Journal
SEMINARS IN PEDIATRIC SURGERY
Volume 27, Issue 1, Pages 25-28Publisher
ELSEVIER SCIENCE INC
DOI: 10.1053/j.sempedsurg.2017.11.005
Keywords
Biorepository; Registry; Necrotizing enterocolitis; Specimen; Intestine
Categories
Funding
- National Institutes of Health [K08DK101608, R03DK111473, UUTR001085]
- March of Dimes Foundation Grant [5-FY17-79]
- Children's Discovery Institute of Washington University
- St. Louis Children's Hospital at Washington University School of Medicine, St. Louis
- Department of Pediatrics at Washington University School of Medicine, St. Louis
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Necrotizing enterocolitis (NEC) is a devastating disease affecting premature infants. New advances in diagnostic and treatment options are desperately needed. Accordingly, the NEC Society initiated a research collaborative with a group of investigators dedicated to advancing the state of NEC-associated knowledge. Recent advances in high-content molecular interrogation and bio-computation (e.g., genomics, transcriptomics, proteomics, and metabolomics) can provide new insights from afflicted infants with NEC, however, individual centers do not have sufficient cases to conduct these studies independently. The development of a NEC Society Biorepository (NSB) has emerged to advance collaboration among institutions through the shared use of biologic samples in the dedicated pursuit of molecular indicators of disease and to gain greater pathophysiologic insights through research. The NSB will provide key infrastructure across several centers to harness the potential for new discoveries, while ensuring specimens are processed consistently, appropriate clinical data is collected, and privacy is maintained. The NSB will provide a comprehensive framework for sharing biological samples and clinical data through a robust and secure system that supports the investigation of research studies on NEC. (C) 2018 Elsevier Inc. All rights reserved.
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