Article
Endocrinology & Metabolism
Shan Cai, Jiajia Dang, Panliang Zhong, Ning Ma, Yunfei Liu, Di Shi, Zhiyong Zou, Yanhui Dong, Jun Ma, Yi Song
Summary: This study analyzed the sex differences in the prevalence of obesity phenotypes and their risk factors among children and adolescents in China. The results showed higher prevalence of obesity phenotypes in boys and identified various risk factors such as parental smoking, birth weight, and lifestyle factors. The findings highlight the importance of considering sex differences in managing obesity phenotypes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Nutrition & Dietetics
An Li, Zhi Tang, Peijun Zhu, Florien van den Bosch, Yuntao Chen, Shulan Xu, Geerten-Has E. Tjakkes
Summary: This study found a correlation between periodontitis and metabolic abnormalities in overweight and obese individuals. Periodontitis increased the risk of dyslipidemia and systemic inflammation, while also decreasing the levels of serum vitamins C and D in adults with overweight and obesity.
Review
Biochemistry & Molecular Biology
Sebastian Kwiatkowski, Anna Kajdy, Katarzyna Stefanska, Magdalena Bednarek-Jedrzejek, Sylwia Dzidek, Piotr Tousty, Malgorzata Sokolowska, Ewa Kwiatkowska
Summary: Obesity is a key factor in the development of preeclampsia, linked to adipose tissue pathologies and aberrant placental development. PPAR gamma plays a crucial role in both conditions, highlighting the importance of health education and physical activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nursing
Chiyoung Lee, Se Hee Min, Kosuke Niitsu
Summary: Despite agreement on the importance of the relationship between C-reactive protein (CRP) and depression, research findings have been inconsistent when considering gender differences. This study used a generalized additive model to analyze the shape of the CRP-depression relationship in men and women. The results showed a linear pattern in men and a curved association in women. The threshold effect was also observed in women, with depression severity increasing with CRP levels up to a certain point and then decreasing. These findings suggest that assuming linearity may not be appropriate for middle-aged obese women when studying the CRP-depression relationship.
Review
Nutrition & Dietetics
Xiaonan Zheng, Ruilin Peng, Hang Xu, Tianhai Lin, Shi Qiu, Qiang Wei, Lu Yang, Jianzhong Ai
Summary: This study presents pooled data comparing cancer risk between patients with metabolically healthy obesity (MHO) and metabolically unhealthy obesity (MUO), and found a lower cancer incidence for MHO phenotype regardless of population heterogeneity or the definitions of obesity and metabolic status.
FRONTIERS IN NUTRITION
(2022)
Article
Engineering, Environmental
Wanzhou Wang, Wenlou Zhang, Dayu Hu, Luyi Li, Liyan Cui, Junxiu Liu, Shan Liu, Junhui Xu, Shaowei Wu, Furong Deng, Xinbiao Guo
Summary: The study found that compared to normal-weight individuals, obese individuals were more susceptible to the negative effects of O-3 on metabolic status, possibly through inflammatory indicators such as leptin, eosinophils, and MCP-1.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Nutrition & Dietetics
Luigi Barrea, Giovanna Muscogiuri, Gabriella Pugliese, Giulia de Alteriis, Annamaria Colao, Silvia Savastano
Summary: This study found that compared to PCOS MHO patients, PCOS MUO patients have more severe metabolic parameters and higher inflammation levels, as well as lower adherence to the Mediterranean diet. Additionally, MUO patients also exhibit more severe hyperandrogenism and cardio-metabolic indices.
Review
Endocrinology & Metabolism
Melissa A. Burmeister, Tara E. Smith, Timothy K. Fincher, Abby J. Weldon
Summary: Obesity poses significant health risks and complications for millions of American adults. It can be classified into metabolically healthy and metabolically unhealthy categories. Metabolically unhealthy obesity is associated with symptoms of metabolic syndrome and gastroesophageal reflux disease (GERD), as well as poor dietary habits. The use of proton-pump inhibitors (PPIs) to treat GERD can adversely affect the gastrointestinal microbiota and lead to dysbiosis. This article discusses the impact of poor diet and PPI use on dysbiosis-induced metabolically unhealthy obesity (MUO) and explores the potential benefits of probiotics in mitigating these effects.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Ruziana Mona Wan Mohd Zin, Muhammad Yazid Jalaludin, Abqariyah Yahya, Ahmad Kamil Nur Zati Iwani, Fuziah Md Zain, Janet Yeow Hua Hong, Abdul Halim Mokhtar, Wan Nazaimoon Wan Mohamud
Summary: This study aimed to compare several parameters related to obesity between metabolically healthy obese (MHO) and metabolically unhealthy obese (MUO) children, and to examine the predictors associated with the MHO phenotype.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Shiori Kawai, Hajime Yamakage, Kazuhiko Kotani, Mitsuhiko Noda, Noriko Satoh-Asahara, Koshi Hashimoto
Summary: The study highlights the importance of adiponectin in maintaining metabolic homeostasis in individuals with metabolically healthy obesity (MHO). Both MHO and metabolically unhealthy obesity (MUO) groups exhibit chronic inflammation, and even individuals with MHO show anti-inflammatory responses during weight reduction therapy.
Review
Endocrinology & Metabolism
Junaid Iqbal, Hui-Xuan Wu, Muhammad Asad Nawaz, Hong-Li Jiang, Shi-Na Xu, Bi-Ling Huang, Long Li, Jun-Min Cai, Hou-De Zhou
Summary: This study evaluated the risk of developing chronic kidney disease in individuals with metabolically healthy obesity and metabolically unhealthy normal weight. The results show that obesity, regardless of metabolic health, increases the risk of chronic kidney disease.
Article
Nutrition & Dietetics
Matina Kouvari, Nathan M. D'Cunha, Thomas Tsiampalis, Manja Zec, Domenico Sergi, Nikolaj Travica, Wolfgang Marx, Andrew J. McKune, Demosthenes B. Panagiotakos, Nenad Naumovski
Summary: The aim of this study was to evaluate the association between metabolically healthy overweight/obesity (MHO) status and longitudinal cognitive function while considering the stability of the condition. The study found that maintaining a healthy metabolic status over time has a greater impact on cognitive function than body weight alone.
Article
Clinical Neurology
Song Heui Cho, Ji-Eun Lim, Jiseung Lee, Jee Soo Lee, Hyun-Ghang Jeong, Moon-Soo Lee, Young-Hoon Ko, Changsu Han, Byung-Joo Ham, Kyu-Man Han
Summary: This study found a significant association between high hsCRP levels and depressive symptoms, with a more prominent relationship observed in the non-geriatric population, males, obese adults, and those without aerobic physical activity.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Biochemistry & Molecular Biology
Carolina Gutierrez-Repiso, Teresa Maria Linares-Pineda, Andres Gonzalez-Jimenez, Francisca Aguilar-Lineros, Sergio Valdes, Federico Soriguer, Gemma Rojo-Martinez, Francisco J. Tinahones, Sonsoles Morcillo
Summary: This study found that DNA methylation status is associated with the stability/worsening of the MHO phenotype, identifying two potential biomarkers for transitioning to an unhealthy state and highlighting immune system-related pathways as therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Hong-Kyu Kim, Min Jung Lee, Eun Hee Kim, Sung-Jin Bae, Kyung Won Kim, Chul-Hee Kim
Summary: The study revealed that metabolically healthy phenotypes have higher-quality muscles, especially higher levels of normal attenuation muscle area (NAMA) and NAMA/TAMA index.
Article
Psychology, Clinical
Mickael Ehrminger, Paul Roux, Mathieu Urbach, Myrtille Andre, Bruno Aouizerate, Fabrice Berna, Anne-Lise Bohec, Delphine Capdevielle, Isabelle Chereau, Julie Clauss, Caroline Dubertret, Julien Dubreucq, Guillaume Fond, Roxana-Mihaela Honciuc, Christophe Lancon, Hakim Laouamri, Sylvain Leigner, Jasmina Mallet, David Misdrahi, Baptiste Pignon, Romain Rey, Franck Schurhoff, Christine Passerieux, Eric Brunet-Gouet
Summary: The determinants of quality of life (QoL) in schizophrenia are complex and interconnected. Better functioning, cognition, insight, and lower levels of depression and schizophrenic symptoms are associated with a higher QoL. Cognitive reserve indirectly influences QoL via cognition. The negative relationship between cognition and subjective QoL remains to be explained.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Psychiatry
D. Grillault Laroche, O. Godin, Y. Dansou, R. Belzeaux, B. Aouizerate, T. Burte, P. Courtet, C. Dubertret, E. Haffen, P. M. Llorca, E. Olie, P. Roux, M. Polosan, R. Schwan, M. Leboyer, F. Bellivier, C. Marie-Claire, B. Etain
Summary: The study found that psychiatric comorbidities and suicide attempts are highly prevalent in patients with Bipolar Disorder, and childhood maltreatment is associated with this. Patients with higher levels of childhood maltreatment are more likely to have multiple psychiatric comorbidities, which accumulate more rapidly before the onset of the disorder.
EUROPEAN PSYCHIATRY
(2022)
Article
Clinical Neurology
Ricard Navines, Giovanni Oriolo, Igor Horrillo, Myriam Cavero, Bruno Aouizerate, Martin Schaefer, Lucile Capuron, J. Javier Meana, Rocio Martin-Santos
Summary: This study found that serum S100B levels are associated with antidepressant response in MDD patients, even when considering inflammatory and metabolic markers.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Ines Delgado, Sofia Cussotto, Andrea Anesi, Sandra Dexpert, Agnes Aubert, Bruno Aouizerate, Cedric Beau, Damien Forestier, Patrick Ledaguenel, Eric Magne, Fulvio Mattivi, Lucile Capuron
Summary: This study found that chronic low-grade inflammation in obesity played an important role in depressive symptoms. One mechanism involved the effects of inflammation on tryptophan metabolism. High levels of high-sensitive C-reactive protein and low levels of indole-3-carboxaldehyde were associated with more severe depressive symptoms.
INTERNATIONAL JOURNAL OF OBESITY
(2022)
Article
Clinical Neurology
Aiste Lengvenyte, Bruno Aouizerate, Valerie Aubin, Josephine Loftus, Emeline Marlinge, Raoul Belzeaux, Caroline Dubertret, Sebastien Gard, Emmanuel Haffen, Raymund Schwan, Pierre-Michel Llorca, Christine Passerieux, Paul Roux, Mircea Polosan, Bruno Etain, Marion Leboyer, Philippe Courtet, Emilie Olie
Summary: This study found that violent suicide attempts were associated with abdominal obesity and poorer verbal memory in older age BD patients, with these factors mediating the association between male sex and violent suicide attempts. However, limitations of a cross-sectional design and retrospective reporting require further long-term studies to confirm these results.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Biochemistry & Molecular Biology
Luca Sforzini, Courtney Worrell, Melisa Kose, Ian M. Anderson, Bruno Aouizerate, Volker Arolt, Michael Bauer, Bernhard T. Baune, Pierre Blier, Anthony J. Cleare, Philip J. Cowen, Timothy G. Dinan, Andrea Fagiolini, I. Nicol Ferrier, Ulrich Hegerl, Andrew D. Krystal, Marion Leboyer, R. Hamish McAllister-Williams, Roger S. McIntyre, Andreas Meyer-Lindenberg, Andrew H. Miller, Charles B. Nemeroff, Claus Normann, David Nutt, Stefano Pallanti, Luca Pani, Brenda W. J. H. Penninx, Alan F. Schatzberg, Richard C. Shelton, Lakshmi N. Yatham, Allan H. Young, Roland Zahn, Georgios Aislaitner, Florence Butlen-Ducuing, Christine Fletcher, Marion Haberkamp, Thomas Laughren, Fanni-Laura Mantyla, Koen Schruers, Andrew Thomson, Gara Arteaga-Henriquez, Francesco Benedetti, Lucinda Cash-Gibson, Woo Ri Chae, Heidi De Smedt, Stefan M. Gold, Witte J. G. Hoogendijk, Valeria Jordan Mondragon, Eduard Maron, Jadwiga Martynowicz, Elisa Melloni, Christian Otte, Gabriela Perez-Fuentes, Sara Poletti, Mark E. Schmidt, Edwin van de Ketterij, Katherine Woo, Yanina Flossbach, J. Antoni Ramos-Quiroga, Adam J. Savitz, Carmine M. Pariante
Summary: The document discusses the criteria for treatment-resistant depression (TRD) and partially responsive depression (PRD) as subtypes of major depressive disorder (MDD) which are not clearly defined, using a Delphi-method-based consensus approach. It reviews literature and gathers international experts to evaluate controversies and provide recommendations on designing clinical trials and guiding research. It aims to support the design of a protocol for platform trials of new medications for TRD/PRD as part of the EUropean Patient-cEntric clinicAl tRial pLatforms, Innovative Medicines Initiative (EU-PEARL, IMI) MDD project.
MOLECULAR PSYCHIATRY
(2022)
Article
Psychiatry
Julien Dubreucq, Franck Gabayet, Ophelia Godin, Myrtille Andre, Bruno Aouizerate, Delphine Capdevielle, Isabelle Chereau, Julie Clauss-Kobayashi, Nathalie Coulon, Thierry D'Amato, Jean-Michel Dorey, Caroline Dubertret, Megane Faraldo, Hakim Laouamri, Sylvain Leigner, Christophe Lancon, Marion Leboyer, Pierre-Michel Llorca, Jasmina Mallet, David Misdrahi, Christine Passerieux, Romain Rey, Baptiste Pignon, Benoit Schorr, Mathieu Urbach, Franck Schurhoff, Andrei Szoke, Guillaume Fond, Fabrice Berna
Summary: Recovery is a multidimensional process aiming at living a meaningful life beyond mental illness, and this study found that clinical recovery and personal recovery predict each other over time. Psychosocial treatment should target subjective aspects such as personal recovery and depression in addition to clinical recovery to achieve full recovery.
SCHIZOPHRENIA BULLETIN
(2022)
Article
Psychiatry
Theo Korchia, Maud Tastevin, Pierre-Louis Sunhary De Verville, Ridha Joober, Christelle Andrieu-Haller, Melanie Faugere, Ophelia Godin, Damien Etchecopar-Etchart, Fabrice Berna, Bruno Aouizerate, Delphine Capdevielle, Isabelle Chereau, Julie Clauss-Kobayashi, Nathalie Coulon, Jean-Michel Dorey, Caroline Dubertret, Julien Dubreucq, Jasmina Mallet, David Misdrahi, Christine Passerieux, Romain Rey, Frank Schurhoff, Andrei Szoke, Mathieu Urbach, Marion Leboyer, Pierre-Michel Llorca, Christophe Lancon, Raphaelle Richieri, Laurent Boyer, Guillaume Fond
Summary: Motivation deficits are common in individuals with schizophrenia and are associated with impaired functioning and quality of life. Factors such as alcohol use disorder, severe nicotine dependence, history of suicide attempt, positive symptoms, current major depressive episode, sleep disorders, and lower medication adherence contribute to motivation deficits in schizophrenia.
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
(2022)
Article
Clinical Neurology
A. Garosi, P. L. Sunhary de Verville, D. Etchecopar-etchart, R. Richieri, O. Godin, F. Schurhoff, F. Berna, B. Aouizerate, D. Capdevielle, I. Chereau, J. Clauss-Kobayashi, J. M. Dorey, C. Dubertret, N. Coulon, S. Leignier, J. Mallet, D. Misdrahi, C. Passerieux, R. Rey, A. Szoke, M. Urbach, M. Leboyer, P. M. Llorca, C. Lancon, L. Boyer, G. Fond
Summary: The parent history of severe mental illness (PHSMI) may have long-term consequences in adult offspring. In this study, patients with PHSMI demonstrated better insight, a higher risk of childhood trauma, and more severe outcomes when compared to patients without PHSMI. Specifically, patients with a paternal history of severe mental illness experienced increased childhood abuse, comorbid major depression, and psychiatric hospitalizations.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2023)
Article
Neurosciences
P. A. Geoffroy, C. M. Schroder, P. Bourgin, J. Maruani, M. Lejoyeux, M. -P. d'Ortho, C. Couffignal, P. Philip, I. Arnulf, S. Royant-Parola, D. Leger, B. Gohier, F. Gagnadoux, A. Amad, I. Poirot, R. Gaillard, F. Limosin, R. Delorme, R. Jardri, P. Fossati, C. Dubertret, B. Rolland, B. Etain, F. Vorspan, B. Aouizerate, P. Courtet, J. L. Castroman, E. Haffen, D. Drapier, A. Dereux, R. Schwan, A. Luquiens, B. Abril, M. Auriacombe, A. Benyamina, R. Lopez, M. Grall-Bronnec, D. Bennabi, J. Frija-Masson, J. -A. Micoulaud Franchii, T. Schwitzer, J. -B. Maranci, U. K. Huck
Summary: To better identify biomarkers of sleep and biological rhythms and validate more homogeneous subgroups of patients with depressive disorders, a French national cohort was built. A Delphi process was conducted to achieve consensus and establish a validated data collection set of questionnaires to assess psychiatry, addiction, sleep, and chronobiology dimensions of depressive disorders.
ENCEPHALE-REVUE DE PSYCHIATRIE CLINIQUE BIOLOGIQUE ET THERAPEUTIQUE
(2023)
Article
Health Care Sciences & Services
Christiaan Vis, Josien Schuurmans, Bruno Aouizerate, Mette Atipei Craggs, Philip Batterham, Leah Buhrmann, Alison Calear, Arlinda Cerga Pashoja, Helen Christensen, Els Dozeman, Claus Duedal Pedersen, David Daniel Ebert, Anne Etzelmueller, Naim Fanaj, Tracy L. Finch, Denise Hanssen, Ulrich Hegerl, Adriaan Hoogendoorn, Kim Mathiasen, Carl May, Andia Meksi, Sevim Mustafa, Bridianne O'Dea, Caroline Oehler, Jordi Piera-Jimenez, Sebastian Potthoff, Gentiana Qirjako, Tim Rapley, Judith Rosmalen, Ylenia Sacco, Ludovic Samalin, Mette Maria Skjoth, Kristine Tarp, Ingrid Titzler, Erik Van der Eycken, Claire Rosalie van Genugten, Alexis Whitton, Enrico Zanalda, Jan H. Smit, Heleen Riper
Summary: This study compared the effectiveness of the ItFits-toolkit with implementation-as-usual in implementing iCBT services in routine mental health care organizations. The ItFits-toolkit performed better in supporting implementers in developing and applying effective tailored implementation strategies, but had a small effect on normalization levels among service providers.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2023)
Article
Clinical Neurology
O. Godin, B. Pignon, A. Szoke, L. Boyer, B. Aouizerate, B. Schorr, M. Andre, D. Capdevielle, I. Chereau, N. Coulon, R. Dassing, C. Dubertret, B. Etain, S. Leignier, P. M. Llorca, J. Mallet, D. Misdrahi, C. Passerieux, R. Rey, M. Urbach, F. Schuerhoff, M. Leboyer, G. Fond
Summary: By conducting a three-year study on patients with schizophrenia, it was found that there is a high incidence of metabolic syndrome (MetS), and smoking and antidepressant use are independent predictors of MetS onset. These results call for prioritizing MetS prevention and research in schizophrenia.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2023)
Article
Clinical Neurology
Julia Maruani, Fanny Moliere, Ophelia Godin, Antoine Yrondi, Djamila Bennabi., Raphaelle Richieri., Wissan El-Hage, Etienne Allauze, Loic Anguill, Alexandra Bouvard, Vincent Camus, Jean-Michel Dorey, Bruno Etain, Guillaume Fond, Jean-Baptiste Genty, Emmanuel Haffen, Jerome Holtzmann, Mathilde Horn, Francois Kazour, Anne-Sophie Nguon, Jean Petrucci, Romain Rey, Florian Stephan, Guillaume Vaiva, Michel Walter, Michel Lejoyeux, Marion Leboyer, Pierre-Michel Llorca, Philippe Courtet, Bruno Aouizerate, Pierre A. Geoffroy
Summary: Patients with treatment-resistant depression (TRD) are at risk of suicide. Sleep and circadian rhythm alterations, including excessive daytime sleepiness and daytime dysfunction, are predictors of suicidal ideations. Hypnotics intake is associated with a reduced risk of suicidal ideations in TRD patients.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Psychiatry
Benedicte Nobile, Raoul Belzeaux, Bruno Aouizerate, Caroline Dubertret, Emmanuel Haffen, Pierre-Michel Llorca, Paul Roux, Mircea Polosan, Raymund Schwan, Michel Walter, Romain Rey, Dominique Januel, Marion Leboyer, Frank Bellivier, Bruno Etain, Philippe Courtet, Emilie Olie
Summary: Suicidal ideation is a major suicide risk factor and it is important to identify individuals with such thoughts. Discrepancies between clinicians and patients' estimation of suicidal ideation can lead to under-evaluation of suicide risk. This study aimed to identify features associated with rating discrepancies in bipolar disorder patients.
PSYCHIATRY RESEARCH
(2023)
Article
Clinical Neurology
Guillaume Fond, Melanie Faugere, Laurent Boyer, Pauline Peri, Florian Stephan, Fanny Moliere, Loic Anguill, Djamila Bennabi, Emmanuel Haffen, Alexandra Bouvard, Michel Walter, Ludovic Samalin, Pierre Michel Llorca, Jean Baptiste Genty, Marion Leboyer, Jerome Holtzmann, Anne Sophie Nguon, Romain Rey, Mathilde Horna, Guillaume Vaiva, Vincent Hennion, Bruno Etain, Wissam El-Hage, Vincent Camus, Philippe Courtet, Bruno Aouizerate, Antoine Yrondi, Christophe Lancon, Raphaelle Richieri
Summary: This study investigated the prevalence of long-term use of benzodiazepines in patients with treatment-resistant depression (TRD) and found that persistent use of benzodiazepines was associated with worse mental health outcomes. Less than 5% of patients successfully withdrew from benzodiazepines during one-year follow-up. The study suggests that gradual and planned withdrawal of benzodiazepines should be recommended in TRD patients with long-term use, and alternative treatments should be promoted whenever possible.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2023)
Article
Endocrinology & Metabolism
Shanshan Xiao, Natalie C. Ebner, Amirhossein Manzouri, Tie-Qiang Li, Diana S. Cortes, Kristoffer N. T. Mansson, Hakan Fischer
Summary: The mechanisms through which intranasal oxytocin affects the brain are not fully understood, but recent research suggests that brain regions with a higher density of oxytocin receptors may play a key role. This study used resting-state fMRI to investigate the effects of intranasal oxytocin administration on connectivity between these receptor-enriched regions and other regions in the brain, and found that the effects varied depending on the age of the participants.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Lisa Haase, Antonia Vehlen, Julia Strojny, Gregor Domes
Summary: This study found no significant changes in the cortisol awakening response (CAR) over the menstrual cycle, and no significant association with variations in estradiol and progesterone. These results suggest that CAR is largely robust against hormonal variations across the menstrual cycle.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Derek Schaeuble, Tyler Wallace, Sebastian A. Pace, Shane T. Hentges, Brent Myers
Summary: Depression and cardiovascular disease are influenced by daily life stress, but the biological mechanisms behind this connection are not well understood. This study shows that the ventromedial prefrontal cortex (vmPFC) plays a role in regulating stress responses and behavior, with sex-specific effects. In males, the vmPFC-PH circuitry promotes positive motivation and reduces stress responses, while in females it elevates stress responses. This suggests that cortical regulation of stress reactivity and behavior is mediated by projections to the hypothalamus in a sex-specific manner.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Jose M. Guzman, Montana H. Boone, Gabriela L. Suarez, Colter Mitchell, Christopher S. Monk, Luke W. Hyde, Nestor L. Lopez-Duran
Summary: The COVID-19 pandemic has led to increased life stress and internalizing disorders, with a disproportionate impact on women. This study focused on the neuroendocrinology of stress-related disorders and found that women have lower cortisol responses and higher DHEA responses to stress. However, lower cortisol and higher DHEA are associated with internalizing disorders in women, while the opposite is true in men. The study also examined the relationship between COVID-related stress and internalizing symptoms and found gender differences in the association between DHEA and cortisol and internalizing outcomes. These findings suggest distinct neuroendocrine pathways for stress-related disorders in young men and women.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Meriah L. Dejoseph, Keira B. Leneman, Alyssa R. Palmer, Emily R. Padrutt, Otiti A. Mayo, Daniel Berry
Summary: Childhood and adolescence are critical periods for the development of the stress response system. This study found a modest positive relation between the adrenocortical and sympathetic systems, as well as between the adrenocortical and parasympathetic systems. The strength of these associations varied based on methodological and sociodemographic characteristics.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Qiong Xiang, Jia-Sheng Tao, Shuai Dong, Xiao-Lin Liu, Liang Yang, Li-Ni Liu, Jing Deng, Xian-Hui Li
Summary: Chronic hyperglycemia accelerates the pathological process of cognitive dysfunction, but the heterogeneity of hippocampal cells under long-term high glucose conditions is not well known. In this study, single-cell RNA sequencing was performed on diabetic mice, and distinct cell sub-clusters and important genes involved in neuroplasticity regulation were identified.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Roger Mcintosh, Hannah Hoogerwoerd, Salman S. Ahmad, Cassandra Michel, Kaitlyn Dillon, Mahendra Kumar, Gail Ironson
Summary: The study found that a 4-session guided written emotional disclosure intervention led to significant reductions in total output and concentration of epinephrine in urine for up to 6 months in individuals living with HIV. This effect was especially pronounced in women. However, there were no significant changes in norepinephrine output in urine.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Meredith Gruhn, Adam Bryant Miller, Tory A. Eisenlohr-Moul, Sophia Martin, Matthew G. Clayton, Matteo Giletta, Paul D. Hastings, Matthew K. Nock, Karen D. Rudolph, George M. Slavich, Mitchell J. Prinstein, Margaret A. Sheridan
Summary: This study investigates how early life adversity characterized by threat impacts the association between neural activity and cortisol production during emotion processing. The results suggest that threat exposure may moderate the relationship between neural activation and cortisol response.
PSYCHONEUROENDOCRINOLOGY
(2024)