Interrelated role of Klotho and calcium-sensing receptor in parathyroid hormone synthesis and parathyroid hyperplasia

α-Klotho is a non-enzymatic molecular scaffold for FGF23 hormone signalling

(2018) Gaozhi Chen et al.   NATURE

Parathyroid hormone controls paracellular Ca2+transport in the thick ascending limb by regulating the tight-junction protein Claudin14

(2017) Tadatoshi Sato et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Persistent fibroblast growth factor 23 signalling in the parathyroid glands for secondary hyperparathyroidism in mice with chronic kidney disease

(2017) Kazuki Kawakami et al.   Scientific Reports

Parathyroid hormone 1 receptor is essential to induce FGF23 production and maintain systemic mineral ion homeostasis

(2016) Yi Fan et al.   FASEB JOURNAL

Diphtheria Toxin- and GFP-Based Mouse Models of Acquired Hypoparathyroidism and Treatment With a Long-Acting Parathyroid Hormone Analog

(2016) Ruiye Bi et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980–2015: a systematic analysis for the Global Burden of Disease Study 2015

(2016) Haidong Wang et al.   LANCET

α-Klotho Expression in Human Tissues

(2015) Kenneth Lim et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

α-Klotho protects against oxidative damage in pulmonary epithelia

(2014) Priya Ravikumar et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

New functional aspects of the extracellular calcium-sensing receptor

(2014) Hakan R. Toka   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Molecular interactions of FGF23 and PTH in phosphate regulation

(2014) Beate Lanske et al.   KIDNEY INTERNATIONAL

Parathyroid hormone activates the orphan nuclear receptor Nurr1 to induce FGF23 transcription

(2014) Tomer Meir et al.   KIDNEY INTERNATIONAL

Analysis of a-Klotho, Fibroblast Growth Factor-, Vitamin-D and Calcium-Sensing Receptor in 70 Patients with Secondary Hyperparathyroidism

(2013) Joerg Latus et al.   KIDNEY & BLOOD PRESSURE RESEARCH

Decreased Parathyroid Klotho Expression Is Associated With Persistent Hyperparathyroidism After Kidney Transplantation

(2013) Y.A. Hong et al.   TRANSPLANTATION PROCEEDINGS

Parathyroid-Specific Deletion of Klotho Unravels a Novel Calcineurin-Dependent FGF23 Signaling Pathway That Regulates PTH Secretion

(2013) Hannes Olauson et al.   PLoS Genetics

Deficiency of the Calcium-Sensing Receptor in the Kidney Causes Parathyroid Hormone-Independent Hypocalciuria

(2012) H. R. Toka et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Update on fibroblast growth factor 23 in chronic kidney disease

(2012) Myles Wolf   KIDNEY INTERNATIONAL

Parathyroid hormone receptor signaling in osteocytes increases the expression of fibroblast growth factor-23 in vitro and in vivo

(2011) Yumie Rhee et al.   BONE

The pathophysiology of early-stage chronic kidney disease-mineral bone disorder (CKD-MBD) and response to phosphate binders in the rat

(2011) Sharon M Moe et al.   JOURNAL OF BONE AND MINERAL RESEARCH

The secretory response of parathyroid hormone to acute hypocalcemia in vivo is independent of parathyroid glandular sodium/potassium-ATPase activity

(2011) Giedre Martuseviciene et al.   KIDNEY INTERNATIONAL

Klotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule

(2010) Ming Chang Hu et al.   FASEB JOURNAL

Parathyroid Klotho and FGF-receptor 1 expression decline with renal function in hyperparathyroid patients with chronic kidney disease and kidney transplant recipients

(2010) Tijana Krajisnik et al.   KIDNEY INTERNATIONAL

Klotho Prevents Renal Calcium Loss

(2009) R. T. Alexander et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Depressed expression of Klotho and FGF receptor 1 in hyperplastic parathyroid glands from uremic patients

(2009) Hirotaka Komaba et al.   KIDNEY INTERNATIONAL

Long-Term Outcome after Total Parathyroidectomy for the Management of Secondary Hyperparathyroidism

(2009) Sylvia Stracke et al.   NEPHRON CLINICAL PRACTICE

Amelioration of the premature ageing-like features ofFgf-23knockout mice by genetically restoring the systemic actions of FGF-23

(2008) S DeLuca et al.   JOURNAL OF PATHOLOGY

Fibroblast Growth Factor 23 and Mortality among Patients Undergoing Hemodialysis

(2008) Orlando M. Gutiérrez et al.   NEW ENGLAND JOURNAL OF MEDICINE

Development and progression of secondary hyperparathyroidism in chronic kidney disease: lessons from molecular genetics

(2007) William G. Goodman et al.   KIDNEY INTERNATIONAL