Article
Biochemical Research Methods
Francisca T. S. M. Ferreira, Karina A. Catalao, Raquel B. R. Mesquita, Antonio O. S. S. Rangel
Summary: A simple and disposable microfluidic paper-based analytical device (muPAD) was developed for the quantification of iron in urine samples, showing a high accuracy and stability in the analysis process.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Spectroscopy
Maria Kochetkova, Irina Timofeeva, Andrey Bulatov
Summary: A novel method for formaldehyde determination in milk samples was developed using derivatization and microextraction techniques without the need for cuvettes. The method allows for spectrofluorometric analysis of formaldehyde on a paper template, providing a simple and efficient approach for analytical measurements.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Chemistry, Analytical
Oldouz Heidary, Morteza Akhond, Bahram Hemmateenejad
Summary: A simple and rapid on-site iodometric titration method utilizing a combination of traditional redox titration and microfluidic paper-based analytical devices (muPADs) is proposed. The proposed method allows for the determination of target analyte concentrations within 30 seconds, without the need for instruments or calibration. The feasibility of the method is confirmed through analysis of real samples, showing highly consistent results with standard methods.
MICROCHEMICAL JOURNAL
(2022)
Article
Chemistry, Applied
Zhaohua Zhang, Zejian He, Tianhang Weng, Laifa Tong, Yongcheng Liu, Yulong Chen, Mi Zhou
Summary: A series of fluorescent starches were prepared using Hantzsch multi-component reaction (MRC), exhibiting bright fluorescence emission. The poly-saccharide skeleton effectively inhibited aggregation-induced quenching effect seen in traditional organic fluorescent materials. The starch derivatives showed excellent stability, maintaining fluorescence emission even after boiling and displaying brighter fluorescence in alkaline solutions. Additionally, the starch acquired hydrophobic properties by connecting long alkyl chains, and it can be processed into film, gel, and coating. These fluorescent starch materials provide a new approach for functional modification of starch and have great application potential in various fields like detection, anti-counterfeiting, and security printing.
CARBOHYDRATE POLYMERS
(2023)
Review
Chemistry, Multidisciplinary
Eka Noviana, Tugba Ozer, Cody S. Carrell, Jeremy S. Link, Catherine McMahon, Ilhoon Jang, Charles S. Henry
Summary: Microfluidic paper-based analytical devices (muPADs) have gained significant interest as a promising analytical platform in the past decade, offering unique advantages over traditional microfluidics. This comprehensive Review highlights fabrication methods, device designs, and detection strategies, as well as the growing applications of muPADs, while discussing the field's need for further advancement to realize its full potential.
Article
Chemistry, Analytical
Ahmed A. Shalaby, Chia-Wen Tsao, Akihiko Ishida, Masatoshi Maeki, Manabu Tokeshi
Summary: Cancer is a leading cause of death worldwide, and early diagnosis is crucial for successful treatment. In developing countries, there is a need for low-cost, accurate, and easy to use point-of-need (PON) devices for cancer diagnosis and treatment follow-up. Paper-based analytical devices (PADs) are considered a key solution as they provide a low-cost platform for developing PON biosensors. This review discusses the various factors involved in the development of PADs for cancer biomarker detection and summarizes the advantages and disadvantages of each method.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Applied
Ana Carolina Rafanhin Sousa, Cleyton Nascimento Makara, Lais Canniatti Brazaca, Emanuel Carrilho
Summary: In order to detect sulfonamides in milk, a simple and portable microfluidic paper-based analytical device (mu PAD) was developed for precise analysis without the need for pretreatment. This device has good linearity and selectivity, potentially allowing for on-site monitoring of milk quality to reduce adverse conditions associated with high concentrations of sulfonamides.
Article
Chemistry, Analytical
Mami Ogawa, Aya Katoh, Ryuichi Matsubara, Haruka Kondo, Mizuki Otsuka, Tetsuya Sawatsubashi, Yuki Hiruta, Daniel Citterio
Summary: Silicate ions cause silica scaling in industrial water, and thus their concentrations need to be monitored and controlled at a low level. This work presents a foldable origami-type microfluidic paper-based analytical device for on-site detection of silicate ions using the molybdenum blue reaction. The device showed selectivity, stability, and semi-quantitative analytical performance, making it attractive for industrial monitoring.
ANALYTICAL SCIENCES
(2023)
Article
Biochemical Research Methods
Nuanlaor Ratanawimarnwong, Vanlada Suksomphot, Khemika Sornpipatpong, Supamit Lengwan, Suchao Donpudsa, Nuthawut Choengchan, Thitirat Mantim
Summary: This paper presents a microfludic device for the determination of sucrose using Benedict's test. By modifying a laboratory filter paper, a unique hydrophobic barrier was created, allowing for the measurement of sucrose and reducing sugars. The device was simple to use, requiring only basic laboratory equipment and a smartphone to capture the results. The method showed good linearity and low standard deviation for sucrose measurement.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Manassawee Janrod, Monpichar Srisa-Art
Summary: A microfluidic paper-based analytical device (mu PAD) with colorimetric detection was developed for simultaneous determination of urinary oxalate, citrate, and uric acid. The detection methods utilized enzymatic reactions and an indicator displacement assay. The mu PAD showed promising results with linear ranges and low detection limits for the three biomarkers, as well as acceptable accuracy and precision in urine sample testing. This development holds great potential for on-site analysis, providing a simple, fast, affordable, and portable tool for simultaneous determination of the biomarkers.
ANALYTICAL METHODS
(2023)
Article
Engineering, Environmental
Seong-Geun Jeong, Dong-Ho Kim, Jingyeong Kim, Ji-Hyun Kim, Sanggeun Song, Chang-Soo Lee
Summary: This study presents a method to achieve automatic multistep digital analysis in a single-sheet 3D paper-based microfluidic analytical device (3D-mu PAD) by controlling the penetration of different wax inks into paper. The methodology allows for sequential fluid delivery and multistep biochemical reactions, which can be integrated with digital assays without the need for external instruments. The potential commercial application of this approach is significant.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Energy & Fuels
Mosfera A. Chowdury, Farrukh Khalid
Summary: Due to the lack of affordable testing infrastructure, low- and medium-income countries are more affected by COVID-19 economically and socially. A proposed COVID-19 Point-of-Care (POC) ecosystem model aims to facilitate technological development and utilize locally available components. Collaboration among academia, government bodies, and entrepreneurs is crucial, and a microfluidic paper-based analytical POC platform for detecting COVID-19 analyte with patient-derived saliva is proposed in the study.
INTERNATIONAL JOURNAL OF ENERGY RESEARCH
(2021)
Review
Chemistry, Analytical
Taiyi Zhang, Feng Ding, Yujing Yang, Gaozhen Zhao, Chuanhao Zhang, Ruiming Wang, Xiaowen Huang
Summary: In vitro diagnosis (IVD) is a hot topic in laboratory research and achievement transformation. Microfluidic paper-based analytical devices (μPADs) have played a significant role in advancing the development of IVD. This paper provides a comprehensive review of μPAD classification and research progress in IVD, and discusses the potential improvements in terms of portability, sensitivity, and automation.
Article
Chemistry, Analytical
Amir Osman Abdelrazig, Bao Thai Tran, Patsamon Rijiravanich, Werasak Surareungchai
Summary: A microfluidic analytical device based on wax-patterned Fusion 5 paper was developed for rapid nucleic acid detection of the main causal agent of chili anthracnose in Asia. The biosensor used DNA-conjugated gold nanoparticles for detection with a detection limit down to 17.42 femtomoles, offering a specific and on-site detection method within 15 minutes. The device shows potential for protein assays and has a significant impact on on-site diagnostics.
ANALYTICAL METHODS
(2021)
Article
Chemistry, Analytical
A. S. Tsagkaris, D. Migliorelli, L. Uttl, D. Filippini, J. Pulkrabova, J. Hajslova
Summary: In this study, a microfluidic paper-based analytical device (μPAD) was developed to rapidly screen for the toxic chlorpyrifos metabolite, chlorpyrifos-oxon, in human serum. The μPAD demonstrated rapid results within 10 minutes, cost efficiency, and a low detection capability, making it potentially applicable for point-of-need use. Additionally, the μPAD was compared to well-established methods such as an in-house BChE microplate assay and liquid chromatography tandem mass spectrometry.
Article
Chemistry, Analytical
Mengmeng Guo, Na Luo, Yueling Bai, Zhenggang Xue, Qingmin Hu, Jiaqiang Xu
Summary: A porous heterostructure WO3-C/In2O3 was designed and prepared for a miniature H2 sensor, which showed higher response value, lower operating temperature, fast response-recovery speed, and low limit of detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Feng Hu, Hui Hu, Yuting Li, Xiaohui Wang, Xiaowen Shi
Summary: Arsenic contamination in water bodies is a significant health risk. This study developed a chitosan-catechol modified electrode for rapid and accurate detection of trace amounts of arsenic. The modified electrode demonstrated good detection capability and resistance to ionic interference, making it suitable for in situ detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Yantao Zhang, Qian Liu, Tao Tian, Chunhua Xu, Pengli Yang, Lianju Ma, Yi Hou, Hui Zhou, Yongjun Gan
Summary: In this study, a lysosome-targeting buffering fluorogenic probe (Lyso-BFP) was designed and synthesized, demonstrating excellent photostability, pH specificity, and responsiveness to lysosomal acidification in living cells. The performance of Lyso-BFP in pH sensing was attributed to the inhibition of the photo-induced electron transfer process. Lyso-BFP allowed for wash-free imaging and long-term real-time monitoring of lysosome pH changes based on its off-on fluorescence behavior and buffer strategy.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Wei Cai, Wenbo Sun, Jiayue Wang, Xiaokui Huo, Xudong Cao, Xiangge Tian, Xiaochi Ma, Lei Feng
Summary: In this study, a near-infrared fluorescent probe HCBG was developed for imaging of alpha-GLC. HCBG exhibited excellent selectivity and sensitivity towards alpha-GLC in complex bio-samples, and showed good cell permeability for in situ real-time imaging. Through the high-throughput screening system established by HCBG, a natural alpha-GLC inhibitor was successfully isolated and identified. This study provides a novel fluorescence visualization tool for discovering and exploring the biological functions of diabetes-related gut microbiota, and a high-throughput screening approach for alpha-GLC inhibitor.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Trey W. Pittman, Xi Zhang, Chamindie Punyadeera, Charles S. Henry
Summary: Heart failure is a growing epidemic and a significant clinical and public health problem. Researchers have developed a portable and affordable diagnostic device for heart failure that can be used at the point-of-care, providing a valid alternative to current diagnostics approaches.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Anders O. Tjell, Barbara Jud, Roland Schaller-Ammann, Torsten Mayr
Summary: An optical hydrogen peroxide sensor based on catalytic degradation and the detection of produced oxygen is presented. The sensor offers higher resolution and better sensitivity at lower H2O2 concentrations. By removing O2 from the sample solution, a more sensitive O2 sensor can be used for measurement. The sensor has been successfully applied in a flow-through cell to measure H2O2 concentration in different flow rates.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Seong Jae Kim, Ji-hun Jeong, Gaabhin Ryu, Yoon Sick Eom, Sanha Kim
Summary: Surface-enhanced Raman spectroscopy (SERS) is a high-sensitivity, label-free detection method with various analytical applications. Researchers have developed a hydrophobic SERS substrate based on engineered carbon nanotube arrays (CNT-SERS) and studied the role of structural design at both micro and nanoscales. The substrate demonstrated controlled self-enrichment capability and enhanced sensitivity, with a significant increase in the SERS signal. The study also proposed a theoretical model and a concentration strategy inspired by plants for analyte deposition on microarrays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Dan Zhao, Renjun Jiang, Xiaoqiang Liu, Subbiah Alwarappan
Summary: In this study, a novel ternary composite material was constructed by assembling cerium vanadate nanorods on reduced graphene oxide-microcrystalline cellulose nanosheets, and it was used for real-time monitoring of the concentration of superoxide anions in vivo. The ternary composite showed excellent conductivity, large surface area, and abundant active sites, leading to a wider linear range, high sensitivity, low detection limit, and fast response time for superoxide anion detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Tengfei Wang, Liwen Wang, Guang Wu, Dating Tian
Summary: In this study, a covalent organic framework material TaTp-COF with porous and uniform spheres was successfully prepared via hydrothermal reaction, and it was found to significantly enhance the aggregation-induced emission (AIE) of berberine. The unique emission properties of berberine on TaTp-COF were studied and utilized for the sensitive detection of berberine.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Lin Li, Yilei Ding, Lei Xu, Shuoran Chen, Guoliang Dai, Pengju Han, Lixin Lu, Changqing Ye, Yanlin Song
Summary: In this study, a novel TTI based on a ratiometric fluorescent nanosensor is designed, which has the advantages of high accuracy and low cost. Experimental and theoretical investigations confirm its pH responsiveness and demonstrate its good sensitivity and reliability. By monitoring the total volatile basic nitrogen, this TTI can accurately predict food spoilage and can be adaptively modified for different types of food. The TTI based on this nanosensor enables visual monitoring of food quality.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Fangju Chen, Xueting Wang, Wei Chen, Chenwen Shao, Yong Qian
Summary: Lung cancer is the second most common malignant tumor worldwide. Drug resistance in lung cancer leads to treatment failure and recurrence in majority of patients. This study developed a fluorescent prodrug that can be activated in cancer cells to release drugs, and its signal can be tracked by imaging. It shows a unique autophagy-driven ferroptosis effect, indicating its potential for targeting drug-resistant cancer cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Weichao Li, Qiming Yuan, Zhangcheng Xia, Xiaoxue Ma, Lifang He, Ling Jin, Xiangfeng Chu, Kui Zhang
Summary: This study developed a high-performance gas sensor for formaldehyde detection by modifying ZnSnO3 with ZnO QDs and SnO2 QDs. The modified sensor showed improved sensing response and lower working temperature. The presence of ZnO QDs formed rich heterojunctions, increased surface area, and provided oxygen deficiency for formaldehyde sensing reaction, thus enhancing the sensor performance. This research provides an alternative method to enhance the sensing properties of MOS by QDs modification.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Joung-Il Moon, Eun Jung Choi, Younju Joung, Jin-Woo Oh, Sang-Woo Joo, Jaebum Choo
Summary: A novel nanoplasmonic substrate was developed for biomedical applications, which showed strong hot spots for detecting biomarkers at low concentrations. The substrate, called AuNPs@M13, was made by immobilizing 60 nm gold nanoparticles onto the surface of an M13 bacteriophage scaffold. It demonstrated higher sensitivity and lower limit of detection compared to commercially available assays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Ning Li, Ya Zhang, Ying Xu, Xiaofang Liu, Jian Chen, Mei Yang, Changjun Hou, Danqun Huo
Summary: The molecular subtype of breast cancer guides treatment and drug selection. Invasive tests can promote cancer cell metastasis, so the development of high-performance, low-cost diagnostic tools for cancer prognosis is crucial. Liquid biopsy techniques enable noninvasive, real-time, dynamic, multicomponent, quantitative, and long-term observations at the cellular, genetic, and molecular levels. A Cu-Zr metal-organic framework (MOF) nanoenzyme with monatomic Cu attachment has been synthesized and proven to have high catalytic performance. The sensor constructed using this nanoenzyme shows potential for accurate classification of breast cancer serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Jeongmin Kim, Hyemin Kim, Seunghyun Park, Hyeonaug Hong, Yong Jae Kim, Jiyong Lee, Jaeho Kim, Seung-Woo Cho, Wonhyoung Ryu
Summary: This study presents a method to fabricate independently functioning microneedle (MN) electrodes with narrow intervals for high precision electrochemical sensing. The optimized mixture of photocurable polymer and single-wall carbon nanotubes was used to mold single composite MNs, which were then attached to pre-patterned electrodes. Plasma etching and electropolymerization were performed to enhance the electrochemical activity, and Prussian blue and glucose oxidase were electrodeposited on the MNs for glucose detection. The MN electrodes showed good sensitivity and linearity, and the feasibility of glucose detection was demonstrated in an in vivo mouse study.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)