Review
Clinical Neurology
Georgiana Soares Leandro, Mario Emilio Teixeira Dourado Junior, Glauciane Costa Santana, Luan Samy Xavier Dantas
Summary: The main coping strategy used by ALS patients is seeking social support, while Confrontive coping and Distancing are less commonly mentioned. The coping strategies of ALS patients do not seem to focus on emotions or stress-triggering problems, and age and gender do not modify the chosen strategy.
JOURNAL OF NEUROLOGY
(2022)
Article
Medicine, General & Internal
Wen-Chao Liu, Na Liu, Yan Wang, Chen Huang, Yan-Fang Li, Hao Wang, Xiao-Gang Li, Min Deng
Summary: Research shows that motor neurons (MNs) derived from ALS patient-specific iPSC lines can replicate key aspects of ALS pathogenesis, providing insights into the disease's pathophysiological processes. Incremental mutant expressions of SOD1 in MNs may disrupt cellular function, leading to intracellular calcium disturbances and contributing to the onset of the disease.
CHINESE MEDICAL JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Mengmeng Jin, Katja Akguen, Tjalf Ziemssen, Markus Kipp, Rene Guenther, Andreas Hermann
Summary: The study revealed that Th17 cells and IL-17A are directly involved in the degeneration of motor neurons in ALS patients. Th17 cells from MS patients induced severe MN degeneration, while IL-17A led to a dose-dependent decline in MN viability and neurite length. Neutralizing IL-17A and anti-IL-17 receptor A treatment reversed all effects of IL-17A, highlighting the importance of this pathway in ALS pathogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Hayley Robinson, Sk Imran Ali, Martha Elena Diaz-Hernandez, Rodrigo Lopez-Gonzalez
Summary: The G4C2 repeat expansion in C9ORF72 gene is the most common genetic cause of ALS and FTD. This study found an age-dependent decrease in telomere length in neurons from C9ORF72 carriers, along with dysregulation in the protein levels of shelterin complex members TRF2 and POT1.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Seung-Hye Choi, Ali Yousefian-Jazi, Seung Jae Hyeon, Phuong Thi Thanh Nguyen, Jiyeon Chu, Sojung Kim, Suhyun Kim, Hannah L. Ryu, Neil W. Kowall, Hoon Ryu, Junghee Lee
Summary: In this study, researchers found that modulating the activity of LSD1 can improve the neuropathology of ALS mice, delay disease onset, and extend lifespan, potentially serving as an effective therapeutic strategy for treating ALS.
JOURNAL OF BIOMEDICAL SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Oluwamolakun Bankole, Ilaria Scambi, Edoardo Parrella, Matilde Muccilli, Roberta Bonafede, Ermanna Turano, Marina Pizzi, Raffaella Mariotti
Summary: This study demonstrates the beneficial effects of combined treatment with valproate and resveratrol in ALS mice, with a sexually dimorphic response. The combination of drugs restores NF-kB to its neuroprotective state, reducing pathology and symptoms, and prolonging survival.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Christine Zizzi, Jamison Seabury, Spencer Rosero, Danae Alexandrou, Ellen Wagner, Jennifer S. Weinstein, Anika Varma, Nuran Dilek, John Heatwole, Joanne Wuu, James Caress, Richard Bedlack, Volkan Granit, Jeffrey M. Statland, Paul Mehta, Michael Benatar, Chad Heatwole
Summary: This study used data from two multi-center randomized controlled trials and found that depression symptoms in patients can be categorized into four clusters, which have differential responses to repetitive transcranial magnetic stimulation (rTMS) treatment. Further research aims to personalize rTMS protocols based on individual clinical presentations.
Article
Food Science & Technology
Salvatore D'Antona, Martina Caramenti, Danilo Porro, Isabella Castiglioni, Claudia Cava
Summary: Amyotrophic lateral sclerosis (ALS) is a fatal disease linked to motor neurons degeneration, with diet components like oxidative stress potentially influencing its onset. Some diets with antioxidant and anti-inflammatory properties may reduce the risk of ALS, but current data remains controversial.
Article
Clinical Neurology
Melina Pazian Martins, Carelis Gonzalez-Salazar, Fabricio Diniz de Lima, Tauana Bernardes Leoni, Alberto R. M. Martinez, Joao Pedro Nunes Goncalves, Anamarli Nucci, Marcondes Cavalcante Franca Jr
Summary: This study characterized and compared the autonomic function of patients with sporadic ALS and familial ALS type 8. The results showed that both types of ALS patients had dysautonomia involving both sympathetic and parasympathetic divisions, but the symptoms were different between the two groups.
CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Pharmacology & Pharmacy
J. Daniel Bireley, John A. Morren
Summary: This article provides an overview of current amyotrophic lateral sclerosis (ALS) treatments, including riluzole, edaravone, AMX0035, and tofersen. It also discusses the potential of CNM-Au8, an energy metabolism catalyst, as a disease-modifying treatment for ALS. While the phase 2/3 clinical trials of CNM-Au8 did not meet primary endpoints, exploratory endpoints suggest its potential in slowing clinical worsening, improving quality of life, and prolonging survival in ALS. Phase 3 clinical trials of CNM-Au8 are currently underway.
EXPERT OPINION ON INVESTIGATIONAL DRUGS
(2023)
Article
Clinical Neurology
Megan Yerton, Allison Winter, Dario Gelevski, Grace Addy, Anthony Kostov, Cassandra Lieberman, Harli Weber, Michael Doyle, Geli Kane, Caroline Cohen, Neil Parikh, Katherine M. Burke, Margot Rohrer, Taylor Stirrat, Margaret Bruno, Alison Hochman, Sarah Luppino, Jennifer Scalia, Derek D'Agostino, Ervin Sinani, Hong Yu, Kristin Drake, Jennifer Hagar, Alexander V. Sherman, Suma Babu, James D. Berry, Merit E. Cudkowicz, Sabrina Paganoni
Summary: This report shares the design, operational features, and costs of an Expanded Access Program (EAP) for ALS, which provides investigational products (IPs) to individuals with serious diseases who are ineligible for clinical trials. From July 2018 to February 2022, 17 EAPs were submitted and approved by the FDA and IRB. A total of 164 participants enrolled in the program, with 77 participants still receiving IP treatment. The average duration of participation was 12.6 months, and no drug-related serious adverse events were reported.
Article
Clinical Neurology
C. Appleby-Mallinder, E. Schaber, J. Kirby, P. J. Shaw, J. Cooper-Knock, P. R. Heath, J. R. Highley
Summary: The study revealed higher levels of 5mC and 5hmC in lower motor neurones (LMNs) of the spinal cord in ALS patients. LMNs with TDP43 pathology showed lower levels of nuclear 5mC and 5hmC, suggesting a particular impact on RNA metabolism.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
(2021)
Article
Clinical Neurology
Robert David Henderson, Kasper Planeta Kepp, Andrew Eisen
Summary: Amyotrophic lateral sclerosis and frontotemporal dementia are neurodegenerative diseases with complex cellular pathology. The paper emphasizes the importance of evolution in the development of higher cortical function and the impact of factors related to increased lifespan on neuronal function.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Giammarco Milella, Stefano Zoccolella, Alessia Giugno, Marco Filardi, Daniele Urso, Salvatore Nigro, Benedetta Tafuri, Ludovica Tamburrino, Valentina Gnoni, Giancarlo Logroscino
Summary: This study found that spinal-onset ALS can be categorized into three groups based on the extent of upper motor neuron (UMN) and lower motor neuron (LMN) involvement. UMN burden is associated with higher diagnostic certainty and broader disease spread, while LMN involvement is associated with more severe disease and shorter survival.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Edoardo Nicolo Aiello, Debora Pain, Alice Radici, Kalliopi Marinou Aktipi, Riccardo Sideri, Ildebrando Appollonio, Gabriele Mora
Summary: This study found cognitive deficits in ALS patients, with classical and predominant-upper motor neuron phenotypes performing the worst. Poorer functional scores correlated with poorer cognitive scores. These findings are important for understanding the cognitive impact of ALS.
NEUROLOGICAL SCIENCES
(2022)
Article
Clinical Neurology
Antonia Ratti, Silvia Peverelli, Elisabetta D'Adda, Claudia Colombrita, Michele Gennuso, Alessandro Prelle, Vincenzo Silani
Summary: This study described an Italian family with a history of Parkinson's disease in the father and frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) in the daughters. Genetic analysis revealed the presence of hexanucleotide repeat expansion (HRE) in the C9orf72 gene in all affected members, with additional rare genetic variants associated with Parkinson's disease in the father. DNA methylation analysis showed unmethylated sites within the C9orf72 promoter in all family members, indicating a potential lack of disease modifiers at this site.
AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION
(2022)
Correction
Genetics & Heredity
Wouter van Rheenen, Rick A. A. van der Spek, Mark K. Bakker, Joke J. F. A. van Vugt, Paul J. Hop, Ramona A. J. Zwamborn, Niek de Klein, Harm-Jan Westra, Olivier B. Bakker, Patrick Deelen, Gemma Shireby, Eilis Hannon, Matthieu Moisse, Denis Baird, Restuadi Restuadi, Egor Dolzhenko, Annelot M. Dekker, Klara Gawor, Henk-Jan Westeneng, Gijs H. P. Tazelaar, Kristel R. van Eijk, Maarten Kooyman, Ross P. Byrne, Mark Doherty, Mark Heverin, Ahmad Al Khleifat, Alfredo Iacoangeli, Aleksey Shatunov, Nicola Ticozzi, Johnathan Cooper-Knock, Bradley N. Smith, Marta Gromicho, Siddharthan Chandran, Suvankar Pal, Karen E. Morrison, Pamela J. Shaw, John Hardy, Richard W. Orrell, Michael Sendtner, Thomas Meyer, Nazli Basak, Anneke J. van der Kooi, Antonia Ratti, Isabella Fogh, Cinzia Gellera, Giuseppe Lauria, Stefania Corti, Cristina Cereda, Daisy Sproviero, Sandra D'Alfonso, Gianni Soraru, Gabriele Siciliano, Massimiliano Filosto, Alessandro Padovani, Adriano Chio, Andrea Calvo, Cristina Moglia, Maura Brunetti, Antonio Canosa, Maurizio Grassano, Ettore Beghi, Elisabetta Pupillo, Giancarlo Logroscino, Beatrice Nefussy, Alma Osmanovic, Angelica Nordin, Yossef Lerner, Michal Zabari, Marc Gotkine, Robert H. Baloh, Shaughn Bell, Patrick Vourc'h, Philippe Corcia, Philippe Couratier, Stephanie Millecamps, Vincent Meininger, Francois Salachas, Jesus S. Mora Pardina, Abdelilah Assialioui, Ricardo Rojas-Garcia, Patrick A. Dion, Jay P. Ross, Albert C. Ludolph, Jochen H. Weishaupt, David Brenner, Axel Freischmidt, Gilbert Bensimon, Alexis Brice, Alexandra Durr, Christine A. M. Payan, Safa Saker-Delye, Nicholas W. Wood, Simon Topp, Rosa Rademakers, Lukas Tittmann, Wolfgang Lieb, Andre Franke, Stephan Ripke, Alice Braun, Julia Kraft, David C. Whiteman, Catherine M. Olsen, Andre G. Uitterlinden, Albert Hofman, Marcella Rietschel, Sven Cichon, Markus M. Nothen, Philippe Amouyel, Giancarlo Comi, Nilo Riva, Christian Lunetta, Francesca Gerardi, Maria Sofia Cotelli, Fabrizio Rinaldi, Luca Chiveri, Maria Cristina Guaita, Patrizia Perrone, Mauro Ceroni, Luca Diamanti, Carlo Ferrarese, Lucio Tremolizzo, Maria Luisa Delodovici, Giorgio Bono, Umberto Manera, Rosario Vasta, Alessandro Bombaci, Federico Casale, Giuseppe Fuda, Paolina Salamone, Barbara Iazzolino, Laura Peotta, Paolo Cugnasco, Giovanni De Marco, Maria Claudia Torrieri, Francesca Palumbo, Salvatore Gallone, Marco Barberis, Luca Sbaiz, Salvatore Gentile, Alessandro Mauro, Letizia Mazzini, Fabiola De Marchi, Lucia Corrado, Sandra D'Alfonso, Antonio Bertolotto, Maurizio Gionco, Daniela Leotta, Enrico Odddenino, Daniele Imperiale, Roberto Cavallo, Pietro Pignatta, Marco De Mattei, Claudio Geda, Diego Maria Papurello, Graziano Gusmaroli, Cristoforo Comi, Carmelo Labate, Luigi Ruiz, Delfina Ferrandi, Eugenia Rota, Marco Aguggia, Nicoletta Di Vito, Piero Meineri, Paolo Ghiglione, Nicola Launaro, Michele Dotta, Alessia Di Sapio, Guido Giardini, Cinzia Tiloca, Silvia Peverelli, Franco Taroni, Viviana Pensato, Barbara Castellotti, Giacomo P. Comi, Roberto Del Bo, Mauro Ceroni, Stella Gagliardi, Lucia Corrado, Letizia Mazzini, Flavia Raggi, Costanza Simoncini, Annalisa Lo Gerfo, Maurizio Inghilleri, Alessandra Ferlini, Isabella L. Simone, Bruno Passarella, Vito Guerra, Stefano Zoccolella, Cecilia Nozzoli, Ciro Mundi, Maurizio Leone, Michele Zarrelli, Filippo Tamma, Francesco Valluzzi, Gianluigi Calabrese, Giovanni Boero, Augusto Rini, Bryan J. Traynor, Andrew B. Singleton, Miguel Mitne Neto, Ruben J. Cauchi, Roel A. Ophoff, Martina Wiedau-Pazos, Catherine Lomen-Hoerth, Vivianna M. van Deerlin, Julian Grosskreutz, Annekathrin Roediger, Nayana Gaur, Alexander Joerk, Tabea Barthel, Erik Theele, Benjamin Ilse, Beatrice Stubendorff, Otto W. Witte, Robert Steinbach, Christian A. Huebner, Caroline Graff, Lev Brylev, Vera Fominykh, Vera Demeshonok, Anastasia Ataulina, Boris Rogelj, Blaz Koritnik, Janez Zidar, Metka Ravnik-Glavac, Damjan Glavac, Zorica Stevic, Vivian Drory, Monica Povedano, Ian P. Blair, Matthew C. Kiernan, Beben Benyamin, Robert D. Henderson, Sarah Furlong, Susan Mathers, Pamela A. McCombe, Merrilee Needham, Shyuan T. Ngo, Garth A. Nicholson, Roger Pamphlett, Dominic B. Rowe, Frederik J. Steyn, Kelly L. Williams, Karen A. Mather, Perminder S. Sachdev, Anjali K. Henders, Leanne Wallace, Mamede de Carvalho, Susana Pinto, Susanne Petri, Markus Weber, Guy A. Rouleau, Vincenzo Silani, Charles J. Curtis, Gerome Breen, Jonathan D. Glass, Robert H. Brown, John E. Landers, Christopher E. Shaw, Peter M. Andersen, Ewout J. N. Groen, Michael A. van Es, R. Jeroen Pasterkamp, Dongsheng Fan, Fleur C. Garton, Allan F. McRae, George Davey Smith, Tom R. Gaunt, Michael A. Eberle, Jonathan Mill, Russell L. McLaughlin, Orla Hardiman, Kevin P. Kenna, Naomi R. Wray, Ellen Tsai, Heiko Runz, Lude Franke, Ammar Al-Chalabi, Philip Van Damme, Leonard H. van den Berg, Jan H. Veldink
Article
Clinical Neurology
Federico Verde, Ilaria Milone, Ilaria Bulgarelli, Silvia Peverelli, Claudia Colombrita, Alessio Maranzano, Narghes Calcagno, Nicola Ticozzi, Giovanni Battista Perego, Gianfranco Parati, Erminio Torresani, Antonia Ratti, Vincenzo Silani
Summary: This study found that neuroaxonal damage, indicated by increased sNFL levels, is present in Covid-19 patients even without major neurological manifestations, potentially influenced by systemic inflammation.
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Eleonora Colombo, Barbara Poletti, Alessio Maranzano, Silvia Peverelli, Federica Solca, Claudia Colombrita, Silvia Torre, Cinzia Tiloca, Federico Verde, Ruggero Bonetti, Laura Carelli, Claudia Morelli, Antonia Ratti, Vincenzo Silani, Nicola Ticozzi
Summary: This study provides a comprehensive characterization of the motor, cognitive, and behavioral features of C9orf72-related ALS, indicating that the size of C9orf72 HRE may serve as a modifier of the cognitive phenotype.
JOURNAL OF NEUROLOGY
(2023)
Review
Clinical Neurology
Jacopo Pasquini, Michael J. Firbank, Roberto Ceravolo, Vincenzo Silani, Nicola Pavese
Summary: This review summarizes the literature on the application of diffusion magnetic resonance imaging (dMRI) in multiple system atrophy (MSA), focusing on microstructural abnormalities, diagnostic applications, and pathophysiological correlates. The studies included in this review identified widespread microstructural abnormalities in white matter, especially in specific brain regions. Gray matter degeneration and its involvement in subcortical structures were also observed. Diagnostic applications of dMRI, particularly for differentiating MSA parkinsonism from Parkinson's disease, showed promising results with high diagnostic accuracy using machine learning algorithms. Additionally, some studies explored the clinical correlates of microstructural abnormalities, highlighting links with motor, ocular, and cognitive impairments. However, the correct diagnosis of MSA in the early stages and further investigation of the pathophysiological mechanisms underlying microstructural abnormalities are still challenging.
MOVEMENT DISORDERS
(2022)
Article
Clinical Neurology
Edoardo Nicolo Aiello, Federica Solca, Silvia Torre, Laura Carelli, Alessia Monti, Roberta Ferrucci, Federico Verde, Nicola Ticozzi, Vincenzo Silani, Barbara Poletti
Summary: This study aimed to provide standardized regression-based reliable change indices for the Italian version of ECAS. The study evaluated ceiling/floor effects, practice effect, and test-retest reliability of ECAS measures. Regression analysis found that T0 scores predicted most ECAS measures, except for the Visuo-spatial subscale. The availability of RCIs for the Italian ECAS will be valuable for ALS-related clinical practice and research in the longitudinal dimension.
AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION
(2023)
Article
Clinical Neurology
Alessio Maranzano, Federico Verde, Eleonora Colombo, Barbara Poletti, Alberto Doretti, Ruggero Bonetti, Delia Gagliardi, Megi Meneri, Luca Maderna, Stefano Messina, Stefania Corti, Claudia Morelli, Vincenzo Silani, Nicola Ticozzi
Summary: Increasing evidence suggests that disease progression in ALS follows a preferential pattern with involvement of neighboring regions from the site of symptom onset. The study aimed to assess the influence of upper and lower motor neuron involvement on the directionality of disease spreading, and the association between specific patterns of disease progression and motor and neuropsychological features of different ALS subtypes. The results showed that ALS patients with lower motor neuron involvement had a higher frequency of horizontal spreading, while those with upper motor neuron involvement displayed a vertical spreading pattern. Non-contiguous disease spreading was associated with more severe upper motor neuron impairment and cognitive impairment. The study also found that regionally entrenching ALS forms were more common in patients with atypical bulbar phenotypes. These findings suggest that disease spreading in ALS may be influenced by the diffusion of toxic factors in the neuron microenvironment.
Review
Biochemistry & Molecular Biology
Matteo Guidetti, Stefano Giannoni-Luza, Tommaso Bocci, Kevin Pacheco-Barrios, Anna Maria Bianchi, Marta Parazzini, Silvio Ionta, Roberta Ferrucci, Natale Vincenzo Maiorana, Federico Verde, Nicola Ticozzi, Vincenzo Silani, Alberto Priori
Summary: Clinical findings suggest that transcutaneous spinal direct current stimulation (tsDCS) can modulate ascending sensitive, descending corticospinal, and segmental pathways in the spinal cord (SC). Realistic computational models based on MRI can predict the interaction between tsDCS-induced electric fields and anatomy. Understanding the electric field distribution in the spinal cord and its relation to clinical findings is important for optimizing tsDCS protocols.
Article
Clinical Neurology
Fabrizio Pasotti, Edoardo Nicolo Aiello, Alessandra Bollani, Matteo Querzola, Sara Cozzi, Francesca Manfrin, Stefania Bruno, Barbara Poletti, Nicola Ticozzi, Vincenzo Silani, Gabriella Bottini
Summary: This study aimed to validate and provide Italian norms for the Single-Matrix Digit Cancellation Test (SMDCT) and to provide clinical evidence for its use in acute stroke patients. The results showed that SMDCT produced reliable results in acute stroke patients and could differentiate between patients and healthy participants.
CEREBROVASCULAR DISEASES
(2023)
Review
Clinical Neurology
Francesca Mameli, Eleonora Zirone, Roberta Girlando, Elena Scagliotti, Giulia Rigamonti, Edoardo Nicolo Aiello, Barbara Poletti, Roberta Ferrucci, Nicola Ticozzi, Vincenzo Silani, Marco Locatelli, Sergio Barbieri, Fabiana Ruggiero
Summary: Deep brain stimulation (DBS) is an effective treatment for motor symptoms in Parkinson's disease (PD), but patients may experience psychological distress and social maladjustments after surgery. This review examines the role of patients' expectations regarding the outcomes of DBS and highlights the need for intervention to improve pre-operative patient education and post-operative psychosocial adjustment.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Fabiana Ruggiero, Eleonora Zirone, Maria Takeko Molisso, Tiziana Carandini, Giorgio Fumagalli, Anna Pietroboni, Roberta Ferrucci, Edoardo Nicolo Aiello, Barbara Poletti, Vincenzo Silani, Giacomo Comi, Elio Scarpini, Sergio Barbieri, Andrea Arighi, Francesca Mameli
Summary: This study evaluated the experience of telemedicine in patients with cognitive impairments and their caregivers. The findings showed positive feedback from both patients and caregivers regarding the usefulness and satisfaction of neurological video consultation. However, successful implementation of telemedicine requires support from staff and care partners in navigating technologies, and adapting technologies to the specific needs of patients and caregivers is crucial for accessible dementia care.
NEUROLOGICAL SCIENCES
(2023)
Article
Clinical Neurology
Silvia Peverelli, Alberto Brusati, Valeria Casiraghi, Marta Nice Sorce, Sabrina Invernizzi, Serena Santangelo, Claudia Morelli, Federico Verde, Vincenzo Silani, Nicola Ticozzi, Antonia Ratti
Summary: This study aimed to investigate if the normal C9orf72 hexanucleotide repeat (HR) length influences C9orf72 gene expression and acts as a disease modifier in ALS patients negative for C9orf72 mutation (ALS-C9Neg). The researchers found that the distribution of HR alleles was similar in ALS-C9Neg patients and healthy controls. Gene expression analysis revealed increased C9orf72 mRNA levels in ALS-C9Neg patients carrying two long alleles, but HR allele genotypes did not correlate with clinical parameters.
AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION
(2023)
Article
Clinical Neurology
I. Kacem, I. Sghaier, S. Peverelli, Y. Abida, H. Ben Brahim, A. Ratti, A. Nasri, N. Ticozzi, V. Silani, R. Gouider
Summary: This study aims to investigate the clinical features of familial ALS patients carrying different variants in the Optineurin (OPTN) gene. The findings reveal that these two families show distinct ALS clinical features and carry different OPTN variants. Screening of the OPTN gene is highly recommended among inbreeding populations, such as the Tunisian population.
AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION
(2023)
Article
Health Care Sciences & Services
Natale Vincenzo Maiorana, Edoardo Nicolo Aiello, Barbara Poletti, Fabrizio Carusi, Angelica De Sandi, Matteo Guidetti, Roberto Prandin, Sara Marceglia, Nicola Ticozzi, Vincenzo Silani, Alberto Priori, Roberta Ferrucci
Summary: Long-COVID refers to the long-term symptoms experienced by patients after recovering from a SARS-CoV-2 infection. This study aimed to investigate the relationship between self-reported long-COVID symptoms and reaction times (RTs) in a visual detection task (VDT) as a measure of attention impairment. The study found that cognition and physical factors were the most important predictors of RTs, with learning, visual impairment, and headache being the top predictors of performance in the VDT.