Journal
SENSORS AND ACTUATORS B-CHEMICAL
Volume 254, Issue -, Pages 1-7Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2017.07.014
Keywords
Surface acoustic wave; Biosensor; Resonator; Lab on chip; Positive and negative reflector; Sub-nanomolar
Funding
- Italian National Research Council
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A label-free sub-nanomolar Rayleigh surface acoustic wave (R-SAW)-based resonator biosensor is demonstrated for biomolecular detection in liquid after drying. The biosensor comprises two interdigital transducers for R-SAW generation and two positive and negative reflectors to confine the acoustic energy in the sensitive area. We benchmark this biosensor against biotin-streptavidin binding, which is a standard, well-known model for a variety of biosensing processes. The experiments demonstrate a limit of detection of 104 pM and a normalized sensitivity of -296 m(2) kg(-1). As a comparison with similar acoustic-wave based systems, both sensitivity and limit of detection are better than that of standard commercial gravimetric sensors (i.e., quartz-crystal-microbalances) and generally better than that of more common Love-SAW biosensors. Our biosensor has a dynamic range potentially compatible with several health- and safety-related assays, among all cancer biomarker detection. (C) 2017 Elsevier B.V. All rights reserved.
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