Review
Biotechnology & Applied Microbiology
Zhengyu Xu, Yifei Fang, Yao Chen, Yushuang Zhao, Wei Wei, Chong Teng
Summary: Rotator cuff tears are a common problem in shoulder disease and disability, and surgical repair techniques do not always resolve postoperative dysfunction. Hydrogel scaffolds have been explored as a potential treatment for improving healing and managing irreparable rotator cuff injuries, but most studies have been limited to animal experiments.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Xiping Jiang, Yunfan Kong, Mitchell Kuss, Joel Weisenburger, Hani Haider, Robert Harms, Wen Shi, Bo Liu, Wen Xue, Jianghu Dong, Jingwei Xie, Philipp Streubel, Bin Duan
Summary: This study presents a novel therapeutic method that combines three-dimensional (3D) bioprinting and melt electrospinning writing techniques to regenerate the tendon-to-bone interface. The use of 3D-bioprinted pre-differentiated autologous adipose-derived mesenchymal stem cells (ADMSC) generated biomimetic multilayered scaffolds that recapitulated the compositional and cellular structures of the interface. In vivo studies demonstrated the superior histological score and improved collagen organization of the scaffold with spatially differentiated autologous ADMSCs.
APPLIED MATERIALS TODAY
(2022)
Article
Orthopedics
Hyojune Kim, In Kyong Shim, Jae Hee Choi, Eui-Sup Lee, Yu Na Lee, In-Ho Jeon, Kyoung Hwan Koh
Summary: The study confirms the long-term presence of extracellular vesicles (EVs) delivered via injectable collagen at the application site and evaluates the efficacy of EVs derived from human umbilical cord-derived mesenchymal stem cells in an injectable collagen gel after rotator cuff repair. The results show that the EVs remain at the repair site for at least 4 weeks and effectively promote bone-to-tendon healing and prevent fatty degeneration of the rotator muscle.
ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY
(2022)
Article
Physiology
Laura S. S. Vasquez-Bolanos, Michael C. C. Gibbons, Severin Ruoss, Isabella T. T. Wu, Mario Vargas-Vila, Sydnee A. A. Hyman, Mary C. C. Esparza, Donald C. C. Fithian, John G. G. Lane, Anshuman Singh, Chanond A. A. Nasamran, Kathleen M. M. Fisch, Samuel R. R. Ward
Summary: This study analyzed transcriptional changes in rabbit supraspinatus muscle tissue at different time points post-tenotomy, revealing unique patterns of gene expression with the greatest changes observed at 1 week and a resurgence at 16 weeks. The findings provide insights into the biological mechanisms of chronic muscle degeneration after rotator cuff tears.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Engineering, Biomedical
Dan Wang, Xu Zhang, Shuting Huang, Yang Liu, Bruma Sai-chuen Fu, Kingston King-lun Mak, Anna Maria Blocki, Patrick Shu-hang Yung, Rocky S. Tuan, Dai Fei Elmer Ker
Summary: The article highlights the tissue engineering strategies for musculoskeletal repair and regeneration, emphasizing the critical factors in addressing clinical challenges of engineering multi-tissue units.
Article
Orthopedics
Claire D. Eliasberg, Camila B. Carballo, Alexander Piacentini, Sarah Caughey, Janice Havasy, Marjan Khan, Yulei Liu, Iryna Ivasyk, Scott A. Rodeo
Summary: This study evaluated the role of CCR2 in tendon healing after rotator cuff repair. The results showed that CCR2KO may improve tendon biomechanical properties by reducing macrophage infiltration and/or suppressing inflammatory mediator pathways.
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
(2023)
Article
Orthopedics
Xu Zhang, Dan Wang, Zuyong Wang, Samuel Ka-kin Ling, Patrick Shu-hang Yung, Rocky S. Tuan, Dai Fei Elmer Ker
Summary: The rotator cuff is a highly integrated complex of bone-tendon-muscle units, and its injury has severe consequences for patients and healthcare systems. Current clinical treatments and recent advances have improved patient outcomes, but targeted regeneration of bone-tendon-muscle units is not emphasized. Engineering multi-tissue grafts may be a potential strategy for rotator cuff injuries.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2022)
Article
Biochemistry & Molecular Biology
Veronika Smolinska, Michaela Debreova, Martina Culenova, Maria Csobonyeiova, Andrey Svec, Lubos Danisovic
Summary: Healing of articular cartilage defects is challenging and traditional reparative approaches are limited. Mesenchymal stromal cells have been extensively studied and proven to have therapeutic effects on articular cartilage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Orthopedics
Chengcheng Fu, Alice H. Huang, Leesa M. Galatz, Woojin M. Han
Summary: This review emphasizes the severity of muscle degeneration caused by rotator cuff tendon tears, the lack of treatment strategies for activating muscle regeneration, and potential therapies to alleviate the hallmarks of this degeneration to address limitations in post-surgical recovery.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2021)
Review
Orthopedics
Zetao Wang, Youguo Liao, Canlong Wang, Chenqi Tang, Cailian Fang, Junchao Luo, Hengzhi Liu, Xianan Mo, Zicheng Wang, Lingfang Shen, Junjuan Wang, Xiao Chen, Zi Yin, Jianyou Li, Weiliang Shen
Summary: Rotator cuff tendinopathy is a common disorder that causes a significant burden. Although stem cell therapy has shown promising results, there are many unresolved issues, such as determining the optimal source and dosage of stem cells, as well as standardizing patient types.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2023)
Review
Biochemistry & Molecular Biology
David A. Hart, Norimasa Nakamura
Summary: After injuries to musculoskeletal tissues, an inflammatory response occurs to promote endogenous repair, but it often results in functionally inferior scar tissue. Injuries in adults no longer have the anabolic processes that contribute to growth and maturation, which can lead to degenerative conditions such as osteoarthritis. Researchers have been exploring cellular therapies, such as Platelet-rich Plasma and mesenchymal stem/medicinal signaling cells, to enhance tissue repair and regeneration. However, implanting these cells or engineered constructs into an inflammatory adult environment may compromise their potential for regeneration. Therefore, it may be necessary to neutralize the inflammatory environment and create an anabolic environment for optimal outcomes.
Article
Engineering, Biomedical
Shuangpeng Jiang, Guangzhao Tian, Zhen Yang, Xiang Gao, Fuxin Wang, Juntan Li, Zhuang Tian, Bo Huang, Fu Wei, Xinyu Sang, Liuqi Shao, Jian Zhou, Zhenyong Wang, Shuyun Liu, Xiang Sui, Quanyi Guo, Weimin Guo, Xu Li
Summary: This study confirms that hWJMSC-Exos can enhance the effect of the ACECM scaffold and promote osteochondral regeneration. The promoting effect may be related to the polarization of macrophages and inhibition of inflammatory response by hWJMSC-Exos. Additionally, hWJMSC-Exos contain miRNAs that can promote hyaline cartilage regeneration.
BIOACTIVE MATERIALS
(2021)
Review
Medicine, Research & Experimental
Mengyuan Wang, Ying Li, Hongqiao Wang, Meng Li, Xiaomin Wang, Rongzhen Liu, Daijun Zhang, Wenhua Xu
Summary: Corneal epithelial defects and excessive wound healing can cause severe complications. Stem cells offer a promising solution for regenerating the corneal epithelium and treating severe corneal epithelial injury. Biological scaffolds such as the amniotic membrane, fibrin, and hydrogels provide the necessary signals for stem cell proliferation and differentiation. Researchers have evaluated these scaffolds as potential therapeutic interventions for corneal disorders, identifying both benefits and drawbacks. This study provides a comprehensive overview of the history and use of stem cells in corneal repair, focusing on biological scaffolds used in stem cell transplantation and innovative materials under investigation.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Engineering, Biomedical
Liaobing Xin, Xiaowen Zheng, Jianmin Chen, Sentao Hu, Yilun Luo, Qunzi Ge, Xiaoying Jin, Lie Ma, Songying Zhang
Summary: This study explores an acellular biomaterial called SDF-1 alpha/E7-modified collagen scaffold (CES), which enables near-complete endometrium regeneration and fertility restoration by mobilizing endogenous MSCs. The results demonstrate that CES can overcome the traditional limitations of cell-based therapies and serve as a clinically feasible and cell-free strategy with high therapeutic efficiency for IUA treatment.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Medicine, General & Internal
Daichi Morikawa, Benjamin C. Hawthorne, Mary Beth R. McCarthy, Nicholas Bellas, Jeremiah D. Johnson, Maxwell T. Trudeau, Kyle Murphy, Michael R. Mancini, Matthew R. LeVasseur, Mark P. Cote, Augustus D. Mazzocca
Summary: The study found that patient demographics did not significantly affect the number of CFUs or NCC of CTPs derived from the SB, but tear size was negatively correlated with CFUs. This suggests that tear size, rather than patient demographics, may influence the viability of CTPs and should be considered in augmenting RC repairs with SB.
JOURNAL OF CLINICAL MEDICINE
(2021)