Review
Chemistry, Multidisciplinary
Eylem Asmatulu, Mohammad Nahid Andalib, Balakrishnan Subeshan, Farhana Abedin
Summary: Nanomaterials, with unique properties, are extensively used in various industries. However, their ubiquitous presence in the environment may induce toxicity issues for humans. This review focuses on the impact of nanomaterial exposure on human cells and animal models, particularly discussing silver, gold, silica, quantum dots, iron oxides, zinc oxide, and titanium dioxide. Accumulation of nanomaterials in the heart, liver, spleen, kidney, and brain through ingestion, dermal penetration, inhalation, and intravenous routes is evidenced.
ENVIRONMENTAL CHEMISTRY LETTERS
(2022)
Article
Green & Sustainable Science & Technology
Renata Wlodarczyk, Anna Kwarciak-Kozlowska
Summary: This paper focuses on the application and role of nanomaterials in the cosmetics and medical industries, discussing the methods of obtaining nanoscale materials and their characteristic structure. It also delves into the hazards and risks associated with nanomaterial properties, as well as legal and environmental considerations and the involvement of the European Commission and other countries in related activities.
Article
Chemistry, Multidisciplinary
Susana I. L. Gomes, Bruno Guimaraes, Elisabetta Campodoni, Monica Sandri, Simone Sprio, Magda Blosi, Anna L. Costa, Janeck J. Scott-Fordsmand, Monica J. B. Amorim
Summary: Developments in nanotechnology must ensure compliance with regulatory requirements, with a focus on safety and sustainability. Nanobiomaterials offer significant advantages in biomedical applications, but their ecotoxicological effects require further investigation to ensure safety.
Article
Environmental Sciences
Edipo Paixao Silva de Jesus, Livia Pitombeira de Figueiredo, Frederico Maia, Roberto Martins, Jeamylle Nilin
Summary: The study found that tropical mysids are more sensitive to the tested compounds, with the combination SiNC-DCOIT-Ag showing lower acute toxicity, although still highly toxic to tropical mysids.
MARINE POLLUTION BULLETIN
(2021)
Article
Computer Science, Software Engineering
Sakshi Ranjan, Subhankar Mishra
Summary: The study focuses on sentiment classification of app reviews and explores university students' behavior towards the app market using machine learning algorithms. Evaluations were conducted using TP, TF, and TF-IDF text representation scheme and Bagging ensemble learning method. The use of GloVe word embedding in deep learning models improved algorithm performance, with LSTM on GloVe embedding achieving the highest accuracy and F-score.
CONCURRENCY AND COMPUTATION-PRACTICE & EXPERIENCE
(2022)
Review
Medicine, Legal
David Kirkland, Marilyn J. Aardema, Ruediger V. Battersby, Carol Beevers, Karin Burnett, Arne Burzlaff, Andreas Czich, E. Maria Donner, Paul Fowler, Helinor J. Johnston, Harald F. Krug, Stefan Pfuhler, Leon F. Stankowsk
Summary: A comprehensive weight of evidence assessment of the genotoxicity of titanium dioxide suggests that the observed genotoxic effects are likely secondary to physiological stress, rather than direct DNA damage. The existing evidence also does not support the mutagenicity of titanium dioxide nanoparticles.
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2022)
Review
Engineering, Mechanical
Yi Han, Gaurav Nanda, Mohsen Moghaddam
Summary: Eliciting informative user opinions from online reviews is crucial for successful product design and development. However, the nature of user reviews often makes large-scale need finding challenging for designers. Recent advances in abstractive text summarization offer the opportunity to generate opinion summaries, but there are knowledge gaps in guiding the generative process and creating annotated training datasets. This article addresses these gaps by devising a framework for abstractive opinion summarization and generating a synthetic training dataset. Numerical experiments demonstrate the feasibility and potential of the framework.
JOURNAL OF MECHANICAL DESIGN
(2023)
Article
Chemistry, Medicinal
Dimitra-Danai Varsou, Nikoletta-Maria Koutroumpa, Haralambos Sarimveis
Summary: This study presents a computational workflow for grouping engineered nanomaterials (ENMs) and predicting their toxicity-related end points. A mixed integer-linear optimization program (MILP) problem is formulated to automatically filter noisy variables and develop specific predictive models for each group. The method demonstrates good performance through application to benchmark datasets and comparison with alternative predictive modeling approaches.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2021)
Article
Materials Science, Multidisciplinary
Nyuk Ling Ma, Nan Zhang, Wilson Thau Lym Yong, Suzana Misbah, Fatimah Hashim, Chin Fhong Soon, Gim Pao Lim, Wanxi Peng, Christian Sonne
Summary: Nanomaterials show promise in various industries, especially in neurological therapeutic applications. However, concerns about their safety have been raised due to their permeability and widespread use, particularly engineered nanomaterials. Therefore, it is urgent to capitalize on new developments in engineered nanomaterial safety evaluation. In recent years, risk assessment and management techniques for nanomaterials across their whole life-cycle have emerged, including systems biology approaches and high-throughput screening platforms.
MATERIALS TODAY ADVANCES
(2023)
Article
Multidisciplinary Sciences
Kunhao Yang, Itsuki Fujisaki, Kazuhiro Ueda
Summary: This study found that outlier reviews were considered more helpful compared to other online reviews because they provided more sufficient, neutral, and concise information.
SCIENTIFIC REPORTS
(2023)
Article
Environmental Sciences
Alex Zabeo, Gianpietro Basei, Georgia Tsiliki, Willie Peijnenburg, Danail Hristozov
Summary: The proposed novel procedure for similarity assessment and grouping of nanomaterials is based on various metrics and hierarchical clustering, ensuring robust grouping independent of the dataset used, and a software tool has been developed to facilitate its application.
Article
Environmental Sciences
Mohammad Behzadi Tayemeh, Hesamoddin Abaei, Kirill Golokhvast, Hamid Salari Joo, Konstantin Pikula, Seyed Ali Johari, Borhan Mansouri
Summary: This study evaluates and compares the toxicity of AgNPs, TiO(2)NPs, and SiO(2)NPs individually and combined on the life cycle of A. salina. AgNPs showed acute toxicity while SiO(2)NPs and TiO(2)NPs induced chronic toxicity in a concentration- and time-dependent manner. The presence of AgNPs shifted the reproductive mode from ovoviviparity to oviparity and the coexistence of AgNPs with SiO(2)NPs or TiO(2)NPs caused infertility. Overall, the individual toxicity of the nanoparticles was AgNPs > TiO(2)NPs > SiO2NPs, and the combined exposure of AgNPs-SiO(2)NPs was more threatening to A. salina than AgNPs-TiO(2)NPs.
ENVIRONMENTAL POLLUTION
(2023)
Review
Engineering, Environmental
Yueyang Zhang, Greg G. Goss
Summary: The use of nanotechnology in agriculture has the potential to boost crop production, but its impact on aquatic organisms is not well understood. This review analyzes existing studies and finds that nano-agrochemicals generally have lower toxicity to non-target aquatic species compared to conventional counterparts. However, the analysis also highlights the need for further research and provides recommendations for future toxicity studies to ensure the effective and sustainable application of nano-agrochemicals.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Environmental Sciences
Yaqi Jiang, Pingfan Zhou, Tengtao Ma, Muhammad Adeel, Noman Shakoor, Yuanbo Li, Mingshu Li, Manlin Guo, Yukui Rui
Summary: This study explores the application of manganese-based nanomaterials (Mn-based NMs) in agriculture and finds that proper application can enhance the growth and stress resistance of soybean, but excessive application can inhibit the absorption of mineral elements in roots.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Toxicology
Fiona Murphy, Nicklas Raun Jacobsen, Emilio Di Ianni, Helinor Johnston, Hedwig Braakhuis, Willie Peijnenburg, Agnes Oomen, Teresa Fernandes, Vicki Stone
Summary: The study developed an Integrated Approach to Testing and Assessment (IATA) to support grouping of high aspect ratio nanomaterials (HARNs) and reduce the burden of toxicity testing.
PARTICLE AND FIBRE TOXICOLOGY
(2022)
Article
Genetics & Heredity
Naouale El Yamani, Andrew R. Collins, Elise Runden-Pran, Lise Marie Fjellsbo, Sergey Shaposhnikov, Shanbeh Zienolddiny, Maria Dusinska
Article
Biochemistry & Molecular Biology
Johanna Samulin Erdem, Yke Jildouw Arnoldussen, Vidar Skaug, Aage Haugen, Shanbeh Zienolddiny
MOLECULAR CARCINOGENESIS
(2017)
Article
Genetics & Heredity
James D. McKay, Rayjean J. Hung, Younghun Han, Xuchen Zong, Robert Carreras-Torres, David C. Christiani, Neil E. Caporaso, Mattias Johansson, Xiangjun Xiao, Yafang Li, Jinyoung Byun, Alison Dunning, Karen A. Pooley, David C. Qian, Xuemei Ji, Geoffrey Liu, Maria N. Timofeeva, Stig E. Bojesen, Xifeng Wu, Loic Le Marchand, Demetrios Albanes, Heike Bickeboeller, Melinda C. Aldrich, William S. Bush, Adonina Tardon, Gad Rennert, M. Dawn Teare, John K. Field, Lambertus A. Kiemeney, Philip Lazarus, Aage Haugen, Stephen Lam, Matthew B. Schabath, Angeline S. Andrew, Hongbing Shen, Yun-Chul Hong, Jian-Min Yuan, Pier Alberto Bertazzi, Angela C. Pesatori, Yuanqing Ye, Nancy Diao, Li Su, Ruyang Zhang, Yonathan Brhane, Natasha Leighl, Jakob S. Johansen, Anders Mellemgaard, Walid Saliba, Christopher A. Haiman, Lynne R. Wilkens, Ana Fernandez-Somoano, Guillermo Fernandez-Tardon, Henricus F. M. van der Heijden, Jin Hee Kim, Juncheng Dai, Zhibin Hu, Michael P. A. Davies, Michael W. Marcus, Hans Brunnstrom, Jonas Manjer, Olle Melander, David C. Muller, Kim Overvad, Antonia Trichopoulou, Rosario Tumino, Jennifer A. Doherty, Matt P. Barnett, Chu Chen, Gary E. Goodman, Angela Cox, Fiona Taylor, Penella Woll, Irene Brueske, H-Erich Wichmann, Judith Manz, Thomas R. Muley, Angela Risch, Albert Rosenberger, Kjell Grankvist, Mikael Johansson, Frances A. Shepherd, Ming-Sound Tsao, Susanne M. Arnold, Eric B. Haura, Ciprian Bolca, Ivana Holcatova, Vladimir Janout, Milica Kontic, Jolanta Lissowska, Anush Mukeria, Simona Ognjanovic, Tadeusz M. Orlowski, Ghislaine Scelo, Beata Swiatkowska, David Zaridze, Per Bakke, Vidar Skaug, Shanbeh Zienolddiny, Eric J. Duell, Lesley M. Butler, Woon-Puay Koh, Yu-Tang Gao, Richard S. Houlston, John McLaughlin, Victoria L. Stevens, Philippe Joubert, Maxime Lamontagne, David C. Nickle, Ma'en Obeidat, Wim Timens, Bin Zhu, Lei Song, Linda Kachuri, Maria Soler Artigas, Martin D. Tobin, Louise V. Wain, Thorunn Rafnar, Thorgeir E. Thorgeirsson, Gunnar W. Reginsson, Kari Stefansson, Dana B. Hancock, Laura J. Bierut, Margaret R. Spitz, Nathan C. Gaddis, Sharon M. Lutz, Fangyi Gu, Eric O. Johnson, Ahsan Kamal, Claudio Pikielny, Dakai Zhu, Sara Lindstroem, Xia Jiang, Rachel F. Tyndale, Georgia Chenevix-Trench, Jonathan Beesley, Yohan Bosse, Stephen Chanock, Paul Brennan, Maria Teresa Landi, Christopher I. Amos
Article
Multidisciplinary Sciences
Beata Peplonska, Agnieszka Bukowska, Edyta Wieczorek, Monika Przybek, Shanbeh Zienolddiny, Edyta Reszka
Article
Nanoscience & Nanotechnology
Santosh Phuyal, Mayes Kasem, Oskar Knittelfelder, Animesh Sharma, Davi de Miranda Fonseca, Vaineta Vebraite, Sergey Shaposhnikov, Geir Slupphaug, Vidar Skaug, Shanbeh Zienolddiny
Article
Biochemistry & Molecular Biology
Yke Jildouw Arnoldussen, Torunn Kringlen Ervik, Mina Baarnes Eriksen, Ida Kero, Vidar Skaug, Shanbeh Zienolddiny
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Biochemistry & Molecular Biology
Yke Jildouw Arnoldussen, Torunn Kringlen Ervik, Johanna Samulin Erdem, Ida Kero, Mina Baarnes Eriksen, Vidar Skaug, Shanbeh Zienolddiny
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Biochemistry & Molecular Biology
Mayes Alswady-Hoff, Johanna Samulin Erdem, Santosh Phuyal, Oskar Knittelfelder, Animesh Sharma, Davi de Miranda Fonseca, Oivind Skare, Geir Slupphaug, Shanbeh Zienolddiny
Summary: This study investigated the long-term effects of TiO2 exposure on pulmonary epithelial cells in vitro, revealing that TiO2 exposure altered the cell cycle, increased apoptosis, and led to lipid accumulation related to cellular stress response. The findings suggest that cell stress response and cell death pathways may play a crucial role in the long-term health effects of TiO2 exposure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Mayes Alswady-Hoff, Johanna Samulin Erdem, Mona Aleksandersen, Kristine Haugen Anmarkrud, Oivind Skare, Fang-Chin Lin, Vincent Simensen, Yke Jildouw Arnoldussen, Vidar Skaug, Erik Ropstad, Shanbeh Zienolddiny-Narui
Summary: This study investigated the effects of exposure to multiwalled carbon nanotubes (MWCNT) on telomere length and its possible mechanism in carcinogenesis. The results showed that long-term exposure to long MWCNT led to significant telomere shortening, which resulted in cell cycle arrest and apoptosis, ultimately leading to inflammation and fibrosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Laura Maria Azzurra Camassa, Elisabeth Elje, Espen Mariussen, Eleonora Marta Longhin, Maria Dusinska, Shan Zienolddiny-Narui, Elise Runden-Pran
Summary: This study aims to test and optimize a 3D lung model for the hazard assessment of nanomaterials. The addition of complexity in the model has resulted in a change in sensitivity, highlighting the importance of detailed protocols for robustness and reproducibility.
Article
Biochemistry & Molecular Biology
Tanya Tacheva, Shanbeh Zienolddiny-Narui, Dimo Dimov, Denitsa Vlaykova, Iva Miteva, Tatyana Vlaykova
Summary: This study investigated the relationship between GSTM1 and GSTT1 gene polymorphisms and COPD risk, finding that the GSTM1 null genotype may be involved in leucocyte telomere shortening and contribute to the pathogenesis of COPD.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2022)
Article
Biology
Edyta Reszka, Edyta Wieczorek, Monika Przybek, Ewa Jablonska, Pawel Kaluzny, Agnieszka Bukowska-Damska, Shanbeh Zienolddiny, Beata Peplonska
CHRONOBIOLOGY INTERNATIONAL
(2018)
Article
Biology
Agnieszka Bukowska-Damska, Edyta Reszka, Pawel Kaluzny, Edyta Wieczorek, Monika Przybek, Shanbeh Zienolddiny, Beata Peplonska
CHRONOBIOLOGY INTERNATIONAL
(2018)
Article
Biology
Agnieszka Bukowska-Damska, Edyta Reszka, Pawel Kaluzny, Edyta Wieczorek, Monika Przybek, Shanbeh Zienolddiny, Beata Peplonska
CHRONOBIOLOGY INTERNATIONAL
(2017)
Article
Medicine, Legal
Fiona Sewell, Ian Ragan, Graham Horgan, David Andrew, Thomas Holmes, Irene Manou, Boris P. Mueller, Tim Rowan, Barbara G. Schmitt, Marco Corvaro
Summary: There are currently three test guidelines for acute oral toxicity studies, but the subjectivity of one guideline may be hindering its wider use. In order to address this, the NC3Rs and EPAA collaborated to analyze historical data and provide recommendations on the recognition of 'evident toxicity'.
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2024)
Article
Medicine, Legal
Michael DeVito, Bas Bokkers, Majorie B. M. van Duursen, Karin van Ede, Mark Feeley, Elsa Antunes Fernandes Gaspar, Laurie Haws, Sean Kennedy, Richard E. Peterson, Ron Hoogenboom, Keiko Nohara, Kim Petersen, Cynthia Rider, Martin Rose, Stephen Safe, Dieter Schrenk, Matthew W. Wheeler, Daniele S. Wikoff, Bin Zhao, Martin van den Berg
Summary: In October 2022, the World Health Organization reevaluated the toxic equivalency factors (TEFs) for chlorinated dioxin-like compounds in a panel convened in Lisbon. This effort utilized an updated database, Bayesian dose response modeling, and meta-analysis to derive Best-Estimate TEFs. Applying these new TEFs may result in lower total toxic equivalents for dioxin-like chemicals.
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2024)