AHR signaling in the development and function of intestinal immune cells and beyond

Cytochrome P4501-inhibiting chemicals amplify aryl hydrocarbon receptor activation and IL-22 production in T helper 17 cells

(2018) Chris Schiering et al.   BIOCHEMICAL PHARMACOLOGY

The ILC World Revisited

(2017) Andreas Diefenbach et al.   IMMUNITY

FICZ generates human tDCs that induce CD4 + CD25 high Foxp3 + Treg-like cell differentiation

(2017) Brenda B. Jurado-Manzano et al.   IMMUNOLOGY LETTERS

Trace derivatives of kynurenine potently activate the aryl hydrocarbon receptor (AHR)

(2017) Seung-Hyeon Seok et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Feedback control of AHR signalling regulates intestinal immunity

(2017) Chris Schiering et al.   NATURE

Indoles from commensal bacteria extend healthspan

(2017) Robert Sonowal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lactobacillus reuteriinduces gut intraepithelial CD4+CD8αα+T cells

(2017) Luisa Cervantes-Barragan et al.   SCIENCE

TCDD, FICZ, and Other High Affinity AhR Ligands Dose-Dependently Determine the Fate of CD4+ T Cell Differentiation

(2017) Allison K Ehrlich et al.   TOXICOLOGICAL SCIENCES

Aryl hydrocarbon receptor signaling modifies Toll-like receptor-regulated responses in human dendritic cells

(2016) Sarah Kado et al.   ARCHIVES OF TOXICOLOGY

Aryl hydrocarbon receptor is required for optimal B‐cell proliferation

(2016) Matteo Villa et al.   EMBO JOURNAL

Ikaros Inhibits Group 3 Innate Lymphoid Cell Development and Function by Suppressing the Aryl Hydrocarbon Receptor Pathway

(2016) Shiyang Li et al.   IMMUNITY

CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands

(2016) Bruno Lamas et al.   NATURE MEDICINE

Role of aryl hydrocarbon receptor polymorphisms on TCDD-mediated CYP1B1 induction and IgM suppression by human B cells

(2016) Natalia Kovalova et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

SHP-1 is directly activated by the aryl hydrocarbon receptor and regulates BCL-6 in the presence of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)

(2016) Ashwini S. Phadnis-Moghe et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Evidence for New Light-Independent Pathways for Generation of the Endogenous Aryl Hydrocarbon Receptor Agonist FICZ

(2015) Anna Smirnova et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Innate lymphoid cells: new insights into function and development

(2015) Victor S. Cortez et al.   CURRENT OPINION IN IMMUNOLOGY

Runx3 specifies lineage commitment of innate lymphoid cells

(2015) Takashi Ebihara et al.   NATURE IMMUNOLOGY

Metabolic control of type 1 regulatory T cell differentiation by AHR and HIF1-α

(2015) Ivan D Mascanfroni et al.   NATURE MEDICINE

The Group 3 Innate Lymphoid Cell Defect in Aryl Hydrocarbon Receptor Deficient Mice Is Associated with T Cell Hyperactivation during Intestinal Infection

(2015) Sagie Wagage et al.   PLoS One

The Aryl Hydrocarbon Receptor: Multitasking in the Immune System

(2014) Brigitta Stockinger et al.   Annual Review of Immunology

Development, Differentiation, and Diversity of Innate Lymphoid Cells

(2014) Andreas Diefenbach et al.   IMMUNITY

The Aryl Hydrocarbon Receptor Promotes IL-10 Production by NK Cells

(2014) S. Wagage et al.   JOURNAL OF IMMUNOLOGY

Aryl hydrocarbon receptor control of a disease tolerance defence pathway

(2014) Alban Bessede et al.   NATURE

AhR sensing of bacterial pigments regulates antibacterial defence

(2014) Pedro Moura-Alves et al.   NATURE

The Transcription Factor AHR Prevents the Differentiation of a Stage 3 Innate Lymphoid Cell Subset to Natural Killer Cells

(2014) Tiffany Hughes et al.   Cell Reports

Tryptophan Catabolites from Microbiota Engage Aryl Hydrocarbon Receptor and Balance Mucosal Reactivity via Interleukin-22

(2013) Teresa Zelante et al.   IMMUNITY

Group 3 Innate Lymphoid Cells Inhibit T-Cell-Mediated Intestinal Inflammation through Aryl Hydrocarbon Receptor Signaling and Regulation of Microflora

(2013) Ju Qiu et al.   IMMUNITY

Regulation of plasmacytoid dendritic cell development in mice by aryl hydrocarbon receptor

(2013) Hao Liu et al.   IMMUNOLOGY AND CELL BIOLOGY

Malassezia Yeasts Produce a Collection of Exceptionally Potent Activators of the Ah (Dioxin) Receptor Detected in Diseased Human Skin

(2013) Prokopios Magiatis et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Transcriptional reprogramming of mature CD4+ helper T cells generates distinct MHC class II–restricted cytotoxic T lymphocytes

(2013) Daniel Mucida et al.   NATURE IMMUNOLOGY

Mutual expression of the transcription factors Runx3 and ThPOK regulates intestinal CD4+ T cell immunity

(2013) Bernardo Sgarbi Reis et al.   NATURE IMMUNOLOGY

Modulation of natural killer cell antitumor activity by the aryl hydrocarbon receptor

(2013) J. H. Shin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Aryl Hydrocarbon Receptor Antagonist StemRegenin 1 Promotes Human Plasmacytoid and Myeloid Dendritic Cell Development from CD34+ Hematopoietic Progenitor Cells

(2013) Soley Thordardottir et al.   STEM CELLS AND DEVELOPMENT

Effects of AhR ligands on the production of immunoglobulins in purified mouse B cells

(2012) Takayuki Yoshida et al.   BIOMEDICAL RESEARCH-TOKYO

Aryl Hydrocarbon Receptor-Mediated Induction of EBV Reactivation as a Risk Factor for Sjogren's Syndrome

(2012) H. Inoue et al.   JOURNAL OF IMMUNOLOGY

Exogenous Stimuli Maintain Intraepithelial Lymphocytes via Aryl Hydrocarbon Receptor Activation

(2011) Ying Li et al.   CELL

The Aryl Hydrocarbon Receptor Regulates Gut Immunity through Modulation of Innate Lymphoid Cells

(2011) Ju Qiu et al.   IMMUNITY

Lactobacillus bulgaricus OLL1181 activates the aryl hydrocarbon receptor pathway and inhibits colitis

(2011) Takeyuki Takamura et al.   IMMUNOLOGY AND CELL BIOLOGY

Transcription factor c-Maf mediates the TGF-β-dependent suppression of IL-22 production in TH17 cells

(2011) Sascha Rutz et al.   NATURE IMMUNOLOGY

Control of the development of CD8αα+ intestinal intraepithelial lymphocytes by TGF-β

(2011) Joanne E Konkel et al.   NATURE IMMUNOLOGY

AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of Notch

(2011) Jacob S Lee et al.   NATURE IMMUNOLOGY

Natural Aryl Hydrocarbon Receptor Ligands Control Organogenesis of Intestinal Lymphoid Follicles

(2011) E. A. Kiss et al.   SCIENCE

Mammalian Per-Arnt-Sim Proteins in Environmental Adaptation

(2010) Brian E. McIntosh et al.   Annual Review of Physiology

An Interaction between Kynurenine and the Aryl Hydrocarbon Receptor Can Generate Regulatory T Cells

(2010) J. D. Mezrich et al.   JOURNAL OF IMMUNOLOGY

The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27

(2010) Lionel Apetoh et al.   NATURE IMMUNOLOGY

Aryl hydrocarbon receptor negatively regulates dendritic cell immunogenicity via a kynurenine-dependent mechanism

(2010) N. T. Nguyen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An endogenous aryl hydrocarbon receptor ligand acts on dendritic cells and T cells to suppress experimental autoimmune encephalomyelitis

(2010) F. J. Quintana et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aryl Hydrocarbon Receptor Antagonists Promote the Expansion of Human Hematopoietic Stem Cells

(2010) Anthony E. Boitano et al.   SCIENCE

The Long Winding Road toward Understanding the Molecular Mechanisms for B-Cell Suppression by 2,3,7,8-Tetrachlorodibenzo-p-dioxin

(2010) C. E. W. Sulentic et al.   TOXICOLOGICAL SCIENCES

Aryl hydrocarbon receptor in combination with Stat1 regulates LPS-induced inflammatory responses

(2009) Akihiro Kimura et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Aryl Hydrocarbon Receptor Activation Inhibits In Vitro Differentiation of Human Monocytes and Langerhans Dendritic Cells

(2009) B. Platzer et al.   JOURNAL OF IMMUNOLOGY

Langerhans Cell Maturation and Contact Hypersensitivity Are Impaired in Aryl Hydrocarbon Receptor-Null Mice

(2009) B. Jux et al.   JOURNAL OF IMMUNOLOGY

Aryl hydrocarbon receptor signaling mediates expression of indoleamine 2,3-dioxygenase

(2008) Christoph F.A. Vogel et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Activation of the aryl hydrocarbon receptor is essential for mediating the anti-inflammatory effects of a novel low-molecular-weight compound

(2008) B. P. Lawrence et al.   BLOOD

Activation of the aryl hydrocarbon receptor promotes allograft-specific tolerance through direct and dendritic cell-mediated effects on regulatory T cells

(2008) E. Hauben et al.   BLOOD

Natural agonists for aryl hydrocarbon receptor in culture medium are essential for optimal differentiation of Th17 T cells

(2008) Marc Veldhoen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

AhR Ligands, Malassezin, and Indolo[3,2-b]Carbazole are Selectively Produced by Malassezia furfur Strains Isolated from Seborrheic Dermatitis

(2008) George Gaitanis et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins

(2008) Marc Veldhoen et al.   NATURE

Control of Treg and TH17 cell differentiation by the aryl hydrocarbon receptor

(2008) Francisco J. Quintana et al.   NATURE

The Search for Endogenous Activators of the Aryl Hydrocarbon Receptor

(2007) Linh P. Nguyen et al.   CHEMICAL RESEARCH IN TOXICOLOGY