Review
Oncology
Mayumi Kobayashi Kato, Yasuhito Tanase, Masaya Uno, Mitsuya Ishikawa, Tomoyasu Kato
Summary: This study investigated the clinical characteristics, diagnosis, treatment, and prognosis of brain metastases from uterine cervical carcinoma and uterine endometrial carcinoma. The findings highlight factors influencing treatment selection and prognosis, with specific high-risk factors and poor prognostic indicators identified for each type of carcinoma. Despite limited evidence, further research is needed to better understand brain metastases from uterine cancer.
Article
Genetics & Heredity
Xiaolin Sun, Ning Yang, Xingguo Zhou, Honghai Dai, Qiang Li, Alei Feng, Gongwen Xu, Yingchao Liu, Linzong Xu, Zhanyu Zhang, Zhe Yang, Xiaomei Li
Summary: This study found that breast cancer brain metastases (BCBM) are closely related to the expression of cartilage intermediate layer protein (CILP). Low expression of CILP is associated with poor prognosis and is an independent prognostic factor for stage III-IV breast cancer. CILP expression is downregulated in BCBM and negatively correlated with vascular endothelial growth factor A (VEGFA). CILP inhibits breast cancer cell proliferation and metastasis by participating in epithelial-mesenchymal transition (EMT). CILP is also associated with immune infiltration in BCBM, possibly through involvement in the T-cell receptor signaling pathway.
FRONTIERS IN GENETICS
(2022)
Article
Oncology
C. Schroder, P. Windisch, J. Lutscher, D. R. Zwahlen, R. Forster
Summary: The study aimed to validate the 2022 graded prognostic assessment (GPA) for patients with brain metastases from adenocarcinoma of the lung and discuss its clinical practicability. A cohort of 137 adenocarcinoma of the lung patients was included, and NSCLC-specific GPA, Lung-molGPA, and GPA for NSCLC adenocarcinoma were calculated. The median overall survival (OS) was 15 months, and there was a significant difference in survival among different GPA groups. The study validated the 2022 GPA for NSCLC adenocarcinoma patients with brain metastases, but the practical applicability might be limited due to evolving treatments and improved overall survival.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Gang Zhou, Zhiyuan Zhang, Peng Yu, Ruixuan Geng, Guige Wang, Wenbin Ma, Jun Gao, Zhibo Zheng, Yongning Li
Summary: This study identified risk factors for synchronous brain metastases (SBM) in small-cell lung cancer (SCLC) patients and examined prognostic indicators. It was found that patients who were black and had higher T, N, and M stages had a higher risk of SBM. Additionally, patients who received combinational treatment had a longer overall survival (OS), with surgery combined with chemotherapy and radiotherapy showing the longest OS.
Article
Oncology
Da Wang, Chao Chen, Xiaoxu Ge, Qi Yang, Yuhuai Huang, Tianyi Ling, Tian Jin, Shaojun Yu, Jian Wang, Lifeng Sun
Summary: This study analyzed clinicopathological, survival, prognostic factors, and timing of brain metastases in 65 colorectal cancer patients from a Chinese center. Surgical treatment of metastatic lesions may be an alternative choice for CRC patients with BM, and early identification of BM timing can lead to a better survival outcome.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Oncology
Tian-Qi Du, Xiang Li, Wei-Si Zhong, Jian-Dong Tian, Yu-Xia Zhao, Dan Liu
Summary: For patients with brain metastasis of lung cancer, SIB-IMRT may be associated with a more favorable prognosis.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Neurosciences
Shuang Wu, Guangqiao Li, Weizheng Guan, Huan Zhao, Jingfeng Wang, Yongchun Zhou, Yufu Zhou, Bo Shi
Summary: This prospective study aimed to evaluate the association between heart rate variability (HRV) and overall survival of lung cancer patients with brain metastases (LCBM). It was found that decreased RMSSD was independently associated with shorter survival time, suggesting that HRV might be a novel predictive biomarker for LCBM prognosis.
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Carolin Czauderna, Kim Luley, Nikolas von Bubnoff, Jens U. Marquardt
Summary: Liver metastases are the most common site of metastasis in colorectal cancer. Current treatment approaches involve systemic therapies and surgical/interventional strategies, with the use of predictive and prognostic biomarkers leading to improved survival rates. Treatment selection based on patient status, tumor characteristics, and molecular/genetic status is recommended for better outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Genetics & Heredity
Rong Wang, Xing Zhang, Changshou He, Wei Guo
Summary: A prognostic RiskScore model with high accuracy was established to predict the occurrence and survival status of brain metastases in NSCLC.
FRONTIERS IN GENETICS
(2023)
Article
Oncology
Muriel Heimann, Niklas Schafer, Christian Bode, Valeri Borger, Lars Eichhorn, Frank A. Giordano, Erdem Guresir, Andreas H. Jacobs, Yon-Dschun Ko, Jennifer Landsberg, Felix Lehmann, Alexander Radbruch, Christina Schaub, Katjana S. Schwab, Johannes Weller, Ulrich Herrlinger, Hartmut Vatter, Patrick Schuss, Matthias Schneider
Summary: In geriatric patients with surgically treated brain metastases, pre-operative frailty is associated with poor survival, with multiple intracranial metastases, infratentorial localization, preoperative CRP >5 mg/l, and frailest patients identified as predictors for reduced overall survival.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Nayan Lamba, Rachel Brigell Kearney, Paul J. Catalano, Michael J. Hassett, Patrick Y. Wen, Daphne A. Haas-Kogan, Ayal A. Aizer
Summary: Elderly patients with brain metastases have a poor prognosis, especially those with synchronous BM, with a median survival rate generally not exceeding 4 months; specific treatments, such as EGFR or ALK therapy, can significantly improve survival rates for NSCLC BM patients.
Article
Oncology
Shizhao Cheng, Lei Yang, Xin Dai, Jing Wang, Xingpeng Han
Summary: The incidence of brain metastases in esophageal cancer patients is rare, with a prognosis of only 5 months. Both bone and lung metastases are significant factors for the development and prognosis of brain metastases. Various clinical characteristics, such as age, race, tumor location, histology subtype, and metastases sites, are associated with the occurrence of brain metastases in esophageal cancer patients. The nomogram is a reliable tool for predicting brain metastases.
Article
Oncology
Angela M. Hong, Cora Waldstein, Brindha Shivalingam, Matteo S. Carlino, Victoria Atkinson, Richard F. Kefford, Grant A. McArthur, Alexander M. Menzies, John F. Thompson, Georgina Long
Summary: The brain is a common site of metastatic disease for patients with advanced melanoma, with treatment approaches including surgery, radiotherapy, and systemic therapy. Management of melanoma brain metastases should involve a multidisciplinary team and consider optimal combinations and sequencing of treatments. It is important to establish appropriate guidelines for the management of melanoma brain metastases and update them regularly as new treatment options become available.
EUROPEAN JOURNAL OF CANCER
(2021)
Article
Biotechnology & Applied Microbiology
Ji Li, Wang Jing, Xiaoyang Zhai, Wenxiao Jia, Hui Zhu, Jinming Yu
Summary: This study validates the feasibility of the Lung-molGPA tool in predicting survival of patients with non-small-cell lung cancer, providing evidence for its usefulness in determining treatment strategies and prognosis. Patients in the adenocarcinoma group with higher Lung-molGPA scores had longer median survival times, while a similar trend was observed in the non-adenocarcinoma group.
ONCOTARGETS AND THERAPY
(2021)
Article
Oncology
Dong Guo, Jiafeng Liu, Yanping Li, Qingqing Chen, Yunzheng Zhao, Xinwei Guo, Shuchai Zhu, Shengjun Ji
Summary: The study evaluated the prognostic significance of combining magnetic resonance spectroscopy (MRS) parameters and systemic immune-inflammation index (SII) in non-small cell lung cancer (NSCLC) patients with brain metastases (BMs) treated with stereotactic radiotherapy. The results showed that the combined C-SII score was more accurate in predicting clinical outcomes in these patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Gastroenterology & Hepatology
Carol Barahona Ponce, Dominique Scherer, Regina Brinster, Felix Boekstegers, Katherine Marcelain, Valentina Garate-Calderon, Bettina Muller, Gonzalo Toro, Javier Retamales, Olga Barajas, Monica Ahumada, Erik Morales, Armando Rojas, Veronica Sanhueza, Denisse Loader, Maria Teresa Rivera, Lorena Gutierrez, Giuliano Bernal, Alejandro Ortega, Domingo Montalvo, Sergio Portino, Maria Enriqueta Bertran, Fernando Gabler, Loreto Spencer, Jordi Olloquequi, Christine Fischer, Mazda Jenab, Krasimira Aleksandrova, Verena Katzke, Elisabete Weiderpass, Catalina Bonet, Tahereh Moradi, Krista Fischer, Willem Bossers, Hermann Brenner, Kristian Hveem, Niina Eklund, Uwe Volker, Melanie Waldenberger, Macarena Fuentes Guajardo, Rolando Gonzalez-Jose, Gabriel Bedoya, Maria C. Bortolini, Samuel Canizales-Quinteros, Carla Gallo, Andres Ruiz-Linares, Francisco Rothhammer, Justo Lorenzo Bermejo
Summary: The study found causal effects of gallstone disease on GBC risk in Chileans and Europeans, and also a causal effect of BMI on GBC risk in Chileans, while higher CRP concentrations increased GBC risk in Europeans. Furthermore, BMI showed a causal effect on gallstone risk in Europeans, which was itself causally linked to GBC risk.
Article
Plant Sciences
Steven L. Stephenson, Nazrana Payal, Gurpreet Kaur, Carlos Rojas
Summary: This study assessed the impact of wildfires on the recovery of myxomycetes associated with different substrates. Samples from areas with lower fire intensity showed more myxomycetes and faster recovery on bark and twigs. Myxomycetes are resilient to wildfires and recover differently depending on the substrate.
PLANT ECOLOGY AND EVOLUTION
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Ryan J. Hoffman, Hillary W. Garner, Carlos A. Rojas, Rolf A. Grage, Sushilkumar K. Sonavane, Elizabeth M. Johnson, Patricia J. Mergo, Christopher M. Walker, Justin T. Stowell
Summary: Dyspnea is a common symptom in cardiopulmonary diseases, but it can also be caused by overlooked neuromuscular and chest wall conditions. These conditions affect the structure and function of the respiratory pump, leading to respiratory failure and other complications.
JOURNAL OF THORACIC IMAGING
(2022)
Book Review
History
Carlos Rojas
SOCIAL HISTORY OF MEDICINE
(2022)
Article
Respiratory System
Daniel Hernandez-Rojas, David Abia-Trujillo, Carlos Rojas, Alejandra Yu Lee-Mateus, Rocio Castillo-Larios, Sai Priyanka Pulipaka, Sebastian Fernandez-Bussy
Summary: Expiratory central airway collapse (ECAC) is a challenging pathology to diagnose. Current invasive diagnosis methods have limited reproducibility, and non-invasive techniques are not as effective. Research suggests that dynamic forced expiratory CT may serve as a feasible alternative.
RESPIROLOGY CASE REPORTS
(2022)
Correction
Multidisciplinary Sciences
Michel S. Naslavsky, Marilia O. Scliar, Guilherme L. Yamamoto, Jaqueline Yu Ting Wang, Stepanka Zverinova, Tatiana Karp, Kelly Nunes, Jose Ricardo Magliocco Ceroni, Diego Lima de Carvalho, Carlos Eduardo da Silva Simoes, Daniel Bozoklian, Ricardo Nonaka, Nayane dos Santos Brito Silva, Andreia da Silva Souza, Heloisa de Souza Andrade, Marilia Rodrigues Silva Passos, Camila Ferreira Bannwart Castro, Celso T. Mendes-Junior, Rafael L. V. Mercuri, Thiago L. A. Miller, Jose Leonel Buzzo, Fernanda O. Rego, Nathalia M. Araujo, Wagner C. S. Magalhaes, Regina Celia Mingroni-Netto, Victor Borda, Heinner Guio, Carlos P. Rojas, Cesar Sanchez, Omar Caceres, Michael Dean, Mauricio L. Barreto, Maria Fernanda Lima-Costa, Bernardo L. Horta, Eduardo Tarazona-Santos, Diogo Meyer, Pedro A. F. Galante, Victor Guryev, Erick C. Castelli, Yeda A. O. Duarte, Maria Rita Passos-Bueno, Mayana Zatz
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Michel S. Naslavsky, Marilia O. Scliar, Guilherme L. Yamamoto, Jaqueline Yu Ting Wang, Stepanka Zverinova, Tatiana Karp, Kelly Nunes, Jose Ricardo Magliocco Ceroni, Diego Lima de Carvalho, Carlos Eduardo da Silva Simoes, Daniel Bozoklian, Ricardo Nonaka, Nayane dos Santos Brito Silva, Andreia da Silva Souza, Heloisa de Souza Andrade, Marilia Rodrigues Silva Passos, Camila Ferreira Bannwart Castro, Celso T. Mendes-Junior, Rafael L. Mercuri, Thiago L. A. Miller, Jose Leonel Buzzo, Fernanda O. Rego, Nathalia M. Araujo, Wagner C. S. Magalhaes, Regina Celia Mingroni-Netto, Victor Borda, Heinner Guio, Carlos P. Rojas, Cesar Sanchez, Omar Caceres, Michael Dean, Mauricio L. Barreto, Maria Fernanda Lima-Costa, Bernardo L. Horta, Eduardo Tarazona-Santos, Diogo Meyer, Pedro A. F. Galante, Victor Guryev, Erick C. Castelli, Yeda A. O. Duarte, Maria Rita Passos-Bueno, Mayana Zatz
Summary: This study presents a high-coverage WGS dataset of elderly Brazilians from a mixed population, providing valuable data on non-European and mixed populations. The results demonstrate that WGS can identify previously undescribed variants and genomic segments, as well as alleles from HLA genes. The study also shows the clinical usefulness of reclassifying and validating variants associated with dominantly-inherited Mendelian disorders. Furthermore, the findings highlight the improved potential of whole-genome and HLA imputation using WGS data.
NATURE COMMUNICATIONS
(2022)
Article
Medicine, General & Internal
Felipe Maldonado, Diego Morales, Catalina Diaz-Papapietro, Catalina Valdes, Christian Fernandez, Nicolas Valls, Marioli Lazo, Carolina Espinoza, Roberto Gonzalez, Rodrigo Gutierrez, Alvaro Jara, Carlos Romero, Oscar Cerda, Monica Caceres
Summary: This study aimed to evaluate whether early detection of endothelial and angiogenic biomarkers predicts mortality and major cardiovascular events in COVID-19 patients. The results showed that certain biomarkers had significantly increased concentrations in COVID-19 patients and could predict mortality. Furthermore, serum samples from COVID-19 patients enhanced the migration ability of endothelial cells.
FRONTIERS IN MEDICINE
(2022)
Meeting Abstract
Oncology
Suraj Rajesh Samtani, Carlos Rojas, Jaime Gonzalez, Luis Godoy, Mauricio Burotto
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Law
Carlos Alberto Jaramillo Rojas
Summary: In Leviathan, Thomas Hobbes explains the obligation to obey the state as a rational or prudential necessity based on his philosophical and epistemological theories of human nature. According to Hobbes, obedience to the sovereign is driven by the need to preserve life motion, and transcendental values are not considered as foundational to moral obligations in his theory.
Meeting Abstract
Biochemistry & Molecular Biology
C. H. Parada Rojas, L. M. Quesada-Ocampo
MOLECULAR PLANT-MICROBE INTERACTIONS
(2021)
Meeting Abstract
Biochemistry & Molecular Biology
C. H. Parada Rojas, L. M. Quesada-Ocampo
MOLECULAR PLANT-MICROBE INTERACTIONS
(2021)
Meeting Abstract
Plant Sciences
C. H. Parada Rojas, L. M. Quesada-Ocampo
Meeting Abstract
Plant Sciences
M. Stahr, C. H. Parada Rojas, K. L. Childs, L. M. Quesada
Article
Oncology
Luis Villanueva, Jaime Anabalon, Jean M. Butte, Pamela Salman, Sergio Panay, Elizabeth Milla, Carlos Gallardo, Sebastian Hoefler, Roberto Charles, Felipe Reyes, Olga Barajas, Luis Matamala, Angelica Molina, Sergio Portino, Marcela Berrios, Christian Caglevic, Mauricio Mahave
Summary: Total neoadjuvant chemotherapy with FLOT regimen presents good safety profile, similar pathologic regression rate, and slightly higher treatment completion rate compared to perioperative FLOT studies. Patients with signet ring carcinoma histology show poorer prognosis.
ECANCERMEDICALSCIENCE
(2021)
