Journal
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
Volume 132, Issue -, Pages 30-33Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.plefa.2018.03.001
Keywords
Adiponectin; Insulin resistance; Linoleic acid; Monounsaturated fat; Polyunsaturated fat; Saturated fat
Funding
- Ohio Agriculture Research and Development Center
- Carol S. Kennedy endowed professorship (MAB)
- Carol S. Kennedy endowed professorship (College of Education & Human Ecology, OSU)
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Dietary fat quality, especially the intake of specific types of fatty acids, impacts the risk of many chronic diseases, including cardiovascular diseases, certain cancers and type 2 diabetes (T2DM). A recent pooled analysis involving 20 studies from around the world revealed that higher linoleic acid (18:2n-6 LA) biomarker is associated with dose-dependent decreases in the incidence of T2DM. This latest study corroborates earlier cross-sectional studies and intervention trials showing that biomarkers of LA intake are associated with reduced risk of T2DM and better glycemic control and/or insulin sensitivity. This review highlights key clinical trials that have evaluated the role of LA in glycemia and the related condition, insulin sensitivity.
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