Journal
SENSORS AND ACTUATORS B-CHEMICAL
Volume 272, Issue -, Pages 296-307Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2018.05.173
Keywords
Copper oxide; Chitosan; Nanocomposite; Sensor; Glucose detection; Glassy carbon modified electrode
Funding
- National Science Centre [2015/17B/ST8/00365]
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This work presents an Extreme Biomimetic approach for the development of a novel non-enzymatic electrochemical glucose sensor based on modification of a glassy carbon electrode (GCE) with CuO-chitosan nanocomposite. The impact of the synthesis conditions on the structure of the formed CuO-chitosan nanocomposites was analyzed in detail using a variety of analytical techniques, including scanning electron microscopy (SEM), Xray diffraction (XRD) and Fourier-transform infrared spectroscopy (FTIR). To investigate electrocatalytic activity towards glucose oxidation and to optimize the synthesis process, the modified electrodes (CuO-CS/GCE) were tested by amperometric and potentiometric methods The CuO-CS sensor based on CuO-CS_100 Exhibits 20% better electrocatalytic activity than a CuO sensor with CuO obtained under the same process conditions. The CuO-CS/GCE sensor for glucose oxidation displays high sensitivity (503 mu AmMcm(-2)) with a high detection limit (LOD of 11 mu M), short response time (within 6 s), and very good long-term stability and reproducibility. Electrochemical measurements confirmed that the CuO-chitosan nanocomposite obtained after 18 h of hydrothermal reaction at 100 degrees C was the most efficient modifier of GCE. These results clearly indicate that the novel CuO-CS/GCE sensor is very promising for future application in devices used to detect glucose in biological fluids.
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