Article
Chemistry, Analytical
Mei Deng, Weiqiang Li, Yanbiao Chen, Keyu Wang, Yifan Sun, Hengyi Xu
Summary: In this study, a detection strategy based on aptamer functionalized magnetic beads was developed for rapid and sensitive detection of fumonisin B1. The strategy showed good linearity and achieved high specificity and excellent accuracy with low limit of detection when tested with spiked corn flour samples.
MICROCHEMICAL JOURNAL
(2022)
Article
Chemistry, Analytical
Hongyu Nie, Zhihui Li, Xiaokun Wang, Rongmeng Gu, Hongyan Yuan, Yong Guo, Dan Xiao
Summary: In this study, a multi-input capacitively coupled contactless conductivity detector (MICD)-D-4 was proposed with high sensitivity, and further improved by combining it with differential detection to form (DFMICD)-D-4. The new detector showed improved performance compared to traditional single-input and double-input detectors, with a higher response-to-baseline ratio and a low limit of detection (0.7 nM). It can be applied to the detection of low-conductivity solutions and total dissolved solids (TDS) analysis, demonstrating its versatility and superiority over standard conductivity meters.
Article
Polymer Science
Nunthiya Deepuppha, Sudarat Khadsai, Boonjira Rutnakornpituk, Filip Kielar, Metha Rutnakornpituk
Summary: The pectin-coated magnetite nanoparticle functionalized with Hg2+-specific aptamer showed high selectivity and facile reusability for Hg2+ detection. The system displayed a wide linear concentration range and good tolerance towards Hg2+, while maintaining stability and dispersibility in water. It exhibited promising recoveries for detecting Hg2+ in real water samples, suggesting potential applications in biological and analytical fields.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2021)
Article
Chemistry, Analytical
Mei Deng, Guanhua Chen, Xiaoyan Feng, Zhengzheng Wang, Qian Xu, Hengyi Xu
Summary: A double mediation system based on polyethylene glycol (PEG) and bovine serum albumin (BSA) was introduced to prepare teicoplanin (Teic)-functionalized magnetic beads (MBs), which, combined with monoclonal antibody-modified quantum dot microspheres (QBs), resulted in a rapid and sensitive strategy for detecting L. monocytogenes. The strategy demonstrated high capture efficiency and a low limit of detection, indicating its potential for specific and sensitive detection of L. monocytogenes.
MICROCHEMICAL JOURNAL
(2021)
Article
Food Science & Technology
Zhengzheng Wang, Ju Liu, Guanhua Chen, Xiaoyan Feng, Mei Deng, Dan Mu, Qian Xu, Hengyi Xu
Summary: A strategy for the detection of S. aureus using magnetic separation technology combined with colorimetry was proposed in this study. By pre-enriching S. aureus and constructing an untargeted magnetic separation based on APBA-MBs, the traditional targeted magnetic separation was successfully replaced. The detection limit of S. aureus under optimal experimental conditions was 3.0 x 10(2) CFU/mL.
Article
Engineering, Electrical & Electronic
Sanath Kumar Honnali, Vikram Srinivasa Raghavan, Roopa Ashwath, Ganapathy Saravanavel, K. R. Gunasekhar, Sanjiv Sambandan, Sai Siva Gorthi, Benjamin O'Driscoll, David Jenkins
Summary: In this study, a multiplexed detection platform using zinc oxide thin-film transistors (TFTs) was demonstrated for the detection of lead and Escherichia coli in water. The functionalized TFTs showed good sensitivity and specificity to the targets, with the ability to integrate with high-density sensor arrays.
IEEE SENSORS JOURNAL
(2022)
Article
Environmental Sciences
Jung-Weon Choi, Sang-June Choi
Summary: Graphene oxide/calcium alginate-polyacrylamide beads effectively removed the antibiotic ciprofloxacin. The adsorption isotherm data fit well with the Langmuir model.
Review
Chemistry, Applied
Petr Tuma, Frantisek Opekar, Pavel Dlouhy
Summary: This paper provides a comprehensive survey of using capillary and microchip electrophoresis with contactless conductivity detection for the analysis of drinking water, beverages, and food items. It highlights the analysis of food on microchips and modern trends such as dual-opposite injection. CE/(CD)-D-4 is characterized by its universality, analysis speed, simple sample preparation, and minimal sample consumption.
Review
Food Science & Technology
Hua Ye, Zhixin Yang, Imran Mahmood Khan, Sobia Niazi, Yuanxin Guo, Zhouping Wang, Hongshun Yang
Summary: Antibiotic contamination is a global issue and there is a need for sensitive, specific and simple technology for antibiotic detection. Biosensors based on split aptamers have gained extensive attention due to their higher sensitivity, lower cost, false positive/negative avoidance and flexibility in sensor design. However, the acquisition and mechanism of splitting antibiotic aptamers are still unknown.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Biochemical Research Methods
Brenda M. C. Costa, Aline G. Coelho, Michael J. Beauchamp, Jacob B. Nielsen, Gregory P. Nordin, Adam T. Woolley, Jose A. F. da Silva
Summary: This work demonstrates the design and fabrication of microchip electrophoresis devices containing cross-shaped channels and spiral electrodes, which were prepared using a 3D printer with high resolution. The device was successfully applied for the separation of sodium, potassium, and lithium cations using microchip electrophoresis.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Food Science & Technology
Xuekun Bai, Guanhua Chen, Zhengzheng Wang, Guoyang Xie, Mei Deng, Hengyi Xu
Summary: A new strategy combining antibiotics, magnetic beads, and multiplex PCR was proposed for detecting B. cereus and S. aureus in juice samples. The method showed high sensitivity and specificity, with lower limit of detection and shorter detection time compared to conventional methods. The results demonstrate successful application for rapid separation and detection of Gram-positive pathogens in food samples.
Article
Chemistry, Analytical
Yutong Wang, Zhengzheng Wang, Zhongxu Zhan, Ju Liu, Tingting Deng, Hengyi Xu
Summary: A strategy for detecting Staphylococcus aureus using magnetic separation technology combined with rolling circle amplification was proposed in this study, where antibiotics were used to capture bacteria and RCA products served as signal output probes, resulting in the enrichment and specific detection of S. aureus by combining magnetic separation and RCA technology.
ANALYTICA CHIMICA ACTA
(2022)
Article
Biochemical Research Methods
Zixuan Ren, Xingchen Zhou, Xingxing Gao, Yan Tan, Huaying Chen, Songwen Tan, Wenfang Liu, Yaonan Tong, Chuanpin Chen
Summary: The study demonstrated the successful detection of two pesticide residues using a gold nanoparticle-modified indium tin oxide electrode in combination with dual-channel microchip electrophoresis and amperometric detection system, achieving rapid and highly sensitive detection. Through hydrolysis and optimized operating conditions, accurate separation and detection of pesticide residues can be carried out.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Lei Tan, Yuling Li, Xiaotong Wu, Wanqiong Liu, Zhihua Peng, Yanshan Dong, Zeyu Huang, Lin Zhang, Yong Liang
Summary: We developed a Janus silica nanoflakes-based fluorescence sensor array using Pickering emulsion and quantum dots doping technology for the recognition of multiple heavy metal ions and aminoglycoside antibiotics. The sensor array successfully discriminated between the target compounds by analyzing the fluorescence response patterns. The detection of Cu2+ and Co2+ in crayfish samples was confirmed using inductively coupled plasma atomic emission spectroscopy.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Review
Chemistry, Analytical
Theo Lienard-Mayor, Myriam Taverna, Stephanie Descroix, Thanh Duc Mai
Summary: This study provides a comprehensive overview of different strategies for combining droplet-based sample handling and preparation with electrophoretic separation. It focuses on three principal interfacing strategies, including droplets in immiscible phases, digital microfluidics with electrowetting-on-dielectric principle, and inkjet droplet generation. Different instrumental developments, pros and cons of designs, and application demonstrations of droplet-interfaced electrokinetic strategies are discussed.
ANALYTICA CHIMICA ACTA
(2021)
Article
Biochemical Research Methods
Jin Zeng, Qiqin Wang, Jianan Gao, Wenhai Wang, Haoyu Shen, Yuting Cao, Meiqin Hu, Wenchao Bi, Ning Gan
JOURNAL OF CHROMATOGRAPHY A
(2020)
Article
Chemistry, Analytical
Feng Hong, Qiqin Wang, Wenhai Wang, Xixue Chen, Yuting Cao, Youren Dong, Ning Gan, Dazhen Wu, Futao Hu
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2020)
Article
Chemistry, Analytical
Liyong He, Zhipeng Shen, Jiaqi Wang, Jin Zeng, Wenhai Wang, Huihui Wu, Qiqin Wang, Ning Gan
Article
Chemistry, Analytical
Wenhai Wang, Lei Tan, Jiayi Wu, Tianhua Li, Hongzhen Xie, Dazhen Wu, Ning Gan
ANALYTICA CHIMICA ACTA
(2020)
Article
Chemistry, Physical
Ning Gan, Kun Liu, Lin Qi, Guojuan Zhang, Yujing Guo, Dipankar Sen, Hua-Zhong Yu
JOURNAL OF PHYSICAL CHEMISTRY C
(2020)
Article
Chemistry, Analytical
Juncheng Hong, Wenhai Wang, Jiaqi Wang, Xiao Wang, Hongzhen Xie, Tianhua Li, Ning Gan
Summary: A novel aptasensor based on POSS-PQDs-Apt and Ti3C2 MXenes composite probes was prepared and successfully applied for VP detection relying on FRET. The method can rapidly and accurately detect VP in the concentration range of 10(2) - 10(6) cfu/mL, suitable for online monitoring in aquaculture industry. The detection method showed good feasibility in screening VP through testing actual seawater samples.
Review
Chemistry, Multidisciplinary
Kai Zhang, Hongyang Li, Wenjing Wang, Jinxuan Cao, Ning Gan, Heyou Han
Article
Chemistry, Analytical
Hongmei Zhong, Yong-Xiang Wu, Shengrong Yu, Xiao Wang, Kangdi He, Dian Li, Yuting Cao, Ning Gan
Summary: Dual-mode imaging, combining TP fluorescence imaging and MRI, shows promise in improving accuracy for early disease diagnosis, especially in pH-related diagnosis and treatment, with great potential to enhance clinical efficacy.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Ming Wang, Jin Zeng, Jiaqi Wang, Xiao Wang, Ye Wang, Ning Gan
Summary: A dual-mode aptasensor utilizing colorimetry and microfluidic chip, along with stir bar sorptive extraction, has been developed for qualifying and precisely determining samples contaminated with Vibrio parahaemolyticus and Salmonella typhimurium. This method can enrich the concentration of bacteria by 1000 times within 15 minutes and provide rapid and accurate multiple detections for positive samples.
Article
Biochemical Research Methods
Tianliang Wang, Hongzhen Xie, Yuting Cao, Qing Xu, Ning Gan
Summary: In this study, a simple, selective, and rapid method for detecting microcystins in complex food samples was developed using a magnetic self-assembled covalent organic framework (mCOF) adsorbent. The method demonstrated good linearity, low detection limits, and high extraction recoveries.
JOURNAL OF CHROMATOGRAPHY A
(2022)
Article
Chemistry, Analytical
Zhenli Xu, Jiaqi Wang, Zhijian Jia, Yong-Xiang Wu, Ning Gan, Shaoning Yu
Summary: DNAzyme-driven DNA walkers are an excellent signal amplification strategy for the simultaneous, rapid, and sensitive analysis of food-borne pathogens. A multivalent DNA walker sensor combined with microfluidic chip technology was developed for the simultaneous, rapid, and sensitive analysis of Vibrio parahaemolyticus, Salmonella typhimurium, and Staphylococcus aureus. The sensor showed low detection limits and wide detection ranges, and achieved double amplification through gold stirring rod enrichment and DNA walker. Moreover, by changing the design of the substrate chain, the sensor has the potential to detect other targets, expanding its practical applications.
Article
Biochemical Research Methods
Binglin Mou, Chengyi Zuo, La Chen, Hongzhen Xie, Wentian Zhang, Qiqin Wang, Luhong Wen, Ning Gan
Summary: In this study, a novel nitrogen and sulfur co-doped carbon dot (N, S-CD) was synthesized and used as a QuEChERS clean-up reagent to reduce matrix interferences in the determination of insecticides in vegetables. A portable mass spectrometer (mu-MS) was employed to directly determine neonicotinoids, carbamates, and benzopyrazole insecticides in the pretreated samples. The N,S-CD mu-MS method exhibited effective clean-up performance with satisfactory matrix effects, recoveries, and linear ranges.
JOURNAL OF CHROMATOGRAPHY A
(2023)
Article
Chemistry, Analytical
Bingqian Li, Shengrong Yu, Rong Feng, Zhiling Qian, Kangdi He, Guo-Jiang Mao, Yuting Cao, Keqi Tang, Ning Gan, Yong-Xiang Wu
Summary: Bioimaging, including fluorescence imaging, is widely used in modern medicine. However, one-photon fluorescence imaging has limitations such as low tissue penetration depth and low spatiotemporal resolution. Two-photon fluorescence imaging can overcome these limitations, but the complexity of organisms can affect the accuracy of results. Fluorescence lifetime imaging (FLIM) is an intrinsic property of materials and independent of material concentration and fluorescence intensity, making it a promising alternative. By combining silica-coated gold nanoclusters (AuNCs@SiO2) with nucleic acid probes, a dual-mode nanoprobe platform for two-photon and FLIM imaging of intracellular miRNA-21 was constructed. The dual-mode nanoprobe exhibited high sensitivity and selectivity, with potential applications in miRNA-based early detection and therapy.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Hang You, Ming Wang, Shuai Wang, Jie Xu, Shuhao Hu, Tianhua Li, Zhenzhong Yu, Dianping Tang, Ning Gan
Summary: This research developed an ultrasensitive and specific Phage@DNAzyme signal probe for the rapid and on-site detection of virulent foodborne pathogens. The probe efficiently catalyzed a click reaction to generate a visual fluorescent signal, allowing for the quantification of target concentrations using a smartphone. The method demonstrated satisfactory sensing performances for Escherichia coli O157:H7 and Salmonella typhimurium, providing a new approach for trace level detection of pathogenic strains in foods.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Kangdi He, Shengrong Yu, Xiao Wang, Dian Li, Jia Chen, Hongmei Zhong, Qing Xu, Yong-Xiang Wu, Ning Gan
Summary: A novel nanoprobe platform, Tf-AuNCs@MnO2, was developed for the TP-NIR fluorescence imaging and magnetic resonance imaging of living cells and tissues. This platform demonstrated high spatiotemporal resolution and a tissue-penetration depth of 300 μm.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Analytical
Mengmeng Guo, Na Luo, Yueling Bai, Zhenggang Xue, Qingmin Hu, Jiaqiang Xu
Summary: A porous heterostructure WO3-C/In2O3 was designed and prepared for a miniature H2 sensor, which showed higher response value, lower operating temperature, fast response-recovery speed, and low limit of detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Feng Hu, Hui Hu, Yuting Li, Xiaohui Wang, Xiaowen Shi
Summary: Arsenic contamination in water bodies is a significant health risk. This study developed a chitosan-catechol modified electrode for rapid and accurate detection of trace amounts of arsenic. The modified electrode demonstrated good detection capability and resistance to ionic interference, making it suitable for in situ detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Yantao Zhang, Qian Liu, Tao Tian, Chunhua Xu, Pengli Yang, Lianju Ma, Yi Hou, Hui Zhou, Yongjun Gan
Summary: In this study, a lysosome-targeting buffering fluorogenic probe (Lyso-BFP) was designed and synthesized, demonstrating excellent photostability, pH specificity, and responsiveness to lysosomal acidification in living cells. The performance of Lyso-BFP in pH sensing was attributed to the inhibition of the photo-induced electron transfer process. Lyso-BFP allowed for wash-free imaging and long-term real-time monitoring of lysosome pH changes based on its off-on fluorescence behavior and buffer strategy.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Wei Cai, Wenbo Sun, Jiayue Wang, Xiaokui Huo, Xudong Cao, Xiangge Tian, Xiaochi Ma, Lei Feng
Summary: In this study, a near-infrared fluorescent probe HCBG was developed for imaging of alpha-GLC. HCBG exhibited excellent selectivity and sensitivity towards alpha-GLC in complex bio-samples, and showed good cell permeability for in situ real-time imaging. Through the high-throughput screening system established by HCBG, a natural alpha-GLC inhibitor was successfully isolated and identified. This study provides a novel fluorescence visualization tool for discovering and exploring the biological functions of diabetes-related gut microbiota, and a high-throughput screening approach for alpha-GLC inhibitor.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Trey W. Pittman, Xi Zhang, Chamindie Punyadeera, Charles S. Henry
Summary: Heart failure is a growing epidemic and a significant clinical and public health problem. Researchers have developed a portable and affordable diagnostic device for heart failure that can be used at the point-of-care, providing a valid alternative to current diagnostics approaches.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Anders O. Tjell, Barbara Jud, Roland Schaller-Ammann, Torsten Mayr
Summary: An optical hydrogen peroxide sensor based on catalytic degradation and the detection of produced oxygen is presented. The sensor offers higher resolution and better sensitivity at lower H2O2 concentrations. By removing O2 from the sample solution, a more sensitive O2 sensor can be used for measurement. The sensor has been successfully applied in a flow-through cell to measure H2O2 concentration in different flow rates.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Seong Jae Kim, Ji-hun Jeong, Gaabhin Ryu, Yoon Sick Eom, Sanha Kim
Summary: Surface-enhanced Raman spectroscopy (SERS) is a high-sensitivity, label-free detection method with various analytical applications. Researchers have developed a hydrophobic SERS substrate based on engineered carbon nanotube arrays (CNT-SERS) and studied the role of structural design at both micro and nanoscales. The substrate demonstrated controlled self-enrichment capability and enhanced sensitivity, with a significant increase in the SERS signal. The study also proposed a theoretical model and a concentration strategy inspired by plants for analyte deposition on microarrays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Dan Zhao, Renjun Jiang, Xiaoqiang Liu, Subbiah Alwarappan
Summary: In this study, a novel ternary composite material was constructed by assembling cerium vanadate nanorods on reduced graphene oxide-microcrystalline cellulose nanosheets, and it was used for real-time monitoring of the concentration of superoxide anions in vivo. The ternary composite showed excellent conductivity, large surface area, and abundant active sites, leading to a wider linear range, high sensitivity, low detection limit, and fast response time for superoxide anion detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Tengfei Wang, Liwen Wang, Guang Wu, Dating Tian
Summary: In this study, a covalent organic framework material TaTp-COF with porous and uniform spheres was successfully prepared via hydrothermal reaction, and it was found to significantly enhance the aggregation-induced emission (AIE) of berberine. The unique emission properties of berberine on TaTp-COF were studied and utilized for the sensitive detection of berberine.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Lin Li, Yilei Ding, Lei Xu, Shuoran Chen, Guoliang Dai, Pengju Han, Lixin Lu, Changqing Ye, Yanlin Song
Summary: In this study, a novel TTI based on a ratiometric fluorescent nanosensor is designed, which has the advantages of high accuracy and low cost. Experimental and theoretical investigations confirm its pH responsiveness and demonstrate its good sensitivity and reliability. By monitoring the total volatile basic nitrogen, this TTI can accurately predict food spoilage and can be adaptively modified for different types of food. The TTI based on this nanosensor enables visual monitoring of food quality.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Fangju Chen, Xueting Wang, Wei Chen, Chenwen Shao, Yong Qian
Summary: Lung cancer is the second most common malignant tumor worldwide. Drug resistance in lung cancer leads to treatment failure and recurrence in majority of patients. This study developed a fluorescent prodrug that can be activated in cancer cells to release drugs, and its signal can be tracked by imaging. It shows a unique autophagy-driven ferroptosis effect, indicating its potential for targeting drug-resistant cancer cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Weichao Li, Qiming Yuan, Zhangcheng Xia, Xiaoxue Ma, Lifang He, Ling Jin, Xiangfeng Chu, Kui Zhang
Summary: This study developed a high-performance gas sensor for formaldehyde detection by modifying ZnSnO3 with ZnO QDs and SnO2 QDs. The modified sensor showed improved sensing response and lower working temperature. The presence of ZnO QDs formed rich heterojunctions, increased surface area, and provided oxygen deficiency for formaldehyde sensing reaction, thus enhancing the sensor performance. This research provides an alternative method to enhance the sensing properties of MOS by QDs modification.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Joung-Il Moon, Eun Jung Choi, Younju Joung, Jin-Woo Oh, Sang-Woo Joo, Jaebum Choo
Summary: A novel nanoplasmonic substrate was developed for biomedical applications, which showed strong hot spots for detecting biomarkers at low concentrations. The substrate, called AuNPs@M13, was made by immobilizing 60 nm gold nanoparticles onto the surface of an M13 bacteriophage scaffold. It demonstrated higher sensitivity and lower limit of detection compared to commercially available assays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Ning Li, Ya Zhang, Ying Xu, Xiaofang Liu, Jian Chen, Mei Yang, Changjun Hou, Danqun Huo
Summary: The molecular subtype of breast cancer guides treatment and drug selection. Invasive tests can promote cancer cell metastasis, so the development of high-performance, low-cost diagnostic tools for cancer prognosis is crucial. Liquid biopsy techniques enable noninvasive, real-time, dynamic, multicomponent, quantitative, and long-term observations at the cellular, genetic, and molecular levels. A Cu-Zr metal-organic framework (MOF) nanoenzyme with monatomic Cu attachment has been synthesized and proven to have high catalytic performance. The sensor constructed using this nanoenzyme shows potential for accurate classification of breast cancer serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Jeongmin Kim, Hyemin Kim, Seunghyun Park, Hyeonaug Hong, Yong Jae Kim, Jiyong Lee, Jaeho Kim, Seung-Woo Cho, Wonhyoung Ryu
Summary: This study presents a method to fabricate independently functioning microneedle (MN) electrodes with narrow intervals for high precision electrochemical sensing. The optimized mixture of photocurable polymer and single-wall carbon nanotubes was used to mold single composite MNs, which were then attached to pre-patterned electrodes. Plasma etching and electropolymerization were performed to enhance the electrochemical activity, and Prussian blue and glucose oxidase were electrodeposited on the MNs for glucose detection. The MN electrodes showed good sensitivity and linearity, and the feasibility of glucose detection was demonstrated in an in vivo mouse study.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)