Article
Gastroenterology & Hepatology
Neil Mehta, Catherine Frenette, Parissa Tabrizian, Maarouf Hoteit, Jennifer Guy, Neehar Parikh, T. Tara Ghaziani, Renu Dhanasekaran, Jennifer L. Dodge, Brahma Natarajan, Matthew L. Holzner, Leana Frankul, Wesley Chan, Austin Fobar, Sander Florman, Francis Y. Yao
Summary: This study is the first multiregional study based on UNOS-DS criteria, showing a successful downstaging rate of >80% and similar efficacy of chemoembolization and yttrium-90 radioembolization as the initial downstaging treatment. Despite a 2-year post-LT survival rate of 95%, a high rate of tumor understaging was observed.
Article
Oncology
Kelley G. Nunez, Tyler Sandow, Daniel Fort, Jai Patel, Mina Hibino, Ian Carmody, Ari J. Cohen, Paul Thevenot
Summary: The biomarkers AFP, AFP-L3, and DCP have implications in HCC surveillance, prognosis, and post-surgical recurrence risk. Accumulation of these biomarkers increases HCC progression risk, but patients with triple negative status for these biomarkers have a higher first-line objective response rate.
Article
Spectroscopy
Jian Zhu, Li-na Meng, Xin Li, Guo-jun Weng, Jian-jun Li, Jun-wu Zhao
Summary: This paper investigates the fluorescence quenching characteristics of Au-Ag-Pt core-shell nanorods and successfully prepares a specific detection probe for AFP. The quenching effect can be optimized by adjusting the concentration of chloroplatinic acid, and surface modification ensures sensing specificity. The specific detection limit for AFP is 4.0 pg/mL, with a linear detection range of 0.03-0.5 ng/mL.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Chemistry, Physical
A. Ibrahim, U. B. Memon, S. P. Duttagupta, R. K. Singh Raman, A. Sarkar, G. Pendharkar, S. S. Tatiparti
Summary: This study reports the hydrogen sensing properties of Pt dispersed graphitic carbon nitride (g-C3N4) nanocomposite at room temperature and in an inert atmosphere. The synthesized nanocomposite showed good sensitivity towards hydrogen gas at different concentrations and film thickness, indicating its potential for reliable hydrogen gas sensing.
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
(2021)
Article
Oncology
Yeliu Fu, Junyao Chen, Caiyang Li, Lie Chen, Zhilan Zhang, Zhenxiu Huang
Summary: The study showed that in patients with low-level AFP liver cancer, ultrasound-guided percutaneous transhepatic puncture has high sensitivity and specificity, with a low complication rate during treatment.
TRANSLATIONAL CANCER RESEARCH
(2021)
Article
Chemistry, Analytical
Navid Taheri, Hosein Khoshsafar, Mostafa Ghanei, Ali Ghazvini, Hasan Bagheri
Summary: A high-performance sensing layer based on dual-template molecularly imprinted polymer (DMIP) was fabricated and successfully applied for one-by-one detection of carcinoembryonic antigen (CEA) and alpha-fetoprotein (AFP) as lung cancer biomarkers. The DMIP sensor showed high sensitivity and good stability, making it a promising method for sensing of AFP and CEA in serum samples.
Article
Chemistry, Physical
Huiqing Fan, Xiaokun Zheng, Qi Shen, Weijia Wang, Wenqiang Dong
Summary: A hierarchical SnO2 nanosheet structure loaded with Pt nano quantum dots was prepared and exhibited high gas sensitivity and excellent response and recovery behavior.
JOURNAL OF ALLOYS AND COMPOUNDS
(2022)
Review
Gastroenterology & Hepatology
Daniel Hoffman, Neil Mehta
Summary: This paper comprehensively reviews the data on assessing risk and managing recurrence for patients undergoing liver transplantation for hepatocellular carcinoma (HCC). Multiple post-transplant prognostic scoring systems have been developed to improve recurrence risk assessment, but translating this information into surveillance and treatment strategies remains a challenge. Immunosuppression strategies post-LT aim to reduce recurrence risk, while evidence-based strategies for managing recurrent HCC are continuously evolving.
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Yankun Tang, Ming Zhang, Sher Ali Nawaz, Xianqing Tian, Hairong Wang, Jiuhong Wang
Summary: A platinum-assisted TiO2 hierarchical nano material was synthesized using hydrothermal method for ultra-low concentration formaldehyde detection at low temperature. The material showed good stability and sensitivity, making it suitable for detecting formaldehyde in air.
Article
Biochemistry & Molecular Biology
Kittiporn Punuch, Chamaiphorn Wongwan, Saranrat Jantana, Chayapol Somboonyosdech, Kamonlatth Rodponthukwaji, Natsuda Kunwong, Kytai T. Nguyen, Vorapan Sirivatanauksorn, Yongyut Sirivatanauksorn, Chatchawan Srisawat, Primana Punnakitikashem
Summary: Angiogenesis inhibitor drugs have limitations in cancer therapy, but combination therapy with small interfering RNA (siRNA) loaded nanoparticles (NPs) could enhance therapeutic efficacy. This study successfully synthesized AFP-siRNA-loaded NPs and demonstrated their synergistic effect with angiogenesis inhibitors in decreasing cell viability in hepatocellular carcinoma (HCC). The combination treatment also significantly silenced AFP-mRNA expression, further enhancing the therapeutic outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Materials Science, Multidisciplinary
Rukan Suna Karatekin, Sedef Kaplan, Sevda Ildan Ozmen, Meltem Kahya Dudukcu
Summary: An effective non-enzymatic H2O2 sensor electrode was developed using nitrogen doped reduced graphene oxide (N-rGO) modified with different amounts of ZnO and Pt nanoparticles. The addition of ZnO and Pt nanoparticles showed a synergistic effect, resulting in higher sensitivity towards H2O2 reduction. The fabricated sensor exhibited excellent selectivity in the presence of other interfering species.
MATERIALS CHEMISTRY AND PHYSICS
(2022)
Article
Oncology
Gian Piero Guerrini, Massimiliano Berretta, Giovanni Guaraldi, Paolo Magistri, Giuseppe Esposito, Roberto Ballarin, Valentina Serra, Stefano Di Sandro, Fabrizio Di Benedetto
Summary: With the introduction of HAART, HIV-infected patients have longer life expectation and liver diseases like HCC now pose a significant threat. However, this study found that HIV-infected patients undergoing LT for HCC have comparable post-LT survival results to uninfected patients. Close surveillance and precise treatment of the tumor while on the waiting list can lead to excellent outcomes for HIV-infected patients with HCC undergoing LT.
Article
Chemistry, Analytical
Zhuo Wang, Xueer Qiu, Wensong Xi, Ming Tang, Jinliang Liu, Hong Jiang, Lining Sun
Summary: The study developed an upconversion hybrid nano fluorescent sensor (HNFS) for evaluating the LDH inhibitors efficacy in cancer cells, showing excellent biocompatibility in living cells. By analyzing the changes in mean fluorescence intensities of confocal images after incubating HNFS with different cells, the efficacy of LDH inhibitors on various cancer cells and differentiation between healthy and cancer cells were illustrated.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Materials Science, Multidisciplinary
Y. M. Bakier, M. Ghali, A. Elkun, A. M. Beltagi, W. K. Zahra
Summary: An ultra-small nitrogen-doped carbon nanodots were used as a turn-off fluorescent chemo-sensor for ultrasensitive detection of aniline in aqueous medium, reaching an exceptional low detection limit. The proposed method provided a simple and interference-free approach for aniline detection.
MATERIALS RESEARCH BULLETIN
(2021)
Article
Materials Science, Multidisciplinary
Guangyao Pei, Binghe Ma, Zhonggang Zhang, Chuqiao Wang, Jinjun Deng, Jian Luo
Summary: This paper proposes a Pt-Al2O3 composite nano-thick interdigital electrode (IDEs) for high-temperature SAW sensors. The IDEs have good structural stability and low impurity concentration at high temperatures. Improved quality factors and matched electrical impedance can be achieved through electroacoustic optimization. Multiple SAW temperature sensors using the composite IDEs also perform well at higher temperatures.
MATERIALS CHEMISTRY AND PHYSICS
(2022)
Article
Chemistry, Analytical
Ayman A. Gouda, Ragaa El Sheikh, Ahmed O. Youssef, Nancy Gouda, Walaa Gamil, Hameeda A. Khadrajy
Summary: A new and sensitive enrichment membrane filtration method was developed for the preconcentration and separation of trace amounts of Cd(II), Co(II), Cu(II), Ni(II), and Pb(II) ions from water and food samples. The method showed high recovery values and low relative standard deviation, making it suitable for the separation and preconcentration of trace metal ions.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Islam M. Fouda, Mohamed Y. El-Kady, Enass M. El-Sheikh, Ahmed H. Orabi, Ahmed O. Youssef
Summary: A new cellulose impregnated phosphorus oxychloride (COP) was prepared and its efficiency in removing Cr6+, Pb2+, V5+ and Cd2+ ions from a diluted sulphuric solution of titanium liquor was evaluated for the first time. The synthetic COP adsorbent was characterized using various instrumental performances such as FTIR, SEM, EDX and H-1 NMR. The factors affecting the adsorption and removal of the target ions were optimized. The new COP showed high adsorption capacity and removal efficiency for Cr6+, Pb2+, V5+ and Cd2+ ions. Finally, the purified titanium dioxide was obtained by treating the titanium sulphate leaching liquor from ilmenite concentrate with the optimized adsorption parameters for the removal of Cr6+, Pb2+, V5+ and Cd2+ ions.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL ANALYTICAL CHEMISTRY
(2023)
Article
Materials Science, Multidisciplinary
M. A. Elhelaly, M. A. El-Zomor, M. S. Attia, A. O. Youssef
Summary: Chromium carbide coatings were successfully deposited on AISI O2 cold work tool steel using pack cementation method at temperatures ranging from 900 to 1100 degrees C for different hold times. The resulting coatings exhibited varying phases and layer thicknesses, with a maximum thickness of 50 μm. The microhardness of the coatings reached 1750 HV0.05, significantly higher than the uncoated/annealed and quench/tempered specimens.
JOURNAL OF MATERIALS ENGINEERING AND PERFORMANCE
(2022)
Article
Microbiology
Amer M. M. Abdelaziz, Mohammed A. A. Elshaer, Mohamed A. A. Abd-Elraheem, Omar M. Omar M. Ali, Muhammad I. I. Haggag, Gharieb S. S. El-Sayyad, Mohamed S. S. Attia
Summary: The study investigates the use of aqueous Ziziphus spina-christi leaves' extract (ZSCE) to produce eco-friendly and cost-effective silver nanoparticles (Ag NPs) with antifungal activity against Fusarium wilt disease. The ZSCE and Ag NPs showed antimicrobial substances and exhibited potential against F. oxysporum. Ag NPs treatment was the most effective in reducing disease severity and promoting plant immunity. Due to their antifungal activity and eco-friendly approach, they can be used as novel therapeutic nutrients in agriculture.
ARCHIVES OF MICROBIOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Sabry M. Attia, Mohammed A. Al-Hamamah, Moureq R. Alotaibi, Abdullah F. Alasmari, Mohamed S. M. Attia, Sheikh F. Ahmad, Mohamed A. Mahmoud, Ahmed Nadeem, Mushtaq A. Ansari, Saleh A. Bakheet
Summary: Rheumatoid arthritis (RA) is associated with increased risk of lymphoma, an autoimmune disorder. Rituximab, approved for non-Hodgkin's lymphoma, is also used to treat RA. In a study using collagen-induced arthritis DBA/1J animal models, rituximab reduced micronucleus formation caused by chromosome loss and decreased the DNA oxidative stress marker 8-hydroxydeoxyguanosine.
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
(2023)
Letter
Surgery
Hitesh Chopra, Mohamed S. Attia, Syed Faisal Badshah, Kuldeep Dhama, Talha B. Emran
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Article
Medicine, General & Internal
Mohamed S. S. Attia, Heba A. A. Ewida, Mohamed Aly Abdel Hafez, Shohda A. A. El-Maraghy, Maha M. M. El-Sawalhi
Summary: This study investigated the expression of lnc-EGFR, SNHG1, and lincRNA-Cox2 in RRMS patients during active relapses and in remission, and their potential roles as biomarkers for RRMS. The results showed significant downregulation of lnc-EGFR and FOXP3 and upregulation of SNHG1, lincRNA-Cox2, NLRP3, ASC, and caspase-1 in RRMS patients. Furthermore, lnc-EGFR, SNHG1, and lincRNA-Cox2 exhibited correlations with disease activity and progression.
Article
Biochemistry & Molecular Biology
Sabry M. Attia, Mohammed A. Al-Hamamah, Mohamed S. M. Attia, Abdulrazaq Alanazi, Sheikh F. Ahmad, Mushtaq A. Ansari, Ahmed Nadeem, Saleh A. Bakheet, Gamaleldin I. Harisa
Summary: Compared to the general population, arthritis patients have a higher risk of fertility abnormalities. Rituximab, a commonly used treatment, has not been fully studied in terms of its effect on germ cells. This study aimed to investigate the impact of rituximab on aneuploidy and redox imbalance in arthritic mouse sperm. Results showed that rituximab did not induce aneuploidy, while arthritis significantly increased the frequency of disomy. Rituximab treatment reduced the levels of disomic sperm and restored markers of oxidative stress. Furthermore, arthritis severity was reduced after rituximab treatment.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Article
Chemistry, Analytical
Huda M. Younis, A. O. Youssef, Said M. El-Sheikh, Sheta M. Sheta, Mohamed S. Attia
Summary: Fe-Gallic acid metal organic framework (MOF) was synthesized and characterized for use as a sensor to detect the antiviral drug Molnupiravir. The Fe-Gallic acid MOF sensor is highly sensitive and cost-effective, and does not require special equipment. It has potential applications in various settings, including clinical laboratories and point-of-care.
MICROCHEMICAL JOURNAL
(2023)
Article
Environmental Sciences
Ali A. Alshamrani, Mohammad Y. Alwetaid, Mohammed A. Al-Hamamah, Mohamed S. M. Attia, Sheikh F. Ahmad, Majed A. Algonaiah, Ahmed Nadeem, Mushtaq A. Ansari, Saleh A. Bakheet, Sabry M. Attia
Summary: The pathophysiology of autism is influenced by a combination of environmental and genetic factors. In addition, individuals with autism have a higher risk of developing cancer, possibly due to Aflatoxin B1 (AFB1) exposure. This study investigated the effects of AFB1 on genomic instability and apoptosis in a mouse model of autism. The findings showed that AFB1 exposure increased micronuclei generation, oxidative DNA strand breaks, and apoptosis in the mice, indicating a disturbed redox balance and dysregulation in the DNA damage/repair pathway. These results suggest that AFB1-related genomic instability may accelerate cancer development and that mitigating redox imbalance and DNA damage/repair dysregulation could be potential therapeutic approaches.
Article
Chemistry, Multidisciplinary
Fagr A. A. Shehata, Amer S. S. El-Kalliny, Mohamed S. S. Attia, Tarek A. A. Gad-Allah
Summary: Magnetic SiO2/Zn0.4Co0.6Fe2O4 aerogels were prepared by sol-gel method with APD and FD. The surface was modified to be hydrophobic. The materials exhibited superparamagnetic behavior and preference for the FD method, with high adsorption capacities and efficient oil separation. The magnetic recovery and reuse were successfully implemented, reducing practical application costs.
Article
Biotechnology & Applied Microbiology
Nahla A. Bouqellah, Gharieb S. El-Sayyad, Mohamed S. Attia
Summary: This study used zinc oxide nanoparticles (ZnO-NPs) synthesized by gamma rays to protect tomato plants against Fusarium wilt. The ZnO-NPs were characterized using various techniques, and it was found that a 20 kGy dose was the most effective in terms of synthesis. The designed ZnO-NPs showed promising activity in inducing plant physiological immunity against Fusarium wilt disease and significantly reduced disease symptoms incidence. Additionally, ZnO-NPs improved various growth parameters and biochemical compounds in infected tomato plants compared to control plants.
INTERNATIONAL MICROBIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Hind A. AlGhamdi, Yasmeen M. AlZahrani, Salha Alharthi, Mohamed S. Mohy-Eldin, Ekram H. Mohamed, Safwat A. Mahmoud, Mohamed S. Attia
Summary: Researchers synthesized and characterized an Fe-gallic acid MOF embedded in a CMC polymer thin film, which served as a novel sensor for detecting CA 15-3 in breast cancer patients' sera. The presence of appropriate functional groups allowed interaction between the CA 15-3 and the MOF. The MOF exhibited sensitivity and proved to be a reliable probe for detecting CA 15-3 with a detection limit of 0.01 U mL(-1).
Article
Chemistry, Multidisciplinary
Yasmeen M. AlZahrani, Salha Alharthi, Hind A. AlGhamdi, A. O. Youssef, Shahenda S. Ahmed, Ekram H. Mohamed, Safwat A. Mahmoud, Mohamed S. Attia
Summary: A low-cost, accurate, and highly selective method using luminescence enhancement of N/S-doped carbon dots (CQDs) was developed to assess β-hCG in serum samples of breast and prostate cancer patients. The synthesized luminescent optical sensor showed blue luminescence at λem = 345 nm and λex = 288 nm at pH 7.8 in DMSO, and the enhancement of luminescence intensity at λem = 345 nm was used to determine β-hCG in serum samples. The method had a dynamic range of 1.35-22.95 mU mL(-1), with a LOD of 0.235 mU mL(-1) and LOQ of 0.670 mU mL(-1).
Article
Chemistry, Analytical
Qian Wu, Li Tian, Xiangyu Shan, Huiling Li, Chao Li, Juan Lu
Summary: A novel ECL sensor was developed by modifying Fe3CuO4-Ru(bpy)3+ and GO-CdS@ZnS on the electrode for the detection of permethrin. The sensor exhibited high sensitivity and a wide detection range.
Article
Chemistry, Analytical
Tingting Gong, Lei Liao, Bingying Jiang, Ruo Yuan, Yun Xiang
Summary: In this study, a fluorescent biosensing system for high sensitivity detection of MT was established using a new Ag+-stabilized DNA triplex probe (Ag+-SDTP) combined with catalytic hairpin assembly (CHA) and CRISPR/Cas12a signal enhancements. The sensing method is able to selectively detect MT from other non-specific molecules and can achieve low level detection of MT in diluted human serums, demonstrating its potential for monitoring disease-specific MT biomarker at trace levels.
Article
Chemistry, Analytical
Estrella Sanz Rodriguez, Kyra Wood, Paul R. Haddad, Brett Paull
Summary: This study presents a simple, rapid, and reliable method for determining boron in aqueous solutions using suppressed ion chromatography coupled to electrospray ionisation-triple quadrupole mass spectrometry. The method achieved a low limit of detection and demonstrated excellent analytical performance.
Article
Chemistry, Analytical
Aline Cournut, Paul Moustiez, Yannick Coffinier, Christine Enjalbal, Claudia Bich
Summary: Alzheimer's disease is a major cause of senile dementia and is characterized by the aggregation of neurofibrillary tangles and amyloid plaques in the brain. The A beta 1-42 peptide is considered the primary cause of neurotoxicity due to its insolubility and subsequent aggregation. A beta 1-42 and A beta 1-40 have been identified as relevant biomarkers for AD diagnosis, and SurfaceAssisted Laser Desorption/Ionization Mass Spectrometry (SALDI-MS) was used to monitor the A beta 1-42/A beta 1-40 ratio without prior sample treatment.
Article
Chemistry, Analytical
Dotse Selali Chormey, Buse Tugba Zaman, Tulay Borahan Kustanto, Sezin Erarpat Bodur, Suleyman Bodur, Elif Ozturk Er, Sezgin Bakirdere
Summary: This review provides an overview of the harmful effects of endocrine disrupting chemicals (EDCs) on human health and introduces the methods for analyzing EDCs. Recent research has focused on using green chemicals, such as deep eutectic solvents (DESs), for microextraction to ensure environmental safety.
Article
Chemistry, Analytical
Yan Zhang, Renfeng Xu, Jingjing Wu, Zhenghong Zhang, Yuhuang Wang, Hongqin Yang, Sheng Zhang
Summary: This study visualized the pore-like structures in prostate cancer cell membranes after treatment with the anticancer drug paclitaxel, demonstrating its mechanism of action related to oxidative damage.
Article
Chemistry, Analytical
Chihong Ma, Qin Zhou, Jinjin Shi, Hua Gao, Di Huang, Huimin Xue, Han Wang, Zhenzhong Zhang, Sen Yang, Junli Zhang, Kaixiang Zhang
Summary: We developed a CRISPR-empowered electrochemical biosensor, named PER-E-CRISPR, for amplification-free and sensitive detection of miR-21. The biosensor combines the advantages of CRISPR/Cas13a and primer exchange reaction (PER) for target amplification. Under optimized conditions, the PER-E-CRISPR assay exhibits a linear range from 10-13 to 10-7 M and a limit of detection of 30.2 fM. The biosensor shows excellent performance in actual plasma, indicating promising prospects for miRNA detection in molecular diagnosis.
Article
Chemistry, Analytical
Gang Liang, Jie Zhao, Yufei Gao, Tao Xie, Jianhui Zhen, Ligang Pan, Wenwen Gong
Summary: Molecular docking (MD) analysis is widely used for studying the interaction between aptamers and small molecules. This study established steady-state aptamers of tertiary structures (SATS) using specific aptamers of tetracycline antibiotics as docking models. Molecular docking results revealed multiple binding sites in the SATS of aptamers, with significant variations in binding free energy (BFE) and docking score (DS). The study also proposed a method for MD analysis based on SATS, providing insights into binding mode and predicting binding sites.
Article
Chemistry, Analytical
Yixuan Xu, Changchang Teng, Huiping Dang, Dalong Yin, Lifeng Yan
Summary: Stable organic radical molecules with high NIR fluorescence quantum efficiency have been synthesized and encapsulated into nanoparticles, which show great potential for both photodynamic therapy (PDT) and photothermal therapy (PTT) of tumors.
Article
Chemistry, Analytical
Yu Su, Dandan Yang, Yanjie Wang, Jie Ding, Lan Ding, Daqian Song
Summary: In this study, a highly selective molecularly imprinted polymer Cu-MIPs@CS was designed and synthesized for bisphenol A (BPA). Cu-MIPs@CS showed significantly enhanced imprinting factor and selective factor towards BPA compared to MIPs@CS. It also exhibited superior discrimination ability between BPA and its structural analogue. Additionally, Cu-MIPs@CS were successfully applied as a solid phase extraction adsorbent for the determination of BPA in drinking water samples.
Article
Chemistry, Analytical
Yi Qiao, Qiongdan Zhang, Yukun He, Tianguang Cheng, Jing Tu
Summary: Single cell heterogeneity plays an important role in many biological phenomena, and distinguishing cells with specific mutations is beneficial for clinical diagnosis and drug screening. This study introduces a gel plate platform that can distinguish cell types based on their phenotypes, with low equipment requirement. The gel platform has potential in point-of-care circumstances and single-cell stimulation responses that prioritize efficiency and simplicity.
Article
Chemistry, Analytical
Chengke Wang, Shuyang Sun, Ping Wang, Huawei Zhao, Wenling Li
Summary: The food safety of aquatic products is a global concern. Nanotechnology-based analyses have advantages in the detection of bacteria, metal ions, and small molecule contaminants. This review summarizes the recent advances in biosensing strategies for aquatic products and highlights the application of nanomaterials, lateral flow-based biosensors, surface-enhanced Raman scattering, microfluidic chips, and molecular imprinting technologies.
Article
Chemistry, Analytical
Liping Zhu, Zeng Tang, Xuemei Zhang, Li Zhu, Tian Meng, Linying Yu, Ting Xiao, Shasha Lu, Xiaoli Xiong, Xiurong Yang
Summary: A sensitive off-on electrochemiluminescence DNA sensor was developed using Exo III-assisted cascade amplification system. The sensor achieved high selectivity and ultra-high sensitivity in detecting target DNA by utilizing ECL and SPR effects. This study provides a new perspective for designing highly sensitive and programmable ECL biosensors.
Article
Chemistry, Analytical
Tong Li, Mengxu Sun, Suping Xia, Ting Huang, Rong-Tian Li, Chunrong Li, Zong Dai, Jin-Xiang Chen, Jun Chen, Nuan Jia
Summary: Here, we developed a binary system based on DNA tetrahedron and fluorogenic RNA aptamers for highly specific and label-free mRNA imaging in living cells. This system achieved high specificity label-free detection of nucleic acids with a detection limit of 1.34 nM. The method has potential applications in early disease diagnosis and new drug development.
Article
Chemistry, Analytical
Yao Zhao, Shu Zhang, Wang Yao, Yuxuan Zhu, Jing Qian, Juan Yang, Nianjun Yang
Summary: A new hierarchical nanostructured composite with high conductivity and catalytic activity is synthesized. The sensor exhibits significant catalytic effect and high sensitivity for monitoring the environmental endocrine disruptor bisphenol A (BPA).