Journal
SUPPORTIVE CARE IN CANCER
Volume 27, Issue 2, Pages 495-503Publisher
SPRINGER
DOI: 10.1007/s00520-018-4334-7
Keywords
Lymphedema; Clinical trials; Neoadjuvant chemotherapy; Prospective surveillance; Breast cancer survivorship
Funding
- National Cancer Institute of the National Institutes of Health [UG1CA189823, U10CA180821, U10CA180882, U10CA180790, U10CA180858, U10CA180868, U10CA180888]
Ask authors/readers for more resources
PurposeLymphedema is a potential complication of breast cancer treatment. This longitudinal substudy aimed to prospectively assess arm measurements and symptoms following neoadjuvant chemotherapy and axillary dissection in the ACOSOG/Alliance Z1071 trial to characterize the optimal approach to define lymphedema.MethodsZ1071 enrolled patients with cT0-4, N1-2, M0 disease treated with neoadjuvant chemotherapy. All patients underwent axillary dissection. Bilateral limb volumes, circumferences, and related symptoms were assessed pre-surgery, 1-2weeks post-surgery, and semiannually for 36months. Lymphedema definitions included volume increase 10% or limb circumference increase 2cm. Symptoms were assessed by the Lymphedema Breast Cancer Questionnaire.ResultsIn 488 evaluable patients, lymphedema incidence at 3years by 10%-volume-increase was 60.3% (95% CI 55.0-66.2%) and by 2cm-circumference increase was 75.4% (95% CI 70.8-80.2%). Symptoms of arm swelling and heaviness decreased from post-surgery for the first 18months and then were relatively stable. The 3-year cumulative incidence of arm swelling and heaviness was 26.0% (95% CI 21.7-31.1%) and 30.9% (95% CI 26.3-36.3%), respectively. There was limited agreement between the two measurements (kappa 0.27) and between symptoms and measurements (kappa coefficients ranging from 0.05-0.09).ConclusionsLymphedema incidence by limb volume and circumference gradually increased over 36months post-surgery, whereas lymphedema symptoms were much lower. These findings underscore the importance of prospective surveillance and evaluation of both limb measurements and symptom assessment. Lymphedema incidence rates varied by definition. We recommend that 10% volume change criterion be used for lymphedema evaluation for referral for specialist care.Trial registrationNCT00881361
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available