Review
Gastroenterology & Hepatology
David P. Lee, Kenneth J. Chang
Summary: This review discusses the various treatment options for gastroesophageal reflux disease (GERD), including traditional medical management and surgical procedures, and highlights the recent advancements in therapeutic endoscopy for GERD.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Rakesh Kalapala, Arun Karyampudi, Zaheer Nabi, Santosh Darisetty, Nitin Jagtap, Mohan Ramchandani, Rajesh Gupta, Sundeep Lakhtakia, Rajesh Goud, G. Venkat Rao, Prateek Sharma, D. Nageshwar Reddy
Summary: This study found that using a novel device for EFTP is safe and effective in improving quality of life in patients with PPI-dependent mainly non-erosive GERD, showing good results in both short-term and long-term outcomes.
Article
Surgery
Jun Liang Teh, Hui Yu Tham, Alex Yu Sen Soh, Corrisa Chee, Guowei Kim, Asim Shabbir, Reuben Kong Min Wong, Jimmy Bok Yan So
Summary: This study focused on reflux after POEM, finding that 43.1% of patients had symptomatic reflux, 60% had endoscopic evidence of esophagitis, and 56% had increased acid exposure on pH-impedance test.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Gastroenterology & Hepatology
Jiaoyang Lu, Feixue Chen, Xiaofen Lv, Baoling Tian, Ruozi Pan, Rui Ji, Jianrong Bai, Xiuli Zuo, Yanqing Li, Xuefeng Lu
Summary: In this study, the novel endoscopic procedure called antireflux mucosal valvuloplasty (ARMV) showed to be a safe, feasible, and effective treatment for patients with gastroesophageal reflux disease (GERD). The procedure successfully reduced acid exposure and improved GERD symptoms and quality of life in the majority of patients. Further prospective and comparative trials are needed to confirm the role of ARMV among endoscopic antireflux therapies.
GASTROINTESTINAL ENDOSCOPY
(2023)
Article
Surgery
Karla Bernardi, Lauren Hawley, Vivian L. Wang, Anahita D. Jalilvand, Kelly R. Haisley, Kyle A. Perry
Summary: This retrospective cohort study evaluated 353 patients who underwent laparoscopic fundoplication (LF) for GERD between 2011 and 2017. The results showed that 16% of patients developed GERD-like symptoms after the surgery, and only 9% of these patients had recurrent pathologic acid reflux.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Biochemistry & Molecular Biology
Boram Cha, Hyejin Kim, Van Gia Truong, Sun-Ju Oh, Seok Jeong, Hyun Wook Kang
Summary: Gastroesophageal reflux disease (GERD) is a global health issue, and this study evaluated the feasibility of endoscopic balloon-assisted laser treatment (EBLT) in a porcine model. GERD was induced in three animals via botulinum toxin injection into the lower esophageal sphincter (LES), and a week later, EBLT was performed on the GERD models. The EBLT demonstrated thicker and shorter LES muscle layers compared to the controls, while still maintaining LES pressure. Histological analysis revealed that EBLT reinforced the muscularis layer with preserved mucosa and mild remodeling of intermuscular collagen in the LES. This study highlights the potential of EBLT as a new endoscopic approach for treating GERD, with further research needed to assess its efficacy and safety in a larger sample size.
Article
Surgery
Zia Kanani, Jon C. Gould
Summary: Laparoscopic fundoplication is the standard treatment for medically refractory gastroesophageal reflux disease. While both primary and reoperative fundoplication patients experience improvement in GERD-related symptoms, the degree of improvement is greater in primary patients. Perioperative morbidity rates following reoperative and primary procedures can be similar when performed by an experienced surgeon.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Gastroenterology & Hepatology
Olaya I. Brewer Gutierrez, Kenneth J. Chang, Petros C. Benias, Alireza Sedarat, Mohamad H. Dbouk, Gala Godoy Brewer, David P. Lee, Patrick I. Okolo, Marcia Canto, Mouen A. Khashab
Summary: The study demonstrates that using transoral incisionless fundoplication (TIF) after peroral endoscopic myotomy (POEM) for treating gastroesophageal reflux (GER) may be effective and safe. Results indicate significant improvements in PPI use, symptom severity, and quality of life in post-POEM patients undergoing TIF.
Article
Gastroenterology & Hepatology
Jan Martinek, Rastislav Hustak, Jan Mares, Zuzana Vackova, Julius Spicak, Eva Kieslichova, Marie Buncova, Daniel Pohl, Sunil Amin, Jan Tack
Summary: In this prospective randomized trial, objective endoscopic pyloromyotomy (G-POEM) was compared with a sham procedure in patients with severe gastroparesis. The results showed that G-POEM was superior to the sham procedure in improving both symptoms and gastric emptying in severe gastroparesis patients, although the results were not entirely conclusive for patients with idiopathic and postsurgical etiologies.
Article
Gastroenterology & Hepatology
Marzio Frazzoni, Leonardo Frazzoni, Mentore Ribolsi, Salvatore Russo, Rita Conigliaro, Nicola De Bortoli, Edoardo Savarino
Summary: This study defined on-PPI cut-offs of impedance-pH metrics to support the diagnosis and treatment of PPI-refractory GERD by evaluating real-time data of impedance-pH monitoring under PPI therapy. The results showed that comprehensive assessment of impedance-pH metrics, including PSPW index and MNBI, can improve the monitoring effectiveness for patients with PPI-refractory GERD.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Review
Medicine, General & Internal
Rupinder Mann, Mahesh Gajendran, Abhilash Perisetti, Hemant Goyal, Shreyas Saligram, Chandraprakash Umapathy
Summary: Gastroesophageal reflux disease (GERD) is a common gastrointestinal disease that can be diagnosed based on clinical presentation and risk factors, although atypical symptoms may make diagnosis challenging. Advanced endoscopic techniques have been developed to enhance the diagnosis of GERD and related complications, providing improved detection of subtle irregularities in the mucosa and vascular structures.
FRONTIERS IN MEDICINE
(2021)
Article
Surgery
Mohamad Rassoul Abu-Nuwar, Sven E. Eriksson, Inanc S. Sarici, Ping Zheng, Toshitaka Hoppo, Blair A. Jobe, Shahin Ayazi
Summary: Peroral endoscopic myotomy (POEM) is effective for achalasia, but postoperative gastroesophageal reflux disease (GERD) is a major concern. This study aimed to characterize post-POEM GERD and identify factors influencing its development and severity. Results showed that 38.8% of patients had subjective GERD symptoms, 50.5% had objective GERD, and 19.2% had severe objective GERD.
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
(2023)
Article
Otorhinolaryngology
Xiao Ma, Xu Zhang, Bing Li, Tingting Zhu, Tingting Ma, Xiaohui Zhang, Bo Qu
Summary: Endoscopic stricturotomy (ES) appears to be an effective treatment modality for refractory esophageal anastomotic strictures, providing significant relief of dysphagia with no notable complications. However, larger prospective clinical trials are needed to confirm its efficacy and its role in the management of these strictures.
Article
Surgery
Ye Zhu, Sachin Mulmi Shrestha, Ting Yu, Ruihua Shi
Summary: M-RIC is an effective technique for treating refractory esophageal stricture, with lower rates and longer times to restenosis. Stricture length >= 5 cm is a risk factor for restenosis, while oral prednisone is helpful in preventing restenosis after M-RIC.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Gastroenterology & Hepatology
Shiyu Zhang, Xiaoyan Wang, Xuelian Xiang, Huiying Yang, Nana Tang, Li Liu, Bo Jiang
Summary: The aim of this study was to assess the safety and effectiveness of resection procedures with different circumferences in patients with treatment-refractory GERD. The results showed that ARMS is an effective treatment for treatment-refractory GERD, and the recommended resection procedure is 2/3 circumference, 1.5 cm wide mucosal resection of the gastric cardia.
JOURNAL OF CLINICAL GASTROENTEROLOGY
(2022)
Article
Oncology
Amr Shaaban Hanafy, Mohamed Sorour Mohamed, Ahmed A. Alnagar
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2020)
Article
Gastroenterology & Hepatology
Waseem M. Seleem, Amr S. Hanafy, Sherief Abd-Elsalam, Rehab Badawi
Summary: Complicated cholecystectomy has a significant impact on the complexity and safety of ERCP procedure, leading to prolonged procedure duration, increased cannulation attempts, difficulty in pancreatic duct cannulation, difficult or failed stone extraction, and higher occurrence of post-ERCP pancreatitis.
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
(2022)
Review
Gastroenterology & Hepatology
Amr Shaaban Hanafy, Sherief Abd-Elsalam
WORLD JOURNAL OF GASTROENTEROLOGY
(2020)
Editorial Material
Gastroenterology & Hepatology
Amr Shaaban Hanafy
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Waseem M. Seleem, Amr Shaaban Hanafy
Summary: The study found that PRP has additional benefits in the treatment of peptic ulcer bleeding, reducing the occurrence of rebleeding and improving patients' recovery rate. No significant complications were reported in the PRP group.
CLINICAL ENDOSCOPY
(2021)
Article
Medicine, Research & Experimental
Amr Shaaban Hanafy, Waseem M. Seleem, Hany A. Elkattawy
Summary: This study retrospectively assessed the impact of yearly administration of recombinant influenza and single administration of pneumococcal conjugate vaccines on the occurrence of serious respiratory infection including COVID-19 in patients with type 2 diabetes mellitus. The results showed that the vaccines led to improvements in respiratory symptoms, inflammatory parameters, and a decrease in the severity of COVID-19 in diabetic patients.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Correction
Oncology
Amr Shaaban Hanafy, Mohamed Sorour Mohamed, Ahmed A. Alnagar
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)
Article
Gastroenterology & Hepatology
Chuan Liu, Jia Li, Yu Jun Wong, Qing Xie, Masashi Hirooka, Hirayuki Enomoto, Tae Hyung Kim, Amr Shaaban Hanafy, Ruiling He, Yohei Koizumi, Yoichi Hiasa, Takashi Nishimura, Hiroko Iijima, Young Kul Jung, Hyung Joon Yim, Jianzhong Ma, Qing-Lei Zeng, Shiv Kumar Sarin, Xiaolong Qi
Summary: Background liver-related death is often preceded by clinical decompensation in compensated advanced chronic liver disease (cACLD), making risk stratification of decompensation extremely important. A new CHESS criteria and ABC model were developed to stratify decompensation risk, showing promising results in predicting hepatic decompensation in cACLD patients. HVPG evaluation can be waived in low and high-risk cACLD patients managed by Baveno VI criteria and non-selective beta-blockers intervention, with medium-risk patients requiring further evaluation.
HEPATOLOGY INTERNATIONAL
(2022)
Article
Gastroenterology & Hepatology
Liu Chuan, Cao Zhujun, Yan Huadong, Wong Yu Jun, Xie Qing, Masashi Hirooka, Hirayuki Enomoto, Tae Hyung Kim, Amr Shaaban Hanafy, Liu Yanna, Huang Yifei, Li Xiaoguo, Kang Ning, Yohei Koizumi, Yoichi Hiasa, Takashi Nishimura, Hiroko Iijima, Young Kul Jung, Hyung Joon Yim, Guo Ying, Zhang Linpeng, Ma Jianzhong, Manoj Kumar, Ankur Jindal, Kok Ban Teh, Shiv Kumar Sarin, Qi Xiaolong
Summary: This study developed a new score (SAVE score) that accurately predicts the risk of hepatic decompensation in cACLD patients and also accurately predicts clinically significant portal hypertension.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Hematology
Ahmed Embaby, Mohamed Gaber Hamed, Huda Ebian, Lobna A. El-Korashi, Mohammad Walaa, Eman M. Abd el-Sattar, Amr Shaaban Hanafy, Shimaa Abdelmoneem
Summary: COVID-19 is a multisystem disease and this study found that PLR, PWR, and RDW levels are significantly associated with mortality in COVID-19 patients. RDW, PLT count, and PWR levels serve as independent prognostic predictors for mortality in COVID-19 patients.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Medicine, Research & Experimental
Osama Mohammed Basha, Raghda A. Hafez, Sara Mohamed Salem, Reham H. Anis, Amr Shaaban Hanafy
Summary: This study assessed the changes in gut microbiome in ulcerative colitis (UC) patients and found that the levels of different bacteria were inversely proportional to disease severity. After treatment, levels of bacteria associated with disease remission increased, while levels of bacteria associated with disease exacerbation decreased. Lower baseline levels of certain bacteria increased the risk of relapse, while lower levels of other bacteria protected against relapse.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Chuan Liu, Jia Li, Yu Jun Wong, Qing Xie, Masashi Hirooka, Hirayuki Enomoto, Tae Hyung Kim, Amr Hanafy, Zhujun Cao, Lili Zhao, Yanna Liu, Yifei Huang, Xiaoguo Li, Ning Kang, Yohei Koizumi, Yoichi Hiasa, Takashi Nishimura, Hiroko Iijima, Young Kul Jung, Hyung Joon Yim, Xin Li, Qing-Lei Zeng, Xiaolong Qi
JOURNAL OF HEPATOLOGY
(2022)
Review
Gastroenterology & Hepatology
Amr Shaaban Hanafy, Essam Elsayed Tharwat
Summary: Portal vein thrombosis is not uncommon in patients with liver cirrhosis, with the malignant variant being the most frequent. Efforts should be focused on excluding benign PVT, which may dramatically change the management of patients.
EGYPTIAN LIVER JOURNAL
(2021)
Article
Gastroenterology & Hepatology
Amr Shaaban Hanafy, Mohamed Sorour Mohamed, Mohamed Abu Taleb, H. M. Mohammed, Tarek M. H. Ibrahim, Sameh Saber, Hesham A. Atia
Summary: Non-invasive parameters of residual hepatic reserve are promising tools to guide therapy and avoid further complications in patients with liver cirrhosis and ablated HCC.
EGYPTIAN LIVER JOURNAL
(2021)
Article
Gastroenterology & Hepatology
Amr Shaaban Hanafy, Mohamed Abdel Khalik Basha, Fady Maher Wadea
WORLD JOURNAL OF HEPATOLOGY
(2020)