Review
Cardiac & Cardiovascular Systems
Krishnan Warrior, Daniel F. Dilling
Summary: Lymphangioleiomyomatosis (LAM) is a rare cystic lung disease with respiratory symptoms and extra-thoracic manifestations. Lung transplantation can improve the life quality of LAM patients with end-stage lung disease, but there are unique considerations and complications associated with LAM. This review provides an overview of evaluation, management, and outcomes for LAM patients undergoing lung transplantation.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2023)
Article
Genetics & Heredity
Teiko Sakurai, Toru Arai, Masaki Hirose, Kensuke Kojima, Tetsuki Sakamoto, Yoshinobu Matsuda, Chikatoshi Sugimoto, Hyung-Eun Yoon, Yoshikazu Inoue
Summary: This retrospective study found that sirolimus treatment after surgical pleural covering significantly reduces the recurrence of pneumothorax in LAM patients. Sirolimus induction after SPC (TPC or mTPC) may be a viable option for managing recurrent pneumothorax in LAM.
ORPHANET JOURNAL OF RARE DISEASES
(2021)
Article
Surgery
Andrew P. Dhanasopon, Justin D. Blasberg, Vincent J. Mase
Summary: Pneumothorax and pleural-based disease have a long history and consistent surgical goals. Pneumothorax requires pleural symphysis and prevention of recurrence, while the management of empyema depends on the patients' immune status, virulence of the organism, and timely treatment to achieve removal of infected fluid/tissue and lung reexpansion.
SURGICAL CLINICS OF NORTH AMERICA
(2022)
Article
Oncology
Eiji Takeuchi, Yoshio Okano, Hisanori Machida, Katsuhiro Atagi, Yoshihiro Kondou, Naoki Kadota, Nobuo Hatakeyama, Keishi Naruse, Tsutomu Shinohara
Summary: This study retrospectively analyzed lung cancer patients with malignant pleural effusion (MPE) and found that those with eosinophilic pleural effusion (EPE) had a better prognosis than those without EPE. Factors such as EPE, Eastern Cooperative Oncology Group (ECOG) Performance Status, sex, and the neutrophil-to-lymphocyte ratio in the serum were identified as independent prognostic factors affecting survival.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Article
Critical Care Medicine
Srinivas R. Mummadi, James K. Stoller, Rocio Lopez, Karthik Kailasam, Colin T. Gillespie, Peter Y. Hahn
Summary: This study investigated the epidemiologic measures related to adult pleural diseases in the United States from 2007 to 2016. Significant trends and changes in various pleural diseases were observed, suggesting opportunities for improvement in their management.
Article
Medical Laboratory Technology
Chuanshen Xu, Weina Zhang, Xin Wang, Zhiqiang Li, Ge Guan, Shuxian Wang, Ning Fan, Yuan Guo, Wei Rao, Jianhong Wang, Taohua Zheng, Yunjin Zang
Summary: The study showed a positive correlation between pleural effusion and lung infection in patients after liver transplantation. Patients in the observation group had greater pleural effusion depth, declined lung function, higher infection rate, and increased inflammatory factor levels compared to the control group, suggesting a strong association between pleural effusion depth and lung infection.
CLINICAL LABORATORY
(2021)
Review
Respiratory System
Biplab K. Saha, Woon H. Chong, Adam Austin, Ritu Kathuria, Praveen Datar, Boris Shkolnik, Scott Beegle, Amit Chopra
Summary: This narrative review provides a detailed overview of pleural abnormalities in patients with coronavirus disease 19 (COVID-19). Radiologic pleural abnormalities are common in COVID-19, but the incidence of pleural effusion appears to be low, and pneumothorax is rare and does not independently predispose the patient to worse outcomes.
JOURNAL OF THORACIC DISEASE
(2021)
Article
Genetics & Heredity
Chongsheng Cheng, Wenshuai Xu, Yani Wang, Tengyue Zhang, Luning Yang, Wangji Zhou, Danjing Hu, Yanli Yang, Xinlun Tian, Kai-Feng Xu
Summary: This study found that high CT grade and age at presentation ≤ 35 years were associated with an increased risk of pneumothorax in patients with LAM, while postmenopausal status correlated with a lower risk of pneumothorax. Additionally, sirolimus was found to reduce the risk of pneumothorax recurrence in LAM patients.
ORPHANET JOURNAL OF RARE DISEASES
(2022)
Article
Infectious Diseases
Ling Ai, Jingyuan Li, Ting Ye, Wenjun Wang, Yuying Li
Summary: This article reports a case of exudative pleural effusion caused by lung fluke infection in a young male. It highlights that lung fluke infection is often overlooked as a cause of pleural effusion. Eosinophilia may serve as a marker for infection, and serological tests can aid in confirming the diagnosis.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Medicine, General & Internal
Xiangxiang Zhou, Jingxuan Wan, Xin Gan
Summary: A 73-year-old male patient with pulmonary tuberculosis was eventually diagnosed with malignant eosinophilic pleural effusion. After receiving chemotherapy, the patient achieved partial response and the effusion disappeared. Multiple Thinprep cytology tests showed no evidence of malignancy, highlighting the importance of pleural biopsy for accurate etiology diagnosis.
Article
Engineering, Biomedical
Zhenhuan Song, Weizhan Luo, Haichong Zheng, Yunxiang Zeng, Jinlin Wang, Tianfeng Chen
Summary: A translational selenium nanoparticles coated with immune-modulating macromolecule lentinan are designed to restore dysfunctional immune cells in patient-derived malignant pleural effusion microenvironment, enhancing immune responses and inhibiting tumor growth, thereby providing a potential therapeutic strategy for advanced lung cancer patients with MPE.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Environmental Sciences
Kuan-Jen Bai, Shu-Chuan Ho, Shu-Chuan Ho, Cheng-Yu Tsai, Jen-Kun Chen, Chun-Nin Lee, Kang-Yun Lee, Chih-Cheng Chang, Tzu-Tao Chen, Po-Hao Feng, Kuan-Yuan Chen, Chien-Ling Su, Hsiao-Chi Chuang
Summary: The study found that PM2.5 exposure and possible Zn in pleural effusion were associated with the development of malignant pleural effusion in lung cancer patients.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Medicine, General & Internal
Ji Zhang, Dong Liu, Bingqing Yue, Le Ban, Min Zhou, Hongmei Wang, Jian Lv, Bo Wu, Zhenguo Zhai, Kai-Feng Xu, Wenhui Chen, Jingyu Chen
Summary: This study summarized the clinical data of 25 patients with pulmonary LAM who underwent lung transplantation at two hospitals in China between 2010 and 2018. The study highlighted the importance of lung transplantation for LAM patients in the Asian population and emphasized the need for further research on sirolimus use and LAM-related complications.
FRONTIERS IN MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Samia Boussouar, Amira Benattia, Jean. -Baptiste Escudie, Laure Gibault, Frederique Capron, Anne Legrand, Pierre-Yves Brillet, Xavier Jeunemaitre, Philippe A. Grenier, Elie Mousseaux, Michael Frank, Olivier Sanchez
Summary: This study describes the CT features of lung involvement in patients with vEDS, with around 57.3% of patients showing abnormalities in lung parenchyma, most commonly emphysema. Surgical samples histologically revealed lung issues often correlated with arterial abnormalities.
EUROPEAN RADIOLOGY
(2021)
Review
Critical Care Medicine
Erik Vakil, Niloofar Taghizadeh, Alain Tremblay
Summary: Pleural diseases encompass pneumothorax and pleural effusion, causing pain, breathlessness, cough, and diminished quality of life. Disease burden varies regionally due to factors such as smoking, pneumonia, tuberculosis, asbestos, cancer, and organ failure. High-income countries have a higher disease burden due to better data availability, while lower-income countries likely have underestimated burdens. In the United States, there were 42,215 treat-and-discharge visits and 361,270 hospitalizations for pleural diseases in 2016, resulting in a national cost of $10.1 billion.
SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Surgery
Tatsuaki Watanabe, Hideo Shimomura, Tatsushi Mutoh, Ryoko Saito, Ryoi Goto, Takehiro Yamada, Hirotsugu Notsuda, Yasushi Matsuda, Masafumi Noda, Akira Sakurada, Yasuyuki Taki, Yoshinori Okada
Article
Pharmacology & Pharmacy
Saki Tanaka, Masafumi Kikuchi, Shinya Takasaki, Tensei Hirasawa, Kensuke Shigeta, Aoi Noda, Miki Akiba, Yasushi Matsuda, Hisashi Oishi, Tetsu Sado, Masafumi Noda, Yoshinori Okada, Nariyasu Mano, Hiroaki Yamaguchi
JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES
(2019)
Article
Biochemical Research Methods
Kensuke Shigeta, Masafumi Kikuchi, Masaki Tanaka, Shinya Takasaki, Hisashi Oishi, Tetsu Sado, Yasushi Matsuda, Masafumi Noda, Yoshinori Okada, Nariyasu Mano, Hiroaki Yamaguchi
BIOMEDICAL CHROMATOGRAPHY
(2020)
Article
Multidisciplinary Sciences
Hisashi Oishi, Masafumi Noda, Tetsu Sado, Yasushi Matsuda, Hiromichi Niikawa, Tatsuaki Watanabe, Akira Sakurada, Yasushi Hoshikawa, Yoshinori Okada
Article
Surgery
Hiroshi Yabuki, Yasushi Matsuda, Tatsuaki Watanabe, Shunsuke Eba, Fumihiko Hoshi, Takashi Hirama, Hisashi Oishi, Tetsu Sado, Masafumi Noda, Akira Sakurada, Masafumi Kikuchi, Hiroaki Yamaguchi, Nariyasu Mano, Yoshinori Okada
CLINICAL TRANSPLANTATION
(2020)
Article
Biochemical Research Methods
Shinya Takasaki, Tensei Hirasawa, Yu Sato, Masamitsu Maekawa, Taku Tsukamoto, Masafumi Kikuchi, Jiro Ogura, Yoshihiro Hayakawa, Yasushi Matsuda, Hisashi Oishi, Tetsu Sado, Masafumi Noda, Yoshinori Okada, Hiroaki Yamaguchi, Nariyasu Mano
Summary: A new liquid chromatography-tandem mass spectrometry method was developed and validated for simultaneous analysis of multiple drugs in lung-transplanted patients, providing accurate and reliable results suitable for therapeutic drug monitoring in this patient population.
BIOMEDICAL CHROMATOGRAPHY
(2021)
Article
Immunology
Yamato Suzuki, Hisashi Oishi, Yasushi Matsuda, Masafumi Noda, Sakiko Kumata, Kazuki Hayasaka, Yoshinori Okada
Summary: This case report highlights a rare but fatal complication of Scedosporium infection after lung transplantation, which occurred in a 13-year-old male patient who underwent bilateral lung transplantation. Despite treatment with voriconazole, the patient's condition worsened and ultimately led to death. Early and aggressive diagnostic measures should be considered for immunocompromised patients at risk of Scedosporium infection.
TRANSPLANTATION PROCEEDINGS
(2021)
Article
Immunology
Kazuki Hayasaka, Yui Watanabe, Takashi Hirama, Hisashi Oishi, Masafumi Noda, Hiroaki Toyama, Yutaka Ejima, Yoshikatsu Saiki, Yoshinori Okada
Summary: Single-lung transplant on the side with better lung function can be challenging but sometimes a realistic option in patients with significantly asymmetrical lung function. A successful case was reported with a recipient having a pulmonary perfusion ratio of 89%, undergoing the transplant under central venoarterial extracorporeal membrane oxygenation, and achieving acceptable short- and long-term outcomes with remarkable improvement of lung function.
TRANSPLANTATION PROCEEDINGS
(2021)
Article
Oncology
Kotaro Abe, Masahiko Kanehira, Shinya Ohkouchi, Sakiko Kumata, Yamato Suzuki, Hisashi Oishi, Masafumi Noda, Akira Sakurada, Eisaku Miyauchi, Tohru Fujiwara, Hideo Harigae, Yoshinori Okada
Summary: The study investigated the potential of targeting STC-1 in tumor cells for gene therapy in lung cancer, confirming the important role of STC-1 in lung cancer cells. The findings suggest that conferring cytotoxicity in STC-1-positive lung cancer cells using a suicide gene may be a promising therapeutic strategy for lung cancer.
Article
Cardiac & Cardiovascular Systems
Hisashi Oishi, Yasushi Matsuda, Yutaka Ejima, Hiroaki Toyama, Takashi Hirama, Tatsuaki Watanabe, Yui Watanabe, Hiromichi Niikawa, Masafumi Noda, Yoshinori Okada
Summary: The study found that VV ECMO can reduce pulmonary arterial systolic pressure during single lung transplantation surgery, even for patients with pulmonary arterial hypertension.
INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Yamato Suzuki, Hisashi Oishi, Masahiko Kanehira, Yasushi Matsuda, Takashi Hirama, Masafumi Noda, Yoshinori Okada
Summary: The study aimed to examine the effect of CTLA4-Ig therapy on chronic lung allograft dysfunction after lung transplantation. Results showed that the obliteration ratio of the transplanted trachea was significantly lower in the CTLA4-Ig group compared to the control group, with a correlation between fibrous obliteration attenuation and inhibition of lymphoid neogenesis observed.
ANNALS OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Article
Medicine, General & Internal
Hirotoshi Suzuki, Masafumi Noda, Tatsuaki Watanabe, Yasushi Matsuda, Yasushi Hoshikawa, Yoshinori Okada
Summary: The median sternotomy approach allows diseased lung ventilation during sleeve pneumonectomy, but the possibility of aortogenic embolic stroke should be considered when ascending aorta calcification is observed on preoperative computed tomography.
JOURNAL OF MEDICAL CASE REPORTS
(2021)
Article
Respiratory System
Hisashi Oishi, Akira Sakurada, Hirotsugu Notsuda, Ryota Tanaka, Kentaro Takanami, Ryoko Saito, Shunsuke Eba, Masafumi Noda, Yoshinori Okada
Summary: This study explored the correlation between preoperative F-18-FDG PET/CT findings and short-term survival in lung cancer patients with idiopathic interstitial pneumonia. The results suggest that F-18-FDG PET/CT may predict acute exacerbation after lung resection and be related to short-term survival in these patients, especially those with high SUVmax in the IIP area.
RESPIRATORY INVESTIGATION
(2021)
Article
Transplantation
Masato Katahira, Takashi Hirama, Shunsuke Eba, Takaya Suzuki, Hirotsugu Notsuda, Hisashi Oishi, Yasushi Matsuda, Tetsu Sado, Masafumi Noda, Akira Sakurada, Aman Sidhu, Yoshinori Okada
TRANSPLANTATION DIRECT
(2020)
Article
Cardiac & Cardiovascular Systems
Hiroshi Yabuki, Akira Sakurada, Shunsuke Eba, Fumihiko Hoshi, Hisashi Oishi, Yasushi Matsuda, Tetsu Sado, Masafumi Noda, Yoshinori Okada
GENERAL THORACIC AND CARDIOVASCULAR SURGERY
(2019)