Review
Environmental Sciences
Valentin Tastet, Marc Le Vee, Arnaud Bruyere, Olivier Fardel
Summary: Human membrane drug transporters interact with chemical additives present in plastics, which can affect the toxicokinetics and toxicity of these pollutants. In vitro assays have shown that various plastic additives can inhibit the activities of drug transporters. The low concentration of plastic additives from environmental or dietary exposure is an important factor to consider for their in vivo relevance.
ENVIRONMENTAL POLLUTION
(2023)
Article
Engineering, Environmental
Ross M. Warner, Lisa M. Sweeney, Brett A. Hayhurst, Michael L. Mayo
Summary: This study proposes an improved toxicokinetic modeling approach to describe the relationship between internal dose and toxicity endpoints in early development zebrafish exposed to PFAS. The study identifies the dynamic volume and hatching of zebrafish as two important physiological transformation phenomena and explores two different modeling strategies to describe mass transfer.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Hao Zhang, Ruijuan Ye, Yuguang Mu, Tianhu Li, Huaqiang Zeng
Summary: This novel class of cation transporters has a simple structure, efficiently and selectively moving K+ ions across cell membranes, while also showing potential anticancer activities.
Review
Biochemistry & Molecular Biology
Michiko Yamashita, Udo R. Markert
Summary: This review summarizes the current knowledge of drug transporters in the human placenta, emphasizing the importance for the health of pregnant women and their fetuses in need of drug treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Jie Shen, Joan Jia Ying Han, Ruijuan Ye, Huaqiang Zeng
Summary: These unconventional ion transporters, molecular rotors, transport ions through a rotating function instead of traditional carrier or channel mechanisms. They consist of a membrane-anchoring stator, a crown ether-containing rotator for ion binding and transport, and a triple bond-based axle allowing rotation. Lipid bilayer experiments show their high efficiency in promoting transmembrane K+ flux, with variations in ion-binding unit and rotator's length affecting activity levels up to 174%.
SCIENCE CHINA-CHEMISTRY
(2021)
Review
Environmental Sciences
Dominika Gadarowska, Joanna Kalka, Anna Daniel-Wojcik, Inga Mrzyk
Summary: This review article discusses the definition of skin sensitization and its importance in chemical hazard and risk assessments. It highlights the shift from using animal testing to alternative methods for identifying skin-sensitizing chemicals. The article reviews the current methods corresponding to each key event in skin sensitization and explores the latest trends in their development and modification.
Article
Chemistry, Multidisciplinary
Haowen Ma, Ruijuan Ye, Lei Jin, Shaoyuan Zhou, Changliang Ren, Haisheng Ren, Jie Shen, Huaqiang Zeng
Summary: This study demonstrates a novel approach to enhance ion transport selectivity and activity in artificial ion channels by applying steric code-based social self-sorting. The use of sterically bulky groups and side chain tuning results in the formation of highly active hetero-oligomeric ion channels with improved selectivity.
CHINESE CHEMICAL LETTERS
(2023)
Article
Biochemical Research Methods
Francisco Zafra, Dolores Piniella
Summary: Membrane proteins play important roles in controlling cellular traffic and transmitting signals across the membrane. Interactions between membrane proteins and other cellular components form complex networks that regulate biological functions. Traditional methods for studying these interactomes may cause loss of components and non-native interactions. Proximity labelling techniques provide an alternative approach to identify interactors in a native cellular environment. This article reviews recent advances in proximity labelling for characterizing membrane interactomes.
JOURNAL OF PROTEOMICS
(2022)
Article
Biochemistry & Molecular Biology
Solveig G. Schmidt, Ulrik Gether, Claus J. Loland
Summary: Sodium-coupled neurotransmitter transporters are important in terminating synaptic neurotransmission, and research into their molecular transport mechanisms has been enlightening. Despite their structural differences, studies on neurotransmitter: sodium symporters and excitatory amino acid transporters are crucial in understanding their ion-dependence and transport kinetics. Single-molecule studies have been instrumental in expanding the understanding of protein-level transport across membranes.
NEUROCHEMICAL RESEARCH
(2022)
Article
Plant Sciences
S. Antony Ceasar
Summary: Foxtail millet, a fully annotated C4 model cereal, has genomic resources that are helpful in understanding and improving nutrient transport in other cereals.
PLANT GROWTH REGULATION
(2023)
Article
Chemistry, Physical
Alex Berlaga, Anatoly B. Kolomeisky
Summary: Antiporters are membrane channel proteins that play a vital role in biological cell functioning by moving species against their concentration gradients. Research indicates that additional kinetic constraints, rather than just thermodynamics, govern the functioning of antiporters, and optimal operating conditions have been discussed for their efficiency. This theoretical analysis sheds light on important aspects of biological membrane transport mechanisms.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2021)
Article
Biodiversity Conservation
Bruno D. Suarez-Tangil, Alejandro Rodriguez
Summary: Reliably assessing the occurrence of medium- and large-sized mammals is necessary to understand their response to rapid environmental changes. Active detection methods, such as track surveys and scat surveys, were found to be more effective than passive detection methods (camera traps and scent stations) for monitoring mammal occurrence.
ECOLOGICAL INDICATORS
(2021)
Article
Chemistry, Multidisciplinary
Y. Anne Pak, Maria M. M. Posada, James Bacon, Amanda Long, William Annes, Jennifer Witcher, Malcolm Mitchell, Rommel G. G. Tirona, Stephen D. D. Hall, Kathleen M. M. Hillgren
Summary: The objective of this work was to demonstrate that clinical OAT1-mediated drug-drug interactions (DDIs) can be predicted using physiologically based pharmacokinetic (PBPK) modeling. The study shows that by measuring the inhibitory potency (IC50) of OAT inhibitors and conducting clinical DDI studies, PBPK modeling can accurately predict the occurrence and clinical effects of DDIs.
PHARMACEUTICAL RESEARCH
(2023)
Article
Computer Science, Artificial Intelligence
Philipp Werner, Daniel Lopez-Martinez, Steffen Walter, Ayoub Al-Hamadi, Sascha Gruss, Rosalind W. Picard
Summary: This paper assesses the current state of pain recognition technology and provides guidance for researchers. It provides an overview of pain's mechanisms, responses, and assessment methods, discusses challenges in technology development, and surveys existing datasets and evaluation methods. The paper then summarizes the latest advances in automated pain recognition, highlighting different approaches and tools used, as well as the challenges faced. It also identifies underexplored areas and promising opportunities for future advancements.
IEEE TRANSACTIONS ON AFFECTIVE COMPUTING
(2022)
Article
Chemistry, Physical
Alex Berlaga, Anatoly B. Kolomeisky
Summary: This article investigates the molecular translocation mechanisms of antiporters and symporters in cellular membrane channels, and discovers that despite the differing transport flux directions, their molecular mechanisms are drastically different. The authors propose chemical-kinetic models to explain this phenomenon, and find that antiporters primarily utilize single-site transportation for translocation, while symporters require simultaneous association of two different molecules for translocation.
JOURNAL OF CHEMICAL PHYSICS
(2022)
Article
Pharmacology & Pharmacy
Daniel Hoer, Hugh A. Barton, Alicia Paini, Michael Bartels, Brandall Ingle, Jeanne Domoradzki, Jeffrey Fisher, Michelle Embry, Philip Villanueva, David Miller, James Nguyen, Qiang Zhang, Stephen W. Edwards, Yu-Mei Tan
Summary: The internal concentration of environmental chemicals has a closer relationship with toxicological response than the external concentration. The methods of absorption, distribution, metabolism, and excretion determine the quantitative relationship between the two concentrations, and these processes can be saturated at high concentrations, resulting in non-linear changes. By using PBPK models, researchers can explore the influence of saturation on the relationship between internal and external concentrations, and also investigate the impact of different factors on this relationship.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Laure-Alix Clerbaux, Nuria Amigo, Maria Joao Amorim, Anna Bal-Price, Sofia Batista Leite, Anna Beronius, Gillina F. G. Bezemer, Ann-Charlotte Bostroem, Annamaria Carusi, Sandra Coecke, Rachel Concha, Evangelos P. Daskalopoulos, Francesca Debernardi, Eizleayne Edrosa, Steve W. Edwards, Julija Filipovska, Natalia Garcia-Reyero, Felicity N. E. Gavins, Sabina Halappanavar, Alan J. Hargreaves, Helena T. Hogberg, Mylene T. Huynh, Daniel Jacobson, Jonathan Josephs-Spaulding, Young Jun Kim, Hyun Joon Kong, Catharine E. Krebs, Ann Lam, Brigitte Landesmann, Adrienne Racanelli Layton, Yong Oh Lee, Donna S. Macmillan, Alberto Mantovani, Luigi Margiotta-Casaluci, Marvin Martens, Rosalinde Masereeuw, Sally A. Mayasich, Liang Merlin Mei, Holly Mortensen, Amalia Munoz, Penny Nymark, Elan Ohayon, Joshi Manoj Ojasi, Alicia Paini, Nikolaos Parissis, Surat Parvatam, Francesca Pistollato, Magdalini Sachana, Jorid Birkelund Sorli, Kristie M. Sullivan, Jukka Sund, Shihori Tanabe, Katya Tsaioun, Mathieu Vinken, Laura Viviani, Jennifer Waspe, Catherine Willett, Clemens Wittwehr
Summary: The CIAO project aims to build a comprehensive understanding of COVID-19 using the Adverse Outcome Pathway (AOP) framework. The workshop discussed the established Key Events (KEs) and AOPs, as well as factors influencing disease progression and severity. It was decided to consolidate the AOPs/KEs and expand the CIAO scientific crowd through outreach campaigns.
ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION
(2022)
Article
Pharmacology & Pharmacy
George Loizou, Kevin McNally, Alicia Paini, Alex Hogg
Summary: A computational workflow integrating PBK modelling, GSA, ABC, MCMC simulation and VCBA was developed for the estimation of chemical concentration in a reaction medium. The workflow was tested using a human PBK model and in vitro concentration-response data from the ToxCast/Tox21 database.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Reproductive Biology
Francesca Pistollato, Mauro Petrillo, Laure-Alix Clerbaux, Gabriele Leoni, Jessica Ponti, Alessia Bogni, Carlo Brogna, Simone Cristoni, Remo Sanges, Emilio Mendoza-De Gyves, Marco Fabbri, Maddalena Querci, Helena Soares, Amalia Munoz, Maurice Whelan, Guy Van De Eede
Summary: The potential neurodevelopmental consequences of SARS-CoV-2 infection are currently unknown, but it is hypothesized that in utero exposure to the virus could disrupt brain development in children. Spike protein and toxin-like peptides found in COVID-19 patients may perturb the expression of genes critical for brain development, and exposure to spike protein could decrease spontaneous electrical activity in differentiated neural cells.
REPRODUCTIVE TOXICOLOGY
(2022)
Review
Medicine, General & Internal
Laure-Alix Clerbaux, Maria Cristina Albertini, Nuria Amigo, Anna Beronius, Gillina F. G. Bezemer, Sandra Coecke, Evangelos P. Daskalopoulos, Giusy del Giudice, Dario Greco, Lucia Grenga, Alberto Mantovani, Amalia Munoz, Elma Omeragic, Nikolaos Parissis, Mauro Petrillo, Laura A. Saarimaki, Helena Soares, Kristie Sullivan, Brigitte Landesmann
Summary: This article utilizes the Adverse Outcome Pathway (AOP) framework to describe how eleven selected factors influence COVID-19 and its underlying mechanisms. The approach helps identify knowledge gaps for further research and proposes biomarkers for high-risk patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, Legal
Carl Westmoreland, Hans J. Bender, John E. Doe, Miriam N. Jacobs, George E. N. Kass, Federica Madia, Catherine Mahony, Irene Manou, Gavin Maxwell, Pilar Prieto, Rob Roggeband, Tomasz Sobanski, Katrin Schutte, Andrew P. Worth, Zvonimir Zvonar, Mark T. D. Cronin
Summary: New Approach Methodologies (NAMs) include in vitro, in silico, or chemistry-based methods that can provide information for chemical safety assessment. The European Union's current chemical legislation has limitations on the widespread use of NAMs, although some are considered suitable for regulatory purposes. A workshop identified key points to increase the use and regulatory acceptance of NAMs, such as changes in regulatory frameworks, education, training, stakeholder engagement, and addressing gaps in the scientific basis of NAMs.
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2022)
Article
Medicine, Legal
Mark T. D. Cronin, Franklin J. Bauer, Mark Bonnell, Bruno Campos, David J. Ebbrell, James W. Firman, Steve Gutsell, Geoff Hodges, Grace Patlewicz, Maria Sapounidou, Nicoleta Spinu, Paul C. Thomas, Andrew P. Worth
Summary: Structure-activity relationships (SARs) are important in in silico toxicology, and this study proposes twelve criteria to assess the confidence associated with structural alerts. The criteria include purpose, chemistry, toxicology, mechanism, performance, and coverage. The evaluation scheme can be applied to various industrial and regulatory applications.
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2022)
Review
Medicine, General & Internal
Laure-Alix Clerbaux, Julija Fillipovska, Amalia Munoz, Mauro Petrillo, Sandra Coecke, Maria-Joao Amorim, Lucia Grenga
Summary: This study outlines three potential mechanistic pathways leading to gut dysbiosis as a result of SARS-CoV-2 presence in the gastrointestinal tract: intestinal infection inducing inflammation, dysregulation of the ACE2 receptor linked to viral S protein binding, and direct infection of intestinal bacteria by SARS-CoV-2. Evaluating the current evidence within the Adverse Outcome Pathway framework supports disease management and highlights inconsistencies and knowledge gaps for further research.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Medicine, General & Internal
Laure-Alix Clerbaux, Sally A. Mayasich, Amalia Munoz, Helena Soares, Mauro Petrillo, Maria Cristina Albertini, Nicolas Lanthier, Lucia Grenga, Maria-Joao Amorim
Summary: This article discusses the potential alternative entry route of SARS-CoV-2 through the gut and analyzes its possible mechanisms and adverse effects on the gastrointestinal tract. The study highlights the importance of understanding the impact of the GI tract on COVID-19 for disease management and the discovery of new treatment approaches.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Cell Biology
Helena T. Hogberg, Ann Lam, Elan Ohayon, Muhammad Ali Shahbaz, Laure-Alix Clerbaux, Anna Bal-Price, Sandra Coecke, Rachel Concha, Francesca De Bernardi, Eizleayne Edrosa, Alan J. Hargreaves, Katja M. Kanninen, Amalia Munoz, Francesca Pistollato, Surat Saravanan, Natalia Garcia-Reyero, Clemens Wittwehr, Magdalini Sachana
Summary: This review organizes available knowledge on the neurobiological mechanisms of COVID-19, identifies four AOPs leading to neurological adverse outcomes, and discusses factors influencing the impact of COVID-19 on neurological AOPs. The use of the AOP framework helps visualize core pathways and shared mechanisms.
Article
Environmental Sciences
Kyeonghee Monica Lee, Richard Corley, Annie M. Jarabek, Nicole Kleinstreuer, Alicia Paini, Andreas O. Stucki, Shannon Bell
Summary: New approach methodologies (NAMs) are emerging chemical safety assessment tools aimed at reducing, refining, or replacing traditional animal testing methods. This paper summarizes the highlights of a symposium that discussed the application of NAMs in evaluating potentially reduced-risk tobacco products.
Article
Gastroenterology & Hepatology
Laure-Alix Clerbaux, Pierre Cordier, Nina Desboeufs, Kristian Unger, Peter Leary, Gabriel Semere, Yannick Boege, Lap Kwan Chan, Chantal Desdouets, Massimo Lopes, Achim Weber
Summary: This study reveals the non-apoptotic effects of Mcl-1 deficiency on nuclear ploidy, mitotic regulation, and chromosomal segregation in hepatocytes in vivo. Furthermore, it shows that Mcl-1 deficiency leads to chromosomal instability and a mutational signature potentially reflecting mitotic issues in hepatocellular tumors. These findings have implications for the development of anti-Mcl-1 therapies to treat hepatocellular carcinoma.
Article
Biochemistry & Molecular Biology
Francesco Pappalardo, Giulia Russo, Emanuela Corsini, Alicia Paini, Andrew Worth
Summary: The identification of immunotoxicity hazard aims to assess the unintended effects of chemical exposure on the immune system. Perfluorinated alkylate substances (PFAS) have been found to be immunotoxic and associated with lower antibody responses and increased susceptibility to diseases. Mathematical modeling and simulation platforms can be utilized to evaluate the adverse effects of immunotoxicants. The Universal Immune System Simulator demonstrates the potential for assessing immunotoxicity through computational models.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Article
Medicine, Research & Experimental
Ewa Bednarczyk, Yanfei Lu, Alicia Paini, Sofia Batista Leite, Leo A. van Grunsven, Andrew Worth, Maurice Whelan
Summary: This study presents a theoretical mathematical description of a quasi-diffusion process to predict chemical concentrations in 3-D spheroid cell cultures. By extending a 2-D model into a 3-D model, the study simulated the correlation between compound concentration and the viability of the 3-D cell culture.
ATLA-ALTERNATIVES TO LABORATORY ANIMALS
(2022)
Article
Environmental Sciences
Toshimi Nakajima, Mao Kuragano, Makoto Yamada, Ryo Sugimoto
Summary: This study compared the contribution of submarine groundwater discharge (SGD) to river nutrient budgets at nearshore and embayment scales, and found that SGD-derived nutrients become more important at larger spatial scales.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Fan Liu, Lei Zhang, Chongyang Zhang, Ziguang Chen, Jingguang Li
Summary: NO2 emissions from wall-mounted gas stoves used for household heating have become a significant source of indoor pollution in Chinese urban areas. The high indoor concentration of NO2 poses potential health risks to residents. It is urgently necessary to establish relevant regulations and implement emission reduction technologies to reduce NO2 emissions from wall-mounted gas stoves.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Letter
Environmental Sciences
Hans Peter H. Arp, Raoul Wolf, Sarah E. Hale, Sivani Baskaran, Juliane Gluege, Martin Scheringer, Xenia Trier, Ian T. Cousins, Harrie Timmer, Roberta Hofman-Caris, Anna Lennquist, Andre D. Bannink, Gerard J. Stroomberg, Rosa M. A. Sjerps, Rosa Montes, Rosario Rodil, Jose Benito Quintana, Daniel Zahn, Herve Gallard, Tobias Mohr, Ivo Schliebner, Michael Neumann
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Philomina Onyedikachi Peter, Binessi Edouard Ifon, Francois Nkinahamira, Kayode Hassan Lasisi, Jiangwei Li, Anyi Hu, Chang-Ping Yu
Summary: This study investigates the relationship between dissolved organic matter (DOM) and Rare Earth Elements (REEs) in sediments from Yundang Lagoon, China. The results show four distinct fluorescent components, with protein-like substances being the most prevalent. Additionally, the total fluorescence intensity and LREE concentrations exhibit a synchronized increase from Outer to Inner to Songbai Lake core sediments. The findings demonstrate a strong correlation between DOM content and pollution levels.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Surya Gupta, Pasquale Borrelli, Panos Panagos, Christine Alewell
Summary: The objective of this study is to incorporate soil hydraulic properties into the erodibility factor (K) of USLE-type models. By modifying and improving the existing equations for soil texture and permeability, the study successfully included information on saturated hydraulic conductivity (Ksat) into the calculation of K factor. Using the Random Forest machine learning algorithm, two independent K factor maps with different spatial resolutions were generated. The results show that the decrease in K factor values has a positive impact on the modeling of soil erosion rates.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Jesmin Akter, Wendy J. M. Smith, Yawen Liu, Ilho Kim, Stuart L. Simpson, Phong Thai, Asja Korajkic, Warish Ahmed
Summary: The choice of workflow in wastewater surveillance has a significant impact on SARS-CoV-2 concentrations, while having minimal effects on HF183 and no effect on HAdV 40/41 concentrations. Certain components in the workflow can be interchangeable, but factors such as buffer type, chloroform, and homogenization speed can affect the recovery of viruses and bacteria.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Yu Luo, Xueting Yang, Diwei Wang, Hongmei Xu, Hongai Zhang, Shasha Huang, Qiyuan Wang, Ningning Zhang, Junji Cao, Zhenxing Shen
Summary: Atmospheric PM2.5, which can generate reactive oxygen species (ROS), is associated with cardiorespiratory morbidity and mortality. The study found that both the mass concentration of PM2.5 and the DTT activity were higher during the heating season than during the nonheating season. Combustion sources were the primary contributors to DTT activity during the heating season, while secondary formation dominated during the nonheating season. The study also revealed that biomass burning had the highest inherent oxidation potential among all sources investigated.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Erin L. Murphy, Leah R. Gerber, Chelsea M. Rochman, Beth Polidoro
Summary: Plastic pollution has devastating consequences for marine organisms. This study uses a trait-based framework to develop a vulnerability index for marine mammals, seabirds, and sea turtles in Hawai'i. The index ranks 63 study species based on their vulnerability to macroplastic pollution, providing valuable information for species monitoring and management priorities.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Kenji Maurice, Amelia Bourceret, Sami Youssef, Stephane Boivin, Liam Laurent-Webb, Coraline Damasio, Hassan Boukcim, Marc-Andre Selosse, Marc Ducousso
Summary: Growing pressure from climate change and agricultural land use is destabilizing soil microbial community interactions. Little is known about microbial community resistance and adaptation to disturbances, hindering our understanding of recovery latency and implications for ecosystem functioning. This study found that anthropic disturbance and natural disturbance have different effects on the topology and stability of soil microbial networks.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Yunhao Li, Yali Feng, Haoran Li, Yisong Yao, Chenglong Xu, Jinrong Ju, Ruiyu Ma, Haoyu Wang, Shiwei Jiang
Summary: Deep-sea mining poses a serious threat to marine ecosystems and human health by disturbing sediment and transmitting metal ions through the food chain. This study developed a new regenerative adsorption material, OMN@SA, which effectively removes metal ions. The adsorption mechanism and performance of the material for metal ion fixation were investigated.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Antonio Medici, Margherita Lavorgna, Marina Isidori, Chiara Russo, Elena Orlo, Giovanni Luongo, Giovanni Di Fabio, Armando Zarrelli
Summary: Valsartan, a widely used antihypertensive drug, has been detected in high concentrations in surface waters due to its unchanged excretion and incomplete degradation in wastewater treatment plants. This study investigated the degradation of valsartan and identified 14 degradation byproducts. The acute and chronic toxicity of these byproducts were evaluated in key organisms in the freshwater trophic chain.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Jiang Lin, Lianbao Chi, Qing Yuan, Busu Li, Mingbao Feng
Summary: This study investigated the photodegradation behavior and product formation of two representative pharmaceuticals in simulated estuary water. The study found that the formed transformation products of these pharmaceuticals have potential toxicity on marine organisms, including oxidative stress and damage to cellular components.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Hua Fang, Dongdong Jiang, Ye He, Siyi Wu, Yuehong Li, Ziqi Zhang, Haoting Chen, Zixin Zheng, Yan Sun, Wenxiang Wang
Summary: This study revealed that exposure to lower levels of air pollutants led to decreased pregnancy rates, with PM10, NO2, SO2, and CO emerging as the four most prominent pollutants. Individuals aged 35 and above exhibited heightened susceptibility to pollutants.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Ali Shaan Manzoor Ghumman, Rashid Shamsuddin, Amin Abbasi, Mohaira Ahmad, Yoshiaki Yoshida, Abdul Sami, Hamad Almohamadi
Summary: In this study, inverse vulcanized polysulfides (IVP) were synthesized by reacting molten sulfur with 4-vinyl benzyl chloride, and then functionalized using N-methyl D-glucamine (NMDG). The functionalized IVP showed a high mercury adsorption capacity and a machine learning model was developed to predict the amount of mercury removed. Furthermore, the functionalized IVP can be regenerated and reused, providing a sustainable and cost-effective adsorbent.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Rita Bonfiglio, Renata Sisto, Stefano Casciardi, Valeria Palumbo, Maria Paola Scioli, Erica Giacobbi, Francesca Servadei, Gerry Melino, Alessandro Mauriello, Manuel Scimeca
Summary: This study investigated the presence of aluminum in human colon cancer samples and its potential association with biological processes involved in cancer progression. Aluminum was found in tumor areas of 24% of patients and was associated with epithelial to mesenchymal transition (EMT) and cell death. Additional analyses revealed higher tumor mutational burden and mutations in genes related to EMT and apoptosis in aluminum-positive colon cancers. Understanding the molecular mechanisms of aluminum toxicity may improve strategies for the management of colon cancer patients.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)