Review
Biochemistry & Molecular Biology
Melanie Aureal, Irma Machuca-Gayet, Fabienne Coury
Summary: Rheumatoid arthritis is characterized by chronic synovial inflammation and irreversible bone erosions. Osteoclast-mediated bone resorption is the main cause of articular bone erosions, with autoantibodies, pro-inflammatory cytokines, and other regulating factors playing important roles in this process.
Review
Endocrinology & Metabolism
D. P. Destiani, S. Naja, S. Dewi, A. R. Rahmadi, S. A. S. Sulaiman, R. Abdulah
Summary: Methotrexate (MTX) remains commonly used for the management of rheumatoid arthritis (RA) despite the development of new drugs. A systematic review of MTX effectiveness in reducing bone erosion risk was presented in this article, with key factors such as gene polymorphism influencing treatment response. Future investigations are needed to clarify the exact mechanism of MTX in preventing bone erosion.
OSTEOPOROSIS INTERNATIONAL
(2021)
Article
Immunology
Emiliano Marasco, Gianluigi Fabbriciani, Laura Rotunno, Matteo Longhi, Paola De Luca, Laura de Girolamo, Alessandra Colombini
Summary: This study analyzed lymphocyte subsets and levels of circulating cytokines in patients with RA with progressive bone erosions. The findings suggest that abnormalities in B cells and the cytokines IL-11 and IL-17A may play a role in bone reabsorption in RA patients with progressive erosive disease.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Eric Toussirot
Summary: Inflammatory rheumatic diseases (IRDs) are characterized by chronic joint inflammation. Rheumatoid arthritis (RA) and spondyloarthritis (SpA), including axial SpA (ax SpA) and psoriatic arthritis (PsA), are the most common forms of IRD. Adipokines, including leptin, adiponectin, visfatin, and resistin, play a role in the pathophysiology of IRDs. In RA, adiponectin and resistin contribute to structural damage, while leptin's role is controversial. In ax SpA, visfatin is associated with radiographic progression, while leptin and adiponectin have negative effects on progression.
Article
Orthopedics
Fernanda Junqueira Cesar Pirola, Murillo Dorio, Ricardo Fuller, Jayme Fogagnolo Cobra, Lucas Peixoto Sales, Camille Pinto Figueiredo
Summary: Rheumatoid Arthritis (RA) is a chronic inflammatory disease that can cause joint damage, deformity, and functional impairment. Shoulder involvement is less common but can be underdiagnosed if not carefully analyzed, especially in uncontrolled disease. This case report presents a 70-year-old male with difficult-to-manage RA showing severe shoulder arthritis and a giant geode in the left humeral head on MRI. The striking MRI image of a giant geode in poorly controlled RA should raise suspicion of shoulder involvement for early investigation and treatment.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Review
Immunology
Ahmadreza Khoshroo, Keyvan Ramezani, Niusha Moghimi, Moein Bonakdar, Nazanin Ramezani
Summary: Rheumatoid arthritis (RA), an autoimmune disease, is associated with bone deterioration, particularly erosion of periarticular cortical bone. There is a complex interaction between inflammation and bone destruction in RA. Biological and targeted medicines have modified RA's bone metabolism. This article discusses the pathomechanisms of bone structure involved in biological and targeted treatments for RA, as well as the clinical implications of disease-modifying antirheumatic drugs (DMARDs).
INFLAMMOPHARMACOLOGY
(2023)
Review
Rheumatology
Camille P. Figueiredo, Mariana O. Perez, Lucas Peixoto Sales, Georg Schett, Rosa M. R. Pereira
Summary: This review summarizes the use of high-resolution peripheral quantitative computed tomography (HR-pQCT) for assessing the hand skeleton in inflammatory joint diseases, including a literature review on hand joint assessment and evaluation of bone changes as erosions and osteophytes in diseases like rheumatoid arthritis and psoriatic arthritis. Additionally, HR-pQCT has helped standardize measurements in these diseases.
MODERN RHEUMATOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Hong Xu, Yuemin Wang, Xiao Rong, Duan Wang, Jinwei Xie, Zeyu Huang, Weinan Zeng, Xiaoxue Fu, Jianshu Li, Zongke Zhou
Summary: A pathology-specific biomimetic multifunctional nanoplatform is synthesized for targeted therapy in rheumatoid arthritis, which effectively delivers nanoparticles to inflamed joints and inhibits inflammation and bone erosion through the synergistic effect of ROS scavenging and inhibiting inflammatory response and osteoclast differentiation.
Article
Endocrinology & Metabolism
Darja Andreev, Katerina Kachler, Georg Schett, Aline Bozec
Summary: Osteoimmunology is an interdisciplinary field that connects osteology with immunology. The interaction between innate and adaptive immune cells and cells involved in bone remodeling is particularly evident in rheumatoid arthritis (RA). RA not only causes inflammation in the joints, but also leads to bone loss and generalized osteoporosis. Current antirheumatic therapies effectively control joint inflammation and bone erosion, but the repair of existing bone lesions still presents a challenge.
Article
Pharmacology & Pharmacy
Xiang Li, Xiaonan Tang, Yufei Wang, Changwei Chai, Zhehui Zhao, Haijing Zhang, Ying Peng, Lianqiu Wu
Summary: CS-semi5 showed positive effects on collagen-induced arthritis in mice, alleviating main pathologies and reducing inflammation and bone loss through NF-kappa B deactivation.
CS-semi5 treatment decreased TNF-alpha and IL-1 beta production in activated macrophages and inhibited osteoclast differentiation from macrophages.
Therefore, CS-semi5 may effectively ameliorate symptoms of rheumatoid arthritis by modulating the immune pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Yuanyuan Ling, Jie Yang, Di Hua, Dawei Wang, Chenglei Zhao, Ling Weng, Dandan Yue, Xueting Cai, Qinghai Meng, Jiao Chen, Xiaoyan Sun, Weikang Kong, Lizhong Zhu, Peng Cao, Chunping Hu
Summary: The study found that ZhiJingSan delayed the onset of arthritis, alleviated joint inflammation, and reduced bone erosion in CIA mice. Additionally, ZJS decreased serum levels of TNF-alpha, IL-6, and reduced the number of osteoclasts, as well as the expression of MMP9 and cathepsin K in the ankle joints of CIA mice.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Manon Peran, Edem Allado, Eliane Albuisson, Marion Couderc, Paul Ornetti, Camille Roux, Julien Grosse, Isabelle Chary-Valckenaere, Damien Loeuille
Summary: Ultrasonography is a highly reproducible method for detecting bone erosion progression in patients with rheumatoid arthritis, with significant findings at the joint level in early RA patients.
EUROPEAN JOURNAL OF RADIOLOGY
(2021)
Article
Orthopedics
Balazs Juhasz, Katalin Gulyas, Agnes Horvath, Edit Vegh, Anita Pusztai, Agnes Szentpetery, Zsofia Petho, Nora Bodnar, Attila Hamar, Levente Bodoki, Harjit Pal Bhattoa, Eva Szekanecz, Katalin Hodosi, Andrea Domjan, Szilvia Szamosi, Csaba Horvath, Sandor Szanto, Gabriella Szucs, Hennie G. Raterman, Willem F. Lems, Oliver FitzGerald, Zoltan Szekanecz
Summary: BMD as determined by QCT did not change over one year of anti-TNF treatment. Disease activity, CATHK, RANKL and VITD may be associated with the effects of anti-TNF treatment on QCT BMD changes. RA and AS may differ in this respect.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Cell Biology
Supriya Murthy, Isabel Karkossa, Caroline Schmidt, Anne Hoffmann, Tobias Hagemann, Kathrin Rothe, Olga Seifert, Ulf Anderegg, Martin von Bergen, Kristin Schubert, Manuela Rossol
Summary: This study reveals the mechanism by which extracellular calcium and calciprotein particles (CPPs) induce the differentiation of monocytes into calcium-macrophages in the absence of a priming signal. This differentiation process may contribute to the pro-inflammatory macrophage response observed in the synovial membrane of rheumatoid arthritis (RA) patients.
CELL DEATH & DISEASE
(2022)
Article
Medicine, General & Internal
Paolo Simoni, Sakina Moussaddykine, Olivier Malaise, Selma Ben Mustapha, Maria Pilar Aparisi Gomez, Alessandro De Leucio
Summary: This study used computed tomography to investigate the bilateral bone erosions in patients with rheumatoid arthritis at the metatarsophalangeal joints, finding that erosions were more frequently found on the tibial side of the metatarsal heads.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Ophthalmology
Francesca Della Casa, Antonio Vitale, Silvana Guerriero, Jurgen Sota, Rolando Cimaz, Gaafar Ragab, Piero Ruscitti, Rosa Maria R. Pereira, Francesca Minoia, Emanuela Del Giudice, Giacomo Emmi, Claudia Lomater, Sara Monti, Claudia Canofari, Carla Gaggiano, Giovanni Alessio, Elisabetta Miserocchi, Alessandro Conforti, Marilia A. Dagostin, Chiara Mapelli, Maria Pia Paroli, Veronica Parretti, Valeria Albano, Rosa Favale, Luca Marelli, Mohamed Tharwat Hegazy, Paola Cipriani, Isabele P. B. Antonelli, Valeria Caggiano, Emma Aragona, Ahmed Hatem Laymouna, Gian Marco Tosi, Maria Tarsia, Marco Cattalini, Francesco La Torre, Giuseppe Lopalco, Ewa Wiesik-Szewczyk, Micol Frassi, Stefano Gentileschi, Heitor F. Giordano, Bruno Frediani, Samuel K. Shinjo, Donato Rigante, Petros P. Sfikakis, Alberto Balistreri, Mohamed A. Hussein, Rana Hussein Amin, Luca Cantarini, Claudia Fabiani
Summary: This paper introduces the design, development, and deployment of the Autoinflammatory Disease Alliance (AIDA) International Registry, which aims to provide medical services for pediatric and adult patients with non-infectious uveitis (NIU). By collecting standardized data, this registry helps generate real-world evidence and facilitates international multicenter collaborative research.
OPHTHALMOLOGY AND THERAPY
(2022)
Article
Ophthalmology
Francesca Della Casa, Antonio Vitale, Rosa Maria Pereira, Silvana Guerriero, Gaafar Ragab, Giuseppe Lopalco, Marco Cattalini, Irene Mattioli, Paola Parronchi, Maria Pia Paroli, Emanuela Del Giudice, Carla Gaggiano, Marilia A. Dagostin, Valeria Albano, Mahmoud M. Soliman, Sergio Colella, Giuseppe Nascimbeni, Jurgen Sota, Isabele P. B. Antonelli, Giovanni Alessio, Valeria Caggiano, Abdurrahman Tufan, Rana Hussein Amin, Maria Tarsia, Mahmoud Ghanema, Florenzo Iannone, Francesca Ricci, Francesco La Torre, Ewa Wiesik-Szewczyk, Edoardo Conticini, Stefano Gentileschi, Rosanna Dammacco, Rolando Cimaz, Bruno Frediani, Anna Abbruzzese, Piero Ruscitti, Gian Marco Tosi, Heitor F. Giordano, Alessandro Conforti, Alberto Balistreri, Donato Rigante, Luca Cantarini, Claudia Fabiani
Summary: This article introduces the design, methods, development and deployment of the international registry promoted by the AutoInflammatory Disease Alliance (AIDA) Network for defining and assessing patients with immune-mediated scleritis. The registry collects real-world data from patients worldwide and allows standardized data collection while ensuring data security and anonymity. It also communicates with similar registries to promote research collaboration. The registry has already involved 99 centers from 20 countries and has shown significant progress in terms of participant numbers and data collection.
OPHTHALMOLOGY AND THERAPY
(2022)
Article
Rheumatology
Carlo Scognamiglio Renner Araujo, Ana Cristina Medeiros-Ribeiro, Carla G. S. Saad, Karina Rossi Bonfiglioli, Diogo Souza Domiciano, Andrea Yukie Shimabuco, Matheus Santos Rodrigues Silva, Emily Figueiredo Neves Yuki, Sandra Gofinet Pasoto, Tatiana Pedrosa, Leonard de Vinci Kanda Kupa, Gioanna Zou, Rosa M. R. Pereira, Clovis Artur Silva, Nadia Emi Aikawa, Eloisa Bonfa
Summary: This study evaluated the effect of discontinuing methotrexate (MTX) for 2 weeks after each dose of the Sinovac-CoronaVac vaccine on immunogenicity and safety in patients with rheumatoid arthritis (RA). The results showed that the group that discontinued MTX had a higher rate of seroconversion and higher antibody titers compared to the group that continued MTX. However, there was an increased risk of flare after the second MTX withdrawal.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Rheumatology
Nadia Emi Aikawa, Leonard de Vinci Kanda Kupa, Ana Cristina Medeiros-Ribeiro, Carla Goncalves Schahin Saad, Emily Figueiredo Neves Yuki, Sandra Gofinet Pasoto, Priscila Tagliaferro Rojo, Rosa Maria Rodrigues Pereira, Samuel Katsuyuki Shinjo, Percival Degrava Sampaio-Barros, Danieli Castro Oliveira Andrade, Ari Stiel Radu Halpern, Ricardo Fuller, Fernando Henrique Carlos Souza, Lissiane Karine Noronha Guedes, Ana Paula Luppino Assad, Julio Cesar Bertacini de Moraes, Michelle Remiao Ugolini Lopes, Victor Adriano de Oliveira Martins, Lorena Betancourt, Carolina Torres Ribeiro, Lucas Peixoto Sales, Isabela Maria Bertoglio, Virginia Lucia Nazario Bonoldi, Renata Lys Pinheiro Mello, Gustavo Guimaraes Moreira Balbi, Ana Marli Christovam Sartori, Leila Antonangelo, Clovis Artur Silva, Eloisa Bonfa
Summary: This study aimed to determine the immunogenicity of the third dose of CoronaVac vaccine in patients with autoimmune rheumatic diseases (ARD) and identify factors associated with impaired response. The results showed a significant increase in antibody positivity rates after the third dose of the vaccine in ARD patients. However, certain medications may reduce immune response. These findings are important for guiding vaccination strategies in patients with ARD.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Review
Geriatrics & Gerontology
Marina Barguil Macedo, Victor Matheus Ostrovski Souza Santos, Rosa Maria Rodrigues Pereira, Ricardo Fuller
Summary: According to this study, there is a certain association between osteoarthritis and atherosclerosis and cardiovascular disease, especially in weight-bearing joints. However, the association with CV death has not reached statistical significance.
EXPERIMENTAL GERONTOLOGY
(2022)
Article
Transplantation
Priscila Ligeiro Goncalves Esper, Fernanda Guedes Rodrigues, Thalita Lima Melo, Milene Subtil Ormanji, Carlos M. Campos, Jackeline Couto Alvarenga, Valeria de Falco Caparbo, Aluizio Barbosa Carvalho, Rosa Maria Rodrigues Pereira, Ita Pfeferman Heilberg
Summary: This study investigated bone mineral density, bone microarchitecture, and biomechanical properties in young stone formers using HR-pQCT and FEA techniques. The findings showed that stone formers had lower trabecular number and higher trabecular separation, with more pronounced bone microarchitecture impairment observed in female patients.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Medicine, General & Internal
Martina Behanova, Judith Haschka, Berthold Reichardt, Hans-Peter Dimai, Heinrich Resch, Jochen Zwerina, Roland Kocijan
Summary: Pelvic fractures are increasingly common in the elderly population, with a greater increase observed in men. Pelvic fracture itself contributes to higher mortality in individuals aged 65 and above.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Lisa C. Wegener, Felix Werner, Arnd Kleyer, David Simon, Michael Uder, Rolf Janka, Siegfried Trattnig, Goetz H. Welsch, Milena L. Pachowsky
Summary: In this study, quantitative MRI techniques were used to assess the relationship between tissue changes in intervertebral discs and clinical outcomes following kyphoplasty for vertebral fractures. The results showed that lower T2 values in adjacent discs were associated with poorer physical outcomes, indicating potential for using quantitative T2 mapping as a tool for evaluating tissue degeneration and its impact on patient quality of life post-kyphoplasty.
Article
Endocrinology & Metabolism
Roland Kocijan, Theresa Stockinger, Judith Haschka, Berthold Reichardt, Heinrich Resch, Jochen Zwerina, Martina Behanova
Summary: The study found that during the COVID-19 pandemic, the average monthly prescriptions for oral bisphosphonates and SERMs decreased, while those for intravenous bisphosphonates and teriparatide increased. Although prescriptions for DMAB decreased during the first lockdown, there was a rebound in the following months.
Article
Rheumatology
Judith Haschka, David Simon, Sara Bayat, Zora Messner, Eleni Kampylafka, Filippo Fagni, Susanna Skalicky, Matthias Hackl, Heinrich Resch, Jochen Zwerina, Arnd Kleyer, Alexander Cavallaro, Michael Sticherling, Goerg Schett, Roland Kocijan, Juergen Rech
Summary: This study aimed to identify circulating miRNA signatures associated with psoriasis (PsO) and psoriatic arthritis (PsA) patients. The results show significant differences in miRNA signatures between PsA and PsO patients compared to controls, with five miRNAs being involved in bone and cartilage metabolism, suggesting a link between psoriatic inflammation and bone/cartilage changes.
Article
Medicine, General & Internal
Hannah Labinsky, Dubravka Ukalovic, Fabian Hartmann, Vanessa Runft, Andre Wichmann, Jan Jakubcik, Kira Gambel, Katharina Otani, Harriet Morf, Jule Taubmann, Filippo Fagni, Arnd Kleyer, David Simon, Georg Schett, Matthias Reichert, Johannes Knitza
Summary: This study aimed to evaluate the accuracy, effectiveness, usability, and acceptance of the Rheuma Care Manager (RCM), a clinical decision support system (CDSS) with an artificial intelligence-powered flare risk prediction tool for managing rheumatoid arthritis (RA). The RCM showed high sensitivity, specificity, and an excellent area under the receiver operating characteristic curve for flare risk prediction. The use of the RCM increased decision confidence, reduced deviations between physicians, and resulted in more treatment reductions. The usability and acceptance of the RCM were rated positively.
Article
Medicine, General & Internal
Marlene Stephan, Koray Tascilar, Melek Yalcin-Mutlu, Melanie Hagen, Judith Haschka, Michaela Reiser, Fabian Hartmann, Arnd Kleyer, Axel J. Hueber, Bernhard Manger, Camille Figueiredo, Jayme Fogagnolo Cobra, Hans-Peter Tony, Stephanie Finzel, Stefan Kleinert, Joerg Wendler, Florian Schuch, Monika Ronneberger, Martin Feuchtenberger, Martin Fleck, Karin Manger, Wolfgang Ochs, Matthias Schmitt-Haendle, Hannes Martin Lorenz, Hubert Nuesslein, Rieke Alten, Joerg Henes, Klaus Krueger, Georg Schett, Juergen Rech
Summary: Multiple studies have shown that tapering or stopping DMARDs in RA patients in sustained remission is possible, but this carries the risk of decline in physical function as the patients may relapse and face increased disease activity.
JOURNAL OF CLINICAL MEDICINE
(2023)
Letter
Rheumatology
Felipe Mendonca de Santana, Jozelio Freire de Carvalho, Natalia Spolidoro, Luiza Fuoco, Jaqueline Barros Lopes, Mariana Ortega Perez, Bruna Giusto Bunjes, Jayme Fogagnolo Cobra, Lucas Peixoto Sales, Camille Pinto Figueiredo
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2023)
Article
Medicine, General & Internal
Isabela M. Bensenor, Alessandra C. Goulart, Alexandre C. Pereira, Andre R. Brunoni, Airlane Alencar, Raul D. Santos, Marcio S. Bittencourt, Rosa W. Telles, Luciana Andrade Carneiro Machado, Sandhi Maria Barreto, Bianca de Almeida-Pititto, Carolina Porto Silva Janovsk, Jose Augusto Sgarbi, William R. Tebar, Vandrize Meneghini, Fernando Barbosa Junior, Ana Cristina de Medeiros Ribeiro, Sandra Gofinet Pasoto, Rosa Maria R. Pereira, Eloisa Bonfa, Aytan M. Sipahi, Itamar de S. Santos, Paulo A. Lotufo
Summary: This study aims to compare the incidence of subclinical atherosclerosis and cardiovascular disease (CVD) in Chronic Inflammatory Disease (CID) participants and non-diseased individuals. Using a case-cohort design and testing specific biomarkers for CID, subclinical atherosclerosis, and CVD morbimortality, the study found differences between the high-risk group and the comparison group in terms of age, gender, income, anthropometric measures, and related diseases and inflammation markers levels.
Article
Rheumatology
Walter P. Maksymowych, Nele Herregods, Nisha Varma, Arthur B. Meyers, Jennifer Stimec, Andrea S. Doria, Nikolay Tzaribachev, Tarimobo M. Otobo, Marion A. van Rossum, Joel Paschke, Stephanie Wichuk, Robert G. Lambert
Summary: This study aimed to investigate whether systematic calibration improves the scoring proficiency of JAMRIS-SIJ and whether contrast-enhancement enhances its performance. The results showed that calibrated readers achieved greater reliability in scoring specific inflammatory and structural lesions. Sensitivity and reliability for scoring inflammatory lesions were higher on fluid-sensitive sequences compared to contrast-enhanced sequences. Therefore, systematic calibration should be implemented before using JAMRIS-SIJ in clinical trials, and it is unlikely that contrast-enhanced MRI will improve the performance of this method.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2024)
Article
Rheumatology
L. van Ouwerkerk, S. A. Bergstra, T. D. Maarseveen, T. W. J. Huizinga, R. Knevel, C. F. Allaart
Summary: This study evaluated whether the initial use of glucocorticoid (GC) bridging in RA patients leads to a higher probability of long-term GC and bDMARD use. The results showed that patients who initially started GC had a higher risk of later GC use, but the risk of bDMARD use was not significantly increased.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2024)
Article
Rheumatology
ShuangHua Liu, YiMei Tan, WeiDong Huang, HongSheng Luo, BingCheng Pan, Shuan Wu
Summary: This study assessed the cardiovascular safety of zoledronic acid in the treatment of primary osteoporosis. The results showed that in women with primary osteoporosis, zoledronic acid may increase the risk of atrial fibrillation and arrhythmias, but the cardiovascular risk in men with osteoporosis is uncertain.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2024)