Article
Endocrinology & Metabolism
Junwei Guo, Lu Dai, Jinmei Luo, Rong Huang, Yi Xiao
Summary: This study found that the average duration of respiratory events is associated with the prevalence of type 2 diabetes. Shorter average apnea duration is a potential mechanism leading to type 2 diabetes along with poor sleep quality and augmented autonomic nervous system responses.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Multidisciplinary Sciences
Abdoulaye Diawara, Djibril Mamadou Coulibaly, Talib Yusuf Abbas Hussain, Cheickna Cisse, Jian Li, Mamadou Wele, Mahamadou Diakite, Kassim Traore, Seydou O. Doumbia, Jeffrey G. Shaffer
Summary: The prevalence of T2D in the Niena community was 7.5%, with rates of 8.6% for females and 5.6% for males. Age, family history of diabetes, hypertension, waist circumference, and fetal macrosomia were significantly associated with T2D. 61.3% of T2D subjects were unaware of their diabetic status before the study.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Agata Gabryelska, Jedrzej Chrzanowski, Marcin Sochal, Piotr Kaczmarski, Szymon Turkiewicz, Marta Ditmer, Filip Franciszek Karuga, Leszek Czupryniak, Piotr Bialasiewicz
Summary: The study found that in OSA patients, basal O2 saturation is independent of AHI, BMI, and age, and is a risk factor for type 2 diabetes. One-way Cox regression analysis showed a higher risk of earlier type 2 diabetes for increased BMI, AHI, decreased basal O2, and O2 nadir values, while lowered mean O2 desaturation did not show statistical significance. In CART analysis, cut-off points of 92.2%, 81.7%, and 87.1% were determined for basal O2, O2 nadir, and mean O2 desaturation, with the first two parameters being statistically significant.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Melkamu A. Zeru, Endalamaw Tesfa, Aweke A. Mitiku, Awoke Seyoum, Tesfaye Abera Bokoro
Summary: This study aimed to assess the prevalence and risk factors of type-2 DM in Ethiopian population. The pooled prevalence of DM in Ethiopia was 6.5%, with identified risk factors including older age, illiteracy, cigarette smoking, MBI >= 25, family history of DM, history of hypertension, and physical inactivity. Awareness of these risk factors is crucial for effective prevention and management of type-2 DM in this population.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
Yingqun Chen, Jiner Ma, Donghui Lu, Yefei Fang
Summary: This study examined the relationship between HTN history and T2DM incidence in a cohort of Chinese hypertensive subjects. The highest DBP and the longest HTN duration were both independently associated with T2DM in hypertensive subjects.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Yaqiong Yan, Tingting Wu, Miao Zhang, Changfeng Li, Qing Liu, Fang Li
Summary: This study examined the prevalence, awareness, and control rates of type 2 diabetes in elderly Chinese individuals and identified key risk factors. The findings highlight the significance of diabetes as a public health issue in this population, with low overall awareness and control rates.
Review
Endocrinology & Metabolism
Joline W. J. Beulens, Maria G. M. Pinho, Taymara C. Abreu, Nicole R. den Braver, Thao M. Lam, Anke Huss, Jelle Vlaanderen, Tabea Sonnenschein, Noreen Z. Siddiqui, Zhendong Yuan, Jules Kerckhoffs, Alexandra Zhernakova, Milla F. Brandao Gois, Roel C. H. Vermeulen
Summary: Type 2 diabetes is primarily influenced by environmental risks and modifiable factors such as lifestyle choices. The external exposome, including built, social, physico-chemical, and lifestyle/food environments, plays a significant role in the prevention of type 2 diabetes. Air pollution, residential noise, and area-level socioeconomic deprivation have been linked to an increased risk of type 2 diabetes, while neighborhood walkability and green space are associated with a reduced risk. The impact of food environment, social environment, and outdoor temperature on type 2 diabetes risk remains inconclusive and requires further investigation.
Review
Biochemistry & Molecular Biology
Leila Ismail, Huned Materwala, Juma Al Kaabi
Summary: Diabetes is a leading cause of severe health complications and death globally, with no cure available, requiring preventive measures. This systematic review identifies major risk factors for type 2 diabetes incidence/prevalence and analyzes their impact on the disease. Insights and recommendations are provided for better diagnosis and prognosis, targeting healthcare professionals, individuals, and government institutions.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2021)
Article
Pediatrics
Mohamed Saleh, Joon Young Kim, Christine March, Nour Gebara, Silva Arslanian
Summary: The study found that the prevalence of dysglycaemia is higher in youth with overweight/obesity and multiple risk factors. The results suggest that screening for dysglycaemia in youth with obesity and any additional risk factor is necessary for early management.
Article
Endocrinology & Metabolism
Roger E. Henriksen, Roy M. Nilsen, Ragnhild B. Strandberg
Summary: Loneliness may be a factor that increases the risk of type 2 diabetes, but there is no strong evidence that the effect of loneliness on type 2 diabetes is mediated by depression or insomnia.
Review
Nutrition & Dietetics
Anna Izzo, Elena Massimino, Gabriele Riccardi, Giuseppe Della Pepa
Summary: Type 2 diabetes mellitus is a major health burden for the elderly, affecting approximately 25% of those over 65 years old. Sarcopenia, characterized by loss of skeletal muscle mass and function, has been identified as a new complication in elderly individuals with T2DM. It is important for researchers and clinicians to understand the risk factors and associations of sarcopenia in T2DM patients in order to provide appropriate therapeutic interventions.
Article
Endocrinology & Metabolism
Khadija Hafidh, Rachid Malek, Khalid Al-Rubeaan, Adri Kok, Fahri Bayram, Akram Echtay, Viraj Rajadhyaksha, Ahmed Hadaoui
Summary: This study evaluated the prevalence of vascular complications and associated risk factors in individuals with type 2 diabetes initiating second-line glucose-lowering therapy in the Middle East and Africa region. The study found a substantial burden of vascular complications in this cohort, with age, male sex, hyperlipidemia, and hypertension being significant risk factors.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Dana Hyassat, Saba Al-Saeksaek, Duha Naji, Awn Mahasneh, Yousef Khader, Mousa Abujbara, Mohammad El-Khateeb, Kamel Ajlouni
Summary: This study investigated the prevalence and patterns of dyslipidemia among patients with type 2 diabetes and its associated risk factors. The results showed that combined dyslipidemia, characterized by high triglycerides and low HDL-cholesterol, was the most common type. Factors such as diabetes duration, statin non-compliance, HbA1c level, and smoking were associated with different types of dyslipidemia.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Public, Environmental & Occupational Health
Lisa T. Crummett, Muhammad H. Aslam
Summary: The study examines the use of specific terms related to causes/risk factors and preventions for type 2 diabetes on diabetes websites and finds that dietary factors are mentioned less frequently, indicating a need for increased emphasis on dietary information to improve public awareness of type 2 diabetes.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Biochemistry & Molecular Biology
Diana Simoniene, Darius Stukas, Albertas Dauksa, Dzilda Velickiene
Summary: The study found that miR-107 expression is higher in T2DM patients and is associated with dyslipidemia, insulin resistance, and certain demographic characteristics (such as BMI, age, and gender).
Article
Neurosciences
A. Mungo, M. Hein, J-P Lanquart, G. Loas
Summary: This study aimed to investigate the prevalence of OSAS in young adults and study the risk of OSAS associated with major depression, finding that atypical depression was associated with an increased risk of OSAS in young adults.
ENCEPHALE-REVUE DE PSYCHIATRIE CLINIQUE BIOLOGIQUE ET THERAPEUTIQUE
(2022)
Article
Psychology, Biological
Ileana Zeoli, Jean-Pol Lanquart, Benjamin Wacquier, Anais Mungo, Gwenole Loas, Matthieu Hein
Summary: The study identified potential polysomnographic markers of suicidal ideation in untreated unipolar major depressed individuals, showing a decrease in deep NREM sleep and an increase in light NREM sleep among those with suicidal ideation compared to those without. These findings offer new perspectives for identifying and managing individuals at high-risk of suicide in this specific subpopulation.
INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY
(2021)
Article
Peripheral Vascular Disease
Hadrien Willame, Benjamin Wacquier, Camille Point, Marjorie Dosogne, Mohammed Al Faker, Gwenole Loas, Matthieu Hein
Summary: This study investigated the association between type 2 diabetes and the anhedonic subtype of major depression in hypertensive individuals. The results showed that only the anhedonic subtype of major depression was significantly associated with a higher likelihood of having type 2 diabetes in hypertensive individuals. This study provides new perspectives for the development of therapeutic strategies for type 2 diabetes in hypertensive individuals.
JOURNAL OF CLINICAL HYPERTENSION
(2022)
Article
Psychiatry
Marjorie Dosogne, Benjamin Wacquier, Mohammed Al Faker, Hadrien Willame, Camille Point, Gwenole Loas, Matthieu Hein
Summary: Individuals with insomnia are at high-risk of suicide. Our study found that recent change of anhedonia is a risk factor for current suicidal ideations in individuals with insomnia, highlighting the need for more systematic research and adequate therapeutic management to prevent suicide.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Clinical Neurology
Mohammed Al Faker, Benjamin Wacquier, Hadrien Willame, Camille Point, Marjorie Dosogne, Gwenole Loas, Matthieu Hein
Summary: This study aimed to investigate the association between type 2 diabetes and major depression in individuals with apnoea. The results showed that moderate to severe major depression was significantly associated with type 2 diabetes in apnoeic individuals. Therefore, it is recommended to conduct systematic screening and provide appropriate therapeutic management for individuals at high risk of diabetic complications.
SLEEP AND BIOLOGICAL RHYTHMS
(2022)
Article
Behavioral Sciences
Matthieu Hein, Anais Mungo, Gwenole Loas
Summary: The study found that after receiving ECT treatment, borderline personality disorder was a risk factor for nonremission in individuals with major depression, with a nonremission rate of 42.9%.
Article
Psychiatry
Matthieu Hein, Anais Mungo, Gwenole Loas
Summary: This study aimed to investigate the risk of relapse within 6 months in major depressed individuals with borderline personality disorder (BPD) treated with electroconvulsive therapy. The findings showed that there was a high risk of relapse within 6 months in major depressed individuals treated with electroconvulsive therapy, and BPD was identified as a risk factor for relapse.
PSYCHIATRY RESEARCH
(2022)
Article
Biology
Matthieu Hein, Benjamin Wacquier, Jean-Pol Lanquart, Gwenole Loas
Summary: This study aimed to examine the 10-year cardiovascular disease (CVD) risk associated with comorbid insomnia disorder and its specific subtypes in apnoeic individuals. The results showed that comorbid insomnia disorder and its subtype were significantly associated with moderate-to-high 10-year CVD risk in apnoeic individuals.
Article
Biochemistry & Molecular Biology
Camille Point, Benjamin Wacquier, Marjorie Dosogne, Mohammed Al Faker, Hadrien Willame, Gwenole Loas, Matthieu Hein
Summary: This study found that alexithymia is a risk factor for dyslipidaemia in major depressed individuals, highlighting the importance of identifying and managing this personality trait for better lipid profile in this high cardiovascular risk subpopulation.
Article
Environmental Sciences
Farah Damerdji, Marianne Rotsaert, Benjamin Wacquier, Matthieu Hein, Gwenole Loas
Summary: The study found that the COVID-19 lockdown led to a significant deterioration in the mental health of the population. The proportion of alexithymic patients increased significantly after lockdown, while the proportions of depressed and anxious subjects remained stable. This suggests that further research is needed to understand the factors responsible for the increase in alexithymia after lockdown.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Environmental Sciences
Matthieu Hein, Francois-Xavier Dekeuleneer, Olivier Hennebert, Dephine Skrjanc, Emilie Oudart, Anais Mungo, Marianne Rotsaert, Gwenole Loas
Summary: This study aimed to explore the relationship between recent suicidal ideation and different types of anhedonia in depression. The findings suggest that trait anhedonia is a strong predictor of recent suicidal ideation in severe depression, while recent change of anhedonia is associated with recent suicidal ideation in mild or moderate depression.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Medicine, General & Internal
Mokhtar Abdelhakim Laoufi, Benjamin Wacquier, Tristan Lartigolle, Gwenole Loas, Matthieu Hein
Summary: This study confirmed the relationship between type D personality and suicidal ideation in major depressed individuals, suggesting the need for systematic research and management of this personality structure to prevent suicidal behaviors.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Martin Manderlier, Julie Navez, Matthieu Hein, Jean-Luc Engelholm, Jean Closset, Maria Antonietta Bali, Dirk Van Gestel, Luigi Moretti, Jean-Luc Van Laethem, Christelle Bouchart
Summary: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive tumor with poor prognosis. Surgical resection is the only potentially curative treatment. The study found that stereotactic body radiotherapy (SBRT) may offer a promising improvement in overall survival compared to conventional chemoradiotherapy (CRT) for localized PDAC.
Article
Oncology
Christelle Bouchart, Jean-Luc Engelholm, Jean Closset, Julie Navez, Patrizia Loi, Yeter Gokburun, Thierry De Grez, Laura Mans, Alain Hendlisz, Maria Antonietta Bali, Pierre Eisendrath, Dirk Van Gestel, Matthieu Hein, Luigi Moretti, Jean-Luc Van Laethem
Summary: The study evaluated the feasibility and safety of isotoxic high-dose SBRT in a total neoadjuvant sequence for the treatment of localized pancreatic adenocarcinoma. The results showed promising oncological outcomes, with improved survival and local control in patients undergoing this treatment strategy, indicating its potential in the treatment of pancreatic cancer.
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY
(2021)
Article
Psychiatry
Sevlin Boz, Jean-Pol Lanquart, Anais Mungo, Marie Delhaye, Gwenole Loas, Matthieu Hein
Summary: This study aimed to investigate the risk of excessive daytime sleepiness (EDS) associated with major depression in adolescents. The prevalence of EDS was 34.3% in the sample, and remitted and severe major depression were found to be risk factors for EDS in adolescents. The study suggests that in adolescents, EDS could be both a residual symptom and a marker of severity for major depression.
PSYCHIATRIC QUARTERLY
(2021)
Article
Clinical Neurology
Melanie Strauss, Lucie Griffon, Maxime Elbaz, Isabelle Arnulf, Mounir Chennaoui, Damien Leger
Summary: This study examines decision-making impairments in individuals with central disorders of hypersomnolence (CDH), specifically narcolepsy type 1 (NT1). The results suggest that both NT1 and other CDH patients have decreased learning abilities to avoid losses, which is associated with alterations in vigilance. The study provides new insights into the nature of decision-making impairments in CDH and suggests the potential for minimizing these alterations by restoring adequate vigilance.
Article
Clinical Neurology
Kyriakos Dimitriadis, Christina Stathakopoulou, Nikolaos Pyrpyris, Eirini Beneki, Elena Adamopoulou, Stergios Soulaidopoulos, Ioannis Leontsinis, Alexandros Kasiakogias, Aggelos Papanikolaou, Panagiotis Tsioufis, Konstantinos Aznaouridis, Dimitris Tsiachris, Konstantina Aggeli, Konstantinos Tsioufis
Summary: This review provides a comprehensive analysis of the common pathophysiology between sleep disordered breathing (SDB) and mitral regurgitation (MR), and discusses the effects of SDB treatment on MR and the effects of mitral valve surgery or transcatheter repair on obstructive and central sleep apnea (OSA and CSA).
Article
Clinical Neurology
Szu-Yu Hou, Ching-Ju Chiu, Jeanne Laraine Shea, Chih-Liang Wang, Hsiao-Han Tang, Po-Ching Kuo, Yi-Chieh Yang, Chih-Hsing Wu
Summary: The study aimed to examine the effects of age, menopausal status, and symptoms on sleep patterns and circadian rhythms in midlife women. Premenopausal women had the most unstable day-to-day rhythms, and women with more severe symptoms experienced greater sleep problems. Psychological symptoms were the strongest predictors for all sleep parameters.
Article
Clinical Neurology
Ya-Wen Hsiao, Wei-Lun Lin, Yu-Hui Chou, Shin-Huei Liu, Ting-Wei Ernie Liao, Shih-Ann Chen, Li-Wei Lo
Summary: This study aimed to investigate the effects of RDN on heart inflammation associated with COSA. The results suggest that RDN treatment may prevent COSA-associated heart inflammation through the JAK2-STAT3 signaling pathway.
Article
Clinical Neurology
Amy C. Reynolds, Kelly A. Loffler, Nicole Grivell, Brandon W. J. Brown, Robert J. Adams
Summary: This study aimed to understand the experience of sleep disorder diagnosis and treatment in shift workers and propose patient-informed solutions to improve access to health services. The findings showed that there were varied experiences with diagnosis and management, often taking a long time to seek help from healthcare providers after noticing symptoms. The study also identified the need for education and awareness initiatives, convenient screening and referral pathways, and tailored models of care.
Article
Clinical Neurology
Hsi -Chung Chen, Nai-Wei Hsu, Ching-Heng Lin
Summary: This study found a relationship between daytime sleepiness and mortality risk among older adults. The moderating effects of sex and physical function were examined. Specifically, the passive factor predicted mortality risk in women with good muscle power, while the active factor predicted mortality risk in men with good muscle power.
Article
Clinical Neurology
Sean P. A. Drummond, Bei Bei
Summary: This study proposes a parsimonious two-stage model for defining stages of Cognitive Behavioural Therapy for Insomnia (CBT-I) based on Sleep Restriction Therapy (SRT). Using data from a randomized clinical trial, the model helps identify patterns of treatment progression and their association with baseline insomnia severity. The model holds potential for further research on various CBT-I processes that are currently not fully understood.
Article
Clinical Neurology
Janet Jezkova, Karel Sonka, Jakub Kreisinger, Petra Prochazkova, Helena Tlaskalova-Hogenova, Sona Nevsimalova, Jitka Buskova, Radana Merkova, Tereza Dvorakova, Iva Prihodova, Simona Dostalova, Radka Roubalova
Summary: In recent years, there has been a growing interest in the influence of gut microbiota on sleep physiology. The gut microbiota affects the central nervous system and circadian rhythms, and can be associated with sleep disorders. This study observed the gut microbiota composition of patients with different types of narcolepsy and idiopathic hypersomnia, and found changes in beta diversity in these patient groups compared to healthy controls. However, after adjusting for confounding factors, the differences were no longer statistically significant. The study suggests that using metabolomics and proteomics approaches to study the role of microbiota in sleep disorders may be beneficial.
Article
Clinical Neurology
Mauro Manconi, Linda C. van der Gaag, Francesca Mangili, Corrado Garbazza, Silvia Riccardi, Christian Cajochen, Susanna Mondini, Francesca Furia, Elena Zambrelli, Simone Baiardi, Alessandra Giordano, Nicola Rizzo, Cristina Fonti, Elsa Viora, Armando D'Agostino, Alessandro Cicolin, Fabio Cirignotta, Daniele Aquilino, Alessandra Barassi, Renata del Giudice, Giulia Fior, Orsola Gambini, Barbara Giordano, Alma Martini, Chiara Serrati, Rossana Stefanelli, Silvio Scarone, Mariapaola Canevini, Valentina Fanti, Hans-Christian Stein, Anna Maria Marconi, Erica Raimondo, Emanuela Viglietta, Rossella Santoro, Giuliana Simonazzi, Alessandra Bianconcini, Francesco Meani, Nicoletta Piazza, Filippos Filippakos, Thomas Gyr
Summary: The Life-ON study provides the largest polysomnographic dataset coupled with longitudinal subjective assessments of sleep quality in pregnant women to date. Sleep disorders are highly frequent and distributed differently during pregnancy and postpartum. Routine assessment of sleep disturbances in the perinatal period is necessary to improve early detection and clinical management.
Article
Clinical Neurology
Zhihua Huang, Anqi Duan, Zhihui Zhao, Qing Zhao, Yi Zhang, Xin Li, Sicheng Zhang, Luyang Gao, Chenhong An, Qin Luo, Zhihong Liu
Summary: This study aims to investigate pulmonary arterial hypertension (PAH) phenotypes and their prognostic implications by clustering overnight cardiorespiratory signals in PAH patients. Three distinct clusters were identified, with patients in Cluster 3 exhibiting worse clinical outcomes. The presence of nocturnal hypoxemia and obstructive sleep apnea (OSA) in PAH patients was associated with increased risk of clinical worsening. Tailored management strategies addressing both PAH and nocturnal hypoxemia may improve clinical outcomes.
Article
Clinical Neurology
Yudan Lv, Yujun Wen, Ramalingam Vetrivelan, Jun Lu
Summary: This study demonstrated that the projections from the pontine parabrachial nucleus (PB) to the basal forebrain (BF) and medial septum (MS) can activate the cerebral cortex and hippocampus, providing important insights into the activities of these brain regions during the sleep-wake cycle.
Article
Clinical Neurology
Annika M. Myers, Megan E. Rech, Bengi Baran, Cara Palmer, Dimitrios Mylonas, Candice A. Alfano
Summary: This study found that N2 sleep spindles are associated with emotional functioning in school-aged children. Higher spindle density is related to decreased state-based emotional arousal towards negative affective images, and higher spindle peak frequency is associated with greater use of the positive emotion regulatory strategy of savoring.
Article
Clinical Neurology
Hung Youl Seok, Yong Won Cho
Summary: This study investigated the long-term impact of dopamine agonist treatment on altered central sensory processing in restless legs syndrome (RLS) patients. The results showed that dopamine agonist treatment effectively reduced RLS symptoms but did not reverse the altered central sensory processing observed on testing. These findings suggest that RLS pathophysiology is multifactorial and not solely driven by dopaminergic dysfunction.
