Review
Oncology
Zsuzsanna Iyizoba-Ebozue, Robin Prestwich, Sarah Brown, Emma Hall, John Lilley, Matthew Lowe, David J. Thomson, Finbar Slevin, Florien Boele, Louise Murray
Summary: When radiotherapy is used in the treatment of head and neck cancers, the brain may also receive radiation, resulting in potential neurocognitive changes and affecting quality of life. However, there has been limited research on this topic. Most studies show that neurocognitive outcomes are worse in patients who received radiotherapy compared to the control group, particularly in memory and language domains. Magnetic Resonance Imaging may be useful in detecting early structural and functional changes that can indicate future neurocognitive changes. Neurocognitive impairment is associated with poorer quality of life. More high-quality and large-scale studies are needed to draw definitive conclusions.
RADIOTHERAPY AND ONCOLOGY
(2023)
Review
Medicine, General & Internal
Matthijs In 't Veld, Derk H. J. Jager, Chayenne N. Chhangur, Kirsten A. Ziesemer, Frank K. J. Leusink, Engelbert A. J. M. Schulten
Summary: Oral-functioning impairment can negatively affect the quality of life of head and neck cancer patients after radiotherapy. This scoping review proposes a definition for oral functioning in these patients and identifies questionnaires for assessing patient-reported oral functioning. The common denominators for oral functioning were found to be chewing, speaking, and swallowing. Based on the included studies, the VHNSS 2.0 questionnaire is recommended for assessing oral functioning in these patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Nauman H. Malik, Manjula Maganti, Maurene McQuestion, Michael C. Tjong, Dana Keilty, Eric Monteiro, Shao Hui Huang, Raymond Woo-Jun Jang, Andrea Gomes, Joanne Pun, Jolie Ringash
Summary: The study found that attending a pre-treatment psychoeducational intervention was associated with higher survival rates and lower recurrence rates in patients receiving radiotherapy for head and neck cancers. Multivariable analysis showed that non-attendees had unfavorable survival and recurrence outcomes. Furthermore, attendees had a lower frequency of treatment-related issues compared to non-attendees.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Public, Environmental & Occupational Health
Chandrika Gibson, Moira O'Connor, Rohen White, Melanie Jackson, Siddhartha Baxi, Georgia K. B. Halkett
Summary: This qualitative study explores the experiences of head and neck cancer (HNC) patients in communicating with health professionals. The loss of speech capacity is found to be distressing and traumatic for survivors of HNC. Tensions arise in the communication between patients and health professionals, including abrupt, hurried communication versus slower, more mindful communication. Disparities in health literacy levels and a lack of empathy are also observed.
PATIENT EDUCATION AND COUNSELING
(2022)
Article
Medicine, General & Internal
Aleksandra Pytel, Anna Zielinska, Jakub Stas, Mariusz Chabowski
Summary: This study assessed the early impact of radiotherapy on health-related quality of life (HRQoL) outcomes, psychological distress, nutritional status, and overall performance of patients with head and neck cancer (HNC) in Poland. The results revealed negative effects of radiotherapy on functioning and symptom scales, as well as changes in nutritional status and depressive symptom severity. These findings highlight the importance of considering the impact of radiotherapy on HNC patients' well-being and the need for supportive interventions.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Sanjoy Chatterjee, Shaurav Maulik, Sriram Prasath, Balakrishnan Arun, Abhijit Das, Santam Chakrabarty, Moses Arunsingh, Chandran Nallathambi, Rimpa Achari, Tapesh Bhattacharya, Indranil Mallick
Summary: This study examines the resource requirements and impact on quality of life of parotid sparing adaptive radiotherapy (PSART). The study found that the time spent on contouring and treatment planning nearly doubled when implementing PSART. Although patients receiving PSART had poorer quality of life scores at 3 months post-treatment, xerostomia-related quality of life recovered to near baseline scores by 9 months.
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Oncology
Sarah Nicole Hamilton, Eric Tran, Cheryl Ho, Eric Berthelet, Jonn Wu, Kimberly DeVries, Vincent LaPointe, Angela Bowman, Minette Lagman, Robert Olson
Summary: Electronic PRO collection during H&N cancer RT is feasible. H&N cancer patients experience significant symptoms during RT, with the most severe symptoms reported being dysgeusia, pain and mucositis. Oropharynx cancer patients reported the highest symptom scores during RT.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Oncology
Elisa Kauark-Fontes, Cesar Augusto Migliorati, Joel B. Epstein, Nathaniel Simon Treister, Carolina Guimaraes Bonfim Alves, Karina Morais Faria, Natalia Rangel Palmier, Leticia Rodrigues-Oliveira, Mariana de Pauli Paglioni, Luiz Alcino Monteiro Gueiros, Karina G. M. da Conceicao Vasconcelos, Gilberto de Castro Jr, Adriana Franco Paes Leme, Marcio Ajudarte Lopes, Ana Carolina Prado-Ribeiro, Thais Bianca Brandao, Alan Roger Santos-Silva
Summary: Prophylactic extraoral PBM can delay onset of OM, reduce pain, and decrease the need for analgesics and anti-inflammatory medications, leading to improved quality of life. However, there was no evidence of PBM impacting oncological outcomes during 1 year of follow-up.
SUPPORTIVE CARE IN CANCER
(2022)
Review
Oncology
Samuel L. Mulder, Jolien Heukelom, Brigid A. McDonald, Lisanne Van Dijk, Kareem A. Wahid, Keith Sanders, Travis C. Salzillo, Mehdi Hemmati, Andrew Schaefer, Clifton D. Fuller
Summary: This article reviews the techniques of organ at risk (OAR) sparing in MR-guided adaptive radiotherapy and discusses future developments to improve treatment outcomes. Increasing the spatial conformity of dose distributions and using biological information for personalized treatment decisions are important steps in reducing normal tissue toxicities. MR-linac devices provide the potential for advancements in radiotherapy treatment by incorporating daily MR imaging during treatment delivery. The incorporation of imaging and clinical biomarkers into adaptive techniques shows promise in improving the therapeutic ratio.
Article
Oncology
Jorge Masia-Gridilla, Javier Gutierrez-Santamaria, Iago Alvarez-Saez, Jorge Pamias-Romero, Manel Saez-Barba, Coro Bescos-Atin
Summary: This study reports the benefits of autologous fat injection for correcting deformities and improving functionality in 40 patients treated for head and neck cancer. Esthetic improvement was achieved in 77.5% of patients and functional improvement in 89.2%. The study confirms the effectiveness of autologous fat grafting as a treatment for sequelae of head and neck cancer treatment.
Correction
Oncology
Marina Kimie Oba, Lara Maria Alencar Ramos Innocentini, Gustavo Viani, Hilton Marcos Alves Ricz, Thiago de Carvalho Reis, Tatiane Cristina Ferrari, Leandro Dorigan de Macedo
Summary: The data in the results section and table 1 is incorrect.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Management
Andrea Raith, Matthias Ehrgott, Fariza Fauzi, Kuan-Min Lin, Andrew Macann, Paul Rouse, John Simpson
Summary: This study demonstrates the use of Data Envelopment Analysis as a real-time decision support tool to assess the quality of radiotherapy plans for head and neck cancer patients. By comparing new plans to a library of previous clinically approved plans, the method provides benchmarking to evaluate the relative quality and improvement potential of each plan. The integration of DEA-based quality feedback into the RT planning process shows significant contributions to planning quality.
EUROPEAN JOURNAL OF OPERATIONAL RESEARCH
(2022)
Article
Otorhinolaryngology
Lauren D. Kudrick, Khalil Baddour, Richard Wu, Mark Fadel, Vusala Snyder, Aakriti Neopaney, Teresa H. Thomas, Lindsay M. Sabik, Marci L. Nilsen, Jonas T. Johnson, Robert L. Ferris, Seyed M. Nouraie, Richard Hass, Leila J. Mady
Summary: This study aimed to evaluate the burden of caregivers in head and neck cancer (HNC) survivorship and identify related risk factors. The results showed that caregiver gender, patient employment status, and patient's social/emotional quality of life were associated with caregiver burden.
JAMA OTOLARYNGOLOGY-HEAD & NECK SURGERY
(2023)
Article
Oncology
Ove Karlsson, Therese Karlsson, Nina Pauli, Paulin Andrell, Caterina Finizia
Summary: The study found that jaw exercise therapy can significantly increase maximal interincisal opening, reduce symptoms related to trismus, and improve health-related quality-of-life. It is recommended to initiate structured jaw exercise therapy early and continue for the long term.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Oncology
Nan Jiang, Siqi Wei, Jan Martensson, Yue Zhao, Kristofer Arestedt
Summary: The study confirmed the validity and reliability of the XQ in Chinese patients with head and neck cancer undergoing radiotherapy. The XQ can be used as a valuable tool for assessing xerostomia, monitoring its severity, and evaluating treatment and intervention outcomes.
Article
Oncology
William C. Jackson, Peter G. Hawkins, George S. Arnould, John Yao, Charles Mayo, Michelle Mierzwa
Article
Urology & Nephrology
Alejandro Berlin, Fabio Y. Moraes, Noelia Sanmamed, Rachel Glicksman, Alexander Koven, Osvaldo Espin-Garcia, Elton T. T. Leite, Joao L. F. Silva, Rafael Gadia, Michael Nesbitt, Charles N. Catton, Samuel Kaffenberger, Simpa S. Salami, Todd M. Morgan, Jason W. D. Hearn, Will C. Jackson, Rohit Mehra, Peter Chung, Neil E. Fleshner, Zachary S. Zumsteg, Robert T. Dess, Felix Y. Feng, Antonio Finelli, Daniel E. Spratt
JOURNAL OF UROLOGY
(2019)
Article
Otorhinolaryngology
Peter G. Hawkins, Michelle L. Mierzwa, Emily Bellile, William C. Jackson, Kelly M. Malloy, Steven B. Chinn, Matthew E. Spector, Andrew G. Shuman, Chaz L. Stucken, Scott A. McLean, Carol R. Bradford, Mark E. Prince, Thomas E. Carey, Francis P. Worden, Paul L. Swiecicki, Jeremy M. G. Taylor, Gregory T. Wolf, Avraham Eisbruch, Keith A. Casper
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2019)
Article
Clinical Neurology
Whitney H. Beeler, Kelly A. Speth, Michael T. Broderick, Neil K. Jairath, Dena Ballouz, Laila A. Gharzai, William C. Jackson, Michelle M. Kim, Dawn Owen, Nicholas J. Szerlip, Kelly C. Paradis, Daniel E. Spratt
Article
Clinical Neurology
Fabio Y. Moraes, Xuguang Chen, Michael Yan, Daniel E. Spratt, Kristen Redmond, William C. Jackson, Yoshiya (Josh) Yamada
NEUROSURGERY CLINICS OF NORTH AMERICA
(2020)
Article
Oncology
Jeffrey J. Tosoian, Samuel R. Birer, R. Jeffrey Karnes, Jingbin Zhang, Elai Davicioni, Eric E. Klein, Stephen J. Freedland, Sheila Weinmann, Bruce J. Trock, Robert T. Dess, Shuang G. Zhao, William C. Jackson, Kosj Yamoah, Alan Dal Pral, Brandon A. Mahal, Todd M. Morgan, Rohit Mehra, Samuel Kaffenberger, Simpa S. Salami, Christopher Kane, Alan Pollack, Robert B. Den, Alejandro Berlin, Edward M. Schaeffer, Paul L. Nguyen, Felix Y. Feng, Daniel E. Spratt
PROSTATE CANCER AND PROSTATIC DISEASES
(2020)
Article
Oncology
Robert T. Dess, Yilun Sun, William C. Jackson, Neil K. Jairath, Amar U. Kishan, David G. Wallington, Brandon A. Mahal, Bradley J. Stish, Zachery S. Zumsteg, Robert B. Den, William A. Hall, Laila A. Gharzai, Elizabeth M. Jaworski, Zachary R. Reichert, Todd M. Morgan, Rohit Mehra, Edward M. Schaeffer, Oliver Sartor, Paul L. Nguyen, William Robert Lee, Seth A. Rosenthal, Jeff M. Michalski, Matthew J. Schipper, James J. Dignam, Thomas M. Pisansky, Anthony L. Zietman, Howard M. Sandler, Jason A. Efstathiou, Felix Y. Feng, William U. Shipley, Daniel E. Spratt
Article
Oncology
Michelle L. Mierzwa, Laila A. Gharzai, Pin Li, Joel R. Wilkie, Peter G. Hawkins, Madhava P. Aryal, Choonik Lee, Benjamin Rosen, Teresa Lyden, Anna Blakely, Christina H. Chapman, Jennifer Thamarus, Caitlin Schonewolf, Jennifer Shah, Avraham Eisbruch, Matthew J. Schipper, Yue Cao
Summary: The study found that midtreatment blood volume increases derived from DCE-MRI serve as an early predictor of dysphagia, with BV increases in the PCM correlating with various parameters of swallowing difficulties. Further investigation of these promising imaging markers to assess individual patient sensitivity to treatment and subsequent risk of toxicities is crucial for improving the personalization of RT planning.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Oncology
Laila A. Gharzai, Pin Li, Matthew J. Schipper, John Yao, Charles S. Mayo, Joel R. Wilkie, Peter G. Hawkins, Teresa Lyden, Anna Blakely, Mohannad Ibrahim, Caitlin A. Schonewolf, Jennifer Shah, Avraham Eisbruch, Keith Casper, Michelle Mierzwa
Article
Oncology
Laila A. Gharzai, Julia Pakela, Elizabeth M. Jaworski, Issam El Naqa, Jennifer Shah, Peter G. Hawkins, Matthew E. Spector, Carol R. Bradford, Steven B. Chinn, Kelly Malloy, Robbi Kupfer, Andrew Shuman, Robert Morrison, Chaz L. Stucken, Andrew Rosko, Mark E. Prince, Keith Casper, Avraham Eisbruch, Gregory Wolf, Paul L. Swiecicki, Francis Worden, Michelle L. Mierzwa
Summary: The study compared the clinical and imaging responses in bioselected patients with larynx cancer to develop predictive models for surgeon-assessed response, laryngectomy-free survival, and overall survival. The results showed that imaging offers a non-invasive opportunity to evaluate response to induction chemotherapy and further evaluation is needed to optimize approaches to bioselection. Additionally, clinical trials utilizing imaging to predict outcomes, including laryngectomy-free survival, are warranted.
CLINICAL AND TRANSLATIONAL RADIATION ONCOLOGY
(2022)
Review
Oncology
Holly E. Hartman, William C. Jackson
Article
Medicine, General & Internal
Lauren J. Beesley, Todd M. Morgan, Daniel E. Spratt, Udit Singhal, Felix Y. Feng, Allison Cullen Furgal, William C. Jackson, Stephanie Daignault, Jeremy M. G. Taylor
Article
Radiology, Nuclear Medicine & Medical Imaging
Madhava P. Aryal, Choonik Lee, Peter G. Hawkins, Christina Chapman, Avraham Eisbruch, Michelle Mierzwa, Yue Cao
Article
Oncology
Nicholas G. Zaorsky, James B. Yu, Sean M. McBride, Robert T. Dess, William C. Jackson, Brandon A. Mahal, Ronald Chen, Ananya Choudhury, Ann Henry, Isabel Syndikus, Timur Mitin, Alison Tree, Amar U. Kishan, Daniel E. Spratt
ADVANCES IN RADIATION ONCOLOGY
(2020)
