Journal
SYSTEMS BIOLOGY IN REPRODUCTIVE MEDICINE
Volume 64, Issue 3, Pages 220-223Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/19396368.2018.1450906
Keywords
Follicular fluid; fertility disorders; anti-Mullerian hormone; insulin-like growth factor 1; leptin
Categories
Ask authors/readers for more resources
Anti-Mullerian hormone (AMH), insulin-like growth factor 1 (IGF1) and leptin are produced in the granulosa cells of follicles and play an important role in the growth and maturation of follicles. The aim of our study was to monitor AMH, IGF1 and leptin levels in a group of healthy women and compare them to a group of women with fertility disorders. The second aim was the evaluation of biomarker levels in relation to the identified cause of infertility. Totally, 146 females were enrolled into our study. Seventy-two healthy controls and seventy-four females with fertility disorders were divided into four subgroups: anovulation, endometriosis, fallopian tube damage, unknown reason. IGF1 was the only biomarker with significantly lower levels throughout the entire group with fertility disorders. We did not identify any statistically significant differences for AMH and leptin. Regarding subgroups, significant differences were only observed in the group of anovulatory women. AMH and leptin showed higher levels while IGF1 showed lower levels. In conclusion, levels of AMH, IGF1 and leptin found in follicular fluid are sensitive markers for anovulatory fertility disorders. AMH, IGF1 and leptin levels in follicular fluid have no relation to the fertility disorders caused by endometriosis, fallopian tube damage or disorders with unknown etiology.Abbreviations: AMH: anti-Mullerian hormone; IGF1: insulin-like growth factor 1; PCOS: polycystic ovary syndrome
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available