Article
Chemistry, Analytical
Xin-Yue Ge, Yi-Ge Feng, Shi-Yun Cen, Ai-Jun Wang, Li-Ping Mei, Xiliang Luo, Jiu-Ju Feng
Summary: A new label-free electrochemical immunosensor was developed for highly sensitive assay of CA15-3 by synthesizing PtCo alloyed nanodendrites with a simple solvothermal method. The sensor showed a wide linear range and low limit of detection for potential application in clinical diagnosis of tumor markers.
ANALYTICA CHIMICA ACTA
(2021)
Article
Chemistry, Multidisciplinary
Chia-Wei Su, Jia-Hao Tian, Jin-Jia Ye, Han-Wei Chang, Yu-Chen Tsai
Summary: Zn-Co-S@G nanocomposites were synthesized through a one-step hydrothermal method and showed promising performance in constructing an electrochemical immunosensor for CA19-9 detection. The strong interaction between Zn-Co-S and graphene facilitated the exposure of numerous electroactive sites, resulting in improved amplified electrochemical signals and a good linear relationship for detecting CA19-9.
Article
Chemistry, Analytical
Mehmet Lutfi Yola, Necip Atar
Summary: The study focuses on the development of an electrochemical immunosensor for CA 19-9 detection using 1D-MoS2 NRs/LNO and AuNPs@POM. The immunosensor shows high selectivity, stability, and reusability, providing a novel opportunity for clinical immunoassays.
MICROCHEMICAL JOURNAL
(2021)
Article
Nanoscience & Nanotechnology
Cancan Bao, Rui Zhang, Yanxia Qiao, Xiaowei Cao, Fangyuan He, Wenli Hu, Ming Wei, Wenbo Lu
Summary: A simple electrochemical immunosensor based on three-dimensional Au nanoparticles anchored on a cobalt boride nanowire array (AuNPs/CoB NWA) electrode is developed for the detection of prostate-specific antigen (PSA). An innovative signal amplification strategy is proposed without using the second labeled antibody to enhance sensitivity of the immunosensor. The electrocatalytic reduction of Nile blue A (NBA) is amplified on AuNPs/CoB NWAs, allowing for the accurate detection of PSA in human serum samples with high sensitivity and fine linearity.
ACS APPLIED NANO MATERIALS
(2021)
Article
Biophysics
Guichun Mo, Xuanming He, Dongmiao Qin, Shuo Meng, Yusheng Wu, Biyang Deng
Summary: A new ECL immunosensor based on spatially-resolved dual-potential technology was developed for simultaneous detection of CA 19-9 and CA 242, showing high selectivity and stability in real sample analysis.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Materials Science, Multidisciplinary
S. M. Patil, V. C. Karade, J. H. Kim, A. D. Chougale, P. B. Patil
Summary: A novel electrochemical immunosensor has been developed for the detection of cancer-specific antibodies anti-CA 15-3. The sensor exhibited a wide linear range, low detection limit, and demonstrated good specificity, reproducibility, and stability in human serum samples.
MATERIALS TODAY COMMUNICATIONS
(2022)
Article
Biochemical Research Methods
Maryam Jozghorbani, Mojtaba Fathi, Sayed Habib Kazemi, Navid Alinejadian
Summary: A label-free electrochemical immunosensor for detecting CEA was developed, which showed promising results for clinical screening through studying the electrochemical behavior of antibody-antigen immune complexes.
ANALYTICAL BIOCHEMISTRY
(2021)
Article
Nanoscience & Nanotechnology
Pushpesh Ranjan, Shalu Yadav, Mohd Abubakar Sadique, Raju Khan, Avanish Kumar Srivastava
Summary: In this study, an electrochemical immunosensor based on a ZrO2-rGO-IL nanocomposite was developed for the detection of CEA breast cancer biomarker. The sensor exhibited high sensitivity and selectivity, and was able to detect CEA in both a broad detection range and serum samples.
ACS APPLIED NANO MATERIALS
(2022)
Article
Chemistry, Analytical
Lin Cao, Yueming Tan, Wenfang Deng, Qingji Xie
Summary: A dual-signal electrochemical immunosensor based on MWCNTs-CoP as an electrocatalytic label has been developed for CEA detection. The sensor shows excellent performance with low detection limits for CEA detection based on both HER and OER signals. This work provides a new platform for double-signal immunosensing based on a bifunctional water splitting electrocatalyst.
Article
Environmental Sciences
Hongli Yang, Zaihua Zhang, Xiaohong Zhou, Norhefozge Binbr Abe Menen, Omid Rouhi
Summary: In this study, electrochemical immunosensing for monitoring carcinoembryonic antigen (CEA) was successfully achieved by immobilizing the antibody on a thionine, chitosan, or graphene oxide nanocomposite modified electrode. The resulting immunosensor showed exceptional sensitivity and selectivity towards CEA compounds, with a low detection limit of 0.8 pg/mL. The application of the immunosensor in detecting CEA in human serum samples demonstrated high accuracy and consistency with ELISA results.
ENVIRONMENTAL RESEARCH
(2023)
Article
Nanoscience & Nanotechnology
Pushpesh Ranjan, Mohd Abubakar Sadique, Shalu Yadav, Raju Khan
Summary: We developed a highly sensitive electrochemical immunosensor for the detection of CD44 antigen, a biomarker for breast cancer. The immunosensor consists of a hybrid nanocomposite composed of graphene oxide, ionic liquid, and gold nanoparticles immobilized on a glassy carbon electrode. The immunosensor exhibits excellent detection ability and high specificity.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Analytical
Nader Amini, Mojtaba Shamsipur, Kazhal Naderi, Afshin Maleki
Summary: The aim of this study is to develop an immunosensor with the ability to detect antigen G using a novel electrochemical approach. By covalently linking antibody molecules using carboxylic groups and 3-(trimethoxysilyl)propylamine on graphene oxide, a highly sensitive immunosensor was created with low detection limit and excellent activity at physiological pH values.
MICROCHEMICAL JOURNAL
(2022)
Review
Biochemical Research Methods
Ika Kustiyah Oktaviyanti, Diyar Salahuddin Ali, Sura A. Awadh, Maria Jade Catalan Opulencia, Shukhrat Yusupov, Rui Dias, Fahad Alsaikhan, Mais Mahmood Mohammed, Himanshu Sharma, Yasser Fakri Mustafa, Marwan Mahmood Saleh
Summary: Breast cancer is a common and deadly form of cancer in women, and CA15-3 is an overregulated tumor marker in breast cancer. CA15-3 is also overexpressed in other types of cancers. Immunosensors based on nanomaterials and antibodies show promise in detecting CA15-3 biomarkers and can overcome the limitations of conventional methods.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Article
Materials Science, Multidisciplinary
Ahmed M. Shawky, Maha El-Tohamy
Summary: This study introduced a new label-free electrochemical immunosensor for the quantitative determination of the breast cancer antigen CA 15-3, showing great selectivity and sensitivity.
MATERIALS CHEMISTRY AND PHYSICS
(2021)
Article
Medicine, General & Internal
Jing Tang, Bo Yan, Gao-Feng Li, Qiu-Yu Li, Wen-Feng Liu, Rong-Bin Liang, Qian-Min Ge, Yi Shao
Summary: This study investigated the predictive value of CA-125, CA15-3, and LDL in identifying IOMs in PBC, suggesting that the combination of CA-125 and CA15-3 has significant diagnostic value.
Article
Biophysics
Fereshteh Vajhadin, Mohammad Mazloum-Ardakani, Maryamsadat Shahidi, Seyed Mohammad Moshtaghioun, Fateme Haghiralsadat, Azar Ebadi, Abbas Amini
Summary: MXenes, a new class of conductive two-dimensional materials, have shown great potential in electrochemical detection of tumor cells. By utilizing magnetic nanohybrids and MXenes for magnetic separation of HER-2 positive cells, label-free cell detection has been achieved successfully.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Chemistry, Physical
Fatemeh Farbod, Mohammad Mazloum-Ardakani, Mohammad Abdollahi-Alibeik, Ali Mirvakili, Zahra Ramazani
Summary: Using covalent graphene derivatives in energy storage applications shows great promise. By incorporating cobalt sulfide nanoparticles into a porous scaffold, a high-value nanocomposite is formed. This nanocomposite exhibits exceptional capacitive capabilities and super stability.
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
(2022)
Article
Chemistry, Analytical
Alireza Khoshroo, Ali Fattahi, Laleh Hosseinzadeh
Summary: This study reports a simple paper-based sensing platform for label-free detection of breast cancer cells. The platform is low-cost, rapid, and robust, and can be used to detect breast cancer cells in serum samples.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2022)
Article
Electrochemistry
Farzaneh Asadpour, Mohammad Mazloum-Ardakani
Summary: This study found that the oxidation of reduced glutathione can occur at a decreased overpotential on a glassy carbon electrode modified with highly ordered mesoporous silica thin films. The electrode adsorbs the copper-glutathione complex due to the anionic nature of the silica walls. The proposed method offers a sensitive voltammetric sensor with a good linear detection range and limit of detection, making it suitable for minimizing interference in biological fluid analysis.
JOURNAL OF SOLID STATE ELECTROCHEMISTRY
(2022)
Article
Energy & Fuels
Fatemeh Farbod, Mohammad Mazloum-Ardakani, Hamid Reza Naderi, Ali Mirvakili, Mengjiao Wang, Dipak Shinde, Silvia Dante, Pejman Salimi, Simone Lauciello, Mirko Prato
Summary: This study successfully synthesized a composite material with excellent electrochemical performance by utilizing the synergistic effect of metal-organic frameworks (MOFs) and carbon nanotubes (CNTs). They found that CNTs helped to improve the conductivity of MOFs and increase their energy storage capacity. The composite material exhibited good energy and power density in supercapacitors, as well as excellent cycling stability.
JOURNAL OF ENERGY STORAGE
(2022)
Article
Biochemical Research Methods
Fereshteh Vajhadin, Mohammad Mazloum-Ardakani, Bikash R. Sahoo, Seyed Mohammad Moshtaghioun, Martin C. Hartel
Summary: The fabrication of an electrochemical cytosensing platform for cancer monitoring by isolating cancer cells using magnetic nanoparticles functionalized with folic acid and chitosan was demonstrated. The platform utilizes a three-dimensional hierarchical structure of polyaniline-folic acid nanohybrids, which exhibit high affinity for folate bioreceptors on cancer cells and good conductivity. The limit of detection is 4 cells mL-1 with a linear range from 50 to 106 cells mL-1.
ANALYTICAL BIOCHEMISTRY
(2023)
Article
Chemistry, Analytical
Na fiseh Sahraei, Mohammad Mazloum-Ardakani, Alireza Khoshroo, Farzaneh Hoseynidokht, Javad Mohiti, Alireza Moradi
Summary: This paper presents a cost-effective and biodegradable electrochemical sensor based on flexible chromatographic paper and lab-made carbon ink. The sensor shows high sensitivity and suitable selectivity for the detection of exosomes in plasma samples, making it a promising tool for early disease detection and screening.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2022)
Article
Electrochemistry
Nafiseh Sahraei, Mohammad Mazloum-Ardakani, Javad Mohiti, Alireza Moradi, Alireza Khoshroo, Elaheh Emadi, Fereshteh Vajhadin
Summary: This study presents an electrochemical paper-based device for selective and sensitive detection of exosomes. The device features a three-electrode platform patterned on a hydrophobic paper using a laser cutter, and synthetic carbon and silver ink screen-printed on the paper. The results demonstrate the successful detection of exosomes in serum samples, offering a new method for early cancer diagnosis.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2022)
Article
Engineering, Electrical & Electronic
Alireza Khoshroo, Laleh Hosseinzadeh, Hermann Ehrlich, Farhad Ahmadi, Mehdi Rahimi-Nasrabadi
Summary: An electrochemical sensor based on cobalt sulfide-graphene nanocomposite was developed for the measurement of 5-fluorouracil in body fluids. It offers a wide linear range, low limit of detection, and acceptable reproducibility, repeatability, and sensitivity for the detection of 5-fluorouracil.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
(2023)
Article
Chemistry, Analytical
Mohammad Mazloum-Ardakani, Farnaz Alvansaz-Yazdi, Farzaneh Hosseini-Dokht, Alireza Khoshroo
Summary: The electrochemical behavior of epinephrine at the catechol-modified glassy carbon electrode in phosphate buffer solution was investigated. Cyclic voltammetry, chronoamperometry, and differential pulse voltammetry were used. The results showed that catechol facilitated the electron transfer process and lowered the overvoltage for EP oxidation. The DPV method exhibited two dynamic ranges with a detection limit of 1.6 μM for low concentration EP. The selectivity of the designed sensor was studied in the presence of interfering substances.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY RESEARCH
(2023)
Review
Electrochemistry
Amin Moradi Hasan-Abad, Mohammad Ali Esmaili, Abbas Ghotaslou, Amir Atapour, Alireza Khoshroo, Ebrahim Naghian
Summary: Male development is influenced by testosterone. This review summarizes the electrochemical biosensors used for detecting testosterone, discussing their immobilization process, analytical performance, and limitations regarding commercialization due to poor reproducibility.
ANALYTICAL & BIOANALYTICAL ELECTROCHEMISTRY
(2022)
Article
Electrochemistry
Laleh Hosseinzadeh, Ali Fattahi, Alireza Khoshroo
Summary: In this study, a simple and disposable electrochemical paper-based immunosensor (e-PI) was developed using manual screen printing method. The e-PI offers the opportunity for economical single-use analysis of biological samples and exhibits acceptable stability, accuracy, and high sensitivity.
ANALYTICAL & BIOANALYTICAL ELECTROCHEMISTRY
(2022)
Article
Electrochemistry
Fatemeh Bagrezaei, Ali Fattahi, Alireza Khoshroo
Summary: In this study, a low-cost carbon paste electrochemical sensor was developed using MgO nanoparticles. A mediator-free sensor for phenobarbital detection was successfully constructed. The experimental results showed that the MgO-CE exhibited excellent catalytic activity, leading to increased oxidation current and reduced oxidation over-potential of phenobarbital. The proposed MgO-CE had a wide linear range, low limit of detection, and good reproducibility, making it potentially applicable for clinical phenobarbital sensing.
ANALYTICAL & BIOANALYTICAL ELECTROCHEMISTRY
(2022)
Article
Chemistry, Analytical
Maryamosadat Mavaei, Ali Fattahi, Alireza Khoshroo
Summary: An electrochemical immunosensor utilizing a nitrogen-doped graphene quantum dot supported by graphene nanoribbon (N-GQD/GNR) composite as a sensing platform was developed in this study for the detection of CA15-3 biomarker. The immunosensor exhibited a wide linear range, low detection limit, and demonstrated high specificity, sensitivity, and accuracy.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY RESEARCH
(2022)
Article
Chemistry, Analytical
Mengmeng Guo, Na Luo, Yueling Bai, Zhenggang Xue, Qingmin Hu, Jiaqiang Xu
Summary: A porous heterostructure WO3-C/In2O3 was designed and prepared for a miniature H2 sensor, which showed higher response value, lower operating temperature, fast response-recovery speed, and low limit of detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Feng Hu, Hui Hu, Yuting Li, Xiaohui Wang, Xiaowen Shi
Summary: Arsenic contamination in water bodies is a significant health risk. This study developed a chitosan-catechol modified electrode for rapid and accurate detection of trace amounts of arsenic. The modified electrode demonstrated good detection capability and resistance to ionic interference, making it suitable for in situ detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Yantao Zhang, Qian Liu, Tao Tian, Chunhua Xu, Pengli Yang, Lianju Ma, Yi Hou, Hui Zhou, Yongjun Gan
Summary: In this study, a lysosome-targeting buffering fluorogenic probe (Lyso-BFP) was designed and synthesized, demonstrating excellent photostability, pH specificity, and responsiveness to lysosomal acidification in living cells. The performance of Lyso-BFP in pH sensing was attributed to the inhibition of the photo-induced electron transfer process. Lyso-BFP allowed for wash-free imaging and long-term real-time monitoring of lysosome pH changes based on its off-on fluorescence behavior and buffer strategy.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Wei Cai, Wenbo Sun, Jiayue Wang, Xiaokui Huo, Xudong Cao, Xiangge Tian, Xiaochi Ma, Lei Feng
Summary: In this study, a near-infrared fluorescent probe HCBG was developed for imaging of alpha-GLC. HCBG exhibited excellent selectivity and sensitivity towards alpha-GLC in complex bio-samples, and showed good cell permeability for in situ real-time imaging. Through the high-throughput screening system established by HCBG, a natural alpha-GLC inhibitor was successfully isolated and identified. This study provides a novel fluorescence visualization tool for discovering and exploring the biological functions of diabetes-related gut microbiota, and a high-throughput screening approach for alpha-GLC inhibitor.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Trey W. Pittman, Xi Zhang, Chamindie Punyadeera, Charles S. Henry
Summary: Heart failure is a growing epidemic and a significant clinical and public health problem. Researchers have developed a portable and affordable diagnostic device for heart failure that can be used at the point-of-care, providing a valid alternative to current diagnostics approaches.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Anders O. Tjell, Barbara Jud, Roland Schaller-Ammann, Torsten Mayr
Summary: An optical hydrogen peroxide sensor based on catalytic degradation and the detection of produced oxygen is presented. The sensor offers higher resolution and better sensitivity at lower H2O2 concentrations. By removing O2 from the sample solution, a more sensitive O2 sensor can be used for measurement. The sensor has been successfully applied in a flow-through cell to measure H2O2 concentration in different flow rates.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Seong Jae Kim, Ji-hun Jeong, Gaabhin Ryu, Yoon Sick Eom, Sanha Kim
Summary: Surface-enhanced Raman spectroscopy (SERS) is a high-sensitivity, label-free detection method with various analytical applications. Researchers have developed a hydrophobic SERS substrate based on engineered carbon nanotube arrays (CNT-SERS) and studied the role of structural design at both micro and nanoscales. The substrate demonstrated controlled self-enrichment capability and enhanced sensitivity, with a significant increase in the SERS signal. The study also proposed a theoretical model and a concentration strategy inspired by plants for analyte deposition on microarrays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Dan Zhao, Renjun Jiang, Xiaoqiang Liu, Subbiah Alwarappan
Summary: In this study, a novel ternary composite material was constructed by assembling cerium vanadate nanorods on reduced graphene oxide-microcrystalline cellulose nanosheets, and it was used for real-time monitoring of the concentration of superoxide anions in vivo. The ternary composite showed excellent conductivity, large surface area, and abundant active sites, leading to a wider linear range, high sensitivity, low detection limit, and fast response time for superoxide anion detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Tengfei Wang, Liwen Wang, Guang Wu, Dating Tian
Summary: In this study, a covalent organic framework material TaTp-COF with porous and uniform spheres was successfully prepared via hydrothermal reaction, and it was found to significantly enhance the aggregation-induced emission (AIE) of berberine. The unique emission properties of berberine on TaTp-COF were studied and utilized for the sensitive detection of berberine.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Lin Li, Yilei Ding, Lei Xu, Shuoran Chen, Guoliang Dai, Pengju Han, Lixin Lu, Changqing Ye, Yanlin Song
Summary: In this study, a novel TTI based on a ratiometric fluorescent nanosensor is designed, which has the advantages of high accuracy and low cost. Experimental and theoretical investigations confirm its pH responsiveness and demonstrate its good sensitivity and reliability. By monitoring the total volatile basic nitrogen, this TTI can accurately predict food spoilage and can be adaptively modified for different types of food. The TTI based on this nanosensor enables visual monitoring of food quality.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Fangju Chen, Xueting Wang, Wei Chen, Chenwen Shao, Yong Qian
Summary: Lung cancer is the second most common malignant tumor worldwide. Drug resistance in lung cancer leads to treatment failure and recurrence in majority of patients. This study developed a fluorescent prodrug that can be activated in cancer cells to release drugs, and its signal can be tracked by imaging. It shows a unique autophagy-driven ferroptosis effect, indicating its potential for targeting drug-resistant cancer cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Weichao Li, Qiming Yuan, Zhangcheng Xia, Xiaoxue Ma, Lifang He, Ling Jin, Xiangfeng Chu, Kui Zhang
Summary: This study developed a high-performance gas sensor for formaldehyde detection by modifying ZnSnO3 with ZnO QDs and SnO2 QDs. The modified sensor showed improved sensing response and lower working temperature. The presence of ZnO QDs formed rich heterojunctions, increased surface area, and provided oxygen deficiency for formaldehyde sensing reaction, thus enhancing the sensor performance. This research provides an alternative method to enhance the sensing properties of MOS by QDs modification.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Joung-Il Moon, Eun Jung Choi, Younju Joung, Jin-Woo Oh, Sang-Woo Joo, Jaebum Choo
Summary: A novel nanoplasmonic substrate was developed for biomedical applications, which showed strong hot spots for detecting biomarkers at low concentrations. The substrate, called AuNPs@M13, was made by immobilizing 60 nm gold nanoparticles onto the surface of an M13 bacteriophage scaffold. It demonstrated higher sensitivity and lower limit of detection compared to commercially available assays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Ning Li, Ya Zhang, Ying Xu, Xiaofang Liu, Jian Chen, Mei Yang, Changjun Hou, Danqun Huo
Summary: The molecular subtype of breast cancer guides treatment and drug selection. Invasive tests can promote cancer cell metastasis, so the development of high-performance, low-cost diagnostic tools for cancer prognosis is crucial. Liquid biopsy techniques enable noninvasive, real-time, dynamic, multicomponent, quantitative, and long-term observations at the cellular, genetic, and molecular levels. A Cu-Zr metal-organic framework (MOF) nanoenzyme with monatomic Cu attachment has been synthesized and proven to have high catalytic performance. The sensor constructed using this nanoenzyme shows potential for accurate classification of breast cancer serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Jeongmin Kim, Hyemin Kim, Seunghyun Park, Hyeonaug Hong, Yong Jae Kim, Jiyong Lee, Jaeho Kim, Seung-Woo Cho, Wonhyoung Ryu
Summary: This study presents a method to fabricate independently functioning microneedle (MN) electrodes with narrow intervals for high precision electrochemical sensing. The optimized mixture of photocurable polymer and single-wall carbon nanotubes was used to mold single composite MNs, which were then attached to pre-patterned electrodes. Plasma etching and electropolymerization were performed to enhance the electrochemical activity, and Prussian blue and glucose oxidase were electrodeposited on the MNs for glucose detection. The MN electrodes showed good sensitivity and linearity, and the feasibility of glucose detection was demonstrated in an in vivo mouse study.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
