Article
Environmental Sciences
Sergi Magester, Aina Barcelona, Jordi Colomer, Teresa Serra
Summary: The study reveals that microplastics have sublethal effects on Daphnia, including decreased swimming velocity, body growth, and survival rates. Even in cases with only microplastics present, Daphnia exhibited the most serious stress.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Environmental Sciences
Katerina Savva, Marinella Farre, Carlos Barata
Summary: This study investigates the toxicity of microplastics (MPLs) from two widely used bioplastics, polylactic acid (PLA) and polyhydroxybutyrate (PHB), on the aquatic species Daphnia magna. The results show that bioplastic microplastics are more toxic than plastic additives alone and more toxic than fossil plastics.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Ik Hwan Kwon, In Young Kim, Min Beom Heo, June-Woo Park, Sang-Won Lee, Tae Geol Lee
Summary: Machine vision techniques have been applied to monitor heart rates in aquatic bioassays for cardiotoxicity assessment. A real-time heart rate monitoring system was developed for individual water fleas in this study, showing that heart rates decrease with increasing ROS levels from H2O2 exposure. Establishing a relaxation heart rate before measurements can improve the accuracy of toxicity assessment in aquatic conditions.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Ecology
Anna Farkas, David Somogyvari, Attila W. Kovacs, Maria Mortl, Andras Szekacs, Janos Gyori
Summary: This study assessed the effects of two commonly used neonicotinoid pesticides on the physiological functions and cytochrome P450 monooxygenase system of Daphnia magna. The results showed that these pesticides significantly affected the limb activity, heart rate, and ECOD activity of the organisms at doses close to their immobility thresholds.
Article
Environmental Sciences
Marina Bellot, Melissa Faria, Cristian Gomez-Canela, Demetrio Raldua, Carlos Barata
Summary: This study assessed the effects of the MAO inhibitor deprenyl on Daphnia magna locomotor activity and determined its mechanisms of action. Results showed that deprenyl exposure inhibited MAO activity and increased neurotransmitter levels, leading to changes in behavioral outcomes. It was concluded that Daphnia magna is a sensitive nonvertebrate model for assessing the effects of short-term exposure to chemicals affecting monoamine signaling.
Article
Environmental Sciences
Marina Bellot, Cristian Gomez-Canela, Carlos Barata
Summary: Animal behavioural responses are increasingly used in environmental risk assessment, but the lack of standardization remains a challenge. This study aimed to test the use of a horizontal multi-well plate maze set up to assess phototactic fish induced responses in D. magna. The results suggest that this method could provide a simple and efficient way to evaluate phototactic behavior in D. magna and potentially other species.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Environmental Sciences
Marina Bellot, Carlos Barata, Cristian Gomez-Canela
Summary: The study evaluated the stability of 17 neuroactive compounds in water and found that most compounds did not degrade, except for apomorphine and 6-hydroxydopamine which degraded completely within 24 hours. Most compounds altered motile responses to light in the crustacean Daphnia magna.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Environmental Sciences
Eun Hye Kim, Ju An Jeong, Eun Kyong Choi, Tae-Yong Jeong
Summary: This study investigated the impact of stress on body length measurement conditions while maintaining Daphnia magna on a slide glass, and validated the shed carapace length as a reflection of body length for potential applications in sublethal effect measurement.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Environmental Sciences
Jin J. Li, Min J. Dai, Jun Z. Xue
Summary: Exposure to disinfection by-products (DBPs) can induce toxic effects in aquatic organisms. This study aimed to investigate the toxicity mechanism of DBPs on Daphnia magna. Results showed that aliphatic DBPs with more bromine substituents had lower toxicity, while aromatic DBPs had higher toxicity. The activities of oxidative stress enzymes CAT and SOD in D. magna showed low correlation with concentration under compound stress, while MDA levels showed a positive correlation. Molecular docking simulations have potential in predicting the toxicity and understanding the mechanism of DBPs. Therefore, it is important to regulate the presence of aromatic DBPs due to their pronounced toxic effects on D. magna.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Review
Environmental Sciences
Angelika Tkaczyk, Adam Bownik, Jaroslaw Dudka, Krzysztof Kowal, Brygida Slaska
Summary: Daphnia magna is commonly used to assess the toxicity of pharmaceuticals, with tests based on immobilisation and lethality standardised by OECD. Analysis of behavioral and physiological parameters can reveal sublethal effects induced by lower concentrations of pharmaceuticals.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Environmental Sciences
Aleksandra Szabelak, Adam Bownik
Summary: The study found that different concentrations of salicylic acid exposure to Daphnia magna resulted in changes in their behavior and physiological endpoints, with behavioral and physiological disturbances observed earlier than lethality.
Article
Biophysics
Ping Shi, Anan Li, Liang Wu, Hongliu Yu
Summary: The objective of this study was to investigate whether passive lower limb training led to alternation in heart rate asymmetry (HRA). The results showed significant changes in normalized HRA during the training trials, and some non-normalized HRA variables were correlated with heart rate variability parameters. These findings suggest that HRA may be useful for assessing cardiovascular modulation during passive lower limb training.
PHYSIOLOGICAL MEASUREMENT
(2022)
Article
Public, Environmental & Occupational Health
Giampiero Merati, Matteo Bonato, Luca Agnello, Dorothee Grevers, Hanns-Christian Gunga, Stefan Mendt, Martina Anna Maggioni
Summary: Research on occupational disorders among sports instructors, specifically those who practice continuously while teaching, is limited. This study evaluated the occupational disorders, cardiorespiratory fitness, and daily workload of fitness and swimming instructors. Fitness instructors showed a higher prevalence of musculoskeletal injuries, while swimming instructors experienced more upper respiratory tract infections. Cardiorespiratory fitness levels were similar for both groups, although female swimming instructors had higher heart rates during work compared to female fitness instructors.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Chemistry, Analytical
Youngsam Kim, Afshin Samadi, Eun Gwag, Jayoung Park, Minjeong Kwak, Jihoon Park, Tae Lee, Young Kim
Summary: The study found that silicon dioxide nanoparticles had negative effects on the heart rate, swimming distance, and body size of the water flea D. magna, while not showing acute or chronic toxicity at limited concentrations. Although exposure to SiO2 NPs seemed to affect cardiac and swimming performance, such endpoint experiments may not be sufficient to fully understand the toxicity of these nanoparticles.
Article
Physiology
Olivier Castagna, Jean-Eric Blatteau, Arnaud Druelle, Jordan Amara, Jean-Rene Lacour
Summary: During military fin swimming, oxygen uptake and pulmonary ventilation may be higher than expected. This study compared these variables in trained military divers during land cycling and snorkeling exercises. The results showed that surface immersion did not significantly reduce the VO2max in trained divers relative to land conditions.
FRONTIERS IN PHYSIOLOGY
(2023)
Review
Environmental Sciences
Angelika Tkaczyk, Adam Bownik, Jaroslaw Dudka, Krzysztof Kowal, Brygida Slaska
Summary: Daphnia magna is commonly used to assess the toxicity of pharmaceuticals, with tests based on immobilisation and lethality standardised by OECD. Analysis of behavioral and physiological parameters can reveal sublethal effects induced by lower concentrations of pharmaceuticals.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Environmental Sciences
Adam Bownik, Aleksandra Szabelak
Summary: The study aimed to determine the short-term effects of FIP on Daphnia magna, showing that FIP induced reduction of swimming speed and distance traveled in a concentration- and time-dependent manner at all the concentrations used. The results indicate that behavioral and physiological endpoints of Daphnia magna are reliable and valuable sublethal indicators of toxic alterations induced by FIP.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Biology
Aleksandra Szabelak, Adam Bownik, Sebastian Knaga, Kornel Kasperek
Summary: The study found that L-proline has protective effects on heat-stressed hen erythrocytes, with the specific effects depending on the concentration and temperature of the amino acid. L-proline may exert thermoprotective effects on some parameters in hen erythrocytes by stimulating HSP70 1A activity and antioxidative defense.
JOURNAL OF THERMAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Kamila P. Liput, Adam Lepczynski, Magdalena Ogluszka, Agata Nawrocka, Ewa Polawska, Agata Grzesiak, Brygida Slaska, Chandra S. Pareek, Urszula Czarnik, Mariusz Pierzchala
Summary: It is recommended to reduce saturated fatty acids (SFA) and increase polyunsaturated fatty acids (PUFAs) n-3 and n-6 in the diet to lower the risk of metabolic disorders. Western-type diet often contains excessive n-6 PUFAs and a high n-6/n-3 ratio. Oxylipins derived from n-3 and n-6 PUFAs play a role in inflammation, while PUFAs have varying effects on cell growth, proliferation, and neoplastic lesion progression, as observed in in vitro studies, animal models, and epidemiological studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Environmental Sciences
Adam Bownik, Donald Wlodkowic
Summary: Despite increasing evidence of ecological risks, the understanding of the eco-neurotoxic impact of most industrially relevant chemicals remains limited. Studies on the acute and chronic exposures to industrial pollutants on nervous systems and ecological fitness alterations are lacking. There is a need to shift towards higher throughput testing models for assessing eco-neurotoxic risks associated with industrial pollutants due to a backlog in risk assessments.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Pharmacology & Pharmacy
Barbara Pawlik-Skowronska, Adam Bownik
Summary: The study showed that AN-B exhibited significant toxicity towards Daphnia, similar to MC-LR and MC-LF. The mixture of AN-B and MC-LR was found to be more toxic than individual oligopeptides. This suggests that cyanobacterial extracts containing a combination of AN-B and microcystins may pose a greater threat to aquatic organisms than individual microcystins.
Article
Veterinary Sciences
Krzysztof Kowal, Angelika Tkaczyk-Wlizlo, Mariusz Pierzchala, Jan Gawor, Brygida Slaska
Summary: This study aimed to determine molecular defects in mitochondrial DNA in malignant canine mammary gland tumors through large-scale genome analysis. Various mutations and polymorphisms were identified, with different genes showing different levels of variability. Some mutations were observed to have deleterious effects on protein function, potentially influencing the carcinogenesis process.
VETERINARY AND COMPARATIVE ONCOLOGY
(2022)
Review
Environmental Sciences
Adam Bownik, Donald Wlodkowic
Summary: Monitoring freshwater quality and potential contamination is crucial for human health and aquatic ecosystems. Although advancements have been made in automated sampling and continuous analysis of water parameters, real-time warning capabilities for unknown chemical mixtures are limited. Biological early warning systems offer sensitive and integrative water quality sensing by continuously monitoring behavioral and physiological parameters of aquatic species.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Pharmacology & Pharmacy
Barbara Pawlik-Skowronska, Adam Bownik
Summary: This study investigated the effects of anabaenopeptins and microcystins on the physiology of Daphnia magna. The results showed that MC-LF was the most potent inhibitor, while AN-B and MC-LR had varying degrees of inhibition on different physiological parameters. The binary mixture of AN-B and MC-LR exhibited the strongest toxic effects, providing the first direct evidence of synergistic toxic effects of cyanopeptides on physiological parameters in Daphnia magna.
Review
Environmental Sciences
Donald Wlodkowic, Adam Bownik, Carola Leitner, Daniel Stengel, Thomas Braunbeck
Summary: In recent years, there has been increased awareness of the impact of anthropogenic pollution on the behavior of aquatic organisms. Behavioral ecotoxicology and eco-neurotoxicology have become popular fields of research, but there is still a lack of understanding in the underlying mechanisms of behavioral alterations. This article discusses the importance of behavioral phenotyping in uncovering the fundamental mechanisms of neurotoxic and neuromodulating contaminants, and highlights the potential applications of neurobiology and neurophysiology analytical strategies.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Biochemistry & Molecular Biology
Paulina Kozakiewicz, Ludmila Grzybowska-Szatkowska, Marzanna Ciesielka, Paulina Calka, Jacek Osuchowski, Pawel Szmygin, Bozena Jarosz, Brygida Slaska
Summary: Mitochondrial DNA changes can affect the likelihood of cancer. This study investigated the relationship between brain gliomas and specific mitochondrial DNA polymorphisms and mutations. The results suggest that certain mitochondrial genetic variants may be involved in the development of brain tumors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Environmental
Adam Bownik, Malgorzata Adamczuk, Barbara Pawlik-Skowronska
Summary: Aquatic animals are exposed to cyanobacterial products released into the environment, but little is known about the toxicity and mechanisms of behavioral toxicity in zooplanktonic organisms. This study assessed the effects of single and mixed cyanobacterial oligopeptides on a model rotifer. The results showed that these oligopeptides inhibited various endpoints and the mixtures had synergistic effects on swimming speed and cytotoxicity.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Environmental Sciences
Adam Bownik, Ma lgorzata Adamczuk, Barbara Pawlik Skowronska, Tomasz Mieczan
Summary: This study examined the effects of cyanobacterial metabolites on the behavior and physiological parameters of Daphnia magna. It was found that some metabolites had lethal effects, while others inhibited swimming speed and influenced physiological endpoints. The mixture of metabolites showed different effects and interactions. These findings suggest that cyanobacterial metabolites can affect swimming behavior and physiological parameters, and their mixtures may have varying total effects.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Adam Bownik, Malgorzata Adamczuk, Barbara Pawlik Skowronska
Summary: The aim of this study was to investigate the effects of different cyanobacterial metabolites and their mixtures on Daphnia magna, particularly on their survival and oxidative stress biomarkers. The results indicated that oligopeptides did not affect daphnid survival, while cylindrospermopsin (CYL) showed inhibitory effects with synergistic interactions. The mixtures of metabolites generally reduced the level of total glutathione (GSH), but the interactions between metabolites were mostly antagonistic. The activities of catalase (CAT) and superoxide dismutase (SOD) were influenced differently by the mixtures, with CAT showing slightly increased activity and SOD showing both increased and decreased activity in response to different mixtures.
Article
Agriculture, Dairy & Animal Science
Marek Babicz, Marcin Pastwa, Magdalena Szyndler-Nedza, Anna Kozubska-Sobocinska, Barbara Danielak-Czech, Kinga Kropiwiec-Domanska, Ewa Skrzypczak, Brygida Slaska, Damian Kapusta
Summary: In this study, the associations between gene polymorphisms and reproductive traits in native Pulawska gilts were investigated. The results showed that mutations in PRL and PRLR genes were associated with farrowing duration and timing of estrus signs, while PTGS2 and FUT1 gene variations showed no significant correlations with sexual and periparturient activity in the gilts. This research expands the understanding of the genetic structure and productivity of Pulawska gilts.
ANNALS OF ANIMAL SCIENCE
(2021)
Article
Environmental Sciences
Toshimi Nakajima, Mao Kuragano, Makoto Yamada, Ryo Sugimoto
Summary: This study compared the contribution of submarine groundwater discharge (SGD) to river nutrient budgets at nearshore and embayment scales, and found that SGD-derived nutrients become more important at larger spatial scales.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Fan Liu, Lei Zhang, Chongyang Zhang, Ziguang Chen, Jingguang Li
Summary: NO2 emissions from wall-mounted gas stoves used for household heating have become a significant source of indoor pollution in Chinese urban areas. The high indoor concentration of NO2 poses potential health risks to residents. It is urgently necessary to establish relevant regulations and implement emission reduction technologies to reduce NO2 emissions from wall-mounted gas stoves.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Letter
Environmental Sciences
Hans Peter H. Arp, Raoul Wolf, Sarah E. Hale, Sivani Baskaran, Juliane Gluege, Martin Scheringer, Xenia Trier, Ian T. Cousins, Harrie Timmer, Roberta Hofman-Caris, Anna Lennquist, Andre D. Bannink, Gerard J. Stroomberg, Rosa M. A. Sjerps, Rosa Montes, Rosario Rodil, Jose Benito Quintana, Daniel Zahn, Herve Gallard, Tobias Mohr, Ivo Schliebner, Michael Neumann
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Philomina Onyedikachi Peter, Binessi Edouard Ifon, Francois Nkinahamira, Kayode Hassan Lasisi, Jiangwei Li, Anyi Hu, Chang-Ping Yu
Summary: This study investigates the relationship between dissolved organic matter (DOM) and Rare Earth Elements (REEs) in sediments from Yundang Lagoon, China. The results show four distinct fluorescent components, with protein-like substances being the most prevalent. Additionally, the total fluorescence intensity and LREE concentrations exhibit a synchronized increase from Outer to Inner to Songbai Lake core sediments. The findings demonstrate a strong correlation between DOM content and pollution levels.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Surya Gupta, Pasquale Borrelli, Panos Panagos, Christine Alewell
Summary: The objective of this study is to incorporate soil hydraulic properties into the erodibility factor (K) of USLE-type models. By modifying and improving the existing equations for soil texture and permeability, the study successfully included information on saturated hydraulic conductivity (Ksat) into the calculation of K factor. Using the Random Forest machine learning algorithm, two independent K factor maps with different spatial resolutions were generated. The results show that the decrease in K factor values has a positive impact on the modeling of soil erosion rates.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Jesmin Akter, Wendy J. M. Smith, Yawen Liu, Ilho Kim, Stuart L. Simpson, Phong Thai, Asja Korajkic, Warish Ahmed
Summary: The choice of workflow in wastewater surveillance has a significant impact on SARS-CoV-2 concentrations, while having minimal effects on HF183 and no effect on HAdV 40/41 concentrations. Certain components in the workflow can be interchangeable, but factors such as buffer type, chloroform, and homogenization speed can affect the recovery of viruses and bacteria.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Yu Luo, Xueting Yang, Diwei Wang, Hongmei Xu, Hongai Zhang, Shasha Huang, Qiyuan Wang, Ningning Zhang, Junji Cao, Zhenxing Shen
Summary: Atmospheric PM2.5, which can generate reactive oxygen species (ROS), is associated with cardiorespiratory morbidity and mortality. The study found that both the mass concentration of PM2.5 and the DTT activity were higher during the heating season than during the nonheating season. Combustion sources were the primary contributors to DTT activity during the heating season, while secondary formation dominated during the nonheating season. The study also revealed that biomass burning had the highest inherent oxidation potential among all sources investigated.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Erin L. Murphy, Leah R. Gerber, Chelsea M. Rochman, Beth Polidoro
Summary: Plastic pollution has devastating consequences for marine organisms. This study uses a trait-based framework to develop a vulnerability index for marine mammals, seabirds, and sea turtles in Hawai'i. The index ranks 63 study species based on their vulnerability to macroplastic pollution, providing valuable information for species monitoring and management priorities.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Kenji Maurice, Amelia Bourceret, Sami Youssef, Stephane Boivin, Liam Laurent-Webb, Coraline Damasio, Hassan Boukcim, Marc-Andre Selosse, Marc Ducousso
Summary: Growing pressure from climate change and agricultural land use is destabilizing soil microbial community interactions. Little is known about microbial community resistance and adaptation to disturbances, hindering our understanding of recovery latency and implications for ecosystem functioning. This study found that anthropic disturbance and natural disturbance have different effects on the topology and stability of soil microbial networks.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Yunhao Li, Yali Feng, Haoran Li, Yisong Yao, Chenglong Xu, Jinrong Ju, Ruiyu Ma, Haoyu Wang, Shiwei Jiang
Summary: Deep-sea mining poses a serious threat to marine ecosystems and human health by disturbing sediment and transmitting metal ions through the food chain. This study developed a new regenerative adsorption material, OMN@SA, which effectively removes metal ions. The adsorption mechanism and performance of the material for metal ion fixation were investigated.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Antonio Medici, Margherita Lavorgna, Marina Isidori, Chiara Russo, Elena Orlo, Giovanni Luongo, Giovanni Di Fabio, Armando Zarrelli
Summary: Valsartan, a widely used antihypertensive drug, has been detected in high concentrations in surface waters due to its unchanged excretion and incomplete degradation in wastewater treatment plants. This study investigated the degradation of valsartan and identified 14 degradation byproducts. The acute and chronic toxicity of these byproducts were evaluated in key organisms in the freshwater trophic chain.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Jiang Lin, Lianbao Chi, Qing Yuan, Busu Li, Mingbao Feng
Summary: This study investigated the photodegradation behavior and product formation of two representative pharmaceuticals in simulated estuary water. The study found that the formed transformation products of these pharmaceuticals have potential toxicity on marine organisms, including oxidative stress and damage to cellular components.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Hua Fang, Dongdong Jiang, Ye He, Siyi Wu, Yuehong Li, Ziqi Zhang, Haoting Chen, Zixin Zheng, Yan Sun, Wenxiang Wang
Summary: This study revealed that exposure to lower levels of air pollutants led to decreased pregnancy rates, with PM10, NO2, SO2, and CO emerging as the four most prominent pollutants. Individuals aged 35 and above exhibited heightened susceptibility to pollutants.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Ali Shaan Manzoor Ghumman, Rashid Shamsuddin, Amin Abbasi, Mohaira Ahmad, Yoshiaki Yoshida, Abdul Sami, Hamad Almohamadi
Summary: In this study, inverse vulcanized polysulfides (IVP) were synthesized by reacting molten sulfur with 4-vinyl benzyl chloride, and then functionalized using N-methyl D-glucamine (NMDG). The functionalized IVP showed a high mercury adsorption capacity and a machine learning model was developed to predict the amount of mercury removed. Furthermore, the functionalized IVP can be regenerated and reused, providing a sustainable and cost-effective adsorbent.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Rita Bonfiglio, Renata Sisto, Stefano Casciardi, Valeria Palumbo, Maria Paola Scioli, Erica Giacobbi, Francesca Servadei, Gerry Melino, Alessandro Mauriello, Manuel Scimeca
Summary: This study investigated the presence of aluminum in human colon cancer samples and its potential association with biological processes involved in cancer progression. Aluminum was found in tumor areas of 24% of patients and was associated with epithelial to mesenchymal transition (EMT) and cell death. Additional analyses revealed higher tumor mutational burden and mutations in genes related to EMT and apoptosis in aluminum-positive colon cancers. Understanding the molecular mechanisms of aluminum toxicity may improve strategies for the management of colon cancer patients.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
