Article
Agriculture, Dairy & Animal Science
Barbora Putnova, Iveta Putnova, Misa Skoric, Marcela Buchtova
Summary: The study revealed significant differences in the expression patterns and levels of Wnt receptor Frizzled-6 (FZD6) between canine oral squamous cell carcinoma (COSCC) and canine acanthomatous ameloblastoma (CAA), indicating differential engagement of the Wnt pathway in these tumors.
Article
Medicine, Research & Experimental
Yi-Xia Lou, Jing Gu, Lei Zhu, Sheng-Qi Sun, Xiang-Lin Hao, Jian-Ping Chen, Fei Han, Dan-Dan Wang, Xiao Jiang, Jin-Yi Liu
Summary: This study demonstrates that TC2N promotes proliferation and metastasis in hepatocellular carcinoma (HCC) by activating the Wnt/I3-catenin signaling pathway. Therefore, TC2N might serve as a potential molecular target for the treatment of HCC.
LABORATORY INVESTIGATION
(2023)
Article
Oncology
Giovana de Godoy Fernandes, Bruna Pedrina, Patricia de Faria Lainetti, Priscila Emiko Kobayashi, Veronica Mollica Govoni, Chiara Palmieri, Veridiana Maria Brianezi Dignani de Moura, Renee Laufer-Amorim, Carlos Eduardo Fonseca-Alves
Summary: The study conducted a comprehensive morphological, phenotypical, and molecular characterization of proliferative inflammatory atrophy (PIA) in dogs, demonstrating that PIA is a common lesion associated with prostate cancer in dogs and has the potential to progress into PC.
Article
Cell Biology
Yanli Li, Yang Tian, Wei Zhong, Ning Wang, Yafeng Wang, Yan Zhang, Zhuangli Zhang, Jianbo Li, Fang Ma, Zhihong Zhao, Youmei Peng
Summary: The study revealed that Artemisia argyi essential oil (AAEO) effectively inhibits HCC metastasis by targeting DEPDC1, showing significant anti-metastatic effects with low toxicity in vivo.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Health Care Sciences & Services
Antonio Fernando Leis-Filho, Patricia de Faria Lainetti, Mayara Simao Franzoni, Chiara Palmieri, Priscila Emiko Kobayshi, Renee Laufer-Amorim, Carlos Eduardo Fonseca-Alves
Summary: CD24 is significantly overexpressed in human and canine prostate cancer, though its prognostic value remains questionable. Tumors overexpressing CD24 may serve as reliable models for new targeted therapies, with dogs potentially providing a unique preclinical model for such studies.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Oncology
Jian-Hua Chang, Bo-Wen Xu, Di Shen, Wei Zhao, Yue Wang, Jia-liang Liu, Guang-Xiao Meng, Guang-Zhen Li, Zong-Li Zhang
Summary: In this study, BRF2 was identified and validated as an oncogene in hepatocellular carcinoma (HCC), shedding light on the pathogenesis and therapeutic possibilities for HCC. BRF2 expression was upregulated in HCC, while its depletion inhibited HCC metastasis and invasion. Additionally, miR-409-3p was identified as a regulator of BRF2, and the Wnt/beta-catenin signaling pathway may play a role in early HCC development.
CANCER CELL INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Yi Liu, Haijun Deng, Li Liang, Guiji Zhang, Jie Xia, Keyue Ding, Ni Tang, Kai Wang
Summary: VPS35 enhances HCC metastasis by activating the Wnt/PCP signaling pathway and regulates the membrane sorting and trafficking of FZD2 and ROR1 in hepatoma cells to facilitate PCP pathway activation.
Review
Cell Biology
Yaoyao Zhu, Xia Li
Summary: Colorectal cancer is a common and deadly cancer worldwide, with a close association to genetic mutations, chronic inflammatory disorders, and poor dietary habits. The Wnt signaling pathway plays a crucial role in various physiological processes of colorectal cancer. This review summarizes the recent advances in understanding the mechanisms and potential regulators of the three branches of the Wnt signaling pathway in colorectal cancer.
Article
Oncology
Yun Wang, Qian Liang, Kefeng Lei, Qingqing Zhu, Delong Zeng, Yuhong Liu, Yingsi Lu, Tingting Kang, Nannan Tang, Lifen Huang, Liping Ye, Di Tang, Chengming Zhu
Summary: MEX3A expression is significantly upregulated in breast cancer, related to tumor grade, and plays a critical role in promoting metastasis and maintaining stemness through the Wnt/beta-catenin pathway.
Article
Pathology
Giulia G. Guiraldelli, Maria Carolina M. Prado, Patricia de F. Lainetti, Antonio F. Leis-Filho, Priscila E. Kobayashi, Sarah S. Cury, Carlos E. Fonseca-Alves, Renee Laufer-Amorim
Summary: This study investigates global gene expression in two canine mammary carcinoma cell cultures associated with the ability for vasculogenic mimicry (VM). Several genes and pathways involved in VM development were identified, providing potential diagnostic and therapeutic targets for canine mammary carcinoma.
JOURNAL OF COMPARATIVE PATHOLOGY
(2022)
Article
Multidisciplinary Sciences
Huawei Xu, Zhibin Hao, Yujie Wang, Deng Zhang, Jie Li, Ling Chen, Ninghua Yao, Binbin Qian, Xiaobo Peng, Xianbao Zhan
Summary: Gastric cancer, a prevalent tumor globally, is often fatal due to peritoneal metastasis. However, the underlying mechanism of peritoneal metastasis remains unclear. Our study using organoids derived from malignant ascites of gastric cancer patients revealed that the interaction between exfoliated cancer cells and the liquid tumor microenvironment plays a crucial role in peritoneal metastasis.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Yuna Landais, Celine Vallot
Summary: This article introduces a computational method called MAYA, which can detect and score multiple modes of activation for each pathway in single-cell datasets. This method improves the granularity of pathway analysis and also has the ability to predict cell types and reveal common modes of pathway activation in tumor cells.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Xiaolong Zhang, Lifei Tian, Zeyu Li, Ruiting Liu, Jiao Yu, Bo Liu
Summary: The study demonstrates a cancer-suppressive function of CAMK2N1 in colorectal carcinoma, exerting tumor-inhibiting effects via suppression of the Wnt/β-catenin pathway.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Feilong Hong, Yanjiao Mao, Xinwen Huang
Summary: UNC119 plays a role in the tumorigenesis of nasopharyngeal carcinoma by promoting cell proliferation, invasion, and migration, as well as epithelial-mesenchymal transition. Knockdown of UNC119 suppresses cell growth and metastasis in nasopharyngeal carcinoma by inhibiting the activation of the Wnt/β-catenin pathway.
Article
Biochemistry & Molecular Biology
Yong-ho Choe, Tai-Young Hur, Sung-Lim Lee, Seunghoon Lee, Dajeong Lim, Bong-Hwan Choi, Haeyun Jeong, Jin-Gu No, Sun A. Ock
Summary: Abnormalities have been reported in animals cloned via somatic cell nuclear transfer (SCNT). This study successfully cloned four healthy dogs for bomb-sniffing purposes, with two showing normal phenotypes and two showing abnormal mandible shortening. Genetic analysis revealed variants in Wnt signaling pathway initiators and cadherin in the cloned dogs with mandible shortening abnormalities.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Otorhinolaryngology
Luis Eduardo Silva Moz, Regina Helena Garcia Martins, Rainer Marco Lopez Lapa, Rolando Andre Rios Villacis, Patricia Pintor dos Reis, Silvia Regina Rogatto
Summary: In this study, genomic imbalances were found in patients with Reinke's Edema, but with limited or no risk of cancer. The findings suggest that a long-term follow-up in a large series of patients could clarify the mechanisms involved in the malignant progression of Reinke's Edema.
BRAZILIAN JOURNAL OF OTORHINOLARYNGOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Andressa Brandi, Patricia de Faria Lainetti, Fabiana Elias, Marcela Marcondes Pinto Rodrigues, Livia Fagundes Moraes, Renee Laufer-Amorim, Laiza Sartori de Camargo, Cristina de Oliveira Massoco Salles Gomes, Carlos Eduardo Fonseca-Alves
Summary: Mammary gland tumors in non-castrated female dogs are a useful model for studying human breast cancer. A study investigated the effects of COX-2 blockers on mammary cancer cells and found that COX-2 inhibitors induced apoptosis in these cells, suggesting a potential therapeutic effect. In vitro and in vivo experiments were conducted to confirm the findings.
Article
Biochemistry & Molecular Biology
Thiago Celestino Chulam, Fernanda Bernardi Bertonha, Rolando Andre Rios Villacis, Joao Goncalves Filho, Luiz Paulo Kowalski, Silvia Regina Rogatto
Summary: This study examines the role of inherited cancer predisposition genes in head and neck cancer families. The results show that multiple first-degree relatives in these families have head and neck cancer or other related tumors, indicating the importance of genetics in cancer development.
Article
Oncology
Lars Henrik Jensen, Silvia Regina Rogatto, Jan Lindebjerg, Birgitte Havelund, Cecilie Abildgaard, Luisa Matos do Canto, Chris Vagn-Hansen, Claus Dam, Soren Rafaelsen, Torben Frostrup Hansen
Summary: This study evaluated the feasibility and clinical outcomes of using patient-derived organoids for metastatic colorectal cancer patients with no satisfactory treatment options. The research found that half of the patients had no disease progression at two months by using sensitivity testing with drugs proven to be active in clinical trials. This study suggests that cancer patients may benefit from functional testing using tumor-derived organoids.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Review
Oncology
Andrigo Barboza De Nardi, Cristina de Oliveira Massoco Salles Gomes, Carlos Eduardo Fonseca-Alves, Felipe Noleto de Paiva, Lais Calazans Menescal Linhares, Gabriel Joao Unger Carra, Rodrigo dos Santos Horta, Felipe Augusto Ruiz Sueiro, Paulo Cesar Jark, Adriana Tomoko Nishiya, Carmen Helena de Carvalho Vasconcellos, Rodrigo Ubukata, Karen Batschinski, Renata Afonso Sobral, Simone Crestoni Fernandes, Luiz Roberto Biondi, Ricardo De Francisco Strefezzi, Julia Maria Matera, Marcelo Monte Mor Rangel, Denner Santos dos Anjos, Carlos Henrique Maciel Brunner, Renee Laufer-Amorim, Karine Germano Cadrobbi, Juliana Vieira Cirillo, Mauro Caldas Martins, Nazilton de Paula Reis Filho, Diego Fernando Silva Lessa, Roberta Portela, Carolina Scarpa Carneiro, Silvia Regina Ricci Lucas, Heidge Fukumasu, Marcus Antonio Rossi Feliciano, Juliany Gomes Quitzan, Maria Lucia Zaidan Dagli
Summary: Hemangiosarcoma is a malignant tumor that originates in the endothelial cells of blood vessels. It can be classified as non-visceral and visceral types based on the location of origin. This article provides data on the epidemiology, etiology, diagnosis, staging, therapeutic modalities, and prognosis of canine hemangiosarcoma based on a consensus meeting organized by the Brazilian Association of Veterinary Oncology (ABROVET) in September 2022.
Article
Veterinary Sciences
Andrea Regina Cardoso de Almeida Moreira, Mayara Simao Franzoni, Denner Santos dos Anjos, Paulo Cesar-Jark, Juliano Nobrega, Renee Laufer-Amorim, Marina Valsecchi Henriques, Osmar Pinto Neto, Carlos Eduardo Fonseca-Alves
Summary: A study evaluated the clinical and pathological staging as well as mitotic count in dogs with soft tissue sarcomas and found that these indicators were associated with patient prognosis.
VETERINARY SCIENCES
(2023)
Article
Medicine, Research & Experimental
Naiade Calanca, Ana Lucia Noronha Francisco, Daniela Bizinelli, Hellen Kuasne, Mateus Camargo Barros Filho, Bianca Campos Troncarelli Flores, Clovis Antonio Lopes Pinto, Claudia Aparecida Rainho, Milena Botelho Pereira Soares, Fabio Albuquerque Marchi, Luiz Paulo Kowalski, Silvia Regina Rogatto
Summary: Oral cavity squamous cell carcinoma (OSCC) is a complex and dynamic disease with clinicopathological and molecular heterogeneity. Aberrant epigenetic profiles in OSCC affect the immune microenvironment by modulating the expression of immune-related lncRNAs. This study investigated the immune cell composition, immune markers alteration, and dysregulation of immune-associated lncRNAs in OSCC samples, which contribute to tumor heterogeneity. The findings suggest that epiimmunotherapy could be a potential alternative treatment for OSCC.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Veterinary Sciences
Cristiana R. Bromberger, Julia Rodrigues Costa, Mariana Herman, Juliana Mira Hernandez, Lukas Garrido Albertino, Carlos Eduardo Fonseca Alves, Alexandre S. Borges, Jose P. Oliveira-Filho
Summary: This study aimed to evaluate the presence of Equus caballus papillomavirus (EcPV) in equine aural plaque samples. PCR analysis revealed that EcPVs 2, 7, 8, and 9 were not detected in any of the evaluated samples, suggesting that these viral types are not involved in the etiology of equine aural plaque in Brazil. EcPV 6 was the most prevalent (81%), followed by EcPVs 3 (72%), 4 (63%), and 5 (47%), emphasizing their important role in the etiology of equine aural plaque in Brazil.
JOURNAL OF EQUINE VETERINARY SCIENCE
(2023)
Article
Genetics & Heredity
Luiza Cortes, Tatiane Ramos Basso, Rolando Andre Rios Villacis, Jeferson dos Santos Souza, Mads Malik Aagaard Jorgensen, Maria Isabel Achatz, Silvia Regina Rogatto
Summary: This study used whole exome sequencing to test three unrelated patients with breast and colorectal cancer who met the clinical criteria for HBOC. Several variants and copy number variations were identified that potentially contribute to cancer risk and prognosis. Copy number imbalances encompassing PMS2, a gene involved in the DNA mismatch repair pathway, were observed in all patients, along with gains in the POLE2 gene associated with DNA replication and other potentially damaging germline variants. Overall, concurrent genomic alterations were described that may increase the risk of breast and colorectal cancers in HBOC patients.
Article
Oncology
George Daniel Grass, Dalia Ercan, Alyssa N. Obermayer, Timothy Shaw, Paul A. Stewart, Jad Chahoud, Jasreman Dhillon, Alex Lopez, Peter A. S. Johnstone, Silvia Regina Rogatto, Philippe E. Spiess, Steven A. Eschrich
Summary: This study provides the first description of the surfaceome in penile cancer and evaluates the impact of human papillomavirus (HPV) infection on surfaceome diversity. The analysis found a diverse surfaceome within patient tumors, with a high proportion of membrane proteins and transporters. The study also identified significant differences in protein classes based on HPV status and a prognostic immunoglobulin protein called BSG/CD147.
Article
Agriculture, Dairy & Animal Science
Caroline Grisoni Sanchez, Marxa Leao Figueiredo, Laiza de Sartori Camargo, Luiz Guilherme Dercore Benevenuto, Zara Alves Lacerda, Carlos Eduardo Fonseca-Alves
Summary: Osteopontin (OPN) expression was investigated in canine mammary gland tumors (MGTs) and prostate cancer (PC) samples, and its association with bone metastasis was explored. Higher OPN expression was detected in primary tumor samples from animals with bone metastasis. In MGT samples, patients with higher OPN expression had significantly lower survival rates. Although not statistically significant, animals with positive OPN expression in PC samples showed a trend toward lower survival. These findings suggest that OPN may be a promising target for future studies on MGTs and PC due to its role in enhancing cell invasion and metastasis.
Article
Veterinary Sciences
Tamires G. W. Teodoro, Maria Eduarda S. T. Campos, Laice A. Silva, Tatiane T. N. Watanabe, Carlos Eduardo F. Alves, Renee Laufer-Amorim, Flademir Wouters, Angelica T. B. Wouters
Summary: This study investigated and characterized the nonpathological presence of intrascleral cartilage in sheep. It was found that 66.66% of the examined sheep eyes had intrascleral cartilage. This research suggests that intrascleral cartilage is a common anatomical component in sheep eyes, despite age, breed, or body condition.
PESQUISA VETERINARIA BRASILEIRA
(2023)
Article
Infectious Diseases
Fabricio Bernardi, Marina Gabriela Possa, Camila Elizandra Rossi, Luiz Guilherme Dercore Benevenuto, Iucif Abrao Nascif Junior, Jacqueline de Jesus, Barbara Cardoso de Oliveira, Carla Zanelatto, Joice Gama Sena, Carlos Eduardo Fonseca-Alves, Fabiana Elias
Summary: This study analyzed the epidemiological characteristics of human brucellosis in Western Santa Catarina from 2013 to 2018. The results showed that brucellosis is an endemic disease in the region, with a higher prevalence among males, individuals aged 20-59, those engaged in agricultural and livestock-related professions, and those who reported consuming unpasteurized dairy products.
REVISTA DO INSTITUTO DE MEDICINA TROPICAL DE SAO PAULO
(2022)
Article
Veterinary Sciences
Jane Karlla de Oliveira Matos, Samoel Ricardo Maldaner, Leonardo Gruchouskei, Luciana Pereira Machado, Fernanda Zuliani, Alexandre Matheus Baesso Cavalca, Carlos Eduardo Fonseca Alves, Fabiana Elias
Summary: This article reports an outbreak of stephanofilariasis in a dairy cattle farm in Brazil and presents a new diagnostic method.
ACTA SCIENTIAE VETERINARIAE
(2022)
Article
Veterinary Sciences
Ygor Amaral Rossi, Leticia Ribeiro, Regina Mendes Medeiros, Enrico Pierluigi Spugnini, Carlos Eduardo Fonseca-Alves, Denner Santos Dos Anjos
Summary: This study reported a case of perianal melanoma in a dog, which was treated with electrochemotherapy (ECT) and achieved good therapeutic effect. The authors suggested that ECT might be a feasible local treatment option in cases with anatomical limitations.
ACTA SCIENTIAE VETERINARIAE
(2022)
Article
Veterinary Sciences
R. Mischke, K. Rumstedt, S. O. Hungerbuehler, K. Rohn, M. Schmicke
Summary: Contrast-enhanced ultrasound (CEUS) can provide an additional tool for the diagnosis of hypothyroidism in dogs and support its differentiation from non-thyroidal illness. Sedation has limited impact on CEUS results.
RESEARCH IN VETERINARY SCIENCE
(2024)
Review
Veterinary Sciences
Lucas Petitemberte de Souza, William Borges Domingues, Eduardo Bierhals Blodorn, Leandro da Silva Nunes, Hadassa Gabriela Ortiz, Eliza Rossi Komninou, Vinicius Farias Campos
Summary: This study performed a systematic review of the differential expression of sperm microRNAs in bulls related to fertility. A total of 182 unique differentially expressed miRNAs were identified, among which 49 miRNAs were found in common between at least two studies. The results suggest that miRNAs such as miR-10a, -10b, -103, -15b, -122, -125b, -126-5p, -151-5p, -193a-5p, -196a, -27a-5p, and -99b may serve as potential universal biomarkers for assessing the reproductive potential of males.
RESEARCH IN VETERINARY SCIENCE
(2024)
Article
Veterinary Sciences
Wonhee Cha, Katinca Fungbrant, Giulio Grandi, Ylva Persson
Summary: This study investigated the prevalence and development of hair loss in outdoor cattle in Sweden. It found a relatively high hair loss rate, with the occurrence of hair loss increasing over time during winters, suggesting a contagious etiology. The study also identified preventative delousing before November, keeping animals clean, and maintaining small group sizes as effective measures to reduce the risk of hair loss, while older age and access to bedding materials increased the risk.
RESEARCH IN VETERINARY SCIENCE
(2024)
Article
Veterinary Sciences
Sheeba Thomas, David Francis Lappin, David Bennett, Christopher Nile, Marcello Pasquale Riggio
Summary: This study found that Feline odontoclastic resorptive lesion (FORL) can be divided into two subgroups, with FORL-1 subgroup having a less diverse oral microbiome and higher levels of proinflammatory cytokines and chemokines, which may be associated with the severity and activity of the disease.
RESEARCH IN VETERINARY SCIENCE
(2024)
Article
Veterinary Sciences
S. L. Gayathri, M. Bhakat, T. K. Mohanty
Summary: This study used infrared thermography (IRT) to identify mastitis in Sahiwal cows. The results showed significant differences in the mean values of udder and teat surface temperature between healthy, subclinical mastitis (SCM), and clinical mastitis (CM) cases during different seasons. IRT is an efficient tool for the early identification of subclinical mastitis.
RESEARCH IN VETERINARY SCIENCE
(2024)
Article
Veterinary Sciences
Zeynep Ozdemir Kutahya, Busra Aslan Akyol, Kubra Deliklitas, Cengiz Gokbulut
Summary: In this study, the pharmacokinetic behavior of Eprinomectin was studied in two different goat breeds. The results showed no significant differences in plasma concentration between the breeds, but the clearance from the body may vary. High concentration of Eprinomectin in feces is beneficial against gastrointestinal parasites but poses an ecotoxicological risk to the environment.
RESEARCH IN VETERINARY SCIENCE
(2024)
Article
Veterinary Sciences
Mohammad Ashrafzadeh-Shiraz, Mousa Tavassoli, Bahram Dalir-Naghadeh, Alireza Sazmand
Summary: This study evaluated the efficacy of fenbendazole and ivermectin on strongyles and Parascaris sp. infecting adult riding horses in different regions of Iran. The results demonstrated varying degrees of resistance of these parasites to both anthelminthics. It emphasizes the urgency of educating horse owners about the importance of a test-and-treatment strategy and suggests evaluating the efficacy of different anthelminthics to choose the most effective treatment in each region.
RESEARCH IN VETERINARY SCIENCE
(2024)
Article
Veterinary Sciences
Moises Gonzalvez, Clara Munoz-Hernandez
Summary: The study evaluated the use of R software in research articles addressing the study of wildlife, showing an increasing trend in the number of publications over time and a wide geographical distribution globally.
RESEARCH IN VETERINARY SCIENCE
(2024)
