Article
Biology
Stefan T. Huber, Edin Sarajlic, Roeland Huijink, Felix Weis, Wiel H. Evers, Arjen J. Jakobi
Summary: Nanofluidic sample supports can be used to prepare cryo-EM specimens with reproducible ice thickness, solving the problem of sample preparation difficulty, aiding in the automation of workflows, and expanding the applications of cryo-EM.
Article
Chemistry, Physical
Juyeol Bae, Ronghui Wu, Taesung Kim
Summary: Micro/nanofluidic devices have been widely used for processing biological, material, and chemical samples, but their reliance on 2D fabrication schemes has limited further innovation. This study proposes a 3D manufacturing method using laminated object manufacturing (LOM) that involves material selection, molding, and lamination techniques. The fabrication method demonstrates the production of interlayer films with multi-layered micro-/nanostructures and through-holes. By using the LOM approach, the number of alignments and laminations can be reduced compared to conventional methods. The 3D manufacturing method enables the development of a nanochannel-based droplet generator for mass production.
Review
Chemistry, Multidisciplinary
Jeongsoo Hur, Aram J. Chung
Summary: This review provides an overview of recent advances in microfluidic and nanofluidic intracellular delivery strategies and discusses new opportunities and challenges for clinical applications. Microfluidic and nanofluidic approaches as emerging solutions have shown remarkable potential for addressing this open challenge.
Article
Chemistry, Multidisciplinary
Phillip Helms, Anthony R. Poggioli, David T. Limmer
Summary: This research demonstrates the use of molecular dynamics simulations and linear response theory to comprehensively characterize nanofluidic transport. The study reveals the specific molecular interactions that underlie unique phenomena and advantages in nanofluidic systems, including the emergence of electrical current and salt selectivity. The results suggest that nanochannels can function as desalination membranes.
Review
Nanoscience & Nanotechnology
Felix Sima, Koji Sugioka
Summary: The advancement of nanofluidics in the past decades has allowed for significant progress in biological and chemical fields, enabling investigation at sub-cellular levels and enhancing detection limits. Nano-scale channels provide opportunities for experimentation at single cell or molecular levels. Technologies like ultrafast laser manufacturing have shown promise in fabricating nanofluidic systems with high resolution and 3D capabilities.
Article
Chemistry, Physical
Jiaxing Liang, Kefeng Xiao, Ruopian Fang, Aditya Rawal, Alison Lennon, Da-Wei Wang
Summary: By adding nanofluidic additives, unimpeded ion transport can be achieved in nanoparticle electrodes, maintaining high density of the electrodes while improving volumetric capacity of the batteries. The use of nanofluidic-enhanced dense electrodes can enhance the performance of lithium-ion batteries, and this approach can be extended to various electroactive nanoparticles in battery design.
ENERGY STORAGE MATERIALS
(2021)
Article
Thermodynamics
Nguyen Van Toan, Truong Thi Kim Tuoi, Naoki Inomata, Megat Muhammad Ikhsan Megat Hasnan, Masaya Toda, Ioana Voiculescu, Suhana Mohd Said, Takahito Ono
Summary: This work demonstrates thermal-to-electric energy conversion based on ionic nanofluidic transport in nano channels induced by a temperature gradient. The performance of the thermally ionic nanofluidic energy harvesting system in cases with and without nanochannels has been evaluated and compared. The results confirm the advantage of nanochannels on energy conversion and the influence of nanochannel materials on power density.
ENERGY CONVERSION AND MANAGEMENT
(2022)
Review
Chemistry, Analytical
Jianyu Han, Songqin Liu, Zhi Wang, Yafeng Wu
Summary: This review systematically summarizes the recent advances in micro/nanofluidic-electrochemical biosensors for in situ tumor cell analysis, including circulating tumor cells, biomarkers on tumor cells, and biomarkers secreted by tumor cells. The technology offers advantages of high sensitivity, easy integration, and low cost.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2022)
Article
Biochemical Research Methods
Charuni A. Amarasekara, Chathurika Rathnayaka, Uditha S. Athapattu, Lulu Zhang, Junseo Choi, Sunggook Park, Aaron C. Nagel, Steven A. Soper
Summary: Nanofluidics has shown promising applications in nucleic acid analysis, allowing for high-resolution free solution electrophoretic analysis. The use of thermoplastic nanochannels for the electrokinetic analysis of ribonucleotide monophosphates (rNMPs) has demonstrated efficient separation and identification of rNMPs, enabling the development of a new single-molecule sequencing platform.
JOURNAL OF CHROMATOGRAPHY A
(2021)
Review
Chemistry, Physical
Lejian Yu, Xipeng Li, Chunyi Luo, Zhenkang Lei, Yilan Wang, Yaqi Hou, Miao Wang, Xu Hou
Summary: Inspired by the information processing mechanism of the human brain, bioinspired nanofluidic iontronics has been developed as a potential solution for efficient brain-like computing. The controllability of charge carriers and the ability to modify structures and chemistry enable the realization of brain-like functions. This review provides a comprehensive framework and design strategy for nanofluidic systems, as well as discusses recent advances and prospects in ion-based brain computing and artificial neuromorphic devices.
Article
Chemistry, Multidisciplinary
Rui Hao, Zitong Yu, Jing Du, Shi Hu, Chao Yuan, Hang Guo, Yi Zhang, Hui Yang
Summary: The ENP is a nanofluidic device designed for efficient loading of various cargos into exosomes without compromising their integrity. The device operates by transporting exosomes through nanochannels, allowing cargo molecules to permeate into the exosomes while maintaining their integrity.
Article
Chemistry, Multidisciplinary
Guanghui Song, Yan Zhan, Yajie Hu, Jun Rao, Nan Li, Zhongxuan Wu, Zhenhua Su, Baozhong Lu, Ruiping Liu, Bo Jiang, Gegu Chen, Feng Peng
Summary: In this study, a nanofluidic membrane made from MXene and xylan nanoparticles derived from paper-mill waste is designed, which exhibits green, low-cost, and excellent mechanical properties and surface-charge-governed ionic transport. The membrane demonstrates high surface charge, high ion selectivity, and reduced steric hindrance, enabling high osmotic energy generation performance. Under a 1000-fold salt concentration gradient, the membrane achieves a potential of approximately 109 mV, a corresponding current of up to 2.73 mu A, and an output power density of 14.52 mW m(-2). With the increase in electrolyte pH, the power density reaches 56.54 mW m(-2). This research demonstrates that CMX nanoparticles effectively enhance the properties of nanofluidic membranes and provide a promising strategy for designing high-performance nanofluidic devices.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Xin Li, Linsen Yang, Shengyang Zhou, Yongchao Qian, Yadong Wu, Xiaofeng He, Weipeng Chen, Zhehua Zhang, Tingyang Li, Qingchen Wang, Congcong Zhu, Xiang-Yu Kong, Liping Wen
Summary: A neuron-inspired nanofluidic biosensor based on a tyrosine-modified artificial nanochannel is developed for sensitive detection of imidacloprid. This biosensor has a wide concentration range and ultralow detection limit, outperforming state-of-the-art sensors.
Article
Nanoscience & Nanotechnology
Ramadan Abu-Rjal, Yoav Green
Summary: The study shows that nanofluidic diodes exhibit unipolar and bipolar behaviors under different geometric and surface charge conditions, with bipolar and semi-bipolar systems showing a wider range of phenomena. Furthermore, the investigation of system characteristics includes not only the steady-state results, but also the time-dependent rectification factors and transport numbers in transient conditions.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Mechanics
Le Zhou, Dachuang Shi, Shiji Lin, Yanguang Zhou, Zhigang Li
Summary: We propose a new strategy to enhance ion transport in nanofluidic systems using counter-charged nanochannels, and validate it through simulations and experiments. The simulations show that the proposed system has ionic current 5.8 times higher than that in traditional fluidic systems. This enhancement is due to the separate transport of cations and anions in positively and negatively charged channels, resulting in a low effective energy barrier for ion transport.
Article
Chemistry, Analytical
Mengmeng Guo, Na Luo, Yueling Bai, Zhenggang Xue, Qingmin Hu, Jiaqiang Xu
Summary: A porous heterostructure WO3-C/In2O3 was designed and prepared for a miniature H2 sensor, which showed higher response value, lower operating temperature, fast response-recovery speed, and low limit of detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Feng Hu, Hui Hu, Yuting Li, Xiaohui Wang, Xiaowen Shi
Summary: Arsenic contamination in water bodies is a significant health risk. This study developed a chitosan-catechol modified electrode for rapid and accurate detection of trace amounts of arsenic. The modified electrode demonstrated good detection capability and resistance to ionic interference, making it suitable for in situ detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Yantao Zhang, Qian Liu, Tao Tian, Chunhua Xu, Pengli Yang, Lianju Ma, Yi Hou, Hui Zhou, Yongjun Gan
Summary: In this study, a lysosome-targeting buffering fluorogenic probe (Lyso-BFP) was designed and synthesized, demonstrating excellent photostability, pH specificity, and responsiveness to lysosomal acidification in living cells. The performance of Lyso-BFP in pH sensing was attributed to the inhibition of the photo-induced electron transfer process. Lyso-BFP allowed for wash-free imaging and long-term real-time monitoring of lysosome pH changes based on its off-on fluorescence behavior and buffer strategy.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Wei Cai, Wenbo Sun, Jiayue Wang, Xiaokui Huo, Xudong Cao, Xiangge Tian, Xiaochi Ma, Lei Feng
Summary: In this study, a near-infrared fluorescent probe HCBG was developed for imaging of alpha-GLC. HCBG exhibited excellent selectivity and sensitivity towards alpha-GLC in complex bio-samples, and showed good cell permeability for in situ real-time imaging. Through the high-throughput screening system established by HCBG, a natural alpha-GLC inhibitor was successfully isolated and identified. This study provides a novel fluorescence visualization tool for discovering and exploring the biological functions of diabetes-related gut microbiota, and a high-throughput screening approach for alpha-GLC inhibitor.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Trey W. Pittman, Xi Zhang, Chamindie Punyadeera, Charles S. Henry
Summary: Heart failure is a growing epidemic and a significant clinical and public health problem. Researchers have developed a portable and affordable diagnostic device for heart failure that can be used at the point-of-care, providing a valid alternative to current diagnostics approaches.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Anders O. Tjell, Barbara Jud, Roland Schaller-Ammann, Torsten Mayr
Summary: An optical hydrogen peroxide sensor based on catalytic degradation and the detection of produced oxygen is presented. The sensor offers higher resolution and better sensitivity at lower H2O2 concentrations. By removing O2 from the sample solution, a more sensitive O2 sensor can be used for measurement. The sensor has been successfully applied in a flow-through cell to measure H2O2 concentration in different flow rates.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Seong Jae Kim, Ji-hun Jeong, Gaabhin Ryu, Yoon Sick Eom, Sanha Kim
Summary: Surface-enhanced Raman spectroscopy (SERS) is a high-sensitivity, label-free detection method with various analytical applications. Researchers have developed a hydrophobic SERS substrate based on engineered carbon nanotube arrays (CNT-SERS) and studied the role of structural design at both micro and nanoscales. The substrate demonstrated controlled self-enrichment capability and enhanced sensitivity, with a significant increase in the SERS signal. The study also proposed a theoretical model and a concentration strategy inspired by plants for analyte deposition on microarrays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Dan Zhao, Renjun Jiang, Xiaoqiang Liu, Subbiah Alwarappan
Summary: In this study, a novel ternary composite material was constructed by assembling cerium vanadate nanorods on reduced graphene oxide-microcrystalline cellulose nanosheets, and it was used for real-time monitoring of the concentration of superoxide anions in vivo. The ternary composite showed excellent conductivity, large surface area, and abundant active sites, leading to a wider linear range, high sensitivity, low detection limit, and fast response time for superoxide anion detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Tengfei Wang, Liwen Wang, Guang Wu, Dating Tian
Summary: In this study, a covalent organic framework material TaTp-COF with porous and uniform spheres was successfully prepared via hydrothermal reaction, and it was found to significantly enhance the aggregation-induced emission (AIE) of berberine. The unique emission properties of berberine on TaTp-COF were studied and utilized for the sensitive detection of berberine.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Lin Li, Yilei Ding, Lei Xu, Shuoran Chen, Guoliang Dai, Pengju Han, Lixin Lu, Changqing Ye, Yanlin Song
Summary: In this study, a novel TTI based on a ratiometric fluorescent nanosensor is designed, which has the advantages of high accuracy and low cost. Experimental and theoretical investigations confirm its pH responsiveness and demonstrate its good sensitivity and reliability. By monitoring the total volatile basic nitrogen, this TTI can accurately predict food spoilage and can be adaptively modified for different types of food. The TTI based on this nanosensor enables visual monitoring of food quality.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Fangju Chen, Xueting Wang, Wei Chen, Chenwen Shao, Yong Qian
Summary: Lung cancer is the second most common malignant tumor worldwide. Drug resistance in lung cancer leads to treatment failure and recurrence in majority of patients. This study developed a fluorescent prodrug that can be activated in cancer cells to release drugs, and its signal can be tracked by imaging. It shows a unique autophagy-driven ferroptosis effect, indicating its potential for targeting drug-resistant cancer cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Weichao Li, Qiming Yuan, Zhangcheng Xia, Xiaoxue Ma, Lifang He, Ling Jin, Xiangfeng Chu, Kui Zhang
Summary: This study developed a high-performance gas sensor for formaldehyde detection by modifying ZnSnO3 with ZnO QDs and SnO2 QDs. The modified sensor showed improved sensing response and lower working temperature. The presence of ZnO QDs formed rich heterojunctions, increased surface area, and provided oxygen deficiency for formaldehyde sensing reaction, thus enhancing the sensor performance. This research provides an alternative method to enhance the sensing properties of MOS by QDs modification.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Joung-Il Moon, Eun Jung Choi, Younju Joung, Jin-Woo Oh, Sang-Woo Joo, Jaebum Choo
Summary: A novel nanoplasmonic substrate was developed for biomedical applications, which showed strong hot spots for detecting biomarkers at low concentrations. The substrate, called AuNPs@M13, was made by immobilizing 60 nm gold nanoparticles onto the surface of an M13 bacteriophage scaffold. It demonstrated higher sensitivity and lower limit of detection compared to commercially available assays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Ning Li, Ya Zhang, Ying Xu, Xiaofang Liu, Jian Chen, Mei Yang, Changjun Hou, Danqun Huo
Summary: The molecular subtype of breast cancer guides treatment and drug selection. Invasive tests can promote cancer cell metastasis, so the development of high-performance, low-cost diagnostic tools for cancer prognosis is crucial. Liquid biopsy techniques enable noninvasive, real-time, dynamic, multicomponent, quantitative, and long-term observations at the cellular, genetic, and molecular levels. A Cu-Zr metal-organic framework (MOF) nanoenzyme with monatomic Cu attachment has been synthesized and proven to have high catalytic performance. The sensor constructed using this nanoenzyme shows potential for accurate classification of breast cancer serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Jeongmin Kim, Hyemin Kim, Seunghyun Park, Hyeonaug Hong, Yong Jae Kim, Jiyong Lee, Jaeho Kim, Seung-Woo Cho, Wonhyoung Ryu
Summary: This study presents a method to fabricate independently functioning microneedle (MN) electrodes with narrow intervals for high precision electrochemical sensing. The optimized mixture of photocurable polymer and single-wall carbon nanotubes was used to mold single composite MNs, which were then attached to pre-patterned electrodes. Plasma etching and electropolymerization were performed to enhance the electrochemical activity, and Prussian blue and glucose oxidase were electrodeposited on the MNs for glucose detection. The MN electrodes showed good sensitivity and linearity, and the feasibility of glucose detection was demonstrated in an in vivo mouse study.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)