Article
Chemistry, Multidisciplinary
Giulia Santopolo, Antonio Clemente, Maria Aranda, Antonia Socias, Alberto Del Castillo, Aniceta Chica, Marcio Borges, Roberto de la Rica
Summary: The proposed plasmonic assay utilizes the aggregation of gold nanoparticles with cationic granule proteins to detect the degranulation status of septic cells colorimetrically, enabling easy detection of sepsis cells with fewer granules. This method shows high specificity and diagnostic performance, making it a promising alternative for diagnosing sepsis in decentralized healthcare schemes.
Article
Chemistry, Analytical
Jing Wang, Kai Mu, Hongjuan Wei, Hong Chen, Yunxiang Wang, Wuxing Zhang, Zhen Rong
Summary: In this study, a paper-based colloidal gold multiplex vertical flow assay was developed for rapid detection of three AKI biomarkers. The assay platform is easy to use, rapid, and low cost, making it a promising diagnostic tool for multiplex detection of disease biomarkers.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Food Science & Technology
Marzieh Sepahvand, Forough Ghasemi, Hossein Mir Seyed Hosseini
Summary: This paper discusses the serious threat of irregular and unknowing use of chemical compounds to the environment, human health, and living organisms, emphasizing the importance of monitoring nitrite and nitrate. It comprehensively discusses the application and advantages of nanoplasmonic colorimetric sensors in the measurement of nitrite and nitrate.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Chemistry, Analytical
Kai-Xin Xie, Qian Liu, Shu-Shu Jia, Xiu-Xian Xiao
Summary: The introduction of a hollow plasmonic structure led to enhanced surface plasmon-coupled emission (SPCE), resulting in significant fluorescence signal enhancements. This was primarily attributed to the unique hot-spot plasmonic structure between GNS and gold substrate, the intense electromagnetic field of GNSs, and the strong coupling interactions between fluorescence and surface plasmons.
ANALYTICA CHIMICA ACTA
(2021)
Article
Chemistry, Multidisciplinary
Xiaojun Song, Yueliang Wang, Yan Hao, Qingqing Zhu, Yanjuan Li, Lei Song, Zhaoxiang Deng
Summary: This study successfully built a series of homo/heterodimeric plasmonic nanomolecules with prescribed compositions using DNA-guided, solvo-driven Ag ion soldering method. Strong in-solution electric-dipole coupling was achieved for materials with strong (Au, Ag) or damped (Pt, Pd) plasmonic responses.
Article
Chemistry, Analytical
Yinyin Chen, Xingying She, Wei Wu, Xianxiang Wang
Summary: A dual-mode optical probe for the detection of organophosphorus pesticides triazophos (TRP) was developed based on the internal filter effect (IFE) between upconversion nanoparticles (UCNPs) and gold nanoparticles (AuNPs) in the presence of protamine (PRO) and trypsin (TRY). The probe demonstrated high sensitivity for TRP detection with good linear relationship and low detection limits. The recovery of TRP in real food samples also showed satisfactory results.
MICROCHEMICAL JOURNAL
(2023)
Article
Chemistry, Analytical
Maria del Mar Gonzalez del Campo, Alejandra Alba-Patino, Carlos Palomino, Marta Bauza, Estrella Rojo-Molinero, Antonio Oliver, Gemma Turnes, Roberto de la Rica
Summary: This study explored the impact of polymer modifications on the storage and release of reagents in paper-based biosensors, revealing that different polymers can enhance reagent concentration and release efficiency. By modifying polymers, the sensitivity of biosensors can be significantly improved and the detection limits can be lowered.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Optics
Raphael M. S. M. Baltar, Sajid Farooq, Renato E. de Araujo
Summary: This study evaluated the use of gold and silver nanoshells as a starting point for colorimetric sensor platforms. The sensitivity and linearity of the nanoplatforms were assessed under various factors, and a computational procedure for selecting high-performance plasmonic sensor platforms was described. Gold nanoshells were found to be highly efficient for colorimetric sensing, while silver nanoshells were better suited for spectroscopic sensors. The optimization approach used in this work can be extended to different nanostructures, contributing to advances in colorimetric biosensors.
JOURNAL OF THE OPTICAL SOCIETY OF AMERICA B-OPTICAL PHYSICS
(2023)
Article
Chemistry, Analytical
Saipriya Ramalingam, Christopher M. Collier, Ashutosh Singh
Summary: Antibiotics are widely used in veterinary science to promote animal health and feed efficiency, but concerns arise due to the potential residues in milk. Therefore, quick and reliable testing methods are essential to ensure the safety of the produced milk.
Article
Chemistry, Analytical
Qian Guo, Lu Ding, Yu Li, Sicheng Xiong, Hao Fang, Xiangmin Li, Lijuan Nie, Yonghua Xiong, Xiaolin Huang
Summary: A novel dynamic light scattering (DLS) immunosensing strategy based on COF@AuNP was reported for highly sensitive protein marker detection. The COF@AuNP was designed as a signal amplifier to boost the release of AuNPs, which were then enlarged by gold growth to amplify the DLS signal transduction and improve the sensitivity. The immunosensor exhibited high selectivity, accuracy, reproducibility, and reliability in spiked and actual whole blood samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Nanoscience & Nanotechnology
Tomas Pinheiro, Ana C. Marques, Patricia Carvalho, Rodrigo Martins, Elvira Fortunato
Summary: The article presents a signal transduction method based on gold nanoparticles for the development of paper-based multiplex colorimetric assay devices for diabetes control, showing the potential for multiparametric colorimetric measurement.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Physical
Jiahao Pan, Xiaoyao Wang, Jinjin Zhang, Qin Zhang, Qiangbin Wang, Chao Zhou
Summary: By assembling helical plasmonic nanorods with intrinsic chirality, we have created plasmonic metamolecules with both chiral coupling and intrinsic chiroptical responses. These metamolecules offer more dimensions for tailoring chiroptical responses and make it more flexible to design plasmonic nanodevices with custom PCD.
Article
Multidisciplinary Sciences
Chi Zhang, Dongyao Li, Guangdi Zhang, Xujie Wang, Li Mao, Quan Gan, Tao Ding, Hongxing Xu
Summary: This study demonstrates a method to reversibly modulate the nanogap plasmons between classical and quantum tunneling regimes using supramolecular interactions. The detailed plasmon shift near the quantum tunneling limit is revealed, and it is shown that plasmonic hot electron tunneling can further blue shift the quantum plasmons.
Article
Chemistry, Analytical
Mona Soroush, Walid Ait Mammar, Axel Wilson, Hedayatollah Ghourchian, Michele Salmain, Souhir Boujday
Summary: We developed a magneto-plasmonic biosensor for immunodetection of antigens in small sample volumes. The biosensor utilized gold nanoparticles and magnetic beads conjugated with antibodies as capture and detection probes, respectively. The sandwich immunocomplex formed by the target analyte and detection probe was separated using a magnetic field, and the signal was measured by UV-Visible spectroscopy. The assay was successfully applied in a microfluidic system for quantification of the analyte.
Article
Chemistry, Analytical
Wenying Lu, Ye Tian, Weipeng Teng, Xuchun Qiu, Ming Li
Summary: This study established a tri-modal readout plasmonic colorimetric immunosensor for small molecule detection. The sensor exhibited changes in color from deep blue to blue violet and finally to shiny red, correlated with the increasing concentration of the target molecule. The readout of the sensor could be obtained through naked eye, smartphone, and UV-spectrum.
Article
Chemistry, Analytical
Giulia Santopolo, Estrella Rojo-Molinero, Antonio Clemente, Marcio Borges, Antonio Oliver, Roberto de la Rica
Summary: The diagnostic kit introduced in this context enables rapid bedside detection of carbapenemase-producing pathogens through colored tests generated by gold nanoparticles. It allows for quick and accurate detection of infections in urine and sputum samples within a few hours, facilitating faster customization of antimicrobial treatments.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Multidisciplinary
Andreu Vaquer, Enrique Baron, Roberto de la Rica
Summary: The manuscript presents a wearable analytical platform that can measure sweat lactate concentration and sample volume simultaneously. The lactate biosensor features a signal modulation mechanism and competitive enzyme inhibitor for precise measurements, while a volume sensor with gold nanoparticles allows estimation of sweat volume. This platform enables quantification of sweat lactate levels independently of sweat rate, making it suitable for developing disposable wearable biosensors.
Article
Chemistry, Analytical
Cristina Adrover-Jaume, Alejandra Alba-Patino, Antonio Clemente, Giulia Santopolo, Andreu Vaquer, Steven M. Russell, Enrique Baron, Maria del Mar Gonzalez del Campo, Joana M. Ferrer, Maria Berman-Riu, Mercedes Garcia-Gasalla, Maria Aranda, Marcio Borges, Roberto de la Rica
Summary: Decentralizing COVID-19 care through the use of biosensors for detecting severe cases in decentralized healthcare settings allows for low limit of detection and semi-quantitative measurements of IL-6 in blood and respiratory samples. This enables stratification of COVID-19 patients based on IL-6 levels and potential adaptation for detecting other cytokines.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Review
Chemistry, Analytical
Alejandra Alba-Patino, Andreu Vaquer, Enrique Baron, Steven M. Russell, Marcio Borges, Roberto de la Rica
Summary: This article reviews recent advances in diagnostic tools for managing sepsis based on micro- and nanostructured materials. It discusses popular biomarkers and detection methods for sepsis diagnosis, and highlights the role of micro- and nanostructured materials in developing biosensors to meet the specific needs of different points of sepsis care. The article also summarizes the most utilized materials and points out future challenges for development.
Article
Chemistry, Multidisciplinary
Andreu Vaquer, Enrique Baron, Roberto de la Rica
Summary: This article presents a chrono-sampling method for fabricating wearable devices made entirely of filter paper. The method uses dried polymers as valves to control the flow of liquids for sequential measurements. The concept was demonstrated with a paper multisensor capable of performing nine consecutive pH measurements and a urea biosensor. The proposed analytical platform can monitor the pH of sweat with accuracy and precision comparable to a laboratory-based method.
Article
Chemistry, Analytical
Steven M. Russell, Alejandra Alba-Patino, Andreu Vaquer, Antonio Clemente, Roberto de la Rica
Summary: This study introduces a minimal reader prototype composed of open-source hardware and software that can automatically measure colorimetric signals in rapid tests. It avoids interoperability issues associated with closed-source readers and utilizes an image-processing algorithm to automatically select an optimal region of interest and measure pixel intensity. The results obtained with the proposed algorithm for detecting antibodies against SARS-CoV-2 were comparable to manual methods but showed improved precision and accuracy in quantifying small spots or faint and patchy signals.
Article
Chemistry, Analytical
Maria del Mar Gonzalez del Campo, Alejandra Alba-Patino, Carlos Palomino, Marta Bauza, Estrella Rojo-Molinero, Antonio Oliver, Gemma Turnes, Roberto de la Rica
Summary: This study explored the impact of polymer modifications on the storage and release of reagents in paper-based biosensors, revealing that different polymers can enhance reagent concentration and release efficiency. By modifying polymers, the sensitivity of biosensors can be significantly improved and the detection limits can be lowered.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Review
Materials Science, Multidisciplinary
Mariadel Mar Gonzalez del Campo, Andreu Vaquer, Roberto de la Rica
Summary: In recent years, paper has become a widely used material for developing various types of sensors, and a polymer-based toolbox has emerged to enhance the functionalities of these devices. This article compiles examples from recent literature on microfluidic systems and polymer-based transducers implemented in paper-based analytical platforms. The use of printing methods to pattern polymers allows for mass production of these advanced paper-based devices without requiring specialized facilities.
ADVANCED MATERIALS TECHNOLOGIES
(2022)
Article
Chemistry, Analytical
Giulia Santopolo, Antonio Clemente, Estrella Rojo-Molinero, Antonio Oliver, Camilla Noe, Roberto de la Rica
Summary: Infections caused by bacteria that produce β-lactamases are a major problem in hospitals. Current methods for detecting these bacteria rely on culturing samples, which is time-consuming. This study proposes a multisensor technology that can rapidly identify different types of β-lactamase-producing pathogens within 90 minutes, without the need for sample culturing. The technology concentrates bacterial cells on a paper-based multisensor and performs 12 parallel assays to determine if the pathogens produce specific enzymes. The proposed technology is fast, simple, and cost-effective, making it promising for developing fully automated platforms for clinical diagnosis.
ANALYTICAL CHEMISTRY
(2022)
Article
Biochemical Research Methods
Giulia Santopolo, Antonio Clemente, Estrella Rojo-Molinero, Sara Fernandez, Maria Concepcion Alvarez, Antonio Oliver, Roberto de la Rica
Summary: The proposed enzymatic liquefaction method is superior to traditional methods in terms of liquefaction efficiency, cell viability, and retention of in vivo functional characteristics. This method is applicable for flow cytometry analysis of respiratory samples and provides valuable insights into the cellular basis of pathological processes in the lungs.
BIOLOGICAL PROCEDURES ONLINE
(2022)
Article
Chemistry, Analytical
Giulia Santopolo, Antonio Clemente, Marta Gonzalez-Freire, Steven M. Russell, Andreu Vaquer, Enrique Baron, Maria Aranda, Antonia Socias, Alberto del Castillo, Marcio Borges, Roberto de la Rica
Summary: This manuscript demonstrates the use of a nanoparticle aggregation test to classify COVID-19 patients according to disease severity, which can help optimize the utilization of hospital resources.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Analytical
Andreu Vaquer, Cristina Adrover-Jaume, Antonio Clemente, Amanda Iglesias, Meritxell Lopez, Rocio Martinez, Isabel M. Roig, Borja G. Cosio, Roberto de la Rica
Summary: A new method for infusing porous materials with concentrated polymers is proposed, which solves the issue of high viscosity during conventional printing methods and reduces manufacturing variability of biosensors. Immunosenors for detecting cytokines IL-6 and IL-5 were developed using this method and showed promising results.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Multidisciplinary
Manuel Gutierrez-Capitan, Ana Sanchis, Estela O. Carvalho, Antonio Baldi, Lluisa Vilaplana, Vanessa F. Cardoso, Alvaro Calleja, Mingxing Wei, Roberto de la Rica, Javier Hoyo, Arnau Bassegoda, Tzanko Tzanov, Maria-Pilar Marco, Senentxu Lanceros-Mendez, Cesar Fernandez-Sanchez
Summary: This study demonstrates a unique and easily deployable multiplex device that can simultaneously measure interleukin-8, tumor necrosis factor-α, and myeloperoxidase biomarkers in sputum, aiming to facilitate the timely detection of acute exacerbations of chronic obstructive pulmonary disease.
Article
Chemistry, Analytical
David Delgado-Cano, Antonio Clemente, Cristina Adrover-Jaume, Andreu Vaquer, Meritxell Lopez, Rocio Martinez, Isabel M. Roig, Amanda Iglesias, Borja G. Cosio, Roberto de la Rica
Summary: Rapid detection and treatment of Pseudomonas aeruginosa (P. aeruginosa) infections in the respiratory tract of patients with chronic lung diseases is crucial. In this study, an alternative diagnosis approach based on analyzing breath aerosols was proposed. The use of nanoparticle immunosensors on the polypropylene layer of surgical facemasks worn by patients allowed for the detection of chronic and acute P. aeruginosa lung infections.
Article
Chemistry, Analytical
Giulia Santopolo, Antonio Clemente, Estrella Rojo-Molinero, Antonio Oliver, Camilla Noe, Roberto de la Rica
Summary: In this study, a multisensor was proposed for the rapid detection of bacterial pathogens carrying different types of β-lactamases. The sensor can generate colored spots that can be quantified and interpreted to identify the presence of specific enzymes.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Mengmeng Guo, Na Luo, Yueling Bai, Zhenggang Xue, Qingmin Hu, Jiaqiang Xu
Summary: A porous heterostructure WO3-C/In2O3 was designed and prepared for a miniature H2 sensor, which showed higher response value, lower operating temperature, fast response-recovery speed, and low limit of detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Feng Hu, Hui Hu, Yuting Li, Xiaohui Wang, Xiaowen Shi
Summary: Arsenic contamination in water bodies is a significant health risk. This study developed a chitosan-catechol modified electrode for rapid and accurate detection of trace amounts of arsenic. The modified electrode demonstrated good detection capability and resistance to ionic interference, making it suitable for in situ detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Yantao Zhang, Qian Liu, Tao Tian, Chunhua Xu, Pengli Yang, Lianju Ma, Yi Hou, Hui Zhou, Yongjun Gan
Summary: In this study, a lysosome-targeting buffering fluorogenic probe (Lyso-BFP) was designed and synthesized, demonstrating excellent photostability, pH specificity, and responsiveness to lysosomal acidification in living cells. The performance of Lyso-BFP in pH sensing was attributed to the inhibition of the photo-induced electron transfer process. Lyso-BFP allowed for wash-free imaging and long-term real-time monitoring of lysosome pH changes based on its off-on fluorescence behavior and buffer strategy.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Wei Cai, Wenbo Sun, Jiayue Wang, Xiaokui Huo, Xudong Cao, Xiangge Tian, Xiaochi Ma, Lei Feng
Summary: In this study, a near-infrared fluorescent probe HCBG was developed for imaging of alpha-GLC. HCBG exhibited excellent selectivity and sensitivity towards alpha-GLC in complex bio-samples, and showed good cell permeability for in situ real-time imaging. Through the high-throughput screening system established by HCBG, a natural alpha-GLC inhibitor was successfully isolated and identified. This study provides a novel fluorescence visualization tool for discovering and exploring the biological functions of diabetes-related gut microbiota, and a high-throughput screening approach for alpha-GLC inhibitor.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Trey W. Pittman, Xi Zhang, Chamindie Punyadeera, Charles S. Henry
Summary: Heart failure is a growing epidemic and a significant clinical and public health problem. Researchers have developed a portable and affordable diagnostic device for heart failure that can be used at the point-of-care, providing a valid alternative to current diagnostics approaches.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Anders O. Tjell, Barbara Jud, Roland Schaller-Ammann, Torsten Mayr
Summary: An optical hydrogen peroxide sensor based on catalytic degradation and the detection of produced oxygen is presented. The sensor offers higher resolution and better sensitivity at lower H2O2 concentrations. By removing O2 from the sample solution, a more sensitive O2 sensor can be used for measurement. The sensor has been successfully applied in a flow-through cell to measure H2O2 concentration in different flow rates.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Seong Jae Kim, Ji-hun Jeong, Gaabhin Ryu, Yoon Sick Eom, Sanha Kim
Summary: Surface-enhanced Raman spectroscopy (SERS) is a high-sensitivity, label-free detection method with various analytical applications. Researchers have developed a hydrophobic SERS substrate based on engineered carbon nanotube arrays (CNT-SERS) and studied the role of structural design at both micro and nanoscales. The substrate demonstrated controlled self-enrichment capability and enhanced sensitivity, with a significant increase in the SERS signal. The study also proposed a theoretical model and a concentration strategy inspired by plants for analyte deposition on microarrays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Dan Zhao, Renjun Jiang, Xiaoqiang Liu, Subbiah Alwarappan
Summary: In this study, a novel ternary composite material was constructed by assembling cerium vanadate nanorods on reduced graphene oxide-microcrystalline cellulose nanosheets, and it was used for real-time monitoring of the concentration of superoxide anions in vivo. The ternary composite showed excellent conductivity, large surface area, and abundant active sites, leading to a wider linear range, high sensitivity, low detection limit, and fast response time for superoxide anion detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Tengfei Wang, Liwen Wang, Guang Wu, Dating Tian
Summary: In this study, a covalent organic framework material TaTp-COF with porous and uniform spheres was successfully prepared via hydrothermal reaction, and it was found to significantly enhance the aggregation-induced emission (AIE) of berberine. The unique emission properties of berberine on TaTp-COF were studied and utilized for the sensitive detection of berberine.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Lin Li, Yilei Ding, Lei Xu, Shuoran Chen, Guoliang Dai, Pengju Han, Lixin Lu, Changqing Ye, Yanlin Song
Summary: In this study, a novel TTI based on a ratiometric fluorescent nanosensor is designed, which has the advantages of high accuracy and low cost. Experimental and theoretical investigations confirm its pH responsiveness and demonstrate its good sensitivity and reliability. By monitoring the total volatile basic nitrogen, this TTI can accurately predict food spoilage and can be adaptively modified for different types of food. The TTI based on this nanosensor enables visual monitoring of food quality.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Fangju Chen, Xueting Wang, Wei Chen, Chenwen Shao, Yong Qian
Summary: Lung cancer is the second most common malignant tumor worldwide. Drug resistance in lung cancer leads to treatment failure and recurrence in majority of patients. This study developed a fluorescent prodrug that can be activated in cancer cells to release drugs, and its signal can be tracked by imaging. It shows a unique autophagy-driven ferroptosis effect, indicating its potential for targeting drug-resistant cancer cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Weichao Li, Qiming Yuan, Zhangcheng Xia, Xiaoxue Ma, Lifang He, Ling Jin, Xiangfeng Chu, Kui Zhang
Summary: This study developed a high-performance gas sensor for formaldehyde detection by modifying ZnSnO3 with ZnO QDs and SnO2 QDs. The modified sensor showed improved sensing response and lower working temperature. The presence of ZnO QDs formed rich heterojunctions, increased surface area, and provided oxygen deficiency for formaldehyde sensing reaction, thus enhancing the sensor performance. This research provides an alternative method to enhance the sensing properties of MOS by QDs modification.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Joung-Il Moon, Eun Jung Choi, Younju Joung, Jin-Woo Oh, Sang-Woo Joo, Jaebum Choo
Summary: A novel nanoplasmonic substrate was developed for biomedical applications, which showed strong hot spots for detecting biomarkers at low concentrations. The substrate, called AuNPs@M13, was made by immobilizing 60 nm gold nanoparticles onto the surface of an M13 bacteriophage scaffold. It demonstrated higher sensitivity and lower limit of detection compared to commercially available assays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Ning Li, Ya Zhang, Ying Xu, Xiaofang Liu, Jian Chen, Mei Yang, Changjun Hou, Danqun Huo
Summary: The molecular subtype of breast cancer guides treatment and drug selection. Invasive tests can promote cancer cell metastasis, so the development of high-performance, low-cost diagnostic tools for cancer prognosis is crucial. Liquid biopsy techniques enable noninvasive, real-time, dynamic, multicomponent, quantitative, and long-term observations at the cellular, genetic, and molecular levels. A Cu-Zr metal-organic framework (MOF) nanoenzyme with monatomic Cu attachment has been synthesized and proven to have high catalytic performance. The sensor constructed using this nanoenzyme shows potential for accurate classification of breast cancer serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Jeongmin Kim, Hyemin Kim, Seunghyun Park, Hyeonaug Hong, Yong Jae Kim, Jiyong Lee, Jaeho Kim, Seung-Woo Cho, Wonhyoung Ryu
Summary: This study presents a method to fabricate independently functioning microneedle (MN) electrodes with narrow intervals for high precision electrochemical sensing. The optimized mixture of photocurable polymer and single-wall carbon nanotubes was used to mold single composite MNs, which were then attached to pre-patterned electrodes. Plasma etching and electropolymerization were performed to enhance the electrochemical activity, and Prussian blue and glucose oxidase were electrodeposited on the MNs for glucose detection. The MN electrodes showed good sensitivity and linearity, and the feasibility of glucose detection was demonstrated in an in vivo mouse study.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)