Biomimetic antimicrobial polymers: recent advances in molecular design

The effects of polymer topology and chain length on the antimicrobial activity and hemocompatibility of amphiphilic ternary copolymers

(2018) Rashin Namivandi-Zangeneh et al.   Polymer Chemistry

Self-immolative nanoparticles for simultaneous delivery of microRNA and targeting of polyamine metabolism in combination cancer therapy

(2017) Ying Xie et al.   JOURNAL OF CONTROLLED RELEASE

Rational Design of Membrane-Pore-Forming Peptides

(2017) Max Pillong et al.   Small

Influence of lipid composition of model membranes on methacrylate antimicrobial polymer–membrane interactions

(2017) Upayan Baul et al.   Soft Matter

Pro-Antimicrobial Networks via Degradable Acetals (PANDAs) Using Thiol–Ene Photopolymerization

(2017) Dahlia N. Amato et al.   ACS Macro Letters

Cationic acrylate oligomers comprising amino acid mimic moieties demonstrate improved antibacterial killing efficiency

(2017) James L. Grace et al.   Journal of Materials Chemistry B

Bactericidal Peptidomimetic Polyurethanes with Remarkable Selectivity against Escherichia coli

(2017) Steven Mankoci et al.   ACS Biomaterials-Science & Engineering

Rational Design of Single-Chain Polymeric Nanoparticles That Kill Planktonic and Biofilm Bacteria

(2017) Thuy-Khanh Nguyen et al.   ACS Infectious Diseases

Hydrophilic Phage-Mimicking Membrane Active Antimicrobials Reveal Nanostructure-Dependent Activity and Selectivity

(2017) Yunjiang Jiang et al.   ACS Infectious Diseases

Bactericidal Peptidomimetic Polyurethanes with Remarkable Selectivity against Escherichia coli

(2017) Steven Mankoci et al.   ACS Biomaterials Science & Engineering

Polycarbonates with Potent and Selective Antimicrobial Activity toward Gram-Positive Bacteria

(2016) Alekhya Nimmagadda et al.   BIOMACROMOLECULES

Side Chain Degradable Cationic–Amphiphilic Polymers with Tunable Hydrophobicity Show in Vivo Activity

(2016) Divakara S. S. M. Uppu et al.   BIOMACROMOLECULES

Modulating Antimicrobial Activity and Mammalian Cell Biocompatibility with Glucosamine-Functionalized Star Polymers

(2016) Edgar H. H. Wong et al.   BIOMACROMOLECULES

Cyclization and unsaturation rather than isomerisation of side chains govern the selective antibacterial activity of cationic-amphiphilic polymers

(2016) D. S. S. M. Uppu et al.   CHEMICAL COMMUNICATIONS

Developments in antimicrobial polymers

(2016) Wei Ren et al.   JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY

Recent Developments in Antimicrobial Polymers: A Review

(2016) Madson Santos et al.   Materials

Antibacterial low molecular weight cationic polymers: dissecting the contribution of hydrophobicity, chain length and charge to activity

(2016) James L. Grace et al.   RSC Advances

Stimuli-responsive dendrimers in drug delivery

(2016) Hui Wang et al.   Biomaterials Science

Combating multidrug-resistant Gram-negative bacteria with structurally nanoengineered antimicrobial peptide polymers

(2016) Shu J. Lam et al.   Nature Microbiology

Self-Immolative Poly(4,5-dichlorophthalaldehyde) and its Applications in Multi-Stimuli-Responsive Macroscopic Plastics

(2015) Anthony M. DiLauro et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Helical cationic antimicrobial peptide length and its impact on membrane disruption

(2015) Melanie L. Juba et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Antimicrobial Peptide Mimicking Primary Amine and Guanidine Containing Methacrylamide Copolymers Prepared by Raft Polymerization

(2015) Sarah E. Exley et al.   BIOMACROMOLECULES

High Efficiency Antimicrobial Thiazolium and Triazolium Side-Chain Polymethacrylates Obtained by Controlled Alkylation of the Corresponding Azole Derivatives

(2015) Rubén Tejero et al.   BIOMACROMOLECULES

Effect of Relative Arrangement of Cationic and Lipophilic Moieties on Hemolytic and Antibacterial Activities of PEGylated Polyacrylates

(2015) Ashish Punia et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Surface-Accessible Detection Units in Self-Immolative Polymers Enable Translation of Selective Molecular Detection Events into Amplified Responses in Macroscopic, Solid-State Plastics

(2015) Kimy Yeung et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Antibacterial Activity of Geminized Amphiphilic Cationic Homopolymers

(2015) Hui Wang et al.   LANGMUIR

APD3: the antimicrobial peptide database as a tool for research and education

(2015) Guangshun Wang et al.   NUCLEIC ACIDS RESEARCH

Controlling macromolecular structures towards effective antimicrobial polymers

(2015) Mitra S. Ganewatta et al.   POLYMER

Correlating antimicrobial activity and model membrane leakage induced by nylon-3 polymers and detergents

(2015) Sara G. Hovakeemian et al.   Soft Matter

Structure–property relationships of antibacterial amphiphilic polymers derived from 2-aminoethyl acrylate

(2015) Ashish Punia et al.   RSC Advances

Nonhemolytic and Antibacterial Acrylic Copolymers with Hexamethyleneamine and Poly(ethylene glycol) Side Chains

(2015) Ashish Punia et al.   ACS Macro Letters

Biodegradable Antimicrobial Polycarbonates with In Vivo Efficacy against Multidrug-Resistant MRSA Systemic Infection

(2015) Junchi Cheng et al.   Advanced Healthcare Materials

Long Hydrophilic-and-Cationic Polymers: A Different Pathway toward Preferential Activity against Bacterial over Mammalian Membranes

(2014) Xin Yang et al.   BIOMACROMOLECULES

Cationic Methacrylate Polymers as Topical Antimicrobial Agents against Staphylococcus aureus Nasal Colonization

(2014) Laura M. Thoma et al.   BIOMACROMOLECULES

Effect of glycounits on the antimicrobial properties and toxicity behavior of polymers based on quaternized DMAEMA

(2014) Marta Álvarez-Paino et al.   BIOMACROMOLECULES

Cationic amphiphilic non-hemolytic polyacrylates with superior antibacterial activity

(2014) Ashish Punia et al.   CHEMICAL COMMUNICATIONS

Design of Aromatic-Containing Cell-Penetrating Peptide Mimics with Structurally Modified π Electronics

(2014) Brittany M. deRonde et al.   CHEMISTRY-A EUROPEAN JOURNAL

Interaction of multiple biomimetic antimicrobial polymers with model bacterial membranes

(2014) Upayan Baul et al.   JOURNAL OF CHEMICAL PHYSICS

Polyglyoxylates: A Versatile Class of Triggerable Self-Immolative Polymers from Readily Accessible Monomers

(2014) Bo Fan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Antimicrobial Metallopolymers and Their Bioconjugates with Conventional Antibiotics against Multidrug-Resistant Bacteria

(2014) Jiuyang Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ternary Nylon-3 Copolymers as Host-Defense Peptide Mimics: Beyond Hydrophobic and Cationic Subunits

(2014) Saswata Chakraborty et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Antimicrobial Polycarbonates: Investigating the Impact of Nitrogen-Containing Heterocycles as Quaternizing Agents

(2014) Victor Wee Lin Ng et al.   MACROMOLECULES

Mechanically triggered heterolytic unzipping of a low-ceiling-temperature polymer

(2014) Charles E. Diesendruck et al.   Nature Chemistry

Learning from Host-Defense Peptides: Cationic, Amphipathic Peptoids with Potent Anticancer Activity

(2014) Wei Huang et al.   PLoS One

RAFT-derived antimicrobial polymethacrylates: elucidating the impact of end-groups on activity and cytotoxicity

(2014) Thomas D. Michl et al.   Polymer Chemistry

Cationic amphipathic D-enantiomeric antimicrobial peptides with in vitro and ex vivo activity against drug-resistant Mycobacterium tuberculosis

(2014) Yun Lan et al.   TUBERCULOSIS

Continuous Head-to-Tail Depolymerization: An Emerging Concept for Imparting Amplified Responses to Stimuli-Responsive Materials

(2014) Scott T. Phillips et al.   ACS Macro Letters

Guanylated Polymethacrylates: A Class of Potent Antimicrobial Polymers with Low Hemolytic Activity

(2013) Katherine E. S. Locock et al.   BIOMACROMOLECULES

Molecular Design, Structures, and Activity of Antimicrobial Peptide-Mimetic Polymers

(2013) Haruko Takahashi et al.   MACROMOLECULAR BIOSCIENCE

End-Capped Poly(benzyl ethers): Acid and Base Stable Polymers That Depolymerize Rapidly from Head-to-Tail in Response to Specific Applied Signals

(2013) Michael G. Olah et al.   MACROMOLECULES

Reproducible and Scalable Synthesis of End-Cap-Functionalized Depolymerizable Poly(phthalaldehydes)

(2013) Anthony M. DiLauro et al.   MACROMOLECULES

A Critical Evaluation of Random Copolymer Mimesis of Homogeneous Antimicrobial Peptides

(2013) Kan Hu et al.   MACROMOLECULES

Biodegradable Broad-Spectrum Antimicrobial Polycarbonates: Investigating the Role of Chemical Structure on Activity and Selectivity

(2013) Willy Chin et al.   MACROMOLECULES

Bacterial programmed cell death: making sense of a paradox

(2013) Kenneth W. Bayles   NATURE REVIEWS MICROBIOLOGY

Enhancement of Cationic Antimicrobial Materials via Cholesterol Incorporation

(2013) Daniel J. Coady et al.   Advanced Healthcare Materials

Self-Powered Microscale Pumps Based on Analyte-Initiated Depolymerization Reactions

(2012) Hua Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Single-Giant Unilamellar Vesicle Method Reveals Lysenin-Induced Pore Formation in Lipid Membranes Containing Sphingomyelin

(2012) Jahangir Md. Alam et al.   BIOCHEMISTRY

Determining the mechanism of membrane permeabilizing peptides: Identification of potent, equilibrium pore-formers

(2012) Aram J. Krauson et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Cationic Spacer Arm Design Strategy for Control of Antimicrobial Activity and Conformation of Amphiphilic Methacrylate Random Copolymers

(2012) Edmund F. Palermo et al.   BIOMACROMOLECULES

Design and Synthesis of Self-Degradable Antibacterial Polymers by Simultaneous Chain- and Step-Growth Radical Copolymerization

(2012) Masato Mizutani et al.   BIOMACROMOLECULES

Controlled Depolymerization: Stimuli-Responsive Self-Immolative Polymers

(2012) Gregory I. Peterson et al.   MACROMOLECULES

Emerging trends in macromolecular antimicrobials to fight multi-drug-resistant infections

(2012) Amanda C. Engler et al.   Nano Today

Amphipathic antibacterial agents using cationic methacrylic polymers with natural rosin as pendant group

(2012) Ying Chen et al.   RSC Advances

Antibacterial Studies of Cationic Polymers with Alternating, Random, and Uniform Backbones

(2011) Airong Song et al.   ACS Chemical Biology

Amplified release through the stimulus triggered degradation of self-immolative oligomers, dendrimers, and linear polymers

(2011) Andrew D. Wong et al.   ADVANCED DRUG DELIVERY REVIEWS

Investigations of the Interactions between Synthetic Antimicrobial Polymers and Substrate-Supported Lipid Bilayers Using Sum Frequency Generation Vibrational Spectroscopy

(2011) Christopher W. Avery et al.   ANALYTICAL CHEMISTRY

Self-Activation in De Novo Designed Mimics of Cell-Penetrating Peptides

(2011) Abhigyan Som et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Block versus Random Amphiphilic Copolymers as Antibacterial Agents

(2011) Yukari Oda et al.   BIOMACROMOLECULES

Triggered Release from Polymer Capsules

(2011) Aaron P. Esser-Kahn et al.   MACROMOLECULES

Antibiotic activities of host defense peptides: more to it than lipid bilayer perturbation

(2011) Miriam Wilmes et al.   NATURAL PRODUCT REPORTS

Biodegradable nanostructures with selective lysis of microbial membranes

(2011) Fredrik Nederberg et al.   Nature Chemistry

Designing antimicrobial peptides: form follows function

(2011) Christopher D. Fjell et al.   NATURE REVIEWS DRUG DISCOVERY

Polymeric materials with antimicrobial activity

(2011) Alexandra Muñoz-Bonilla et al.   PROGRESS IN POLYMER SCIENCE

Structural determinants of antimicrobial activity in polymers which mimic host defense peptides

(2010) Edmund F. Palermo et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Antimicrobial polymers: mechanism of action, factors of activity, and applications

(2010) Larisa Timofeeva et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Probing the “Charge Cluster Mechanism” in Amphipathic Helical Cationic Antimicrobial Peptides

(2010) Raquel F. Epand et al.   BIOCHEMISTRY

Investigating the effects of L- to D-amino acid substitution and deamidation on the activity and membrane interactions of antimicrobial peptide anoplin

(2010) Amy Won et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Escherichia coliCell Surface Perturbation and Disruption Induced by Antimicrobial Peptides BP100 and pepR

(2010) Carla S. Alves et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of Cationic Group Structure in Membrane Binding and Disruption by Amphiphilic Copolymers

(2010) Edmund F. Palermo et al.   JOURNAL OF PHYSICAL CHEMISTRY B

A reduction sensitive cascade biodegradable linear polymer

(2010) Matthew A. Dewit et al.   JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY

Programmable Microcapsules from Self-Immolative Polymers

(2010) Aaron P. Esser-Kahn et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Orientation, Dynamics, and Lipid Interaction of an Antimicrobial Arylamide Investigated by19F and31P Solid-State NMR Spectroscopy

(2010) Yongchao Su et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Revealing the Lytic Mechanism of the Antimicrobial Peptide Gomesin by Observing Giant Unilamellar Vesicles

(2010) Tatiana M. Domingues et al.   LANGMUIR

Kinetics of antimicrobial peptide activity measured on individual bacterial cells using high-speed atomic force microscopy

(2010) Georg E. Fantner et al.   Nature Nanotechnology

Sequence-controlled polymerizations: the next Holy Grail in polymer science?

(2010) Jean-François Lutz   Polymer Chemistry

De Novo Design of Antimicrobial Polymers, Foldamers, and Small Molecules: From Discovery to Practical Applications

(2009) Gregory N. Tew et al.   ACCOUNTS OF CHEMICAL RESEARCH

Dependence of Antimicrobial Selectivity and Potency on Oligomer Structure Investigated Using Substrate Supported Lipid Bilayers and Sum Frequency Generation Vibrational Spectroscopy

(2009) Christopher W. Avery et al.   ANALYTICAL CHEMISTRY

Lipid Segregation Explains Selective Toxicity of a Series of Fragments Derived from the Human Cathelicidin LL-37

(2009) R. F. Epand et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Rapid and Reliable Detection of Antimicrobial Peptide Penetration into Gram-Negative Bacteria Based on Fluorescence Quenching

(2009) M. Benincasa et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Chemical Structure of Cationic Groups in Amphiphilic Polymethacrylates Modulates the Antimicrobial and Hemolytic Activities

(2009) Edmund F. Palermo et al.   BIOMACROMOLECULES

Hydrophilic Modifications of an Amphiphilic Polynorbornene and the Effects on its Hemolytic and Antibacterial Activity

(2009) Semra Colak et al.   BIOMACROMOLECULES

Synthetic Mimics of Antimicrobial Peptides-A Versatile Ring-Opening Metathesis Polymerization Based Platform for the Synthesis of Selective Antibacterial and Cell-Penetrating Polymers

(2009) Karen Lienkamp et al.   CHEMISTRY-A EUROPEAN JOURNAL

“Doubly Selective” Antimicrobial Polymers: How Do They Differentiate between Bacteria?

(2009) Karen Lienkamp et al.   CHEMISTRY-A EUROPEAN JOURNAL

Structure and Mode of Action of Microplusin, a Copper II-chelating Antimicrobial Peptide from the Cattle TickRhipicephalus(Boophilus)microplus

(2009) Fernanda D. Silva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Different mechanisms of action of antimicrobial peptides: insights from fluorescence spectroscopy experiments and molecular dynamics simulations

(2009) Gianfranco Bocchinfuso et al.   JOURNAL OF PEPTIDE SCIENCE

A Cascade Biodegradable Polymer Based on Alternating Cyclization and Elimination Reactions

(2009) Matthew A. DeWit et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structure−activity Relationships among Random Nylon-3 Copolymers That Mimic Antibacterial Host-Defense Peptides

(2009) Brendan P. Mowery et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Insight into the Mechanism of Antimicrobial Poly(phenylene ethynylene) Polyelectrolytes: Interactions with Phosphatidylglycerol Lipid Membranes†† Langmuir 25th Year: Molecular and macromolecular self-assemblies

(2009) Liping Ding et al.   LANGMUIR

Structure–function relationships in peptoids: Recent advances toward deciphering the structural requirements for biological function

(2009) Sarah A. Fowler et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Beyond NMR spectra of antimicrobial peptides: Dynamical images at atomic resolution and functional insights

(2009) Ayyalusamy Ramamoorthy   SOLID STATE NUCLEAR MAGNETIC RESONANCE

Antibacterial and Hemolytic Activities of Pyridinium Polymers as a Function of the Spatial Relationship between the Positive Charge and the Pendant Alkyl Tail

(2008) Varun Sambhy et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Toroidal pores formed by antimicrobial peptides show significant disorder

(2008) Durba Sengupta et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Investigating the Effect of Increasing Charge Density on the Hemolytic Activity of Synthetic Antimicrobial Polymers

(2008) Zoha M. AL-Badri et al.   BIOMACROMOLECULES

Synthetic mimics of antimicrobial peptides

(2008) Abhigyan Som et al.   BIOPOLYMERS

The Role of Hydrophobicity in the Antimicrobial and Hemolytic Activities of Polymethacrylate Derivatives

(2008) Kenichi Kuroda et al.   CHEMISTRY-A EUROPEAN JOURNAL

Comparison of Facially Amphiphilic versus Segregated Monomers in the Design of Antibacterial Copolymers

(2008) Gregory J. Gabriel et al.   CHEMISTRY-A EUROPEAN JOURNAL

Bad Bugs, No Drugs: No ESKAPE! An Update from the Infectious Diseases Society of America

(2008) Helen W. Boucher et al.   CLINICAL INFECTIOUS DISEASES

Dual Mechanism of Bacterial Lethality for a Cationic Sequence-Random Copolymer that Mimics Host-Defense Antimicrobial Peptides

(2008) Raquel F. Epand et al.   JOURNAL OF MOLECULAR BIOLOGY

Bacterial Membranes as Predictors of Antimicrobial Potency

(2008) Richard M. Epand et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Antimicrobial Polymers Prepared by ROMP with Unprecedented Selectivity: A Molecular Construction Kit Approach

(2008) Karen Lienkamp et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Self-Immolative Polymers

(2008) Amit Sagi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Antibacterial and Hemolytic Activities of Quaternary Pyridinium Functionalized Polynorbornenes

(2008) Tarik Eren et al.   MACROMOLECULAR CHEMISTRY AND PHYSICS

APD2: the updated antimicrobial peptide database and its application in peptide design

(2008) Guangshun Wang et al.   NUCLEIC ACIDS RESEARCH