Article
Medicine, General & Internal
Timothy Y. Y. Lai, Ziqi Tang, Adrian C. W. Lai, Simon K. H. Szeto, Ricky Y. K. Lai, Carol Y. Cheung
Summary: The specific form of drusen, known as pachydrusen, is associated with pachychoroid eye diseases, such as central serous chorioretinopathy (CSC) and polypoidal choroidal vasculopathy (PCV). This study found that pachydrusen are more prevalent in PCV than CSC and may be linked to age and more extensive abnormalities in fundus autofluorescence (FAF).
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Young Ho Kim, Yoo-Ri Chung, Chungwoon Kim, Kihwang Lee, Won Ki Lee
Summary: This study investigated the relationship between pachydrusen and choroidal thickness and age in eyes with polypoidal choroidal vasculopathy (PCV) and eyes with central serous chorioretinopathy (CSC). The presence of pachydrusen was more frequent in PCV eyes compared to CSC eyes, and subfoveal choroidal thickness was associated with pachydrusen in PCV eyes while age was associated with pachydrusen in CSC eyes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, General & Internal
Kenji Yamashiro, Yasuo Yanagi, Hideki Koizumi, Hidetaka Matsumoto, Chui Ming Gemmy Cheung, Fumi Gomi, Tomohiro Iida, Akitaka Tsujikawa
Summary: Previous studies have shown inconsistent classification and understanding of pachychoroid neovasculopathy (PNV) and polypoidal choroidal vasculopathy (PCV). This study summarizes previous research and proposes a refined conceptual framework for future studies on PNV, PCV, and neovascular age-related macular degeneration (nAMD).
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Ophthalmology
Naoya Imanaga, Nobuhiro Terao, Shozo Sonoda, Shota Sawaguchi, Yukihide Yamauchi, Taiji Sakamoto, Hideki Koizumi
Summary: The purpose of this study was to investigate the relationship between scleral thickness and choroidal structure in CSC eyes. The results showed a significant positive correlation between scleral thickness and the luminal/stromal ratio in the posterior choroid. Scleral thickness had a stronger correlation with the ratio compared to subfoveal choroidal thickness.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2023)
Article
Multidisciplinary Sciences
Te-An Wang, Wei-Chun Chan, Shawn H. Tsai, Lee-Jen Chen
Summary: This study investigated the association between chronic central serous chorioretinopathy (CSC) and subsequent development of polypoidal choroidal vasculopathy (PCV). It found that pachyvessel characteristics in chronic CSC are associated with the development of PCV.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Filippo Tatti, Claudio Iovino, Giuseppe Demarinis, Emanuele Siotto Pintor, Marco Pellegrini, Oliver Beale, Kiran Kumar Vupparaboina, Mohammed Abdul Rasheed, Giuseppe Giannaccare, Jay Chhablani, Enrico Peiretti
Summary: The aim of this study was to evaluate choroidal vascularity in unilateral central serous chorioretinopathy (CSC) using en face optical coherence tomography (OCT) images. The study included 40 eyes of 20 CSC patients and 20 eyes of 10 healthy individuals. The results showed no significant differences in choroidal vascularity index (CVI) between different layers of the choroid in CSC-affected eyes and fellow eyes.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Ophthalmology
Sampurna Bhattacharyya, Kumar Saurabh, Sudipta Das, Sukanya Gorhe, Zubin D'souza, Rupak Roy
Summary: This study compared the clinical features and outcomes of central serous chorioretinopathy (CSC) with and without pachychoroid. The results showed that CSC eyes with pachychoroid had higher recurrence rates, lower spontaneous resolution rates, and worse final visual acuity compared to CSC eyes without pachychoroid.
Article
Ophthalmology
Jiyang Tang, Xinyao Han, Ran Tang, Mengyang Li, Zongyi Wang, Mingwei Zhao, Jinfeng Qu
Summary: Pachychoroid pigment epitheliopathy (PPE) may transform into central serous chorioretinopathy (CSC) and polypoidal choroidal vasculopathy (PCV) during follow-up. Long-term regular follow-up is recommended for patients with PPE.
Article
Medicine, General & Internal
Leonie F. Keidel, Benedikt Schworm, Julian Langer, Nikolaus Luft, Tina Herold, Felix Hagenau, Julian E. Klaas, Siegfried G. Priglinger, Jakob Siedlecki
Summary: This study investigates the association between anterior scleral thickness (AST) and pachychoroid disorders. The results show that patients with central serous chorioretinopathy (CSC) and pachychoroid neovasculopathy (PNV) have a significantly thicker anterior sclera compared to the control group. This suggests that scleral thickness may contribute to the development of pachychoroid phenotypes by increasing venous overload.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Ophthalmology
Ryoh Funatsu, Shozo Sonoda, Hiroto Terasaki, Hideki Shiihara, Naohisa Mihara, Juun Horie, Taiji Sakamoto
Summary: This study used UWF-OCT to analyze the choroidal morphological changes in CSC patients and found that the choroid is thicker in CSC patients, even in the peripheral areas. The macular choroidal thickening is more severe in the upper-dominant type of VVDP.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Monica Ravenstijn, Elon H. C. van Dijk, Annechien E. G. Haarman, Talia R. Kaden, Koenraad A. Vermeer, Camiel J. F. Boon, Lawrence A. Yannuzzi, Caroline C. W. Klaver, Suzanne Yzer
Summary: This study compared myopic patients with central serous chorioretinopathy (CSC) to emmetropic patients with CSC and myopic, non-CSC patients. It found that myopic CSC presents similar imaging and clinical characteristics as emmetropic CSC, except for thinner choroids. Other imaging characteristics may aid in the diagnostic process considering the structural changes of myopia.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2021)
Article
Medicine, General & Internal
Rita Serra, Antonio Pinna, Francine Behar-Cohen, Florence Coscas
Summary: This study investigated the incidence and features of choroidal neovascularization (CNV) in central serous chorioretinopathy (CSCR) patients using optical coherence tomography angiography (OCT-A). Complex CSCR is often complicated by type 1 CNV and polypoidal choroidal vasculopathy (PCV) with similar neovascular architecture, suggesting they may be different stages of the same neovascular process. Future studies incorporating demographic data, imaging morphology, and treatment response are needed for definitive conclusions.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Ophthalmology
Areum Jeong, Wonki Kang, Min Sagong
Summary: The purpose of this study was to investigate the features of central serous chorioretinopathy with choroidal neovascularization (CNV) on multimodal imaging and analyze their association with treatment response. The results showed that CNV accompanying central serous chorioretinopathy had heterogeneous features of choroidal hyperpermeability, thickness, and CNV morphology, which were associated with different therapeutic responses to bevacizumab and photodynamic therapy treatments.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2022)
Article
Ophthalmology
Hidetaka Matsumoto, Junki Hoshino, Kosuke Nakamura, Yoshiaki Ohyama, Masahiro Morimoto, Ryo Mukai, Hisako Sumiyoshi, Tetsuya Nakamura, Shoji Kishi, Hideo Akiyama
Summary: This study aimed to investigate the efficacy and safety of quadrant laser photocoagulation for ameliorating choroidal congestion in central serous choroidopathy (CSC). Laser photocoagulation was applied to the macular leakage point(s) as well as the quadrant of the fundus showing vortex vein dilatation. The results showed a significant reduction in central choroidal thickness (CCT) and vertical diameter of dilated vortex vein in the quadrant laser group. However, attention should be paid to possible complications such as choroidal neovascularization (CNV) and visual field deterioration.
JAPANESE JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Yuichiro Shimizu, Manabu Miyata, Sotaro Ooto, Masahiro Miyake, Yuki Mori, Hiroshi Tamura, Naoko Ueda-Arakawa, Akihito Uji, Yuki Muraoka, Ayako Takahashi, Tomotaka Wakazono, Kenji Yamashiro, Masayuki Hata, Akitaka Tsujikawa
Summary: The study found that anti-VEGF monotherapy had similar efficacy for pachychoroid and non-pachychoroid phenotype eyes with PCV over at least 5 years, though further research is needed for confirmation.
ACTA OPHTHALMOLOGICA
(2022)