Review
Obstetrics & Gynecology
Alice Beardmore-Gray, Paul T. Seed, Jessica Fleminger, Eva Zwertbroek, Thomas Bernardes, Ben W. Mol, Cheryl Battersby, Corine Koopmans, Kim Broekhuijsen, Kim Boers, Michelle Y. Owens, Jim Thornton, Marcus Green, Andrew H. Shennan, Henk Groen, Lucy C. Chappell
Summary: This individual participant data meta-analysis compared planned delivery to expectant management in women with preeclampsia. The results showed that planned delivery from 34 weeks gestation onward reduced the risk of maternal morbidity and the likelihood of the infant being born small for gestational age. However, it also increased the risk of short-term neonatal respiratory morbidity.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Obstetrics & Gynecology
Florence Cadoret, Paul Guerby, Marie Cavaignac-Vitalis, Christophe Vayssiere, Olivier Parant, Fabien Vidal
Summary: HELLP syndrome is a rare and severe pregnancy complication with controversial management strategies. Identifying baseline parameters predictive of disease evolution is crucial in determining the appropriate obstetrical approach for each patient.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2021)
Article
Medicine, General & Internal
Jiao Yi, Lei Chen, Xianglian Meng, Yi Chen
Summary: This study aimed to identify factors affecting expectant management of early-onset preeclampsia and evaluate the correlation between expectant treatment and fetal growth restriction. The duration of 24-h proteinuria showed a negative correlation with expectant treatment, but expectant treatment could not improve the occurrence of fetal growth restriction.
ANNALS OF MEDICINE
(2022)
Article
Peripheral Vascular Disease
Maged M. Costantine, Baha Sibai, Allan T. Bombard, Mark Sarno, Holly West, David M. Haas, Alan T. Tita, Michael J. Paidas, Erin A. S. Clark, Kim Boggess, Chad Grotegut, William Grobman, Emily J. Su, Irina Burd, George Saade, Martin R. Chavez, Michael J. Paglia, Audrey Merriam, Carlos Torres, Mounira Habli, Georges Macones, Tony Wen, James Bofill, Anna Palatnik, Rodney K. Edwards, Sina Haeri, Pankaj Oberoi, Amin Mazloom, Matthew Cooper, Steven Lockton, Gary D. Hankins
Summary: This study validates a novel multianalyte assay that is associated with the time to develop preeclampsia. The assay has moderate sensitivity and negative likelihood ratio but high negative predictive value when used as an aid to rule out preeclampsia within 7 days of enrollment.
Review
Obstetrics & Gynecology
Christos Chatzakis, Anastasios Liberis, Apostolos Zavlanos, Stamatis Petousis, Evangelia Tsakmaki, Konstantinos Dinas, Alexandros Sotiriadis
Summary: This study compared expectant management with immediate delivery in women with non-severe preeclampsia at the late preterm period. Immediate delivery increased the risk of neonatal intensive care unit (NICU) admission but decreased the risk of composite adverse maternal outcome.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2021)
Letter
Medicine, General & Internal
John van den Anker
Summary: This article discusses the management of patent ductus arteriosus (PDA) and finds that expectant management is noninferior to early ibuprofen treatment in preventing complications and death. However, the study did not consider the fact that a significant percentage of infants in both groups also received acetaminophen, which has been found to have similar effectiveness to ibuprofen for PDA closure.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Review
Peripheral Vascular Disease
Christina Antza, Stella Stabouli, Vasilios Kotsis
Summary: Hypertensive disorders of pregnancy, such as gestational hypertension, preeclampsia, and eclampsia, are a global health problem affecting over 10% of pregnancies and causing increased mortality and morbidity for both mothers and fetuses. In addition to the focus on patient outcomes and family experiences, the economic impact of this disease is also noteworthy. Compared to pregnancies without hypertension, those with hypertension require more hospitalizations and incur higher healthcare costs. Therefore, this article aims to analyze hypertensive disorders of pregnancy and provide practical tips for their clinical management.
JOURNAL OF HYPERTENSION
(2022)
Review
Obstetrics & Gynecology
Bhavisha A. Bakrania, Eric M. George, Joey P. Granger
Summary: Animal models play a critical role in investigating the pathogenesis and treatment options for preeclampsia. They allow researchers to study the detailed mechanisms of this disease and are important tools in the search for novel therapies.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Obstetrics & Gynecology
Aalok R. Sanjanwala, Victoria C. Jauk, Gabriella D. Cozzi, David A. Becker, Lorie M. Harper, Brian M. Casey, Alan T. Tita, Akila Subramaniam
Summary: The study aimed to compare outcomes in women with severe preeclampsia before and after the implementation of guidelines. The results showed that perinatal outcomes were similar before and after the implementation of severe preeclampsia management guidelines at the institution.
AMERICAN JOURNAL OF PERINATOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Julia Binder, Pilar Palmrich, Erkan Kalafat, Petra Pateisky, Ebru Oeztuerk, Johanna Mittelberger, Asma Khalil
Summary: This study evaluated the predictive value of the sFlt-1/PlGF ratio in women with chronic hypertension for delivery due to superimposed preeclampsia, finding that angiogenic imbalance can predict delivery related to superimposed preeclampsia and is associated with a significantly shorter time to delivery interval.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Peripheral Vascular Disease
Leandro De Oliveira, James M. Roberts, Arundhathi Jeyabalan, Kasey Blount, Christopher W. Redman, Lucilla Poston, Paul T. Seed, Lucy C. Chappell, Marcos Augusto Bastos Dias
Summary: The implementation of a risk stratification model based on biomarkers and clinical factors did not lead to reductions in preterm deliveries. Further training and development of additional risk stratification methods are needed before adopting this intervention into clinical practice.
Article
Peripheral Vascular Disease
Eva G. Mulder, Chahinda Ghossein-Doha, Ella Cauffman, Veronica A. Lopes van Balen, Veronique M. M. M. Schiffer, Robert-Jan Alers, Jolien Oben, Luc Smits, Sander M. J. van Kuijk, Marc E. A. Spaanderman
Summary: Tailored circulatory normalization of nonphysiological hemodynamic changes during pregnancy can reduce the risk of recurrent preeclampsia in high-risk populations. This simple and innovative treatment strategy shows no adverse effects on offspring outcomes.
Article
Obstetrics & Gynecology
Shenaz Ahmed, Alina Brewer, Eleni Z. Tsigas, Caryn Rogers, Lucy Chappell, Jenny Hewison
Summary: The research found that women with experience of hypertensive disorders were enthusiastic about improved predictive and diagnostic tests, although there were varied views about treatment options and expectant management. Most participants opted to put the baby's interests first.
BMC PREGNANCY AND CHILDBIRTH
(2021)
Article
Obstetrics & Gynecology
Geum Joon Cho, Un Suk Jung, Ho Yeon Kim, Soo Bin Lee, Minjeong Kim, Ki-Hoon Ahn, Sung Won Han, Soon-Cheol Hong, Hai-Joong Kim, Younghan Kim, Min-Jeong Oh
Summary: This study aimed to investigate the association between multiple gestations and hypertension later in life. The results showed that women with multiple gestations had a higher risk of developing hypertension compared to those with singleton gestations.
BMC PREGNANCY AND CHILDBIRTH
(2021)
Article
Pharmacology & Pharmacy
Zongli Ren, Ning Cui, Minglin Zhu, Raouf A. Khalil
Summary: The study suggests that placental ischemia-induced proinflammatory cytokines may be one of the causes of preeclampsia. Modulating cytokines and metalloproteinases can improve vascular and uteroplacental remodeling, alleviating symptoms of preeclampsia.
BIOCHEMICAL PHARMACOLOGY
(2021)
Review
Gastroenterology & Hepatology
Alexandra Guillaume, Ahmed E. Salem, Patricia Garcia, Bani Chander Roland
JOURNAL OF CLINICAL GASTROENTEROLOGY
(2017)
Review
Gastroenterology & Hepatology
Rajdeep Singh, Ahmed Salem, Julie Nanavati, Gerard E. Mullin
GASTROENTEROLOGY CLINICS OF NORTH AMERICA
(2018)
Review
Gastroenterology & Hepatology
Ahmed E. Salem, Rajdeep Singh, Younan K. Ayoub, Ahmed M. Khairy, Gerard E. Mullin
ARAB JOURNAL OF GASTROENTEROLOGY
(2018)
Article
Gastroenterology & Hepatology
Bani Chander Roland, Gerard E. Mullin, Monica Passi, Xi Zheng, Ahmed Salem, Robert Yolken, Pankaj Jay Pasricha
DIGESTIVE DISEASES AND SCIENCES
(2017)