Article
Clinical Neurology
Camilla Gelormini, Eleonora Ioannoni, Angela Scavone, Luca Pisapia, Francesco Signorelli, Nicola Montano, Marco Piastra, Anselmo Caricato
Summary: This study found that an increase in velocity in the middle cerebral artery (MCA) was associated with intracranial hypertension in traumatic brain injury (TBI) patients. Transcranial EcoDoppler (TCD) monitoring could be a useful method to detect and guide the therapy for this condition. It may serve as a tool for cause-oriented therapy of intracranial hypertension.
FRONTIERS IN NEUROLOGY
(2023)
Article
Biophysics
Jie Chen, Pei Dong, Kehui Dong, Dapeng Mo, Yilong Wang, Xingquan Zhao, Yongjun Wang, Xiping Gong
Summary: The study found that dynamic cerebral autoregulation was impaired in IIH patients, but improved after venous sinus stenting, suggesting that CA assessment could be useful in investigating hemodynamics in IIH patients.
PHYSIOLOGICAL MEASUREMENT
(2021)
Editorial Material
Endocrinology & Metabolism
Kyriaki Kostoglou, David M. Simpson, Stephen J. Payne
Summary: Studies have shown evidence of asymmetry in the response of cerebral autoregulation (CA) to increasing and decreasing pressure challenges. CA appears to be stronger during transient increases in arterial blood pressure and weaker during decreases. The measurement of this effect and its relevance in clinical settings remain questionable.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Article
Physiology
Arjen Mol, Carel G. M. Meskers, Marit L. Sanders, Martin Mueller, Andrea B. Maier, Richard J. A. van Wezel, Jurgen A. H. R. Claassen, Jan Willem J. Elting
Summary: The study assessed the criterion validity of cerebral autoregulation (CA) derived from near-infrared spectroscopy (NIRS) as an alternative to Transcranial Doppler (TCD). The results showed that NIRS-derived CA estimates were significantly correlated with TCD-derived CA estimates, but may not be sufficient for clinical application at the individual level.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Article
Clinical Neurology
Navpreet Reehal, Stephanie Cummings, Michael T. Mullen, Wesley B. Baker, David Kung, William Tackett, Christopher G. Favilla
Summary: This study compared cerebral autoregulation in all major cerebral vessels and found that while the time course of autoregulation was similar in all vessels, the magnitude of hemodynamic regulation was lower in the posterior cerebral artery. However, after adjusting for baseline flow differences, normalized gain was similar in all vessels.
FRONTIERS IN NEUROLOGY
(2021)
Article
Obstetrics & Gynecology
Marta M. Martinez-Martinez, Jorge Fernandez-Travieso, Nieves Gomez Munoz, Beatriz Varela Mezquita, Maria Luisa Almarcha-Menargues, Ambrosio Miralles Martinez
Summary: Patients with preeclampsia showed significantly higher intracranial artery mean velocities at diagnosis and within the first week postpartum, which normalized by day 30. Vasoconstriction was present in about one-third of preeclampsia cases, but mostly mild and asymptomatic. Severe preeclampsia was associated with vasoconstriction development.
PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH
(2021)
Article
Physiology
Emmett E. Whitaker, Abbie C. Johnson, Sarah M. Tremble, Conor McGinn, Nicole DeLance, Marilyn J. Cipolla
Summary: Preeclampsia, a hypertensive disorder during pregnancy, has long-term cardiovascular effects on both mothers and offspring. An experimental study found that preeclampsia affected the size and blood flow regulation of middle cerebral arteries in offspring, potentially influencing brain perfusion. The study also revealed that experimental preeclampsia may cause changes in the upper range of blood pressure in adult offspring.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Clinical Neurology
Baglan Mustafayev, Alina Mustafayeva, Askar Bakhtiyarov, Kuanysh Nikatov
Summary: Severe traumatic brain injury disrupts cerebral autoregulation, and mild TBI also impairs autoregulation. The use of non-invasive cross-spectral analysis can assess cerebral autoregulation, and about one-third of mild TBI patients require individualized treatment strategies.
NEUROSURGICAL REVIEW
(2023)
Review
Endocrinology & Metabolism
Jui-Lin Fan, Ricardo C. Nogueira, Patrice Brassard, Caroline A. Rickards, Matthew Page, Nathalie Nasr, Yu-Chieh Tzeng
Summary: This article discusses the importance of reperfusion treatment in acute ischemic stroke patients and highlights the impact of blood pressure on cerebral perfusion. It emphasizes the importance of effective blood pressure management in the early stages of stroke, and suggests that bedside monitoring of cerebral perfusion and oxygenation can help guide treatment and improve outcomes.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Article
Psychology, Biological
Weijun Zhang, Wen Fu, Luda Yan, Mengyu Wang, Baile Ning, Xiuyun Mo, Li Xiong, Jia Liu, Pandeng Zhang, Jingxin Zhong, Lu Sun, Wenbin Fu
Summary: The study found that impaired cerebral autoregulation (CA) was present in young adults with mild depression, and was negatively correlated with HAMD scores. The phase difference was identified as a valid indicator for identifying patients with depression, with a cutoff value of 29.66.
Article
Biochemistry & Molecular Biology
Vladimir Semenyutin, Valery Antonov, Galina Malykhina, Vyacheslav Salnikov
Summary: The authors conducted a study on the systemic and cerebral hemodynamics in various neurosurgical pathologies using signal processing methods. Their proposed method based on continuous wavelet transform shows higher sensitivity and better localization compared to traditional methods. This research is important for finding effective treatment solutions for patients with different pathologies.
Article
Cardiac & Cardiovascular Systems
Olivier Desebbe, Etienne Bachelard, Marie Deperdu, Romain Manet, Brenton Alexander, Johanne Beuvelot, Joseph Nloga, Alexandre Joosten, Laurent Gergele
Summary: Maintaining a mean arterial pressure within the range of cerebral autoregulation is important during cardiac surgery to prevent postoperative morbidity. This study compared a quick determination of the lower limit of cerebral autoregulation using a two second averaging period with the reference lower limit using a ten second averaging period. The results showed that the quick determination had a higher detection rate but had large limits of agreement and significant interobserver variability, limiting its clinical utility.
REVIEWS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Physiology
Lucy Beishon, Rebecca H. Clough, Meeriam Kadicheeni, Tamara Chithiramohan, Ronney B. Panerai, Victoria J. Haunton, Jatinder S. Minhas, Thompson G. Robinson
Summary: Global aging is increasing the burden of common age-related disorders, with cerebrovascular diseases playing a significant role. Understanding and promoting healthy vascular brain aging is becoming a growing priority for healthcare systems. Normal aging affects cerebral autoregulation and neurovascular coupling processes, leading to physiological adaptations that mitigate age-related declines.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2021)
Review
Pharmacology & Pharmacy
Alwyn Gomez, Logan Froese, Amanjyot Singh Sainbhi, Carleen Batson, Frederick A. Zeiler
Summary: The study explores the association of continuous time-domain TCD based indices of cerebrovascular reactivity with global functional outcomes, cerebral physiologic correlates, and imaging evidence of lesion change. The findings suggest that these indices have prognostic utility following TBI. Indices based on mean flow velocities have the largest body of literature support, but recent studies indicate that indices based on systolic flow velocities may have the most prognostic utility and closely follow established measures of cerebrovascular reactivity.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Obstetrics & Gynecology
Lina Bergman, Catherine Cluver, Niclas Carlberg, Michael Belfort, Mary C. Tolcher, Ronney B. Panerai, Teelkien van Veen
Summary: Dynamic cerebral autoregulation and cerebral perfusion pressure are altered in pregnancies complicated by preeclampsia, which may be important in the pathophysiological pathway and constitute a therapeutic target in the prevention of cerebral complications in preeclampsia.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)