Zyxin promotes colon cancer tumorigenesis in a mitotic phosphorylation-dependent manner and through CDK8-mediated YAP activation
Published 2018 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Zyxin promotes colon cancer tumorigenesis in a mitotic phosphorylation-dependent manner and through CDK8-mediated YAP activation
Authors
Keywords
-
Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 115, Issue 29, Pages E6760-E6769
Publisher
Proceedings of the National Academy of Sciences
Online
2018-07-03
DOI
10.1073/pnas.1800621115
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Cyclin-dependent kinase 1 (CDK1)-mediated mitotic phosphorylation of the transcriptional co-repressor Vgll4 inhibits its tumor-suppressing activity
- (2017) Yongji Zeng et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Cofilin – a protein controlling dynamics of actin filaments
- (2017) Zofia Ostrowska et al. Postepy Higieny I Medycyny Doswiadczalnej
- Intraoperative radiation therapy for colon and rectal cancers: a clinical review
- (2017) Michael G. Haddock Radiation Oncology
- LIM kinases: cofilin and beyond
- (2017) Chloé Prunier et al. Oncotarget
- MST2 phosphorylation at serine 385 in mitosis inhibits its tumor suppressing activity
- (2016) Xingcheng Chen et al. CELLULAR SIGNALLING
- Osmotic stress‐induced phosphorylation by NLK at Ser128 activates YAP
- (2016) Audrey W Hong et al. EMBO REPORTS
- Phosphorylation by NLK inhibits YAP‐14‐3‐3‐interactions and induces its nuclear localization
- (2016) Sungho Moon et al. EMBO REPORTS
- Mechanisms of Hippo pathway regulation
- (2016) Zhipeng Meng et al. GENES & DEVELOPMENT
- Ajuba Phosphorylation by CDK1 Promotes Cell Proliferation and Tumorigenesis
- (2016) Xingcheng Chen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Discovery of Potent, Selective, and Orally Bioavailable Small-Molecule Modulators of the Mediator Complex-Associated Kinases CDK8 and CDK19
- (2016) Aurélie Mallinger et al. JOURNAL OF MEDICINAL CHEMISTRY
- The Hippo pathway in intestinal regeneration and disease
- (2016) Audrey W. Hong et al. Nature Reviews Gastroenterology & Hepatology
- Cytokinesis involves a nontranscriptional function of the Hippo pathway effector YAP
- (2016) Duyen Amy Bui et al. Science Signaling
- Development of a Potent, Specific CDK8 Kinase Inhibitor Which Phenocopies CDK8/19 Knockout Cells
- (2016) Michael F. T. Koehler et al. ACS Medicinal Chemistry Letters
- Zyxin-Siah2–Lats2 axis mediates cooperation between Hippo and TGF-β signalling pathways
- (2016) Biao Ma et al. Nature Communications
- Assessing the mechanism and therapeutic potential of modulators of the human Mediator complex-associated protein kinases
- (2016) Paul A Clarke et al. eLife
- Cytokinesis involves a nontranscriptional function of the Hippo pathway effector YAP
- (2016) Duyen Amy Bui et al. Science Signaling
- CDK8 kinase—An emerging target in targeted cancer therapy
- (2015) Tomasz Rzymski et al. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
- ERG Activates the YAP1 Transcriptional Program and Induces the Development of Age-Related Prostate Tumors
- (2015) Liem T. Nguyen et al. CANCER CELL
- Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer
- (2015) Fa-Xing Yu et al. CELL
- Zyxin Antagonizes the FERM Protein Expanded to Couple F-Actin and Yorkie-Dependent Organ Growth
- (2015) Pedro Gaspar et al. CURRENT BIOLOGY
- Cdk8deletion in theApcMinmurine tumour model represses EZH2 activity and accelerates tumourigenesis
- (2015) Mark L McCleland et al. JOURNAL OF PATHOLOGY
- The Hippo Pathway Effector YAP Regulates Motility, Invasion, and Castration-Resistant Growth of Prostate Cancer Cells
- (2015) Lin Zhang et al. MOLECULAR AND CELLULAR BIOLOGY
- Tumor-selective proteotoxicity of verteporfin inhibits colon cancer progression independently of YAP1
- (2015) Huabing Zhang et al. Science Signaling
- Skp2–MacroH2A1–CDK8 axis orchestrates G2/M transition and tumorigenesis
- (2015) Dazhi Xu et al. Nature Communications
- Active YAP promotes pancreatic cancer cell motility, invasion and tumorigenesis in a mitotic phosphorylation-dependent manner through LPAR3
- (2015) Shuping Yang et al. Oncotarget
- Tumor-selective proteotoxicity of verteporfin inhibits colon cancer progression independently of YAP1
- (2015) Huabing Zhang et al. Science Signaling
- Mutant Gq/11 Promote Uveal Melanoma Tumorigenesis by Activating YAP
- (2014) Fa-Xing Yu et al. CANCER CELL
- Hippo-Independent Activation of YAP by the GNAQ Uveal Melanoma Oncogene through a Trio-Regulated Rho GTPase Signaling Circuitry
- (2014) Xiaodong Feng et al. CANCER CELL
- Hippo Coactivator YAP1 Upregulates SOX9 and Endows Esophageal Cancer Cells with Stem-like Properties
- (2014) S. Song et al. CANCER RESEARCH
- Tead2 expression levels control the subcellular distribution of Yap and Taz, zyxin expression and epithelial-mesenchymal transition
- (2014) M. Diepenbruck et al. JOURNAL OF CELL SCIENCE
- Angiomotins link F-actin architecture to Hippo pathway signaling
- (2014) Sebastian Mana-Capelli et al. MOLECULAR BIOLOGY OF THE CELL
- PhosphoSitePlus, 2014: mutations, PTMs and recalibrations
- (2014) Peter V. Hornbeck et al. NUCLEIC ACIDS RESEARCH
- Multiplex genome engineering in human cells using all-in-one CRISPR/Cas9 vector system
- (2014) Tetsushi Sakuma et al. Scientific Reports
- CDK1 Phosphorylation of YAP Promotes Mitotic Defects and Cell Motility and Is Essential for Neoplastic Transformation
- (2013) S. Yang et al. CANCER RESEARCH
- A Mechanical Checkpoint Controls Multicellular Growth through YAP/TAZ Regulation by Actin-Processing Factors
- (2013) Mariaceleste Aragona et al. CELL
- Phosphorylation of Angiomotin by Lats1/2 Kinases Inhibits F-actin Binding, Cell Migration, and Angiogenesis
- (2013) Xiaoming Dai et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Requirement for Cyclin D Function in Tumor Maintenance
- (2012) Yoon Jong Choi et al. CANCER CELL
- Signaling mechanisms and functional roles of cofilin phosphorylation and dephosphorylation
- (2012) Kensaku Mizuno CELLULAR SIGNALLING
- Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP
- (2012) Y. Liu-Chittenden et al. GENES & DEVELOPMENT
- Cell detachment activates the Hippo pathway via cytoskeleton reorganization to induce anoikis
- (2012) B. Zhao et al. GENES & DEVELOPMENT
- KIBRA Regulates Aurora Kinase Activity and Is Required for Precise Chromosome Alignment During Mitosis
- (2012) Lin Zhang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- YAP induces malignant mesothelioma cell proliferation by upregulating transcription of cell cycle-promoting genes
- (2012) T Mizuno et al. ONCOGENE
- CDK8 regulates E2F1 transcriptional activity through S375 phosphorylation
- (2012) J Zhao et al. ONCOGENE
- Hippo signalling in the G2/M cell cycle phase: Lessons learned from the yeast MEN and SIN pathways
- (2012) Alexander Hergovich et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Actin-Capping Protein and the Hippo pathway regulate F-actin and tissue growth in Drosophila
- (2011) B. G. Fernandez et al. DEVELOPMENT
- Modulating F-actin organization induces organ growth by affecting the Hippo pathway
- (2011) Leticia Sansores-Garcia et al. EMBO JOURNAL
- KIBRA Protein Phosphorylation Is Regulated by Mitotic Kinase Aurora and Protein Phosphatase 1
- (2011) Ling Xiao et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- KIBRA Regulates Hippo Signaling Activity via Interactions with Large Tumor Suppressor Kinases
- (2011) Ling Xiao et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Zyxin Links Fat Signaling to the Hippo Pathway
- (2011) Cordelia Rauskolb et al. PLOS BIOLOGY
- The Hippo Signaling Pathway in Development and Cancer
- (2010) Duojia Pan DEVELOPMENTAL CELL
- The histone variant macroH2A suppresses melanoma progression through regulation of CDK8
- (2010) Avnish Kapoor et al. NATURE
- Rac1 Activation Controls Nuclear Localization of β-catenin during Canonical Wnt Signaling
- (2008) Ximei Wu et al. CELL
- Mechanical forces facilitate actin polymerization at focal adhesions in a zyxin-dependent manner
- (2008) H. Hirata et al. JOURNAL OF CELL SCIENCE
- E2F1 represses β-catenin transcription and is antagonized by both pRB and CDK8
- (2008) Erick J. Morris et al. NATURE
- CDK8 is a colorectal cancer oncogene that regulates β-catenin activity
- (2008) Ron Firestein et al. NATURE
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now