Article
Chemistry, Analytical
Xiao Wang, Xiaochen Liao, Bingjian Zhang, Mengmeng Zhang, Lisha Mei, Fangwai Wang, Siyu Chen, Xiuwen Qiao, Chenglin Hong
Summary: An electrochemical immunosensor was developed for monitoring CEA antigen concentration, utilizing CuCo/CNC and Au/g-C3N4 NSs for labeling and modification, showing good selectivity, precision, and stability, with a wide dynamic range and low detection limit.
Article
Biophysics
Fubin Pei, Shasha Feng, Yi Wu, Xuchu Lv, Hualai Wang, Shen-Ming Chen, Qingli Hao, Yang Cao, Wu Lei, Zhaoyang Tong
Summary: A label-free photoelectrochemical immunosensor using a Z-scheme heterojunction of gold nanoparticles loaded on graphitic carbon nitride sheet and tungsten trioxide sphere composite was fabricated for sensitive detection of Aflatoxin B1. The immunosensor displayed a linear concentration range from 1.0 pg mL(-1) to 100 ng mL(-1) with a low detection limit of 0.33 pg mL(-1) for AFB1. Good reproducibility, stability, and specificity provide a solid foundation for practical application.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Biophysics
Zhujun Ai, Min Zhao, Daobin Han, Ke Chen, Dongmei Xiong, Hua Tang
Summary: A novel dual-quenching ECL immunosensor for detecting PIVKA-II was developed, showing excellent sensitivity and linear range, which could be a potential alternative tool for early clinical diagnostics of hepatocellular carcinoma.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Chemistry, Analytical
Xing-Pei Liu, Na Chang, Jing-Shuai Chen, Chang-Jie Mao, Bao-Kang Jin
Summary: A novel amplified photoelectrochemical immunosensor based on g-C3N4/SnS2 nanocomposite was constructed for detecting PSA, showing excellent sensitivity, selectivity, and repeatability. The sensor utilized a signal amplification factor to enhance PSA detection, with a detection limit of 1.3 fg.mL(-1) and a range of 10 fg.mL(-1) - 10 ng.mL(-1). This sensor also has the potential to detect other protein targets, indicating its significance in early clinical diagnosis.
MICROCHEMICAL JOURNAL
(2021)
Article
Chemistry, Physical
Tingcha Wei, Juan Xu, Caixia Kan, Le Zhang, Xingzhong Zhu
Summary: The study focuses on the construction of a g-C3N4/TiO2 heterostructure with tailored Au nanoparticles for efficient charge separation in photocatalysis. The enhanced charge separation leads to excellent photocatalytic activity for pollutant degradation and water splitting, with superoxide radicals identified as playing a crucial role in the catalytic process. Insights into the distinct roles of Au in heterostructure for significantly enhanced charge separation are provided, paving the way for the design of high-efficiency heterostructure photocatalysts with noble metal decoration.
JOURNAL OF ALLOYS AND COMPOUNDS
(2022)
Article
Chemistry, Analytical
Atefeh Nasri, Babak Jaleh, Milad Daneshnazar, Rajender S. Varma
Summary: To combat environmental pollution, the development of gas sensor platforms using nanomaterials, such as graphitic carbon nitride (g-C3N4) and gold nanoparticles, has been proposed. The g-C3N4 nanosheets were prepared from urea through a simple heating process and then loaded with gold nanoparticles synthesized by laser ablation. The resulting nanocomposite demonstrated enhanced sensing sensitivity towards organic vapors, especially methanol, making it a promising sensing compound for electronic and electrochemical applications.
Article
Chemistry, Analytical
Furong Chen, Layue Bao, Ying Zhang, Ruili Wang, Jinghai Liu, Wenfeng Hai, Yushuang Liu
Summary: An ultra-sensitive and facile electrochemical biosensor for procalcitonin (PCT) detection was developed based on NiCoP/g-C3N4 nanocomposites. The sensor showed a wider detection range (1 ag/mL to 10 ng/mL) and an ultra-low limit of detection (0.6 ag/mL). This strategy was also successfully applied to the detection of PCT in diluted human serum samples, demonstrating its potential for clinical testing.
Article
Chemistry, Analytical
Xiaoting Cui, Xi Fang, Yunlei Zhou, Ziqi Ren, Lianxiang Wei, Yulin Zheng, Huanshun Yin, Jun Wang, Shiyun Ai
Summary: A photoelectrochemical immunosensor for RNA methylation detection was constructed, which showed simplicity, sensitivity, and selectivity. The impact of Pb2+ -antibiotics binary pollutants was also investigated.
MICROCHEMICAL JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Xiaochen Liao, Xiao Wang, Chaoyun Ma, Li Zhang, Chulei Zhao, Siyu Chen, Keqiang Li, Mengmeng Zhang, Lisha Mei, Yu Qi, Chenglin Hong
Summary: In this study, a sandwich-type electrochemical immunosensor was prepared for the quantitative detection of CEA. The sensor utilized Ag/g-C3N4 as the base platform and Au@SiO2/Cu2O as the signal label to achieve accurate measurement of CEA. The immunosensor showed good sensitivity and a low detection limit in the range from 0.01 pg/mL to 80 ng/mL.
BIOELECTROCHEMISTRY
(2021)
Article
Chemistry, Physical
Mohib Ullah, He Lv, Zhuo Liu, Xue Bai, Junkun Chen, Yang Zhang, Jue Wang, Baihe Sun, Li Li, Keying Shi
Summary: A high-performance and cost-effective NO2-based gas sensor of metal oxides operating at room temperature was developed using a design strategy that combines two-dimensional graphitic carbon nitride and nickel oxide nanosheets to create a three-dimensional hierarchical nanostructure. The optimized nanocomposite showed long-term stability, a low detection limit, and higher selectivity towards NO2 gas. This study provides a new strategy for the formation of heterostructures between metal oxides and g-C3N4 for excellent gas sensitivity and addresses the fabrication of highly potent gas sensors.
APPLIED SURFACE SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Qingshan Yang, Ping Wang, Enhui Ma, Haoxuan Yu, Kaiwei Zhou, Chunyuan Tang, Jie Ren, Yueyun Li, Qing Liu, Yunhui Dong
Summary: A sandwich-type electrochemical immunosensor combining Au core, Pd shell nanodendrites, and silver nanoparticles was successfully fabricated for effective detection of hepatitis B surface antigen. The synergistic effect of the designed structure provided high sensitivity and accuracy, showing promising application prospects in clinical detection.
BIOELECTROCHEMISTRY
(2021)
Article
Chemistry, Physical
Nosheen Farooq, Aziz Ur Rehman, Ashfaq Mehmood Qureshi, Zohaib Ur Rehman, Awais Ahmad, Muhammad Kashif Aslam, Hafiz Muhammad Asif Javed, Shahid Hussain, Mohamed A. Habila, Najla AlMasoud, Taghrid S. Alomar
Summary: The study synthesized Au/GOCNIONPs nanocomposite using four different routes and evaluated its structural and performance characteristics. The nanocomposite showed excellent degradation efficiency against methylene blue and Rhodamine B dyes, as well as superior Photo Luminescence results, antibacterial activity, and stability.
SURFACES AND INTERFACES
(2021)
Article
Chemistry, Analytical
Xing-Pei Liu, Jing-Shuai Chen, Chang-Jie Mao, Bao-Kang Jin
Summary: A label-free photoelectrochemical immunosensor based on a g-C3N4/CdSe nanocomposite was successfully established for detecting carcinoembryonic antigen (CEA). The sensor showed excellent selectivity and repeatability for CEA detection with a detection limit of 0.21 ng mL(-1) and the potential to detect other protein targets.
Article
Chemistry, Physical
Wenjun Zhang, Datong Xu, Fengjue Wang, Meng Chen
Summary: In this study, ternary composites containing AgCl and Au nanoparticles on g-C3N4 were prepared, showing excellent photocatalytic performance in degrading cationic dyes.
JOURNAL OF ALLOYS AND COMPOUNDS
(2021)
Article
Chemistry, Analytical
Juan Yang, Dongmiao Qin, Na Wang, Yusheng Wu, Kanjun Fang, Biyang Deng
Summary: An electrochemiluminescence resonance energy transfer (ECL-RET) immunosensor was constructed to detect beta-2-microglobulin (B2M) by using carbon nitride nanosheet and nickel- and iron-based organic framework modified with gold nanoparticles. The sandwich immunosensor showed a decrease in ECL intensity with increasing B2M concentration due to low conductivity of B2M. The ECL-RET immunosensor had a linear range of 10 fg/mL to 10 ng/mL and a limit of detection of 2.3 fg/mL (S/N = 3), exhibiting high sensitivity, specificity, and stability for B2M detection.
Article
Chemistry, Analytical
Mengmeng Guo, Na Luo, Yueling Bai, Zhenggang Xue, Qingmin Hu, Jiaqiang Xu
Summary: A porous heterostructure WO3-C/In2O3 was designed and prepared for a miniature H2 sensor, which showed higher response value, lower operating temperature, fast response-recovery speed, and low limit of detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Feng Hu, Hui Hu, Yuting Li, Xiaohui Wang, Xiaowen Shi
Summary: Arsenic contamination in water bodies is a significant health risk. This study developed a chitosan-catechol modified electrode for rapid and accurate detection of trace amounts of arsenic. The modified electrode demonstrated good detection capability and resistance to ionic interference, making it suitable for in situ detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Yantao Zhang, Qian Liu, Tao Tian, Chunhua Xu, Pengli Yang, Lianju Ma, Yi Hou, Hui Zhou, Yongjun Gan
Summary: In this study, a lysosome-targeting buffering fluorogenic probe (Lyso-BFP) was designed and synthesized, demonstrating excellent photostability, pH specificity, and responsiveness to lysosomal acidification in living cells. The performance of Lyso-BFP in pH sensing was attributed to the inhibition of the photo-induced electron transfer process. Lyso-BFP allowed for wash-free imaging and long-term real-time monitoring of lysosome pH changes based on its off-on fluorescence behavior and buffer strategy.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Wei Cai, Wenbo Sun, Jiayue Wang, Xiaokui Huo, Xudong Cao, Xiangge Tian, Xiaochi Ma, Lei Feng
Summary: In this study, a near-infrared fluorescent probe HCBG was developed for imaging of alpha-GLC. HCBG exhibited excellent selectivity and sensitivity towards alpha-GLC in complex bio-samples, and showed good cell permeability for in situ real-time imaging. Through the high-throughput screening system established by HCBG, a natural alpha-GLC inhibitor was successfully isolated and identified. This study provides a novel fluorescence visualization tool for discovering and exploring the biological functions of diabetes-related gut microbiota, and a high-throughput screening approach for alpha-GLC inhibitor.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Trey W. Pittman, Xi Zhang, Chamindie Punyadeera, Charles S. Henry
Summary: Heart failure is a growing epidemic and a significant clinical and public health problem. Researchers have developed a portable and affordable diagnostic device for heart failure that can be used at the point-of-care, providing a valid alternative to current diagnostics approaches.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Anders O. Tjell, Barbara Jud, Roland Schaller-Ammann, Torsten Mayr
Summary: An optical hydrogen peroxide sensor based on catalytic degradation and the detection of produced oxygen is presented. The sensor offers higher resolution and better sensitivity at lower H2O2 concentrations. By removing O2 from the sample solution, a more sensitive O2 sensor can be used for measurement. The sensor has been successfully applied in a flow-through cell to measure H2O2 concentration in different flow rates.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Seong Jae Kim, Ji-hun Jeong, Gaabhin Ryu, Yoon Sick Eom, Sanha Kim
Summary: Surface-enhanced Raman spectroscopy (SERS) is a high-sensitivity, label-free detection method with various analytical applications. Researchers have developed a hydrophobic SERS substrate based on engineered carbon nanotube arrays (CNT-SERS) and studied the role of structural design at both micro and nanoscales. The substrate demonstrated controlled self-enrichment capability and enhanced sensitivity, with a significant increase in the SERS signal. The study also proposed a theoretical model and a concentration strategy inspired by plants for analyte deposition on microarrays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Dan Zhao, Renjun Jiang, Xiaoqiang Liu, Subbiah Alwarappan
Summary: In this study, a novel ternary composite material was constructed by assembling cerium vanadate nanorods on reduced graphene oxide-microcrystalline cellulose nanosheets, and it was used for real-time monitoring of the concentration of superoxide anions in vivo. The ternary composite showed excellent conductivity, large surface area, and abundant active sites, leading to a wider linear range, high sensitivity, low detection limit, and fast response time for superoxide anion detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Tengfei Wang, Liwen Wang, Guang Wu, Dating Tian
Summary: In this study, a covalent organic framework material TaTp-COF with porous and uniform spheres was successfully prepared via hydrothermal reaction, and it was found to significantly enhance the aggregation-induced emission (AIE) of berberine. The unique emission properties of berberine on TaTp-COF were studied and utilized for the sensitive detection of berberine.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Lin Li, Yilei Ding, Lei Xu, Shuoran Chen, Guoliang Dai, Pengju Han, Lixin Lu, Changqing Ye, Yanlin Song
Summary: In this study, a novel TTI based on a ratiometric fluorescent nanosensor is designed, which has the advantages of high accuracy and low cost. Experimental and theoretical investigations confirm its pH responsiveness and demonstrate its good sensitivity and reliability. By monitoring the total volatile basic nitrogen, this TTI can accurately predict food spoilage and can be adaptively modified for different types of food. The TTI based on this nanosensor enables visual monitoring of food quality.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Fangju Chen, Xueting Wang, Wei Chen, Chenwen Shao, Yong Qian
Summary: Lung cancer is the second most common malignant tumor worldwide. Drug resistance in lung cancer leads to treatment failure and recurrence in majority of patients. This study developed a fluorescent prodrug that can be activated in cancer cells to release drugs, and its signal can be tracked by imaging. It shows a unique autophagy-driven ferroptosis effect, indicating its potential for targeting drug-resistant cancer cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Weichao Li, Qiming Yuan, Zhangcheng Xia, Xiaoxue Ma, Lifang He, Ling Jin, Xiangfeng Chu, Kui Zhang
Summary: This study developed a high-performance gas sensor for formaldehyde detection by modifying ZnSnO3 with ZnO QDs and SnO2 QDs. The modified sensor showed improved sensing response and lower working temperature. The presence of ZnO QDs formed rich heterojunctions, increased surface area, and provided oxygen deficiency for formaldehyde sensing reaction, thus enhancing the sensor performance. This research provides an alternative method to enhance the sensing properties of MOS by QDs modification.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Joung-Il Moon, Eun Jung Choi, Younju Joung, Jin-Woo Oh, Sang-Woo Joo, Jaebum Choo
Summary: A novel nanoplasmonic substrate was developed for biomedical applications, which showed strong hot spots for detecting biomarkers at low concentrations. The substrate, called AuNPs@M13, was made by immobilizing 60 nm gold nanoparticles onto the surface of an M13 bacteriophage scaffold. It demonstrated higher sensitivity and lower limit of detection compared to commercially available assays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Ning Li, Ya Zhang, Ying Xu, Xiaofang Liu, Jian Chen, Mei Yang, Changjun Hou, Danqun Huo
Summary: The molecular subtype of breast cancer guides treatment and drug selection. Invasive tests can promote cancer cell metastasis, so the development of high-performance, low-cost diagnostic tools for cancer prognosis is crucial. Liquid biopsy techniques enable noninvasive, real-time, dynamic, multicomponent, quantitative, and long-term observations at the cellular, genetic, and molecular levels. A Cu-Zr metal-organic framework (MOF) nanoenzyme with monatomic Cu attachment has been synthesized and proven to have high catalytic performance. The sensor constructed using this nanoenzyme shows potential for accurate classification of breast cancer serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Jeongmin Kim, Hyemin Kim, Seunghyun Park, Hyeonaug Hong, Yong Jae Kim, Jiyong Lee, Jaeho Kim, Seung-Woo Cho, Wonhyoung Ryu
Summary: This study presents a method to fabricate independently functioning microneedle (MN) electrodes with narrow intervals for high precision electrochemical sensing. The optimized mixture of photocurable polymer and single-wall carbon nanotubes was used to mold single composite MNs, which were then attached to pre-patterned electrodes. Plasma etching and electropolymerization were performed to enhance the electrochemical activity, and Prussian blue and glucose oxidase were electrodeposited on the MNs for glucose detection. The MN electrodes showed good sensitivity and linearity, and the feasibility of glucose detection was demonstrated in an in vivo mouse study.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)