Journal
RESEARCH ON CHEMICAL INTERMEDIATES
Volume 44, Issue 9, Pages 5063-5073Publisher
SPRINGER
DOI: 10.1007/s11164-018-3409-x
Keywords
Antifungal drug; Dihydromyricetin; Flavonoid; Fungi; Nanomedicine; Silver nanoparticles
Categories
Ask authors/readers for more resources
Dihydromyricetin-mediated silver nanoparticles (DMY-AgNPs) were synthesized and their efficacy against fungal pathogens tested in vitro. The shape of DMY-AgNPs appeared to be spherical with size of similar to 34 nm. Fourier-transform infrared (FT-IR) analysis indicated that -OH and C=O groups were involved in nanoparticle formation. The XRD pattern of DMY-AgNPs showed strong peaks at 38 degrees, 44 degrees, and 64 degrees, corresponding to reflection from (111), (200), and (220) planes. Five opportunistic fungal pathogens, namely Aspergillus fumigatus, Aspergillus niger, Paecilomyces formosus, Candida albicans, and Candida parapsilosis, were isolated from patients suffering from respiratory tract infections. Growth of each fungal strain was inhibited by DMY-AgNPs. The zone of inhibition of DMY-AgNPs against A. fumigatus, A. niger, P. formosus, C. albicans, and C. parapsilosis was 17.6, 19.2, 22.2, 15.8, and 18.5 mm. The minimal inhibitory concentration was found to be 0.83, 0.73, 0.67, 0.95, and 0.89 mu g mL(-1), respectively. This is the first report on DMY-AgNPs as an effective antifungal agent. DMY-AgNPs are a potential alternative to commercially available antifungal fungicidals.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available