Article
Automation & Control Systems
Xiaoming Liu, Yuyang Li, Lei Li, Masaru Kojima, Qing Shi, Qiang Huang, Toshio Fukuda, Tatsuo Arai
Summary: This article proposes a cost-effective solution for three-dimensional orientation control at the microscale, combining hydrodynamic rotation and piezo-actuator. Experimental results demonstrate the successful achievement of three-dimensional orientation control for microbeads and mouse oocytes.
IEEE-ASME TRANSACTIONS ON MECHATRONICS
(2022)
Article
Chemistry, Multidisciplinary
Eugene Jia Hao Soh, Hippolyte P. A. G. Astier, Dan Daniel, Jia Qing Isaiah Chua, Ali Miserez, Zian Jia, Ling Li, Sean J. O'Shea, Harish Bhaskaran, Nikodem Tomczak, Christian A. Nijhuis
Summary: In this study, we demonstrate the direct manipulation and control of liquid metal droplets using an atomic force microscope, achieving repeated contact and separation with self-assembled monolayers in different environments. We successfully create well-defined contact areas of liquid droplets on alkanethiolate SAMs in ethanol, and achieve smaller geometric contact areas in air compared to previous studies.
Article
Automation & Control Systems
Dan Liu, Xiaoming Liu, Pengyun Li, Xiaoqing Tang, Masaru Kojima, Qiang Huang, Tatsuo Arai
Summary: This article presents an all-purpose magnetically driven micromanipulation system with designed contact and noncontact modes for industrial and biological applications. The system allows for high-precision and high-speed motions to grasp, release, and operate microtargets efficiently at the microscale.
IEEE-ASME TRANSACTIONS ON MECHATRONICS
(2022)
Article
Chemistry, Multidisciplinary
Binjie Gao, Jisen Wen, Guiyuan Zhu, Linhua Ye, Li-Gang Wang
Summary: Experimental demonstration of the manipulation and precise measurement of microparticle rotation at the focal plane of fractional vortex beams. The measured orbital angular momentum is roughly proportional to the fractional OAM of the beams. Average trap stiffness obtained from power spectra evaluation provides insight into the trapping strength of practical focused FVB intensity ring.
Article
Chemistry, Analytical
Dan Liu, Xiaoming Liu, Pengyun Li, Xiaoqing Tang, Masaru Kojima, Qiang Huang, Tatsuo Arai
Summary: This paper presented a micronewton force-controlled two-finger microhand with a soft magnetic end-effector for stable grasping, showing great potential in force-controlled manipulation in biological and industrial micromanipulation.
Article
Automation & Control Systems
Longgang Song, Bo Chang, Yuhang Feng, Jialong Jin, Quan Zhou
Summary: In this article, a novel self-alignment capillary gripper for microfiber manipulation is reported. The gripper is facile and convenient to use, and can achieve high precision self-alignment of microfibers. It is versatile and can be used with different types of microfibers, and can also construct two-dimensional patterns and plug fibers into microglass capillaries.
IEEE-ASME TRANSACTIONS ON MECHATRONICS
(2023)
Article
Chemistry, Analytical
Zachary J. Walker, Tanner Wells, Ethan Belliston, Seth B. Walker, Carson Zeller, Mohammad Julker Neyen Sampad, S. M. Saiduzzaman, Holger Schmidt, Aaron R. Hawkins
Summary: This article presents an optofluidic device that utilizes optical scattering and gradient forces to trap particles. Two different designs are compared and the second design is shown to have higher efficiency.
Article
Chemistry, Physical
Zhenzhen Chen, Zhewei Cai, Wenbo Liu, Zijie Yan
Summary: Optical tweezers can control the position and orientation of individual colloidal particles in solution, providing unique prospects for single-particle spectroscopy and microscopy. This perspective discusses the underlying principles, combinations, and applications of optical tweezers with different spectroscopy and microscopy techniques, as well as the challenges and opportunities for performing spectroscopy and microscopy on single nanoparticles with optical tweezers.
JOURNAL OF CHEMICAL PHYSICS
(2022)
Article
Physics, Applied
Yan-Chun Luo, Xin-Rui Li, Da-Jian Wu, Jie Yao, Xing-Feng Zhu, Liang-Fen Du, Xiao-Jun Liu
Summary: This study proposes a method for capturing and manipulating large Mie particles in three dimensions using acoustic manipulation technology, based on a hybrid acoustic artificial plate to generate a hybrid acoustic focused petal beam. By adjusting the topological charge of the beam, the zero-intensity zone in the beam can be adjusted, enabling stable trapping and manipulation of large Mie particles.
PHYSICAL REVIEW APPLIED
(2022)
Review
Chemistry, Analytical
Yuting Zhou, Liguo Dai, Niandong Jiao
Summary: Microbubbles have been widely used in the field of microrobots due to their unique properties. They can serve as power sources, manipulation tools, or even microrobots themselves. This review provides a comprehensive overview of bubble applications in microrobotics, including propulsion, manipulation, and assembly, highlighting the advantages and challenges.
Article
Chemistry, Multidisciplinary
Iveta Ukropcova, Radek Dao, Martin Stubian, Miroslav Kolibal, Tomas Sikola, Marc G. Willinger, Zhu-Jun Wang, Jakub Zlamal, Petr Babor
Summary: This study investigates the manipulation of AuGe droplets on a germanium substrate using an electron beam in a scanning electron microscope. Experimental observations and simulations are combined to analyze the phenomenon of directional thermomigration induced by the electron beam. It is found that the motion of the droplets is limited by the dissolution of the substrate and the electron tractor beam can both control and split the droplets, offering new possibilities for droplet manipulation inside an SEM.
ADVANCED MATERIALS INTERFACES
(2023)
Article
Engineering, Electrical & Electronic
Md Abeed Hasan, Ahmed Zubair
Summary: This paper proposes a silver-based cross diabolo hollow notch plasmonic nanotweezer, which manipulates nanoparticles using field enhancement and electric field gradients. It has strong trapping capability and low power consumption.
IEEE PHOTONICS JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Dann de la Torre, Veneranda Garces-Chavez, Juan De Dios Sanchez-Lopez, Kevin A. O'Donnell, Juan Ivan Nieto-Hipolito, Rosario Isidro Yocupicio-Gaxiola
Summary: In this work, an optofluidic system is presented for manipulating the orientation of zeolite crystals in a microfluidic channel. The system uses computer-controlled syringe pumps to generate hydrodynamic forces for translation and rotation of the crystals. This system allows complete assessment of a single crystal by shifting its orientation between two major faces, and offers control over the surrounding medium. The proposed system is a novel tool that opens up new possibilities for individual zeolite crystal assessment.
APPLIED SCIENCES-BASEL
(2023)
Article
Engineering, Biomedical
Zenan Wang, Jie Tao, Jun Tian, Jun Wei, Ying Hu
Summary: This paper proposes a system using surface acoustic wave (SAW) for noninvasive cell orientation. The system successfully recognizes cellular structures and rotates the cells to the desired position, showing significant importance for noninvasive cell manipulation tasks.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2023)
Article
Chemistry, Multidisciplinary
Ayoola T. Brimmo, Anoop Menachery, Pavithra Sukumar, Mohammad A. Qasaimeh
Summary: The study introduces a multifunctional noncontact scanning probe that allows precise manipulation of living single cells within their physiological tissue environment. The technology showcases adjustable spatial ability by transfecting adjacent single cells with different DNA plasmid vectors.
Article
Chemistry, Analytical
Xiaoqing Tang, Xiaoming Liu, Pengyun Li, Fengyu Liu, Masaru Kojima, Qiang Huang, Tatsuo Arai
ANALYTICAL CHEMISTRY
(2020)
Article
Physics, Applied
Yuyang Li, Xiaoming Liu, Qiang Huang, Tatsuo Arai
Summary: A noncontact rotational micromanipulation method using acoustically driven microbubble is reported in this study, allowing trapping and rotating micro-objects at the microscale. The rotation frequency can be controlled over a broad range by adjusting the frequency and voltage of the sinusoidal wave applied to the piezoelectric transducer.
APPLIED PHYSICS LETTERS
(2021)
Article
Chemistry, Analytical
Zhuo Chen, Xiaoming Liu, Masaru Kojima, Qiang Huang, Tatsuo Arai
Summary: The paper introduces a wearable navigation device integrating semantic visual SLAM and a powerful mobile computing platform, providing real-time feedback of environmental information to visually impaired individuals. Testing shows the system performs well on a wearable navigation device.
Article
Chemistry, Analytical
Dan Liu, Xiaoming Liu, Pengyun Li, Xiaoqing Tang, Masaru Kojima, Qiang Huang, Tatsuo Arai
Summary: This paper presented a micronewton force-controlled two-finger microhand with a soft magnetic end-effector for stable grasping, showing great potential in force-controlled manipulation in biological and industrial micromanipulation.
Article
Robotics
Pengyun Li, Xiaoming Liu, Dan Liu, Xiaoqing Tang, Masaru Kojima, Qiang Huang, Tatsuo Arai
Summary: This study presents an automated 8-DOF alignment system assisted by computer vision for the alignment and bonding of PDMS multi-layer microfluidic devices. Experimental results show high alignment accuracy and short bonding time, indicating great potential for development.
IEEE ROBOTICS AND AUTOMATION LETTERS
(2021)
Article
Robotics
Xiaoqing Tang, Xiaoming Liu, Pengyun Li, Dan Liu, Masaru Kojima, Qiang Huang, Tatsuo Arai
Summary: In this study, cell stiffness as a label-free biomarker for diagnosing and sorting cells at the single-cell level was evaluated using integrated magnetic tweezers on a microfluidic device. Two motion modes for magnetic beads under pulsed electromagnetic fields were proposed, demonstrating the rationality of the motion mode setting. The proposed method was deemed dependable for measuring Young's modulus of cells and showed potential for future applications in the efficient and flexible measurement of biomechanical properties.
IEEE ROBOTICS AND AUTOMATION LETTERS
(2021)
Article
Chemistry, Multidisciplinary
Pengyun Li, Xiaoming Liu, Masaru Kojima, Qiang Huang, Tatsuo Arai
Summary: This study proposed a new method for characterizing cell mechanical properties by analyzing the dynamic behavior of cells as they pass through multiple constrictions. Experimental results showed a decrease in passage time and an increase in dynamic deformability as cells passed through multiple constrictions. The deformability increase rate of HeLa cells was eight times higher than that of MEF cells, and the weak correlation between the deformability increase rate and cell size suggests that this new method has the potential for cancer cell recognition.
Article
Acoustics
Ling Shu, Jinxing Shen, Xiaoming Liu
Summary: The HAAPE method, by constructing high and low-frequency operators, simultaneously extracts features from different frequency bands of time series, avoiding information loss. Successfully applied in fault diagnosis of rotating machinery from vibration signals, achieving high accuracy.
SHOCK AND VIBRATION
(2021)
Article
Chemistry, Analytical
Xiaoqing Tang, Yuke Li, Xiaoming Liu, Dan Liu, Zhuo Chen, Tatsuo Arai
Summary: This paper presents an automated control and path planning method for magnetic microrobots based on computer vision. By using microscopic visual navigation, robust target tracking is achieved through PID-based closed-loop control combined with the Kalman filter, and intelligent obstacle avoidance control can be achieved using the dynamic window algorithm. Experimental results demonstrate that the proposed method performs well in complex environments, enabling precise control of magnetic microrobots to reach the target position.
Article
Automation & Control Systems
Xiaoming Liu, Xiaoqing Tang, Zhuo Chen, Masaru Kojima, Qiang Huang, Tatsuo Arai
Summary: Microfluidic devices based on passive hydrodynamics and uniform geometric design principle were proposed for arraying different quantities of cells. The trapping force was adjusted by modifying geometric parameters, and the procedure was monitored and automatized by computer vision technology. The experiments showed high success rates in arraying single, double, and triple cells, with no significant association between trapping quantity and cell survivability.
IEEE TRANSACTIONS ON AUTOMATION SCIENCE AND ENGINEERING
(2022)
Review
Chemistry, Multidisciplinary
Chuankai Dai, Xiaoming Liu, Rongyu Tang, Jiping He, Tatsuo Arai
Summary: In recent years, microfluidics has been crucial to the advancement of nerve regeneration research. Microfluidic devices accurately simulate the in vivo microenvironment for various research purposes such as analyzing growth inhibitory factors, screening drugs, evaluating nerve growth factors, and investigating neural injury and regeneration mechanisms. The platform enables precise control of cell behavior, such as neuron isolation, single-cell manipulation, neural patterning, and axon guidance, providing technical support for nerve regeneration.
APPLIED SCIENCES-BASEL
(2022)
Article
Automation & Control Systems
Dan Liu, Xiaoming Liu, Pengyun Li, Xiaoqing Tang, Masaru Kojima, Qiang Huang, Tatsuo Arai
Summary: This article presents an all-purpose magnetically driven micromanipulation system with designed contact and noncontact modes for industrial and biological applications. The system allows for high-precision and high-speed motions to grasp, release, and operate microtargets efficiently at the microscale.
IEEE-ASME TRANSACTIONS ON MECHATRONICS
(2022)
Article
Chemistry, Multidisciplinary
Fengyu Liu, Xiaoming Liu, Qing Shi, Christopher Maffeo, Masaru Kojima, Lixin Dong, Aleksei Aksimentiev, Qiang Huang, Toshio Fukuda, Tatsuo Arai
Summary: The article discusses a stable tetrahedral DNA nanorobot that can undergo controlled conformational changes in response to the stimulation of a specific molecular biomarker, EpCAM. The nanorobot shows low cytotoxicity and target specificity, making it a promising tool for precise monitoring of EpCAM-positive cells.
Review
Engineering, Biomedical
Xiaoming Liu, Tao Yue, Masaru Kojima, Qiang Huang, Tatsuo Arai
Summary: Blood vessels play a key role in maintaining homeostasis in the human body, and the engineering of microvessels is a challenging task. Modular tissue engineering using a bottom-up approach may be an effective way to overcome this challenge.
INTERNATIONAL JOURNAL OF BIOPRINTING
(2021)
Review
Biochemical Research Methods
Yuyang Li, Xiaoming Liu, Qiang Huang, Aaron T. Ohta, Tatsuo Arai
Summary: The integration of microfluidic devices and various actuation technologies has significantly advanced related fields in recent decades. Microbubbles are increasingly important in microfluidics due to their unique characteristics and specific responses to different energy sources and gas-liquid interactions. Effective bubble-based micromanipulation strategies have enabled non-invasive, selective, and precise operations at the microscale.