry, Analytical
Weixing Gao, Weiman Duan, Dandan Peng, Juan Li, Zhangmei Hu, Dongmei Wang, Zhengjun Gong, Meikun Fan
Summary: The complexity of substances in environmental water bodies is leading to severe ecotoxicological problems. Evaluating water quality accurately based on the species and concentration of chemicals alone is difficult due to the intricate interaction among various chemicals. Therefore, the acute toxicity evaluation of water is of significant importance in environmental monitoring, especially in emergency situations. This study proposes a SERS approach to evaluate the acute toxicity of fresh water for the first time, using indole as an indicator. It demonstrates the feasibility of using SERS-based microbial sensors to assess acute toxicity in water.
MICROCHEMICAL JOURNAL
(2023)
Article
Biophysics
Jinyoung Kim, Joowon Park, Jisun Ki, Hyun Wook Rho, Yong-Min Huh, Eunjung Kim, Hye Young Son, Seungjoo Haam
Summary: Breast cancer is a common global cancer, and early detection is crucial for improving the 5-year survival rate. In this study, the combination of seed-mediated grown silver nanopillars and surface-enhanced Raman spectroscopy was used for rapid and sensitive detection of circulating miRNA in breast cancer.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Chemistry, Physical
Runzi Zhou, Cheng Wen, Jiameng Lv, Haijun Xu, Zenghui Qiu, Zhenglong Wu, Xin Zhang
Summary: A ultrasensitive surface-enhanced Raman scattering sensor for detecting trace lead ion (Pb2+) in water is developed. Silicon nanowire arrays were grown and gold nanoparticles were deposited on the surface to enhance the sensor performance. With crystal violet modification, the sensor can detect Pb2+ at a concentration as low as 10^-13 M level, showing excellent selectivity without interference from other metal ions. The sensor is easy to prepare and can be used repeatedly.
CHEMICAL PHYSICS LETTERS
(2023)
Article
Biophysics
Eungyeong Park, Wijin Kim, Shuang Guo, Sila Jin, Yeonju Park, Jongmin Park, Hyuk Sang Yoo, Ju Hyun Park, Young Mee Jung
Summary: Cell surface proteins (CSPs) play important roles in biological functions and are used for cancer prognosis. Current detection strategies lack selectivity and in situ analysis capability. In this study, we developed nanoprobes for surface-enhanced Raman scattering (SERS) immunoassays to achieve highly sensitive and selective in situ detection of CSPs in different types of cells. Our biosensing system demonstrated quantitative features and showed high selectivity and low cytotoxicity, making it suitable for various biomedical applications.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Chemistry, Analytical
W. Cheuquepan, S. Hernandez, M. Perez-Estebanez, L. Romay, A. Heras, A. Colina
Summary: Electrochemistry can be used to generate SERS substrates, utilizing the plasmonic properties of nanos-tructures and the chemical mechanism, with time-resolved Raman spectroelectrochemistry providing valuable information. Comparing Au and Ag metals for folic acid detection in drugs, it was found that Ag SERS substrates outperformed Au SERS substrates in complex samples.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2021)
Review
Engineering, Environmental
Lifang Xie, Kedong Gong, Yangyang Liu, Liwu Zhang
Summary: Nanoplastics, at sizes smaller than 1000 nm, are found ubiquitously in various environmental media and pose a potential health risk due to their ability to easily enter cells. In this review, we summarize the prevalent analytical techniques for identifying nanoplastics, with a focus on the advantages and disadvantages of surface-enhanced Raman spectroscopy (SERS). We discuss the principles of SERS, advances in nanoplastic detection using SERS, and the application of SERS in real environmental samples. Furthermore, we highlight the importance of efficient SERS substrates and pretreatment methodologies to enable practical nanoplastic detection and identify future research needs in this field.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Biochemical Research Methods
Huasheng Lai, Zhongning Yu, Gongke Li, Zhuomin Zhang
Summary: Surface-enhanced Raman spectroscopy (SERS) is a powerful analytical technique for fast and sensitive analysis of trace analytes. However, the matrix interference effect in complex samples limits its rapid analysis. Therefore, proper sample preparation techniques are necessary to address this limitation and improve SERS analysis.
JOURNAL OF CHROMATOGRAPHY A
(2022)
Article
Chemistry, Analytical
Yan Wu, Jin-Yang Chen, Wei-Min He
Summary: In this study, a peroxidase-mimicking nanozyme was prepared by growing silver nanoparticles on the surface of a metal-organic framework. The nanozyme not only served as a surface-enhanced Raman spectroscopy substrate, but also effectively catalyzed the oxidation of leucomalachite green into malachite green. The nanozyme was successfully applied for the sensitive detection of cholesterol.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Multidisciplinary
Shi Xuan Leong, Charlynn Sher Lin Koh, Howard Yi Fan Sim, Yih Hong Lee, Xuemei Han, Gia Chuong Phan-Quang, Xing Yi Ling
Summary: The study successfully achieves direct, label-free SERS sensing of biologically important enantiomers by synergizing asymmetric nanoporous gold (NPG) nanoparticles with electrochemical-SERS. This strategy is versatile and can be readily extended to detect various enantiomers, and allows for multiplex quantification of enantiomeric ratios with excellent predictive performance. The research offers a paradigm shift in achieving label-free chiral SERS sensing of various enantiomers.
Article
Chemistry, Applied
Xiaojuan Xie, Jing Jiang, Jiali Ma, Chenjie Gu, Tao Jiang, Jinjie Zhang
Summary: This paper proposes a non-destructive pluggable sensor for effective detection of food substances by considering the actual solute concentration and different water activities (Aw) in the environment. The impact of Aw on purine detection and its deviation corrections are investigated, and the reliability of the proposed method is validated through purine recoveries from three food products. The results show that the proposed non-destructive pluggable sensor performs better when Aw is considered. Thus, rectifying deviations based on Aw can significantly help monitor food quality.
Article
Electrochemistry
Sheila Hernandez, Juan Perales-Rondon, Aranzazu Heras, Alvaro Colina
Summary: EC-SOERS is a new phenomenon that enhances the Raman signal during the oxidation of a metal surface. Studies show that carbonyl and carboxyl groups are necessary to observe this phenomenon, with a delocated charge being important factor. Evaluating the enhancement factors for different molecules with highly delocated charge and a carboxyl group sheds more light on the interaction of molecules with the electrochemically generated SOERS substrates.
ELECTROCHIMICA ACTA
(2021)
Review
Biochemistry & Molecular Biology
Antonio Sasso, Angela Capaccio, Giulia Rusciano
Summary: This review focuses on the recent studies conducted by our group in the past decade, where novel nanofabrication techniques were successfully applied to SERS and TERS experiments for studying bio-systems and molecular species of environmental interest.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Analytical
Qian Wu, Li Tian, Xiangyu Shan, Huiling Li, Chao Li, Juan Lu
Summary: A novel ECL sensor was developed by modifying Fe3CuO4-Ru(bpy)3+ and GO-CdS@ZnS on the electrode for the detection of permethrin. The sensor exhibited high sensitivity and a wide detection range.
Article
Chemistry, Analytical
Tingting Gong, Lei Liao, Bingying Jiang, Ruo Yuan, Yun Xiang
Summary: In this study, a fluorescent biosensing system for high sensitivity detection of MT was established using a new Ag+-stabilized DNA triplex probe (Ag+-SDTP) combined with catalytic hairpin assembly (CHA) and CRISPR/Cas12a signal enhancements. The sensing method is able to selectively detect MT from other non-specific molecules and can achieve low level detection of MT in diluted human serums, demonstrating its potential for monitoring disease-specific MT biomarker at trace levels.
Article
Chemistry, Analytical
Estrella Sanz Rodriguez, Kyra Wood, Paul R. Haddad, Brett Paull
Summary: This study presents a simple, rapid, and reliable method for determining boron in aqueous solutions using suppressed ion chromatography coupled to electrospray ionisation-triple quadrupole mass spectrometry. The method achieved a low limit of detection and demonstrated excellent analytical performance.
Article
Chemistry, Analytical
Aline Cournut, Paul Moustiez, Yannick Coffinier, Christine Enjalbal, Claudia Bich
Summary: Alzheimer's disease is a major cause of senile dementia and is characterized by the aggregation of neurofibrillary tangles and amyloid plaques in the brain. The A beta 1-42 peptide is considered the primary cause of neurotoxicity due to its insolubility and subsequent aggregation. A beta 1-42 and A beta 1-40 have been identified as relevant biomarkers for AD diagnosis, and SurfaceAssisted Laser Desorption/Ionization Mass Spectrometry (SALDI-MS) was used to monitor the A beta 1-42/A beta 1-40 ratio without prior sample treatment.
Article
Chemistry, Analytical
Dotse Selali Chormey, Buse Tugba Zaman, Tulay Borahan Kustanto, Sezin Erarpat Bodur, Suleyman Bodur, Elif Ozturk Er, Sezgin Bakirdere
Summary: This review provides an overview of the harmful effects of endocrine disrupting chemicals (EDCs) on human health and introduces the methods for analyzing EDCs. Recent research has focused on using green chemicals, such as deep eutectic solvents (DESs), for microextraction to ensure environmental safety.
Article
Chemistry, Analytical
Yan Zhang, Renfeng Xu, Jingjing Wu, Zhenghong Zhang, Yuhuang Wang, Hongqin Yang, Sheng Zhang
Summary: This study visualized the pore-like structures in prostate cancer cell membranes after treatment with the anticancer drug paclitaxel, demonstrating its mechanism of action related to oxidative damage.
Article
Chemistry, Analytical
Chihong Ma, Qin Zhou, Jinjin Shi, Hua Gao, Di Huang, Huimin Xue, Han Wang, Zhenzhong Zhang, Sen Yang, Junli Zhang, Kaixiang Zhang
Summary: We developed a CRISPR-empowered electrochemical biosensor, named PER-E-CRISPR, for amplification-free and sensitive detection of miR-21. The biosensor combines the advantages of CRISPR/Cas13a and primer exchange reaction (PER) for target amplification. Under optimized conditions, the PER-E-CRISPR assay exhibits a linear range from 10-13 to 10-7 M and a limit of detection of 30.2 fM. The biosensor shows excellent performance in actual plasma, indicating promising prospects for miRNA detection in molecular diagnosis.
Article
Chemistry, Analytical
Gang Liang, Jie Zhao, Yufei Gao, Tao Xie, Jianhui Zhen, Ligang Pan, Wenwen Gong
Summary: Molecular docking (MD) analysis is widely used for studying the interaction between aptamers and small molecules. This study established steady-state aptamers of tertiary structures (SATS) using specific aptamers of tetracycline antibiotics as docking models. Molecular docking results revealed multiple binding sites in the SATS of aptamers, with significant variations in binding free energy (BFE) and docking score (DS). The study also proposed a method for MD analysis based on SATS, providing insights into binding mode and predicting binding sites.
Article
Chemistry, Analytical
Yixuan Xu, Changchang Teng, Huiping Dang, Dalong Yin, Lifeng Yan
Summary: Stable organic radical molecules with high NIR fluorescence quantum efficiency have been synthesized and encapsulated into nanoparticles, which show great potential for both photodynamic therapy (PDT) and photothermal therapy (PTT) of tumors.
Article
Chemistry, Analytical
Yu Su, Dandan Yang, Yanjie Wang, Jie Ding, Lan Ding, Daqian Song
Summary: In this study, a highly selective molecularly imprinted polymer Cu-MIPs@CS was designed and synthesized for bisphenol A (BPA). Cu-MIPs@CS showed significantly enhanced imprinting factor and selective factor towards BPA compared to MIPs@CS. It also exhibited superior discrimination ability between BPA and its structural analogue. Additionally, Cu-MIPs@CS were successfully applied as a solid phase extraction adsorbent for the determination of BPA in drinking water samples.
Article
Chemistry, Analytical
Yi Qiao, Qiongdan Zhang, Yukun He, Tianguang Cheng, Jing Tu
Summary: Single cell heterogeneity plays an important role in many biological phenomena, and distinguishing cells with specific mutations is beneficial for clinical diagnosis and drug screening. This study introduces a gel plate platform that can distinguish cell types based on their phenotypes, with low equipment requirement. The gel platform has potential in point-of-care circumstances and single-cell stimulation responses that prioritize efficiency and simplicity.
Article
Chemistry, Analytical
Chengke Wang, Shuyang Sun, Ping Wang, Huawei Zhao, Wenling Li
Summary: The food safety of aquatic products is a global concern. Nanotechnology-based analyses have advantages in the detection of bacteria, metal ions, and small molecule contaminants. This review summarizes the recent advances in biosensing strategies for aquatic products and highlights the application of nanomaterials, lateral flow-based biosensors, surface-enhanced Raman scattering, microfluidic chips, and molecular imprinting technologies.
Article
Chemistry, Analytical
Liping Zhu, Zeng Tang, Xuemei Zhang, Li Zhu, Tian Meng, Linying Yu, Ting Xiao, Shasha Lu, Xiaoli Xiong, Xiurong Yang
Summary: A sensitive off-on electrochemiluminescence DNA sensor was developed using Exo III-assisted cascade amplification system. The sensor achieved high selectivity and ultra-high sensitivity in detecting target DNA by utilizing ECL and SPR effects. This study provides a new perspective for designing highly sensitive and programmable ECL biosensors.
Article
Chemistry, Analytical
Tong Li, Mengxu Sun, Suping Xia, Ting Huang, Rong-Tian Li, Chunrong Li, Zong Dai, Jin-Xiang Chen, Jun Chen, Nuan Jia
Summary: Here, we developed a binary system based on DNA tetrahedron and fluorogenic RNA aptamers for highly specific and label-free mRNA imaging in living cells. This system achieved high specificity label-free detection of nucleic acids with a detection limit of 1.34 nM. The method has potential applications in early disease diagnosis and new drug development.
Article
Chemistry, Analytical
Yao Zhao, Shu Zhang, Wang Yao, Yuxuan Zhu, Jing Qian, Juan Yang, Nianjun Yang
Summary: A new hierarchical nanostructured composite with high conductivity and catalytic activity is synthesized. The sensor exhibits significant catalytic effect and high sensitivity for monitoring the environmental endocrine disruptor bisphenol A (BPA).