Journal
SURGICAL ONCOLOGY CLINICS OF NORTH AMERICA
Volume 27, Issue 2, Pages 269-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.soc.2017.11.003
Keywords
Colitis-associated cancer; Colitis cancer surveillance; Colitis-associated cancer management; 3D human models
Funding
- National Institutes of Health (NIH) [R01 CA142808, R01 CA157663, U01 CA214300]
- Cleveland Clinic Research Project Committees Award [47]
- National Center for Advancing Translational Sciences [UL1TR000439]
- Velosano Pilot Award
- Metastatic Colon Cancer Research Center of Excellence Award (Cleveland Clinic Digestive Disease and Surgery Institute, Lerner Research Institute, Taussig Cancer Center)
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Colitis-associated cancer is a relatively rare form of cancer with an unclear pathogenesis. Colitis-associated cancer serves as a prototype of inflammation-associated cancers. Advanced colonoscopic techniques are considered standard of care for surveillance in patients with long-standing colitis, especially those with other risk factors, including sclerosing cholangitis and a family history of colorectal cancer. When colitis-associated cancer is diagnosed, the standard operation involves total proctocolectomy. Restorative procedures and surveillance after colectomy require special considerations. In these contexts, new 3-dimensional human models may be used to usher in personalized medicine.
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