Journal
RUSSIAN CHEMICAL REVIEWS
Volume 87, Issue 4, Pages 350-373Publisher
TURPION LTD
DOI: 10.1070/RCR4752
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Funding
- Russian Science Foundation [16-13-00114]
- Russian Science Foundation [16-13-00114] Funding Source: Russian Science Foundation
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The pathogenesis of many socially significant diseases such as neurodegenerative dementias and neuroendocrine tumours involves imbalance of neurotransmitters. Among the known neuroimaging methods, positron emission tomography (PET) is the most perfect and informative technique for diagnosing these diseases. The potential of PET is largely determined by the inventory of available radiopharmaceuticals, that is, biologically active molecules containing short-lived nuclides with positron decay. This review gives a systematic account of the application of fluorine-18-labelled catecholamine type radiopharmaceuticals in clinical investigations of the sympathetic and central nervous systems. The methods for the synthesis of these agents and existing problems are considered. The material is arranged according to the mechanisms of reactions that underlie the synthetic approaches: electrophilic, nucleophilic and metal-catalyzed reactions.
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