Article
Pharmacology & Pharmacy
Sherry R. Black, John W. Nichols, Kellie A. Fay, Sharlene R. Matten, Scott G. Lynn
Summary: This study measured C-Lint values for various industrial and pesticidal chemicals using in vitro systems, emphasizing the importance of negative controls in quality assessment and noting a decline in in vitro test performance with increasing chemical hydrophobicity. Determining C-Lint for poorly soluble chemicals remains a challenge.
Article
Multidisciplinary Sciences
Julita Stadnicka-Michalak, Nadine Bramaz, Rene Schonenberger, Kristin Schirmer
Summary: A complementary empirical model framework was developed to predict chemical medium concentrations in different well-plate formats, focusing on chemicals' volatility and hydrophobicity. The type of plate cover and medium volume were identified as important drivers of volatile chemical loss, accurately predicted by the framework.
SCIENTIFIC REPORTS
(2021)
Article
Environmental Sciences
Steven T. J. Droge, James M. Armitage, Jon A. Arnot, Patrick N. Fitzsimmons, John W. Nichols
Summary: Research investigated the metabolism rates of different cationic surfactants in rainbow trout, revealing rapid clearance of N,N-dimethylalkylamines and slower clearance of N-methylalkylamines.
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
(2021)
Article
Environmental Sciences
Lawrence P. Burkhard, Tylor J. Lahren, Kaila B. Hanson, Alex J. Kasparek, David R. Mount
Summary: Rainbow trout was exposed to a mixture of non-ionic organic chemicals through the diet, and the study found that highly hydrophobic chemicals were less bioavailable and bioaccumulative compared to other chemicals.
ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
(2023)
Article
Environmental Sciences
Fabian Balk, Juliane Hollender, Kristin Schirmer
Summary: A method using the rainbow trout liver-derived RTL-W1 cell line was developed to assess the bioaccumulation potential of anionic organic compounds in fish. Based on in vivo data and charge state, four anionic compounds were selected and bioaccumulation experiments were conducted using the fish cell line acute toxicity assay. The RTL-W1-based Bioconcentration Factors (BCF) showed good agreement with model predictions based on octanol-water partitioning, but all methods overestimated the in vivo Biomagnification Factors (BMF), indicating the need for adaptation or a multiple cell line approach for BMF estimations.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Physiology
Buying Han, Yuqiong Meng, Haining Tian, Changzhong Li, Yaopeng Li, Caidan Gongbao, Wenyan Fan, Rui Ma
Summary: This experiment studied the effects of acute hypoxia on the physiological and metabolic responses of triploid rainbow trout. The results showed that hypoxia increased stress response and altered metabolism response, and the hepatic HIF-2 alpha pathway might regulate the changes in metabolism.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Environmental Sciences
Jessy Le Du-Carree, Joelle Cabon, Thierry Morin, Morgane Danion
Summary: The study found that rainbow trout acutely exposed to glyphosate or GBHs showed no major physiological changes, but viral infection led to disruptions in hematological and metabolic parameters, potentially modulated by co-formulants. This highlights the importance of considering the stressful natural environment of fish in chemical assessments.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Biochemistry & Molecular Biology
Megan E. Solan, Marco E. Franco, Ramon Lavado
Summary: Exposure to PFASs may affect biotransformation pathways in organisms, especially in detoxification mechanisms. Changes in CYP1A-like activity were observed in vivo after exposure to PFAS-BaP mixtures, while no such alterations were seen in vitro.
FISH PHYSIOLOGY AND BIOCHEMISTRY
(2022)
Article
Zoology
B. Greenaway, C. Veneruzzo, M. D. Rennie
Summary: In variable environments, individual phenotypic differences provide the necessary variation for natural selection. The pace-of-life syndrome (POLS) links individual physiology, life history, and behavior, where fast-growing individuals demonstrate higher rates of metabolic rate. Comparing domesticated and wild strains of rainbow trout, we found that fast-growing fish have 1.25 times higher metabolic rate scaling coefficients compared to slower growing fish.
CANADIAN JOURNAL OF ZOOLOGY
(2023)
Article
Food Science & Technology
Jelena Babic Milijasevic, Milan Milijasevic, Slobodan Lilic, Jasna Djinovic-Stojanovic, Ivan Nastasijevic, Tamara Geric, Matteo Alessandro Del Nobile
Summary: The quality changes of gutted rainbow trout in different packaging methods were evaluated. The results showed that modified atmosphere packaging (MAP) significantly extended the shelf life of the fish.
Article
Biology
H. E. Cohen, W. Ray, O. H. Hawkins, E. A. Kane
Summary: In fishes, damage to important morphological structures such as fins can have cascading effects on prey capture performance and individual fitness. This study examined the effect of sub-lethal fin damage on bluegill sunfish and found that damaged fish exhibited lower stability and consistency in kinematics, which could impact higher-order ecological interactions.
INTEGRATIVE ORGANISMAL BIOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Shanli Zhu, Mark Portman, Beth M. Cleveland, Andrew D. Magnuson, Kun Wu, Wendy Sealey, Xin Gen Lei
Summary: Replacing fish oil with DHA-rich microalgae in juvenile rainbow trout diets resulted in more negative metabolic responses compared to substituting synthetic astaxanthin with microalgal source. These substitutions had significant impacts on growth and nutrient utilization in rainbow trout.
JOURNAL OF ANIMAL SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Andreas Brezas, Vikas Kumar, Ken Overturf, Ronald W. Hardy
Summary: The study investigated physiological differences related to growth performance in rainbow trout strains fed an all plant protein diet, revealing that gene expression of intestinal amino acid transporters and other factors play a role in improved growth and protein retention of the selected strain.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
(2021)
Article
Toxicology
Saeed Hajirezaee, Ahmad Rafieepour, Ruhollah Rahimi, Shafigh Shafiei
Summary: The study examined the protective effects of Ginkgo biloba (GB) against the toxic effects of diazinon in rainbow trout, showing that at optimal dietary levels (1-2 g GB/kg diet), GB could stimulate growth, moderate growth suppression effects, alleviate stress, and reduce liver tissue damages induced by diazinon.
Article
Toxicology
Ina Bischof, Jon A. Arnot, Heinrich Juerling, Georg Knipschild, Christian Schlechtriem, Anna Schauerte, Helmut Segner
Summary: This study validated the use of primary hepatocytes from rainbow trout for predicting bioconcentration factors (BCF) of chemicals in fish. The study compared biotransformation rate values and BCF predictions between trout and carp hepatocytes, and found that the predicted BCF values were significantly higher in trout than in carp. However, the measured in vivo BCF values did not differ significantly between the two species. This suggests the need for species-specific extrapolation models.
FRONTIERS IN TOXICOLOGY
(2022)
Article
Medicine, Legal
Fiona Sewell, Ian Ragan, Graham Horgan, David Andrew, Thomas Holmes, Irene Manou, Boris P. Mueller, Tim Rowan, Barbara G. Schmitt, Marco Corvaro
Summary: There are currently three test guidelines for acute oral toxicity studies, but the subjectivity of one guideline may be hindering its wider use. In order to address this, the NC3Rs and EPAA collaborated to analyze historical data and provide recommendations on the recognition of 'evident toxicity'.
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2024)
Article
Medicine, Legal
Michael DeVito, Bas Bokkers, Majorie B. M. van Duursen, Karin van Ede, Mark Feeley, Elsa Antunes Fernandes Gaspar, Laurie Haws, Sean Kennedy, Richard E. Peterson, Ron Hoogenboom, Keiko Nohara, Kim Petersen, Cynthia Rider, Martin Rose, Stephen Safe, Dieter Schrenk, Matthew W. Wheeler, Daniele S. Wikoff, Bin Zhao, Martin van den Berg
Summary: In October 2022, the World Health Organization reevaluated the toxic equivalency factors (TEFs) for chlorinated dioxin-like compounds in a panel convened in Lisbon. This effort utilized an updated database, Bayesian dose response modeling, and meta-analysis to derive Best-Estimate TEFs. Applying these new TEFs may result in lower total toxic equivalents for dioxin-like chemicals.
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2024)