Article
Oncology
Tenny Mudianto, Katie M. Campbell, Jason Webb, Paul Zolkind, Zachary L. Skidmore, Rachel Riley, Erica K. Barnell, Ibrahim Ozgenc, Tusar Giri, Gavin P. Dunn, Douglas R. Adkins, Malachi Griffith, Ann Marie Egloff, Obi L. Griffith, Ravindra Uppaluri
Summary: The study revealed a Yap1-dependent resistance to trametinib therapy in HNSCCs, with downstream effectors of the Hippo pathway being activated. Combined targeting of Yap1 and MEK may enhance the therapeutic response in head and neck squamous cell carcinoma. The findings suggest potential strategies to overcome resistance and improve treatment outcomes.
CLINICAL CANCER RESEARCH
(2021)
Review
Oncology
Nathalia Meireles Da Costa, Fabio A. Mendes, Bruno Pontes, Luiz Eurico Nasciutti, Luis Felipe Ribeiro Pinto, Antonio Palumbo Junior
Summary: Head and neck squamous cell carcinomas (HNSCC) are common and deadly tumors, mainly occurring in oral cavity, pharynx, and larynx tissues. Alterations in the extracellular matrix (ECM), particularly involving laminin, play a crucial role in HNSCC development and progression. Laminin subtypes 111 (LN-111) and 332 (LN-332) are associated with malignant transformation, influencing key processes such as proliferation, adhesion, migration, invasion, and metastasis in HNSCC by regulating various pathways, including the EGFR/MAPK signaling pathway. This suggests that laminin may serve as a potential therapeutic target for HNSCC.
Article
Oncology
Yazan Abu-Shama, Julia Salleron, Florent Carsuzaa, Xu-Shan Sun, Carole Pflumio, Idriss Troussier, Claire Petit, Matthieu Caubet, Arnaud Beddok, Valentin Calugaru, Stephanie Servagi-Vernat, Joel Castelli, Jessica Miroir, Marco Krengli, Paul Giraud, Edouard Romano, Jonathan Khalifa, Melanie Dore, Nicolas Blanchard, Alexandre Coutte, Charles Dupin, Shakeel Sumodhee, Yungan Tao, Vincent Roth, Lionel Geoffrois, Bruno Toussaint, Duc Trung Nguyen, Jean-Christophe Faivre, Juliette Thariat
Summary: A retrospective multicentric study on 322 patients with head and neck cancers of unknown primary (HNCUP) found that neck dissection (ND) improved progression-free survival (PFS) regardless of nodal stage, but did not improve survival rates. The extent of ND did not affect the benefits of the procedure, and the benefits decreased with a more advanced nodal stage.
Article
Biochemistry & Molecular Biology
Nadege Kindt, Fabrice Journe, Stephane Carlier, Anne Trelcat, Alessandro Scalia, Sven Saussez
Summary: The study suggests that oxLDL may decrease the migration of HNC cell lines by regulating the CD36/beta-catenin pathway.
Article
Biochemistry & Molecular Biology
Cheng-Ming Hsu, Ming-Yu Yang, Ming-Shao Tsai, Geng-He Chang, Yao-Hsu Yang, Yao-Te Tsai, Ching-Yuan Wu, Shun-Fu Chang
Summary: HNSCCs, the most common cancers of the head and neck, present a clinical challenge due to high recurrence rates and treatment resistance. This study explored the potential anticancer effects of DT, a compound in danshen, on HNSCCs, showing promising results in inducing cell apoptosis and reducing tumor size.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Cristina Porcheri, Thimios A. Mitsiadis
Summary: Head and neck squamous cell carcinoma (HNSCC) is a common type of cancer with a high fatality rate. HNSCC is primarily linked to factors like tobacco use, areca nut/betel quid consumption, alcohol intake, and HPV infection. The high intratumor heterogeneity in HNSCC and other head and neck cancers makes treatment challenging and contributes to drug resistance, emphasizing the need for new therapeutic approaches and drug testing models.
Article
Oncology
Christian Idel, Julika Ribbat-Idel, Luise Klapper, Rosemarie Krupar, Karl-Ludwig Bruchhage, Eva Dreyer, Dirk Rades, Christina Polasky, Anne Offermann, Jutta Kirfel, Sven Perner, Barbara Wollenberg
Summary: This study analyzed the immune status and spatial distribution of immune cells in head and neck squamous cell carcinomas (HNSCC) and found that different immune cell distribution patterns within tumors might be crucial for the response to immune checkpoint inhibitor (ICI) treatment. Hot tumors showed higher expressions of PD-1 and PD-L1 compared to cold and excluded tumors, while excluded tumors had higher expression of pSMAD, indicating a potential therapeutic target for determining immune cell distribution patterns.
FRONTIERS IN ONCOLOGY
(2021)
Review
Biology
Delphine Avril, Jean-Philippe Foy, Jebrane Bouaoud, Vincent Gregoire, Pierre Saintigny
Summary: This article aims to review recently proposed biomarkers of radioresistance in HPV-negative HNSCC, which can be useful for stratifying tumor patients based on their predicted level of radioresistance.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2023)
Article
Health Care Sciences & Services
Li-Hsing Chi, Alexander T. H. Wu, Michael Hsiao, Yu-Chuan (Jack) Li
Summary: This study utilized survival analysis to identify three significant biomarker candidates associated with overall survival in the TCGA HNSCC cohort. Clinical tumor stage and surgical margin involvement were identified as independent risk factors for prognosis. Validation using another independent HNSCC dataset highlighted the importance of transcriptomic analysis in biomarker discovery.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Oncology
Rogelio Gonzalez-Gonzalez, Gamaliel Ortiz-Sarabia, Nelly Molina-Frechero, Jose Manuel Salas-Pacheco, Sergio Manuel Salas-Pacheco, Jesus Lavalle-Carrasco, Sandra Lopez-Verdin, Omar Tremillo-Maldonado, Ronell Bologna-Molina
Summary: Mesenchymal conversion occurring in malignant epithelial neoplasms promotes aggressive tumor behavior. Head and neck squamous cell carcinomas are aggressive, recurrent, and metastatic neoplasms involving various molecules and signaling pathways in the malignant conversion process. The review focuses on main molecules related to EMT, interactions with the tumor microenvironment, epigenetic regulation, hypoxia, inflammation, immune cell relationships, and EMT inhibition in the context of HNSCCs.
Review
Oncology
Philipp Baumeister, Jiefu Zhou, Martin Canis, Olivier Gires
Summary: Head and neck squamous cell carcinomas (HNSCC) are common malignancies with resistance to multi-modal therapy modalities, leading to metastasis, local recurrence, and poor survival. Understanding the molecular heterogeneity of HNSCC and its impact on treatment response is crucial for improving patient stratification and developing new therapeutic approaches to overcome therapy resistance.
Review
Oncology
Lucas dos Santos, Carina M. Abrahao, William N. William
Summary: This article discusses the immune evasion and resistance mechanisms in head and neck squamous cell carcinomas, with a focus on the role of PD-L1 and PD-1 inhibitors in this disease. It also mentions research on predicting patient benefit from immunotherapy and studying resistance mechanisms, along with novel strategies to overcome resistance.
FRONTIERS IN ONCOLOGY
(2021)
Review
Cell Biology
Ana Belen Griso, Lucia Acero-Riaguas, Beatriz Castelo, Jose Luis Cebrian-Carretero, Ana Sastre-Perona
Summary: This review examines the mechanisms involved in the development of cisplatin resistance in head and neck squamous cell carcinomas (HNSCCs) and discusses potential strategies to overcome these complications. Classical resistance mechanisms and the prevalence of these mechanisms in the population of cancer stem cells (CSC) are highlighted. The influence of cell intrinsic and extrinsic cues, as well as the stromal composition and tumor microenvironment, on resistance and CSC characteristics are also discussed. Furthermore, the impact of epigenetic modifiers and signaling pathways on tumor behavior and cell plasticity in inducing chemotherapy resistance is explored.
Article
Oncology
Anders Berglund, Clarisse Muenyi, Erin M. Siegel, Abidemi Ajidahun, Steven A. Eschrich, Denise Wong, Leah E. Hendrick, Ryan M. Putney, Sungjune Kim, D. Neil Hayes, David Shibata
Summary: HPV16 and other HPV types within the same alpha species exhibit distinct methylation profiles in head and neck squamous cell carcinomas (HNSCC). Understanding these differences could provide insights into the clinical behavior of HPV-associated HNSCC and contribute to a better understanding of the biological mechanisms underlying HPV-related tumors.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Article
Pharmacology & Pharmacy
Valeri Roschenko, Abdallah M. Ayoub, Konrad Engelhardt, Jens Schaefer, Muhammad Umair Amin, Eduard Preis, Robert Mandic, Udo Bakowsky
Summary: Infection with HPV is a major risk factor for head and neck squamous cell carcinomas (HNSCCs), but photodynamic therapy (PDT) using CUR-LCNPs shows promise as an alternative treatment regardless of HPV status.
Article
Optics
Stephen Holler, Stephen D. Fuerstenau, Charles R. Skelsey
JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER
(2016)
Article
Optics
Matthew J. Berg, Stephen Holler
Article
Physics, Applied
V. R. Dantham, S. Holler, V. Kolchenko, Z. Wan, S. Arnold
APPLIED PHYSICS LETTERS
(2012)
Article
Chemistry, Multidisciplinary
Venkata R. Dantham, Stephen Holler, Curtis Barbre, David Keng, Vasily Kolchenko, Stephen Arnold
Article
Multidisciplinary Sciences
Matthew J. Berg, Yuli W. Heinson, Osku Kemppinen, Stephen Holler
SCIENTIFIC REPORTS
(2017)
Article
Biochemistry & Molecular Biology
Jaeda M. Mendoza, Kenzie Chen, Sequoyah Walters, Emily Shipley, Kevin B. Aptowicz, Stephen Holler
Summary: In this study, computationally generated light scattering patterns were used to classify aerosol particles through morphological descriptors. The results showed improved accuracy compared to previous efforts, demonstrating the utility of the proposed descriptors.
Article
Chemistry, Analytical
Stephen Holler, Elaina Mansley, Christopher Mazzeo, Michael J. Donovan, Maximiliano Sobrero, Brett A. Miles
Proceedings Paper
Chemistry, Analytical
Stephen Holler, Matthew Speck
ADVANCED ENVIRONMENTAL, CHEMICAL, AND BIOLOGICAL SENSING TECHNOLOGIES XIII
(2016)
Proceedings Paper
Engineering, Biomedical
Stephen Holler, Charles R. Skelsey, Stephen D. Fuerstenau
ADVANCED ENVIRONMENTAL, CHEMICAL, AND BIOLOGICAL SENSING TECHNOLOGIES XII
(2015)
Proceedings Paper
Engineering, Biomedical
S. Holler, V. R. Dantham, D. Keng, V. Kolchenko, S. Arnold, B. Mulroe, M. Paspaley-Grbavac
BIOSENSING AND NANOMEDICINE VII
(2014)
Proceedings Paper
Engineering, Biomedical
S. Holler, V. R. Danthan, D. Keng, V. Kolchenko, S. Arnold
SENSING TECHNOLOGIES FOR GLOBAL HEALTH, MILITARY MEDICINE, AND ENVIRONMENTAL MONITORING IV
(2014)
Proceedings Paper
Optics
V. R. Dantham, S. Holler, V. Kolchenko, Z. Wan, S. Arnold
LASER RESONATORS, MICRORESONATORS, AND BEAM CONTROL XV
(2013)
Proceedings Paper
Instruments & Instrumentation
S. Holler, V. R. Dantham, V. Kolchenko, Z. Wan, S. Arnold
FIBER OPTIC SENSORS AND APPLICATIONS X
(2013)
Proceedings Paper
Engineering, Electrical & Electronic
S. I. Shopova, R. Rajmangal, S. Holler, S. Arnold
PHOTONIC MICRODEVICES/MICROSTRUCTURES FOR SENSING IV
(2012)