Article
Health Care Sciences & Services
Elena Olariu, Raluca Caplescu, Luke Vale, Ileana Gabriela Niculescu-Aron, Yemi Oluboyede, Marian Sorin Paveliu
Summary: The study aimed to estimate population norms for the Romanian versions of EQ-5D-5L, EQ-5D-3L, their indexes, and EQ VAS. A cross-sectional survey was conducted using a representative sample, and descriptive statistics were used to estimate population norms by age groups and sex. The findings provide reference values for healthcare professionals, researchers, and decision-makers in Romania.
HEALTH AND QUALITY OF LIFE OUTCOMES
(2023)
Article
Economics
Ben A. van Hout, James W. Shaw
Summary: This research developed algorithms to map EQ-5D-3L responses to EQ-5D-5L value sets and found that including indicants of problems for other dimensions as regressors in the model improved prediction accuracy. Adding age and gender lowered AIC without improving predictions, while including a latent factor slightly improved predictive accuracy. Models conditioning on problems in other dimensions yielded more accurate predictions than an alternative copula-based approach.
Article
Neurosciences
Bernhard Michalowsky, Wolfgang Hoffmann, Feng Xie
Summary: The study compared the psychometric properties of EQ-5D-5L and EQ-5D-3L in patients with dementia, finding that EQ-5D-5L had lower acceptability and discriminative ability compared to EQ-5D-3L, especially in moderate to severe dementia cases.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Multidisciplinary Sciences
Chun-Hsiang Yu, Sheng-Mao Chang, Chih-Hui Hsu, Sheng-Han Tsai, Xin-Min Liao, Chang-Wei Chen, Ching-Hsiung Lin, Jung-Der Wang, Tzuen-Ren Hsiue, Chiung-Zuei Chen
Summary: This study predicts the utility of the European Quality of Life-5 Dimensions (EQ-5D-3L) questionnaire from the chronic obstructive pulmonary disease (COPD) assessment test (CAT) using a multinomial logistic regression (MLR) model and response mapping. The MLR model performs as well as other models in terms of prediction accuracy. Bubble chart analysis suggests that the model developed in this study and the Mean Rank Method (MRM) may be better predictive models.
SCIENTIFIC REPORTS
(2022)
Article
Cell & Tissue Engineering
L. Z. Yapp, C. E. H. Scott, C. R. Howie, D. J. MacDonald, A. H. R. W. Simpson, N. D. Clement
Summary: This study aimed to report the meaningful values of EQ-5D-3L questionnaire and EQ-VAS in patients undergoing primary knee arthroplasty. The study found that EQ-5D-3L questionnaire demonstrated good internal consistency and determined the minimum clinically important difference for evaluating clinically relevant changes. The findings of this study are of significance for assessing postoperative changes in patients' quality of life.
BONE & JOINT RESEARCH
(2022)
Article
Health Care Sciences & Services
Bernhard Michalowsky, Wolfgang Hoffmann, Wiebke Mohr, Anika Raedke, Feng Xie
Summary: Assessing health-related quality of life (HRQoL) among persons with dementia is challenging. This study compared the psychometric properties of the EQ-5D-3L and EQ-5D-5L versions, and the differences in proxy ratings. The EQ-5D-5L demonstrated higher feasibility and acceptability, with a reduction in ceiling effects and improved informativity, discriminative ability, and convergent validity compared to the EQ-5D-3L.
HEALTH AND QUALITY OF LIFE OUTCOMES
(2022)
Article
Health Care Sciences & Services
Juan Zhu, Xin-Xin Yan, Cheng-Cheng Liu, Hong Wang, Le Wang, Su-Mei Cao, Xian-Zhen Liao, Yun-Feng Xi, Yong Ji, Lin Lei, Hai-Fan Xiao, Hai-Jing Guan, Wen-Qiang Wei, Min Dai, Wanqing Chen, Ju-Fang Shi
Summary: The study found that EQ-5D-5L has better discriminatory power and lower ceiling effect in cancer patients, which may be more suitable for assessing HRQoL.
QUALITY OF LIFE RESEARCH
(2021)
Article
Health Care Sciences & Services
Alex Bato, Valentin Brodszky, L. Hunor Gergely, Krisztian Gaspar, Norbert Wikonkal, Agnes Kinyo, Akos Szabo, Zsuzsanna Beretzky, Andrea Szegedi, Eva Remenyik, Norbert Kiss, Miklos Sardy, Fanni Rencz
Summary: The study aimed to compare the measurement properties of two adult versions of EQ-5D in patients with Hidradenitis suppurativa (HS), with EQ-5D-5L outperforming EQ-5D-3L in terms of feasibility, informativity, and validity for important clinical characteristics. EQ-5D-5L was recommended for assessing HS patients across various settings.
QUALITY OF LIFE RESEARCH
(2021)
Article
Health Policy & Services
Satar Rezaei, Abraha Woldemichael, Sina Ahmadi, Amjad Mohamadi Bolbanabad, Farman Zahir Abdullah, Bakhtiar Piroozi
Summary: This study compared the measurement properties of EQ-5D-3L and EQ-5D-5L in Iran, finding that the 5L version had lower celling effects, better convergent validity, known-groups validity, and efficiency compared to the 3L. The 5L index score showed higher relative efficiency in most conditions and the 5L classification system had higher Shannon index in all dimensions compared to the 3L.
INTERNATIONAL JOURNAL OF HEALTH PLANNING AND MANAGEMENT
(2021)
Article
Health Care Sciences & Services
Jie Jiang, Yanming Hong, Tiantian Zhang, Zhihao Yang, Tengfei Lin, Zhuoru Liang, Peiyao Lu, Lishun Liu, Binyan Wang, Yongmei Xu, Nan Luo
Summary: This study compared the measurement properties of EQ-5D-3L and EQ-5D-5L in hypertensive patients in rural China. The results showed that the 5L version had a lower ceiling effect and higher informativity compared to the 3L version, with good agreement between the two.
QUALITY OF LIFE RESEARCH
(2021)
Article
Oncology
Li-Fei Sun, Sheng Huang, Yun-Fen Li, Zhuang-Qing Yang, Xiao-Juan Yang, Jie-Ya Zou, Xiao-Wen Wang, Jian-Yun Nie
Summary: This study explored the factors influencing the health-related quality of life of spouses of breast cancer patients and the suitable questionnaires for assessment. The results showed that social support and cognition of the treatment effect were important factors influencing the health-related quality of life of spouses. The EQ-5D-3L questionnaire demonstrated good reliability and validity in measuring the quality of life of spouses of breast cancer patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Health Care Sciences & Services
Titi Sahidah Fitriana, Fredrick Dermawan Purba, Rina Rahmatika, Riski Muhaimin, Nur Melani Sari, Gouke Bonsel, Elly Stolk, Jan J. Busschbach
Summary: This study compared the measurement properties and responsiveness of EQ-5D-Y-3L and EQ-5D-Y-5L in pediatric patients. The results showed that the feasibility, convergent validity, and disease-specific measures were similar between the two versions, but EQ-5D-Y-5L had better test-retest reliability and sensitivity for detecting health changes.
HEALTH AND QUALITY OF LIFE OUTCOMES
(2021)
Article
Health Care Sciences & Services
Titi Sahidah Fitriana, Fredrick Dermawan Purba, Elly Stolk, Jan J. Busschbach
Summary: Background: Self-report is the standard method for measuring health-related quality of life (HRQoL) in children, but sometimes children are unable to report their own health. This study investigated the agreement between self-report and proxy-report measures of HRQoL in children using the EQ-5D-Y questionnaire. The study also explored the potential benefits of extending the response levels of the proxy questionnaire from 3 to 5.
HEALTH AND QUALITY OF LIFE OUTCOMES
(2022)
Article
Oncology
Nasrin Moradi, Thomas G. Poder, Hossein Safari, Mohammad M. Mojahedian, Hosein Ameri
Summary: This study aimed to test the validity and reliability of the EQ-5D-5L (5L) in cancer patients compared to EQ-5D-3L (3L). The results showed that compared to 3L, 5L performed better in terms of ceiling effect, inconsistency, discriminatory power, convergent validity, and relative efficiency.
FRONTIERS IN ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Alina Khabibullina, Ekaterina Aleksandrova, Christopher J. Gerry, Vasily Vlassov
Summary: This study systematically presents the EQ-5D-3L instrument and its characteristics among a representative sample of the Russian population. The results show that the instrument is sensitive to health experiences and mirrors many familiar characteristics, but also has Russian-specificities, particularly in the anxiety/depression dimension.
Article
Health Care Sciences & Services
Ting Zhou, Zhiyuan Chen, Hongchao Li, Feng Xie
Summary: The study identified significant discrepancies in using published health utilities for cardiovascular disease cost-utility analysis, mainly due to differences in description and value. Authors of such analyses are recommended to refer to original studies for health utilities and transparently explain their selection and incorporation process.
MEDICAL DECISION MAKING
(2021)
Article
Medicine, Research & Experimental
Ting Zhou, Yanan Sheng, Haijing Guan
Summary: The study compared the cost-effectiveness of vedolizumab with conventional therapy in patients with moderate-to-severe active Crohn's disease in China, finding that vedolizumab resulted in more quality-adjusted life years and lower costs over a lifetime horizon. Vedolizumab appeared to be a cost-effective strategy option for adult patients with moderate-to-severe active CD in China, in both anti-TNF-naive and anti-TNF-failure populations.
ADVANCES IN THERAPY
(2021)
Review
Public, Environmental & Occupational Health
Ting Zhou, Haijing Guan, Luying Wang, Yao Zhang, Mingjun Rui, Aixia Ma
Summary: The EQ-5D-5L is widely used to measure health-related quality of life in patients with different diseases worldwide. The variation in utility values for the same disease is influenced by patient characteristics, living environment, and the EQ-5D-5L value set.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Public, Environmental & Occupational Health
Ting Zhou, Yanan Sheng, Haijing Guan, Rui Meng, Zijing Wang
Summary: The study found that vedolizumab is a more cost-effective option compared to infliximab in the treatment of anti-TNF-alpha naive adult patients with moderate-to-severe active UC in China. Sensitivity analyses indicated that the annual discount rate and health-state costs had the greatest impact on the results.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Medicine, Research & Experimental
Ting Zhou, Yingdan Cao, Xintian Wang, Lan Yang, Zijing Wang, Aixia Ma, Hongchao Li
Summary: This study evaluated the cost-effectiveness of sintilimab plus bevacizumab versus sorafenib as a first-line treatment for unresectable hepatocellular carcinoma (HCC) in China. The results showed that sintilimab plus bevacizumab incurred higher lifetime costs but yielded more quality-adjusted life-years (QALYs) compared to sorafenib. The combination therapy was found to be a cost-effective option for patients with unresectable HCC in China.
ADVANCES IN THERAPY
(2022)
Article
Health Care Sciences & Services
Rui Meng, Xueke Zhang, Ting Zhou, Mengjie Luo, Yijin Qiu
Summary: This study evaluated the cost-effectiveness of donafenib compared with lenvatinib for first-line treatment of advanced HCC in China. The results showed that donafenib is a cost-effective strategy compared with lenvatinib.
EXPERT REVIEW OF PHARMACOECONOMICS & OUTCOMES RESEARCH
(2022)
Article
Public, Environmental & Occupational Health
Rui Meng, Yingdan Cao, Ting Zhou, Hongfei Hu, Yijin Qiu
Summary: This study assessed the cost effectiveness of donafenib compared with sorafenib for the treatment of patients with unresectable or metastatic HCC in China. The results showed that donafenib incurred a higher cost but yielded more quality-adjusted life years. Donafenib is unlikely to be cost effective compared with sorafenib.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Health Care Sciences & Services
Ting Zhou, Feng Xie
Summary: The study aims to assess the association between industry sponsorship and cost effectiveness analysis (CEA) results in oncology. The findings show that CEAs sponsored by the industry are more likely to report lower ICERs, indicating a sponsorship bias in CEA.
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2023)
Article
Health Care Sciences & Services
Menglu Che, Feng Xie, Stephanie Thomas, Eleanor Pullenayegum
Summary: This study compared different models for predicting the value sets of EQ-5D-5L and found that Bayesian models with spatial correlation and CALE models can improve the precision of the value sets.
MEDICAL DECISION MAKING
(2023)
Article
Oncology
Ting Zhou, Shuyue Wang, Yao Zhang, Runhui Wu, Hongchao Li
Summary: The study evaluates the cost-effectiveness of recombinant factor IX Fc fusion protein (rFIXFc) and recombinant factor IX (rFIX) for treating hemophilia B (HB) in China. A decision-analytic Markov model was used, with three health states: alive, surgery required, and dead. The model estimated the lifetime cost and quality-adjusted life-years (QALYs) of prophylaxis in childhood followed by on-demand treatment in adulthood for moderate-severe to severe HB patients from China's healthcare system perspective. The results show that rFIXFc is more cost-effective and provides more QALYs than rFIX for moderate-severe to severe HB in China.
PEDIATRIC BLOOD & CANCER
(2023)