The unfolded protein response regulator ATF6 promotes mesodermal differentiation

Autosomal recessive cone-rod dystrophy can be caused by mutations in the ATF6 gene

(2017) Anna Skorczyk-Werner et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

ATF6 Decreases Myocardial Ischemia/Reperfusion Damage and Links ER Stress and Oxidative Stress Signaling Pathways in the HeartNovelty and Significance

(2016) Jung-Kang Jin et al.   CIRCULATION RESEARCH

Protein misfolding in the endoplasmic reticulum as a conduit to human disease

(2016) Miao Wang et al.   NATURE

Enrichr: a comprehensive gene set enrichment analysis web server 2016 update

(2016) Maxim V. Kuleshov et al.   NUCLEIC ACIDS RESEARCH

Achromatopsia mutations target sequential steps of ATF6 activation

(2016) Wei-Chieh Chiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6α branch

(2016) Ciara M Gallagher et al.   eLife

Ceapins inhibit ATF6α signaling by selectively preventing transport of ATF6α to the Golgi apparatus during ER stress

(2016) Ciara M Gallagher et al.   eLife

Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation

(2016) Lars Plate et al.   eLife

Multiple Mechanisms of Unfolded Protein Response–Induced Cell Death

(2015) Nobuhiko Hiramatsu et al.   AMERICAN JOURNAL OF PATHOLOGY

Achromatopsia

(2015) Meredith H. Remmer et al.   CURRENT OPINION IN OPHTHALMOLOGY

Mutation of ATF6 causes autosomal recessive achromatopsia

(2015) Muhammad Ansar et al.   HUMAN GENETICS

Efficient generation of endothelial cells from human pluripotent stem cells and characterization of their functional properties

(2015) Wei Song et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Deletion ofAtf6α impairs astroglial activation and enhances neuronal death following brain ischemia in mice

(2015) Akifumi Yoshikawa et al.   JOURNAL OF NEUROCHEMISTRY

Mutations in the unfolded protein response regulator ATF6 cause the cone dysfunction disorder achromatopsia

(2015) Susanne Kohl et al.   NATURE GENETICS

Efficient differentiation of human embryonic stem cells to arterial and venous endothelial cells under feeder- and serum-free conditions

(2015) Gopu Sriram et al.   Stem Cell Research & Therapy

Targeting the IRE1α/XBP1 and ATF6 Arms of the Unfolded Protein Response Enhances VEGF Blockade to Prevent Retinal and Choroidal Neovascularization

(2013) Li Liu et al.   AMERICAN JOURNAL OF PATHOLOGY

Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool

(2013) Edward Y Chen et al.   BMC BIOINFORMATICS

ATF6α/β-mediated adjustment of ER chaperone levels is essential for development of the notochord in medaka fish

(2013) Tokiro Ishikawa et al.   MOLECULAR BIOLOGY OF THE CELL

Adaptation of the central retina for high acuity vision: Cones, the fovea and the avascular zone

(2013) Jan M. Provis et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Stress-Independent Activation of XBP1s and/or ATF6 Reveals Three Functionally Diverse ER Proteostasis Environments

(2013) Matthew D. Shoulders et al.   Cell Reports

Evaluation of Normal Human Foveal Development Using Optical Coherence Tomography and Histologic Examination

(2012) Adam M. Dubis et al.   ARCHIVES OF OPHTHALMOLOGY

Atf6α-null mice are glucose intolerant due to pancreatic β-cell failure on a high-fat diet but partially resistant to diet-induced insulin resistance

(2012) Masahiro Usui et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

ATF6alpha Promotes Astroglial Activation and Neuronal Survival in a Chronic Mouse Model of Parkinson’s Disease

(2012) Koji Hashida et al.   PLoS One

Basic and Therapeutic Aspects of Angiogenesis

(2011) Michael Potente et al.   CELL

Efficient differentiation of hESCs into endothelial cells in vitro is secured by epigenetic changes

(2011) Maria A. Lagarkova et al.   CELL CYCLE

The Unfolded Protein Response Mediates Adaptation to Exercise in Skeletal Muscle through a PGC-1α/ATF6α Complex

(2011) Jun Wu et al.   Cell Metabolism

Vertebrate Unfolded Protein Response: Mammalian Signaling Pathways Are Conserved in Medaka Fish

(2011) Tokiro Ishikawa et al.   CELL STRUCTURE AND FUNCTION

BMP2 Protein Regulates Osteocalcin Expression via Runx2-mediatedAtf6Gene Transcription

(2011) Won-Gu Jang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular mechanisms and clinical applications of angiogenesis

(2011) Peter Carmeliet et al.   NATURE

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

Stepwise differentiation of human embryonic stem cells into early endoderm derivatives and their molecular characterization

(2011) Oded Kopper et al.   Stem Cell Research

Derivation of Endothelial Cells From Human Embryonic Stem Cells by Directed Differentiation

(2010) Nicole M. Kane et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The Endoplasmic Reticulum Stress Sensor, ATF6α, Protects against Neurotoxin-induced Dopaminergic Neuronal Death

(2010) Naohiro Egawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Induction of Liver Steatosis and Lipid Droplet Formation in ATF6α-Knockout Mice Burdened with Pharmacological Endoplasmic Reticulum Stress

(2010) Keisuke Yamamoto et al.   MOLECULAR BIOLOGY OF THE CELL

Transcriptional Regulation of VEGF-A by the Unfolded Protein Response Pathway

(2010) Rajarshi Ghosh et al.   PLoS One

VEGF Induces Differentiation of Functional Endothelium From Human Embryonic Stem Cells

(2009) Marilyn B. Nourse et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

ATF6  induces XBP1-independent expansion of the endoplasmic reticulum

(2009) H. Bommiasamy et al.   JOURNAL OF CELL SCIENCE

In vitro reconstitution of ER-stress induced ATF6 transport in COPII vesicles

(2009) A. J. Schindler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differentiation of Embryonic Stem Cells to Clinically Relevant Populations: Lessons from Embryonic Development

(2008) Charles E. Murry et al.   CELL