Review
Gastroenterology & Hepatology
Noel Pin-Vieito, Manuel Puga, Daniel Fernandez-de-Castro, Joaquin Cubiella
Summary: FIT is widely used as a biomarker for colorectal cancer diagnosis and plays a crucial role in screening and surveillance. This review summarizes the diagnostic efficacy of FIT in symptomatic patients and post-adenoma resection, as well as discusses the potential impact of FIT strategies on healthcare resources and CRC prognosis.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Medical Laboratory Technology
Sally C. Benton, Carolyn Piggott, Zahida Zahoor, Shane O'Driscoll, Callum G. Fraser, Nigel D'Souza, Michelle Chen, Theo Georgiou Delisle, Muti Abulafi
Summary: This study assessed the comparability of faecal haemoglobin concentrations obtained with four quantitative FIT systems at different thresholds. The results showed differences between systems at lower thresholds, highlighting the need for further understanding of their clinical impact and efforts to minimize these differences.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2022)
Article
Immunology
Eunyoung Lee, Gil Ho Lee, Bumhee Park, Sung Soo Ahn, Choong-Kyun Noh
Summary: This study investigated the association between abnormal FIT results and the onset of inflammatory bowel disease (IBD). The results indicated that a positive FIT result was associated with a higher risk of IBD. These findings suggest that abnormal FIT results could be a preceding sign of incident IBD in the general population, and regular screening for early disease detection might be beneficial for individuals with positive FIT results and suspected IBD symptoms.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Sara G. Ribe, Edoardo Botteri, Magnus Loberg, Kristin R. Randel, Mette Kalager, Jens Aksel Nilsen, Elisabeth H. Gulichsen, Oyvind Holme
Summary: This study investigated the impact of time interval between faecal immunochemical testing (FIT) cycles on the detection rate of colorectal cancer (CRC) and advanced neoplasia (AN). The results showed that although the detection rates of CRC and AN increased with increasing time interval between FITs, individuals who had undetectable faecal haemoglobin (f-Hb) at the first screening round had a substantially lower risk of CRC at the next screening round compared to individuals with detectable f-Hb.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Review
Medicine, General & Internal
Karen N. Barnett, Gavin R. C. Clark, Robert J. C. Steele, Callum G. Fraser
Summary: Elevated faecal haemoglobin concentration is associated with increased mortality and various chronic conditions, showing promise as a biomarker for chronic disease and multimorbidity. Longitudinal data-linkage methodology is needed to further explore its potential in identifying individuals at risk of developing chronic diseases.
Review
Medical Laboratory Technology
Gavin R. C. Clark, Robert J. C. Steele, Callum G. Fraser
Summary: Women are at a disadvantage in colorectal cancer screening due to lower faecal haemoglobin concentrations, leading to poorer outcomes. Risk scoring strategies that consider sex have not been extensively tested or introduced. Governments and agencies should prioritize allocating resources to implement simple strategies, such as using different haemoglobin thresholds, to achieve equal positivity in both sexes.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2022)
Review
Medicine, General & Internal
Esmee J. Grobbee, Pieter Ha Wisse, Eline H. Schreuders, Aafke van Roon, Leonie van Dam, Ann G. Zauber, Iris Lansdorp-Vogelaar, Wichor Bramer, Sarah Berhane, Jonathan J. Deeks, Ewout W. Steyerberg, Monique E. van Leerdam, Manon Cw Spaander, Ernst J. Kuipers
Summary: FIT is superior to gFOBT in detecting advanced colorectal neoplasia and colorectal cancer in average-risk individuals. The specificity of both tests was similar, while the sensitivity of FIT was significantly higher than gFOBT at pre-specified specificities.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2022)
Article
Gastroenterology & Hepatology
Manuel Zorzi, Jessica Battagello, Kevin Selby, Giulia Capodaglio, Susanna Baracco, Silvia Rizzato, Enrico Chinellato, Stefano Guzzinati, Massimo Rugge
Summary: A study conducted in the Veneto region of Italy found that the risk of colorectal cancer mortality is significantly higher among individuals who do not undergo colonoscopy after a positive FIT result, highlighting the importance of increasing compliance in this high-risk population.
Article
Multidisciplinary Sciences
Miriam P. van der Meulen, Esther Toes-Zoutendijk, Manon C. W. Spaander, Evelien Dekker, Johannes M. G. Bonfrer, Anneke J. van Vuuren, Ernst J. Kuipers, Folkert J. van Kemenade, M. F. van Velthuysen, Maarten G. J. Thomeer, Harriet van Veldhuizen, Harry J. de Koning, Iris Lansdorp-Vogelaar, Monique E. van Leerdam
Summary: The participation rate in FIT screening is lower for individuals with a lower socioeconomic status (SES), but they have a higher detection rate for advanced neoplasia. Screening has the potential to reduce health inequalities in CRC mortality.
Article
Public, Environmental & Occupational Health
Johanna Wangmar, Yvonne Wengstrom, Anna Jervaeus, Kaisa Fritzell
Summary: The acceptability of colorectal cancer screening procedures is crucial for the success of screening programs. This study explored how individuals experience CRC screening, finding that experiences vary from having no worries to experiencing bothersome emotions, logistical concerns, inconsistent information, and unmet expectations. Improving patient experiences may involve using one-sample FITs, optimizing bowel preparation for colonoscopies, and delivering clear information and emotional support at the right time.
EUROPEAN JOURNAL OF PUBLIC HEALTH
(2021)
Article
Gastroenterology & Hepatology
Gavin Clark, Judith A. Strachan, Frank A. Carey, Thomas Godfrey, Audrey Irvine, Alisson McPherson, Jess Brand, Annie S. Anderson, Callum G. Fraser, Robert J. C. Steele
Summary: The transition from FOBT to FIT screening resulted in higher uptake and positivity rates, with a lower PPV for CRC but a higher PPV for adenomas. The FIT pilot evaluation underestimated uptake and positivity rates, leading to a significant increase in colonoscopy demand.
Article
Medical Laboratory Technology
Sally C. Benton, Erin Symonds, Natasha Djedovic, Samantha Jones, Liesbet Deprez, Petr Kocna, Josep Maria Auge
Summary: FIT is increasingly used in colorectal cancer screening and patient symptom assessment, but faces challenges such as pre-analytical variation and quality control materials.
CLINICA CHIMICA ACTA
(2021)
Article
Medicine, General & Internal
Lasse Kaalby, Ulrik Deding, Issam Al-Najami, Gabriele Berg-Beckhoff, Thomas Bjorsum-Meyer, Tinne Laurberg, Aasma Shaukat, Robert J. C. Steele, Anastasios Koulaouzidis, Morten Rasmussen, Morten Kobaek-Larsen, Gunnar Baatrup
Summary: New research suggests that faecal haemoglobin concentration (f-Hb) can indicate the presence of serious diseases not related to colorectal cancer (CRC). This study found an association between increasing f-Hb and the risk of mortality, as well as an increased risk of dying from respiratory disease, cardiovascular disease, and other cancers. f-Hb may be a potential biomarker for non-CRC diseases.
Article
Oncology
Anton Gies, Tobias Niedermaier, Elizabeth Alwers, Thomas Hielscher, Korbinian Weigl, Thomas Heisser, Petra Schrotz-King, Michael Hoffmeister, Hermann Brenner
Summary: This study evaluated the performance of nine fecal immunochemical tests in screening colonoscopy participants, with differences in diagnostic performance observed by sex and age. Females consistently showed lower sensitivities and higher specificities than males, with higher negative predictive values. A negative FIT was found to be less reliable in ruling out AN among men and older participants than among women and younger participants.
Article
Gastroenterology & Hepatology
Hirotaka Shimizu, Ryo Ebana, Takahiro Kudo, Takuro Sato, Tomoko Hara, Kenji Hosoi, Masaaki Usami, Masashi Yoshida, Ichiro Takeuchi, Hiroshi Nakase, Itaru Iwama, Katsuhiro Arai, Toshiaki Shimizu
Summary: Fecal calprotectin (FCP) and fecal immunochemical test (FIT) correlate well with endoscopic activity in pediatric patients with inflammatory bowel disease (IBD), and FCP is a superior marker for predicting mucosal healing (MH).
JOURNAL OF GASTROENTEROLOGY
(2022)