Journal
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume 75, Issue -, Pages 50-60Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2017.08.008
Keywords
Epithelial-mesenchymal transition; Alternative splicing; Circular RNA
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Funding
- National Health and Medical Research Council of Australia [GNT1068773, GNT1026191, GNT1118170, GNT1128479]
- National Breast Cancer Foundation [IN-16-072, CG-10-04] Funding Source: researchfish
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Interconversions between epithelial and mesenchymal states, often referred to as epithelial mesenchymal transition (EMT) and its reverse MET, play important roles in embryonic development and are recapitulated in various adult pathologies including cancer progression. These conversions are regulated by complex transcriptional and post-transcriptional mechanisms including programs of alternative splicing which are orchestrated by specific splicing factors. This review will focus on the latest developments in our understanding of the splicing factors regulating epithelial mesenchymal plasticity associated with cancer progression and the induction of pluripotency, including potential roles for circular RNAs (circRNAs) which have been recently implicated in these processes. (c) 2017 Elsevier Ltd. All rights reserved.
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