MicroRNA-focused CRISPR-Cas9 library screen reveals fitness-associated miRNAs

Evolved Cas9 variants with broad PAM compatibility and high DNA specificity

(2018) Johnny H. Hu et al.   NATURE

Induction of miR-3648 Upon ER Stress and Its Regulatory Role in Cell Proliferation

(2017) Farooq Rashid et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A MicroRNA Screen Identifies the Wnt Signaling Pathway as a Regulator of the Interferon Response during Flavivirus Infection

(2017) Jessica L. Smith et al.   JOURNAL OF VIROLOGY

Pooled CRISPR screening with single-cell transcriptome readout

(2017) Paul Datlinger et al.   NATURE METHODS

CRISPRpred: A flexible and efficient tool for sgRNAs on-target activity prediction in CRISPR/Cas9 systems

(2017) Md. Khaledur Rahman et al.   PLoS One

MiR-139-3p induces cell apoptosis and inhibits metastasis of cervical cancer by targeting NOB1

(2016) Ping Huang et al.   BIOMEDICINE & PHARMACOTHERAPY

Dissecting Immune Circuits by Linking CRISPR-Pooled Screens with Single-Cell RNA-Seq

(2016) Diego Adhemar Jaitin et al.   CELL

Perturb-Seq: Dissecting Molecular Circuits with Scalable Single-Cell RNA Profiling of Pooled Genetic Screens

(2016) Atray Dixit et al.   CELL

A Multiplexed Single-Cell CRISPR Screening Platform Enables Systematic Dissection of the Unfolded Protein Response

(2016) Britt Adamson et al.   CELL

MicroRNA-555 has potent antiviral properties against poliovirus

(2016) Byoung-Shik Shim et al.   JOURNAL OF GENERAL VIROLOGY

Frizzled proteins are colonic epithelial receptors for C. difficile toxin B

(2016) Liang Tao et al.   NATURE

Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9

(2016) John G Doench et al.   NATURE BIOTECHNOLOGY

OGEE v2: an update of the online gene essentiality database with special focus on differentially essential genes in human cancer cell lines

(2016) Wei-Hua Chen et al.   NUCLEIC ACIDS RESEARCH

Let-7a suppresses cell proliferation via the TGF-β/SMAD signaling pathway in cervical cancer

(2016) Tianhui Wu et al.   ONCOLOGY REPORTS

Structures of a CRISPR-Cas9 R-loop complex primed for DNA cleavage

(2016) F. Jiang et al.   SCIENCE

Down-regulation of miR-320 associated with cancer progression and cell apoptosis via targeting Mcl-1 in cervical cancer

(2016) Ting Zhang et al.   TUMOR BIOLOGY

miR-196b regulates gastric cancer cell proliferation and invasion via PI3K/AKT/mTOR signaling pathway

(2016) NA LI et al.   Oncology Letters

CRISPR Screens Provide a Comprehensive Assessment of Cancer Vulnerabilities but Generate False-Positive Hits for Highly Amplified Genomic Regions

(2016) D. M. Munoz et al.   Cancer Discovery

Genomic Copy Number Dictates a Gene-Independent Cell Response to CRISPR/Cas9 Targeting

(2016) A. J. Aguirre et al.   Cancer Discovery

Dual microRNA Screens Reveal That the Immune-Responsive miR-181 Promotes Henipavirus Entry and Cell-Cell Fusion

(2016) Chwan Hong Foo et al.   PLoS Pathogens

Genome-Wide CRISPR-Cas9 Screen Identifies MicroRNAs That Regulate Myeloid Leukemia Cell Growth

(2016) Jared Wallace et al.   PLoS One

CRISPR/cas9, a novel genomic tool to knock down microRNA in vitro and in vivo

(2016) Hong Chang et al.   Scientific Reports

Using genome-wide CRISPR library screening with library resistant DCK to find new sources of Ara-C drug resistance in AML

(2016) Morito Kurata et al.   Scientific Reports

miR-31 functions as an oncogene in cervical cancer

(2015) Wenjing Zheng et al.   ARCHIVES OF GYNECOLOGY AND OBSTETRICS

C/EBPα-induced miR-100 expression suppresses tumor metastasis and growth by targeting ZBTB7A in gastric cancer

(2015) Duan-Bo Shi et al.   CANCER LETTERS

Disruption of microRNA-21 by TALEN leads to diminished cell transformation and increased expression of cell–environment interaction genes

(2015) Buyuan Chen et al.   CANCER LETTERS

Genome-wide CRISPR Screen in a Mouse Model of Tumor Growth and Metastasis

(2015) Sidi Chen et al.   CELL

High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities

(2015) Traver Hart et al.   CELL

A Genome-wide CRISPR Screen in Primary Immune Cells to Dissect Regulatory Networks

(2015) Oren Parnas et al.   CELL

Cpf1 Is a Single RNA-Guided Endonuclease of a Class 2 CRISPR-Cas System

(2015) Bernd Zetsche et al.   CELL

A global microRNA screen identifies regulators of the ErbB receptor signaling network

(2015) Annabell Bischoff et al.   Cell Communication and Signaling

The role of miR-100-mediated Notch pathway in apoptosis of gastric tumor cells

(2015) Geng Yang et al.   CELLULAR SIGNALLING

MicroRNA-339, an epigenetic modulating target is involved in human gastric carcinogenesis through targeting NOVA1

(2015) Bo Shen et al.   FEBS LETTERS

A Genome-wide CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) Screen Identifies NEK7 as an Essential Component of NLRP3 Inflammasome Activation

(2015) Jonathan L. Schmid-Burgk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In vivo genome editing using Staphylococcus aureus Cas9

(2015) F. Ann Ran et al.   NATURE

MicroRNA-148a regulates LDL receptor and ABCA1 expression to control circulating lipoprotein levels

(2015) Leigh Goedeke et al.   NATURE MEDICINE

A Cas9-guide RNA complex preorganized for target DNA recognition

(2015) F. Jiang et al.   SCIENCE

Identification and characterization of essential genes in the human genome

(2015) T. Wang et al.   SCIENCE

Synthesis of an arrayed sgRNA library targeting the human genome

(2015) Tobias Schmidt et al.   Scientific Reports

Small indels induced by CRISPR/Cas9 in the 5′ region of microRNA lead to its depletion and Drosha processing retardance

(2015) Qian Jiang et al.   RNA Biology

The Ensembl REST API: Ensembl Data for Any Language

(2014) Andrew Yates et al.   BIOINFORMATICS

MicroRNA-196a/-196b promote cell metastasis via negative regulation of radixin in human gastric cancer

(2014) Ming-Ming Tsai et al.   CANCER LETTERS

Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA

(2014) Hiroshi Nishimasu et al.   CELL

MiR-31 is an independent prognostic factor and functions as an oncomir in cervical cancer via targeting ARID1A

(2014) Nan Wang et al.   GYNECOLOGIC ONCOLOGY

High-throughput screening of a CRISPR/Cas9 library for functional genomics in human cells

(2014) Yuexin Zhou et al.   NATURE

Improved vectors and genome-wide libraries for CRISPR screening

(2014) Neville E Sanjana et al.   NATURE METHODS

A Screen Identifies the Oncogenic Micro-RNA miR-378a-5p as a Negative Regulator of Oncogene-Induced Senescence

(2014) Susanne Marije Kooistra et al.   PLoS One

MicroRNA Screen of Human Embryonic Stem Cell Differentiation Reveals miR-105 as an Enhancer of Megakaryopoiesis from Adult CD34+ Cells

(2014) Viraj Kamat et al.   STEM CELLS

Primate-specific miR-576-3p sets host defense signalling threshold

(2014) Melanie L. Yarbrough et al.   Nature Communications

Diverse functions of miR-125 family in different cell contexts

(2013) Yu-Meng Sun et al.   Journal of Hematology & Oncology

Genome-wide recessive genetic screening in mammalian cells with a lentiviral CRISPR-guide RNA library

(2013) Hiroko Koike-Yusa et al.   NATURE BIOTECHNOLOGY

DNA targeting specificity of RNA-guided Cas9 nucleases

(2013) Patrick D Hsu et al.   NATURE BIOTECHNOLOGY

Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease

(2013) Seung Woo Cho et al.   NATURE BIOTECHNOLOGY

TALEN-based knockout library for human microRNAs

(2013) Young-Kook Kim et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

miRBase: annotating high confidence microRNAs using deep sequencing data

(2013) Ana Kozomara et al.   NUCLEIC ACIDS RESEARCH

RNA-Guided Human Genome Engineering via Cas9

(2013) P. Mali et al.   SCIENCE

Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells

(2013) Ophir Shalem et al.   SCIENCE

Genetic Screens in Human Cells Using the CRISPR-Cas9 System

(2013) Tim Wang et al.   SCIENCE

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

RNA-programmed genome editing in human cells

(2013) Martin Jinek et al.   eLife

The role of miRNAs in human papilloma virus (HPV)-associated cancers: bridging between HPV-related head and neck cancer and cervical cancer

(2012) C B Lajer et al.   BRITISH JOURNAL OF CANCER

Dysregulated microRNAs in the pathogenesis and progression of cervical neoplasm

(2012) Tak-hong Cheung et al.   CELL CYCLE

MicroRNA-149 Inhibits Proliferation and Cell Cycle Progression through the Targeting of ZBTB2 in Human Gastric Cancer

(2012) Ying Wang et al.   PLoS One

MicroRNA-181a promotes gastric cancer by negatively regulating tumor suppressor KLF6

(2012) Xiangyang Zhang et al.   TUMOR BIOLOGY

Btrim: A fast, lightweight adapter and quality trimming program for next-generation sequencing technologies

(2011) Yong Kong   GENOMICS

Aberrant microRNA expression in human cervical carcinomas

(2011) Qunxian Rao et al.   MEDICAL ONCOLOGY

Ultra-high throughput sequencing-based small RNA discovery and discrete statistical biomarker analysis in a collection of cervical tumours and matched controls

(2010) Daniela Witten et al.   BMC BIOLOGY

MicroRNAs as Regulators of Differentiation and Cell Fate Decisions

(2010) Kathryn N. Ivey et al.   Cell Stem Cell

Epigenetic regulation of miR-196b expression in gastric cancer

(2010) Kuo-Wang Tsai et al.   GENES CHROMOSOMES & CANCER

A MicroRNA Screen to Identify Modulators of Sensitivity to BCL2 Inhibitor ABT-263 (Navitoclax)

(2010) L. T. Lam et al.   MOLECULAR CANCER THERAPEUTICS

MicroRNA Expression Variability in Human Cervical Tissues

(2010) Patrícia M. Pereira et al.   PLoS One

Conserved vertebrate mir-451 provides a platform for Dicer-independent, Ago2-mediated microRNA biogenesis

(2010) J.-S. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Novel miRNA Processing Pathway Independent of Dicer Requires Argonaute2 Catalytic Activity

(2010) D. Cifuentes et al.   SCIENCE

MicroRNAs and Cancer: Short RNAs Go a Long Way

(2009) Andrea Ventura et al.   CELL

Transfection of small RNAs globally perturbs gene regulation by endogenous microRNAs

(2009) Aly A Khan et al.   NATURE BIOTECHNOLOGY

Ultrafast and memory-efficient alignment of short DNA sequences to the human genome

(2009) Ben Langmead et al.   GENOME BIOLOGY

Altered MicroRNA Expression in Cervical Carcinomas

(2008) J.-W. Lee et al.   CLINICAL CANCER RESEARCH

Most mammalian mRNAs are conserved targets of microRNAs

(2008) R. C. Friedman et al.   GENOME RESEARCH

Aberrant Expression of Oncogenic and Tumor-Suppressive MicroRNAs in Cervical Cancer Is Required for Cancer Cell Growth

(2008) Xiaohong Wang et al.   PLoS One