Journal
POLYMER DEGRADATION AND STABILITY
Volume 147, Issue -, Pages 123-131Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.polymdegradstab.2017.11.023
Keywords
N-isopropylacrylamide; beta-Cydodextrin; Thermo/pH-responsive hydrogels; Controlled release
Categories
Funding
- National Natural Science Foundation of China [31200719]
- Science and Technology Plans of Tianjin [15PTSYJC00250]
- Applied Basic Research and Advanced Technology Programs of Science and Technology Commission Foundation of Tianjin [15JCYBJC18300]
- Tianjin Science Technology Research Funds of China [16JCZDJC37500]
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The lack of identified binding sites for drugs and the undegradability limited the development of the thermosensitive hydrogels based on N-isopropylacrylamide (NIPAAm) in the intelligent drug delivery system (DDS). Therefore, the poly (Maleic anhydride-beta-cyclodextrin-co-NIPAAm) (poly (MAH-beta-CD-co-NIPAAm)) hydrogels were obtained to overcome these disadvantages. beta-cyclodextrin (beta-CD) with the drug inclusion properties and degradation capacity was modified by maleic anhydride (MAH) and the resultant monomer was fixed in the gel network by a series of polymerization reactions. The physical and chemical properties of the monomer and the poly (MAH-beta-CD-co-NIPAAm) hydrogels were systemically investigated. The swelling/deswelling kinetics at different temperature and pH indicated that the gels exhibit dual responsiveness. The model drug naproxen sodium was identified by MAN-beta-CD, so it was efficiently loaded on the hydrogels. The drug released in a controlled manner from the copolymerization hydrogels, especially displayed slower release efficiency in simulates stomach conditions. And these hydrogels also showed biodegradability in the presence of a-amylase. The above facts demonstrated that the poly (MAH-beta-CD-co-NIPAAm) hydrogels was an effective oral drug system.
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