Article
Ophthalmology
Enrico Borrelli, Marco Battista, Costanza Barresi, Domenico Grosso, Maria Cristina Gabela, Alberto Quarta, Andrea Saladino, Riccardo Sacconi, Lea Querques, Francesco Bandello, Giuseppe Querques
Summary: The purpose of this study was to quantitatively evaluate the inner and outer choroidal changes in the fellow eyes of patients with unilateral central serous chorioretinopathy (CSC). The results showed that both the choriocapillaris and stromal areas were increased in the unaffected eyes of unilateral CSC patients, along with a higher choroidal vascularity index. Additionally, the percentage and number of choriocapillaris flow deficits were also increased in these patients.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2022)
Article
Ophthalmology
Pauline Eymard, Melvin Gerardy, Lucas Bouys, Chadi Mehanna, Jerome Bertherat, Francine Behar-Cohen, Elodie Bousquet
Summary: The study found a higher prevalence of pachychoroid spectrum disease in patients with Cushing syndrome, along with a higher occurrence of pachyvessels and specific abnormalities in the eyes of these patients.
ACTA OPHTHALMOLOGICA
(2021)
Article
Ophthalmology
Richard F. Spaide, Gerardo Ledesma-Gil, Robert F. Mullins
Summary: The study investigated the reflectivity of the inner choroid and found that the reflectivity changes with age, with increasing compaction of collagen fibers in the choroidal stroma. This suggests that the optical coherence tomography reflectance from the inner choroid is related to the packing density of collagen fibers present there.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2021)
Article
Multidisciplinary Sciences
Hidetaka Matsumoto, Junki Hoshino, Ryo Mukai, Kosuke Nakamura, Shoji Kishi, Hideo Akiyama
Summary: In this study, choroidal congestion in PNV patients was assessed using multimodal imaging. The findings showed an overlap between areas of choriocapillaris filling delay, dilated outer choroidal vessels, CNV, and RPE atrophy. The results suggest that chronic choriocapillaris ischemia due to vortex vein congestion may lead to CNV development and RPE atrophy in eyes with PNV.
SCIENTIFIC REPORTS
(2021)
Article
Biotechnology & Applied Microbiology
Weiran Zhang, Chang Li, Yibo Gong, Nianen Liu, Yunshan Cao, Zhiqing Li, Yan Zhang
Summary: Using an advanced ultrawide-field optical coherence tomography angiography (OCTA) system, we detected previously undetectable changes in the peripheral and central fundi of nonpathological myopic eyes, including reduced vessel density and thickness of the inner retina segments. These changes were associated with the severity of myopia.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Multidisciplinary Sciences
Woo-Hyuk Lee, Yong-Jin Na, Hyung-Bin Lim, Jae-Yun Sung, Jung-Yeul Kim, Min-Woo Lee
Summary: This study aimed to investigate the changes in the inner retinal layer and microvasculature in healthy eyes with age. The results showed that the ganglion cell-inner plexiform layer (GC-IPL) thickness and macular vessel density (VD) started to decrease in the age group above 50 years, while the GC-IPL/VD ratio significantly increased in the 60s age group. Furthermore, the GC-IPL/VD ratio was positively associated with age in subjects aged 50 years and above, indicating a more pronounced decline in VD over time compared to GC-IPL thickness.
Article
Medicine, General & Internal
Aniruddha Agarwal, Sabia Handa, Alessandro Marchese, Salvatore Parrulli, Alessandro Invernizzi, Roel J. Erckens, Tos T. J. M. Berendschot, C. A. B. Webers, Reema Bansal, Vishali Gupta
Summary: This study analyzed OCT findings in PIC eyes suggestive of CNV, showing that quantitative and qualitative OCT analysis can help predict the presence of CNV in these eyes. Lesions with CNV+ had larger dimensions and distinct features compared to CNV- lesions.
FRONTIERS IN MEDICINE
(2021)
Article
Medicine, General & Internal
Filippo Tatti, Claudio Iovino, Giuseppe Demarinis, Emanuele Siotto Pintor, Marco Pellegrini, Oliver Beale, Kiran Kumar Vupparaboina, Mohammed Abdul Rasheed, Giuseppe Giannaccare, Jay Chhablani, Enrico Peiretti
Summary: The aim of this study was to evaluate choroidal vascularity in unilateral central serous chorioretinopathy (CSC) using en face optical coherence tomography (OCT) images. The study included 40 eyes of 20 CSC patients and 20 eyes of 10 healthy individuals. The results showed no significant differences in choroidal vascularity index (CVI) between different layers of the choroid in CSC-affected eyes and fellow eyes.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Paulina Szabelska, Justyna Medrzycka, Joanna Brydak-Godowska, Radoslaw Rozycki, Joanna Golebiewska
Summary: This study reviewed 5076 OCT scans in 2538 patients and confirmed that FCE is a rare ocular condition, which may be more common in the Caucasian population than previously known. OCT is a crucial method for diagnosing FCE.
Review
Ophthalmology
Ines Lains, Jay C. Wang, Ying Cui, Raviv Katz, Filippos Vingopoulos, Giovanni Staurenghi, Demetrios G. Vavvas, Joan W. Miller, John B. Miller
Summary: The introduction of Swept-Source OCT and Swept-Source OCTA technology has revolutionized the clinical assessment and research of vitreoretinal conditions. Despite their numerous advantages, the widespread adoption remains relatively limited. These technologies have important implications in improving our understanding of retinal health and disease.
PROGRESS IN RETINAL AND EYE RESEARCH
(2021)
Article
Multidisciplinary Sciences
Rion Ozawa, Keiko Azuma, Yoko Nomura, Hiroshi Murata, Ryo Asaoka, Kohdai Kitamoto, Kohei Ueda, Tatsuya Inoue, Ryo Obata
Summary: This study found that the presence of nonexudative choroidal neovascularization (CNV) in eyes with pachychoroid diseases leads to a decrease in retinal sensitivity (RS).
Article
Ophthalmology
Yiming Lu, Hao Zhou, Xiao Zhou, Yuxuan Chen, Ruikang K. Wang
Summary: The study found a positive correlation between LSFG signals and choroidal thickness and vessel volume, suggesting choroidal blood flows dominate LSFG signals in areas lacking large retinal vessels.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2022)
Article
Medicine, General & Internal
Dominika Szkodny, Edward Wylegala, Paulina Sujka-Franczak, Edyta Chlasta-Twardzik, Rafal Fiolka, Tomasz Tomczyk, Adam Wylegala
Summary: This study aimed to compare optic nerve, retina, and retinal vessel parameters in recovered COVID-19 patients and healthy patients using OCT-a. The results showed no significant differences in the measured parameters, indicating that COVID-19 did not have a noticeable impact on these parameters.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Public, Environmental & Occupational Health
Qing Zhao, Chuting Wang, Lihui Meng, Shiyu Cheng, Xingwang Gu, Youxin Chen, Xinyu Zhao
Summary: This study used ultrawide-field swept-source optical coherence tomography angiography (UWF-SS-OCTA) to investigate retinal and choroidal changes in diabetic patients without clinical diabetic retinopathy (DM-NoDR). The results showed that DM-NoDR eyes had increased nonperfusion area and capillary tortuosity in both central and peripheral areas. Central capillary tortuosity was associated with higher levels of serum creatinine and blood urea nitrogen. In DM-NoDR eyes, there were changes in retinal and choroidal parameters, including vessel flow, thickness, and volume. Choriocapillaris vessel flow density increased in the central area, while vessel flow in the large and medium choroidal vessel layer decreased in the whole image.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Optics
Daewoon Seong, Won Ki, Pilun Kim, Jaeyul Lee, Sangyeob Han, Soojin Yi, Hong Kyun Kim, Mansik Jeon, Jeehyun Kim
Summary: This study developed a virtual intraoperative OCT angiography integrated surgical microscope, which can simultaneously visualize the morphological tissue structure and microvasculature data of the surgical region, demonstrating its potential application in in vivo imaging and simulated surgeries of small animals.
OPTICS AND LASERS IN ENGINEERING
(2022)
Review
Ophthalmology
Meira Fogel-Levin, SriniVas R. Sadda, Philip J. Rosenfeld, Nadia Waheed, Giuseppe Querques, Bailey K. Freund, David Sarraf
Summary: Imaging is crucial in the evaluation and management of retinal disorders, and different imaging modalities have unique capabilities to show different aspects of the disease. Multimodal retinal imaging provides abundant and insightful information, but integrating the complex data can be overwhelming. This article discusses the applications, strengths, and limitations of various retinal imaging tools, including color fundus photography, widefield imaging, fundus autofluorescence, near infrared reflectance, optical coherence tomography angiography, and en face optical coherence tomography, as well as the advantages and disadvantages of a multimodal approach.
SURVEY OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Marc J. Sirks, Elon H. C. van Dijk, Noa Rosenberg, Carla E. M. Hollak, Stamatios Aslanis, Chui Ming Gemmy Cheung, Itay Chowers, Chiara M. Eandi, K. Bailey Freund, Frank G. Holz, Peter K. Kaiser, Andrew J. Lotery, Kyoko Ohno-Matsui, Giuseppe Querques, Yousif Subhi, Ramin Tadayoni, Charles C. Wykoff, Dinah Zur, Roselie M. H. Diederen, Camiel J. F. Boon, Reinier O. Schlingemann
Summary: Since July 2021, there has been a worldwide shortage of verteporfin (Visudyne (R)), which has had a significant impact on the care of ophthalmic patients worldwide and may result in serious and irreversible vision loss.
ACTA OPHTHALMOLOGICA
(2022)
Article
Ophthalmology
Santiago Montolio-Marzo, Roberto Gallego-Pinazo, Rosa Dolz-Marco, Aitor Lanzagorta-Aresti, Marta Perez-Lopez
Summary: This case report describes a healthy female who developed NAION following in vitro fertilisation and uneventful cesarean section. The only risk factor identified was a small cup-to-disc ratio. Hemodynamic and hormonal changes during late pregnancy and uneventful cesarean section may have triggered this condition.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
K. Bailey Freund, Giovanni Staurenghi, Jesse J. Jung, Sandrine A. Zweifel, Mariano Cozzi, Lauren Hill, Steven Blotner, Min Tsuboi, Shamika Gune
Summary: The study aimed to investigate the relationship between the Consensus on Neovascular Age-Related Macular Degeneration (CONAN) Study Group classifications of macular neovascularization (MNV) and visual responses to ranibizumab therapy in patients with neovascular age-related macular degeneration (nAMD). Results showed that the different lesion types had varying effects on best-corrected visual acuity (BCVA) outcomes, supporting the use of an anatomic classification system to evaluate and predict visual responses to anti-vascular endothelial growth factor therapy for nAMD.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
Review
Ophthalmology
Ghazi Bou Ghanem, Piergiorgio Neri, Rosa Dolz-Marco, Thomas Albini, Amani Fawzi
Summary: Inflammatory choroidal neovascularization (iCNV) is a rare complication of uveitis and can cause vision compromise. Fluorescein angiography (FA) is the gold standard for diagnosis, but it can be difficult to distinguish iCNV from inflammatory lesions. Optical coherence tomography (OCT) is a noninvasive imaging modality that can assist in diagnosing iCNV. OCT angiography (OCTA) uses motion contrast to visualize flow and is useful in distinguishing iCNV from inflammatory lesions. However, further studies are needed to determine its role in evaluating iCNV activity and treatment response.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Editorial Material
Ophthalmology
Prithvi Ramtohul, Diogo Cabral, K. Bailey Freund
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2023)
Article
Ophthalmology
Santiago Montolio-Marzo, Roberto Gallego-Pinazo, Elena Palacios-Pozo, Rosa Dolz-Marco
Summary: The purpose of this study was to use high dynamic range optical coherence tomography imaging to study subretinal hyperreflective material in patients with age-related macular degeneration. The study found that the disappearance rates, visual acuity improvement, and disruption of outer retinal layers varied among different types of subretinal hyperreflective material. This easily accessible tool may be helpful as a prognostic factor in age-related macular degeneration cases.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2023)
Letter
Ophthalmology
Prithvi Ramtohul, Maria Vittoria Cicinelli, K. Bailey Freund
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2023)
Article
Ophthalmology
Francisco Pastor-Pascual, Rafael Pastor-Pascual, Patricia Galvez-Perez, Rosa Dolz-Marco, Roberto Gallego-Pinazo
Summary: The study found that while the use of artificial tears may help stabilize the tear film, there was not enough statistical evidence to prove significant differences in treatment parameters compared to not receiving treatment.
CLINICAL OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Riccardo Sacconi, David Sarraf, SriniVas R. Sadda, K. Bailey Freund, Andrea Servillo, Meira Miri Fogel Levin, Eliana Costanzo, Giulia Corradetti, Diogo Cabral, Dinah Zur, Omer Trivizki, Mariacristina Parravano, Francesco Bandello, Anat Loewenstein, Giuseppe Querques
Summary: This study investigated the association between nascent geographic atrophy (GA) and the development of exudative type 3 macular neovascularization (MNV) in patients with age-related macular degeneration (AMD). The results showed that 22.7% of the patients had nascent GA preceding exudative type 3 MNV. Therefore, the detection of nascent GA in AMD patients may require closer surveillance to identify early exudative type 3 MNV warranting treatment.
OPHTHALMOLOGY RETINA
(2023)
Article
Ophthalmology
Pierre-Henry Gabrielle, Vuong Nguyen, Louis Arnould, Francesco Viola, Javier Zarranz-Ventura, Daniel Barthelmes, Catherine Creuzot-Garcher, Mark Gillies
Summary: This study retrospectively analyzed the incidence, probability, risk factors, and 1-year outcomes of rhegmatogenous retinal detachment (RRD) in eyes receiving intravitreal injections (IVTs) of VEGF inhibitors. The results showed that RRD is a rare complication of VEGF inhibitor IVT in routine clinical practice with poor visual outcomes at 1 year.
OPHTHALMOLOGY RETINA
(2022)
Article
Ophthalmology
Prithvi Ramtohul, Maria Vittoria Cicinelli, Rosa Dolz-Marco, Orly Gal-Or, Sarah Mrejen, Jesus R. Garcia-Martinez, Alla Goldberg, Eduardo Cunha de Souza, Elisabetta Miserocchi, Emmett T. Cunningham, Lawrence A. Yannuzzi, K. Bailey Freund, Edmund Tsui
Summary: This study described a distinctive subtype of active idiopathic multifocal choroiditis (iMFC) lesions, characterized by grey-yellow chorioretinal lesions surrounded by smaller satellite dots, referred to as chrysanthemum lesions. The study retrospectively observed the multimodal imaging features of eyes with active iMFC and chrysanthemum lesions.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2023)
Article
Ophthalmology
Prithvi Ramtohul, Diogo Cabral, Daniel Oh, Daniel Galhoz, K. Bailey Freund
Summary: The purpose of this study was to investigate whether noninvasive en face ultrawidefield (UWF) OCT can demonstrate distinctive features of choroidal vasculature in eyes with central serous chorioretinopathy (CSC). Patients diagnosed with CSC underwent UWF indocyanine green angiography (ICGA) and widefield OCT imaging. The results showed that en face UWF OCT imaging can show distinctive features of choroidal venous insufficiency previously identified with UWF ICGA in eyes with CSC.
OPHTHALMOLOGY RETINA
(2023)
Review
Ophthalmology
Costanza Barresi, Jay Chhablani, Rosa Dolz-Marco, Robero Gallego-Pinazo, Alessandro Berni, Francesco Bandello, Enrico Borrelli
Summary: Age-related macular degeneration (AMD) is a complex and multifactorial disease that damages the unit comprising the photoreceptors, retinal pigment epithelium (RPE), Bruch's membrane, and choriocapillaris. While the outer retina is primarily affected, evidence suggests that the inner retina may also be impaired. Structural optical coherence tomography (OCT) technology has shown that both the inner and outer retina are impacted by AMD and that these impairments are associated. This review aims to describe the role of neurodegeneration in AMD to better understand the relationship between neuronal loss and outer retinal damage in this disease.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Rosa Dolz-Marco, Javier Munoz-Solano, Jan F. Dechent, Roberto Gallego-Pinazo
Summary: This study aimed to compare treatment decisions by ophthalmologists with reading center fluid identification from optical coherence tomography. The results showed that treatment and reading center fluid determination agreed in the majority of visits, with more pronounced treatment response and smaller fluid areas contributing to discrepancies. Positive fluid discrepancy did not have a substantial impact on subsequent visual acuity.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2023)
